| Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins has been reported. | Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins.
Miliara X, Tatsuta T, Berry JL, Rouse SL, Solak K, Chorev DS, Wu D, Robinson CV, Matthews S, Langer T., Free PMC Article | 04/6/2019 |
| crystal structure of Ups1-Mdm35 bound with a phosphatidic acid (PA) molecule at 2.0 A resolution; study reveals molecular basis of Ups1-Mdm35-mediated PA binding and transfer and sheds new light on mechanism of intramitochondrial lipid transport by MSF1/PRELI family proteins | Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex.
Yu F, He F, Yao H, Wang C, Wang J, Li J, Qi X, Xue H, Ding J, Zhang P., Free PMC Article | 04/23/2016 |
| The Ups1-Mdm35 complex constitutes a single domain that has a deep pocket and flexible Omega-loop lid. A basic residue at the pocket bottom and the Omega-loop lid are important for phosphatidic acid extraction from the membrane following Ups1 binding. | Structural and mechanistic insights into phospholipid transfer by Ups1-Mdm35 in mitochondria.
Watanabe Y, Tamura Y, Kawano S, Endo T., Free PMC Article | 04/16/2016 |
| PS is transferred from the mitochondrial outer membrane to the inner membrane independently of Psd1p, Ups1p, and Ups2p and decarboxylated to PE by Psd1p in the inner membrane | Phosphatidylethanolamine biosynthesis in mitochondria: phosphatidylserine (PS) trafficking is independent of a PS decarboxylase and intermembrane space proteins UPS1P and UPS2P.
Tamura Y, Onguka O, Itoh K, Endo T, Iijima M, Claypool SM, Sesaki H., Free PMC Article | 03/2/2013 |
| study identified Ups1 as a lipid transfer protein that can shuttle phosphatidic acid between mitochondrial membranes; lipid transfer required the dynamic assembly of Ups1 with Mdm35 and allowed conversion of phosphatidic acid to cardiolipin in the inner membrane | Intramitochondrial transport of phosphatidic acid in yeast by a lipid transfer protein.
Connerth M, Tatsuta T, Haag M, Klecker T, Westermann B, Langer T. | 12/8/2012 |
| Data suggest that Ups1p and Up2p proteins may function in phospholipid trafficking between the outer and inner mitochondrial membranes. | Role for two conserved intermembrane space proteins, Ups1p and Ups2p, [corrected] in intra-mitochondrial phospholipid trafficking.
Tamura Y, Onguka O, Hobbs AE, Jensen RE, Iijima M, Claypool SM, Sesaki H., Free PMC Article | 08/4/2012 |
| The authors show that Ups1, Ups2 and Ups3 protein import is mediated by another mitochondrial intermembrane space protein, Mdm35p. | Mdm35p imports Ups proteins into the mitochondrial intermembrane space by functional complex formation.
Tamura Y, Iijima M, Sesaki H., Free PMC Article | 10/4/2010 |
| The authors identified Mdm35, a member of the twin Cx9C protein family, as a novel interaction partner of Ups1 and Ups2. | Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35.
Potting C, Wilmes C, Engmann T, Osman C, Langer T., Free PMC Article | 10/4/2010 |
| Data report that two homologous intermembrane space proteins, Ups1p and Ups2p, control cardiolipin metabolism and affect the assembly state of TIM23 and its association with PAM in an opposing manner. | Ups1p and Ups2p antagonistically regulate cardiolipin metabolism in mitochondria.
Tamura Y, Endo T, Iijima M, Sesaki H., Free PMC Article | 01/21/2010 |
| deletion strains, ylr193cDelta/ylr193cDelta, yor305wDelta/yor305wDelta, and ypr170cDelta/ypr170cDelta, mate at very low frequencies with haploids of either or both MATa/MATalpha mating types. | Single-gene deletions that restore mating competence to diploid yeast.
Schmidlin T, Kaeberlein M, Kudlow BA, MacKay V, Lockshon D, Kennedy BK. | 01/21/2010 |
| The UPS1 protein is a novel mitochondrial protein required for the unique processing of Mgm1p and for normal mitochondrial shape. | Ups1p, a conserved intermembrane space protein, regulates mitochondrial shape and alternative topogenesis of Mgm1p.
Sesaki H, Dunn CD, Iijima M, Shepard KA, Yaffe MP, Machamer CE, Jensen RE., Free PMC Article | 01/21/2010 |