| Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents. | Kir2.1 Interactome Mapping Uncovers PKP4 as a Modulator of the Kir2.1-Regulated Inward Rectifier Potassium Currents.
Park SS, Ponce-Balbuena D, Kuick R, Guerrero-Serna G, Yoon J, Mellacheruvu D, Conlon KP, Basrur V, Nesvizhskii AI, Jalife J, Rual JF., Free PMC Article | 06/19/2021 |
| p0071 is required for directional vesicle movement and secretion of different KIF3-transported carriers, thereby regulating the transport of intracellular membrane vesicles along microtubules. | The armadillo protein p0071 controls KIF3 motor transport.
Becher A, Eiseler T, Porzner M, Walther P, Keil R, Bobrovich S, Hatzfeld M, Seufferlein T. | 05/26/2018 |
| Data show that patients with both abnormal expression of p0071 and E-cadherin had a statistically significant shorter survival than the patients without both abnormal expression. | p0071 interacts with E-cadherin in the cytoplasm so as to promote the invasion and metastasis of non-small cell lung cancer.
Zhao H, Zhang D, Yang L, Wang E. | 12/23/2017 |
| p0071 has a key role in regulating recycling through the Rab11a-dependent perinuclear recycling compartment. | The armadillo protein p0071 is involved in Rab11-dependent recycling.
Keil R, Hatzfeld M. | 08/23/2014 |
| This review article focuses on the functions of the p0071 protein and its closest relatives in regulating cell adhesion and cytoskeletal organization, which are critically involved in the control of cell polarity. [review] | p0071/PKP4, a multifunctional protein coordinating cell adhesion with cytoskeletal organization.
Keil R, Schulz J, Hatzfeld M. | 02/1/2014 |
| Findings suggest that aspects of folliculin tumour suppressor function are linked to interaction with p0071 and the regulation of RhoA signalling. | Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis.
Nahorski MS, Seabra L, Straatman-Iwanowska A, Wingenfeld A, Reiman A, Lu X, Klomp JA, Teh BT, Hatzfeld M, Gissen P, Maher ER., Free PMC Article | 06/1/2013 |
| These data support a model in which dysregulation of the FLCN-p0071 interaction leads to alterations in cell adhesion, cell polarity, and RhoA signaling. | Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion.
Medvetz DA, Khabibullin D, Hariharan V, Ongusaha PP, Goncharova EA, Schlechter T, Darling TN, Hofmann I, Krymskaya VP, Liao JK, Huang H, Henske EP., Free PMC Article | 04/27/2013 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| The structural and functional roles of p0071 are suggested by its preferential occurrence in distinct tubule segments, and its potential use as a cytodiagnostic cell type marker in renal pathology is discussed. | Protein p0071, an armadillo plaque protein of adherens junctions, is predominantly expressed in distal renal tubules.
Walter B, Krebs U, Berger I, Hofmann I. | 04/12/2010 |
| Data indicate that p0071 and Ect2 are transported via distinct motors and identify a novel pathway implicating KIF3 in the regulation of actin organization during cytokinesis. | Targeting of p0071 to the midbody depends on KIF3.
Keil R, Kiessling C, Hatzfeld M. | 01/21/2010 |
| Protein p0071 has been localized as a plaque protein in adhaerens junctions of diverse epithelia and certain vascular endothelia. | Protein p0071, a major plaque protein of non-desmosomal adhering junctions, is a selective cell-type marker.
Hofmann I, Kuhn C, Franke WW. | 01/21/2010 |
| Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. | Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW. | 01/28/2009 |
| Observational study of gene-disease association. (HuGE Navigator) | Replication of a genome-wide case-control study of esophageal squamous cell carcinoma.
Ng D, Hu N, Hu Y, Wang C, Giffen C, Tang ZZ, Han XY, Yang HH, Lee MP, Goldstein AM, Taylor PR., Free PMC Article | 09/24/2008 |
| These findings support an essential role for p0071 in spatially regulating restricted Rho signalling during cytokinesis. | The armadillo protein p0071 regulates Rho signalling during cytokinesis.
Wolf A, Keil R, Götzl O, Mun A, Schwarze K, Lederer M, Hüttelmaier S, Hatzfeld M. | 01/21/2010 |
| ERBIN interacts in vivo with p0071 and that it may be involved in the organization of adherens junctions and the desmosomes of epithelia | ERBIN associates with p0071, an armadillo protein, at cell-cell junctions of epithelial cells.
Izawa I, Nishizawa M, Tomono Y, Ohtakara K, Takahashi T, Inagaki M. | 01/21/2010 |
| p0071 bound to the first 160 amino-terminal residues of desmoplakin and also interacted directly with plakoglobin, suggesting that p0071 may regulate desmosome assembly by controlling plakoglobin availability | Comparative analysis of armadillo family proteins in the regulation of a431 epithelial cell junction assembly, adhesion and migration.
Setzer SV, Calkins CC, Garner J, Summers S, Green KJ, Kowalczyk AP. | 01/21/2010 |
| In addition to plakoglobin, p0071 is the second armadillo protein present in both types of adhesive junctions and may play a role in regulating crosstalk between adherens junctions and desmosomes. | Targeting of p0071 to desmosomes and adherens junctions is mediated by different protein domains.
Hatzfeld M, Green KJ, Sauter H. | 01/21/2010 |
| In this review p0071 catenin, a close relative of p120 catenin, associates and regulates RhoA-GTPase at the cleavage furrow during cytokinesis. | Beyond regulation of cell adhesion: local control of RhoA at the cleavage furrow by the p0071 catenin.
Keil R, Wolf A, Hüttelmaier S, Hatzfeld M. | 01/21/2010 |