| RPS12 and UBC4 Are Related to Senescence Signal Production in the Ribosomal RNA Gene Cluster. | RPS12 and UBC4 Are Related to Senescence Signal Production in the Ribosomal RNA Gene Cluster.
Yanagi S, Iida T, Kobayashi T., Free PMC Article | 05/28/2022 |
| Together, these data point to an important role for Tom1, Ubc4 and Ubc5 in normal physiology and prompt the authors to refer to this pathway as ERISQ, for excess ribosomal protein quality control. | A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins.
Sung MK, Porras-Yakushi TR, Reitsma JM, Huber FM, Sweredoski MJ, Hoelz A, Hess S, Deshaies RJ., Free PMC Article | 10/28/2017 |
| the UBA domain of Ubc1 ensures efficient polyubiquitination of substrate by balancing Ubc1 affinity with that of Ubc4 | An E2 accessory domain increases affinity for the anaphase-promoting complex and ensures E2 competition.
Girard JR, Tenthorey JL, Morgan DO., Free PMC Article | 01/16/2016 |
| Rad25 turnover requires the ubiquitin-conjugating enzyme Ubc4 and the ubiquitin ligase Ufd4. | Rad25 protein is targeted for degradation by the Ubc4-Ufd4 pathway.
Bao X, Johnson JL, Rao H., Free PMC Article | 06/6/2015 |
| The major ubiquitin ligase targeting the superfluous Fas2 subunit to the proteasome is Ubr1. The ubiquitin-conjugating enzymes Ubc2 and Ubc4 assist the degradation process. | Quality control of a cytoplasmic protein complex: chaperone motors and the ubiquitin-proteasome system govern the fate of orphan fatty acid synthase subunit Fas2 of yeast.
Scazzari M, Amm I, Wolf DH., Free PMC Article | 05/9/2015 |
| Ubc4 and Ubc5 are 1) the primary E2s for Rsp5 in yeast and 2) act as monoubiquitinating E2s in RING E3-catalyzed pathways | The essential Ubc4/Ubc5 function in yeast is HECT E3-dependent, and RING E3-dependent pathways require only monoubiquitin transfer by Ubc4.
Stoll KE, Brzovic PS, Davis TN, Klevit RE., Free PMC Article | 07/16/2011 |
| Data suggest that regular turnover of Cdc17 via Ubc4 and Not4 is required for proper cell proliferation. | Ubc4 and Not4 regulate steady-state levels of DNA polymerase-α to promote efficient and accurate DNA replication.
Haworth J, Alver RC, Anderson M, Bielinsky AK., Free PMC Article | 02/26/2011 |
| Gap1 was removed from the plasma membrane in the presence of ethanol in a Rsp5-dependent manner, and that the disappearance of Gap1 required Ubc4 and involved the lysine residues of ubiquitin. | A functional analysis of the yeast ubiquitin ligase Rsp5: the involvement of the ubiquitin-conjugating enzyme Ubc4 and poly-ubiquitination in ethanol-induced down-regulation of targeted proteins.
Hiraishi H, Okada M, Ohtsu I, Takagi H. | 02/8/2010 |
| Data demonstrated that excess histones associate with Rad53, and also identified Ubc4 and Ubc5, as well as Tom1 as enzymes involved in the ubiquitylation of excess histones. | Histone levels are regulated by phosphorylation and ubiquitylation-dependent proteolysis.
Singh RK, Kabbaj MH, Paik J, Gunjan A., Free PMC Article | 01/21/2010 |
| Ubc4 is required for Chf2-dependent G(1) cell cycle delay. | Yeast Chfr homologs retard cell cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-dependent ubiquitination.
Loring GL, Christensen KC, Gerber SA, Brenner C., Free PMC Article | 01/21/2010 |
| These results show that Not4p functions as an E3 ligase by modulating Ubc4p/Ubc5p-mediated stress responses in vivo. | Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger-dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae.
Mulder KW, Inagaki A, Cameroni E, Mousson F, Winkler GS, De Virgilio C, Collart MA, Timmers HT., Free PMC Article | 01/21/2010 |
| Saccharomyces cerevisiae Ub-conjugating enzyme Ubc4 binds the proteasome in the presence of translationally damaged proteins. | Saccharomyces cerevisiae Ub-conjugating enzyme Ubc4 binds the proteasome in the presence of translationally damaged proteins.
Chuang SM, Madura K., Free PMC Article | 01/21/2010 |
| These results point to Ubc4p as an important enzyme in the process of cell wall remodelling in myo1 cells. | Dosage rescue by UBC4 restores cell wall integrity in Saccharomyces cerevisiae lacking the myosin type II gene MYO1.
Díaz-Blanco NL, Rodríguez-Medina JR., Free PMC Article | 01/21/2010 |