| The Atg1 complex, Atg9, and Vac8 recruit PI3K complex I to the pre-autophagosomal structure. | The Atg1 complex, Atg9, and Vac8 recruit PI3K complex I to the pre-autophagosomal structure.
Hitomi K, Kotani T, Noda NN, Kimura Y, Nakatogawa H., Free PMC Article | 07/14/2023 |
| The RNA polymerase II subunit Rpb9 activates ATG1 transcription and autophagy. | The RNA polymerase II subunit Rpb9 activates ATG1 transcription and autophagy.
Huang T, Jiang G, Zhang Y, Lei Y, Liu S, Li H, Lu K., Free PMC Article | 11/12/2022 |
| Post-transcriptional regulation of ATG1 is a critical node that modulates autophagy during distinct nutrient stresses. | Post-transcriptional regulation of ATG1 is a critical node that modulates autophagy during distinct nutrient stresses.
Lahiri V, Metur SP, Hu Z, Song X, Mari M, Hawkins WD, Bhattarai J, Delorme-Axford E, Reggiori F, Tang D, Dengjel J, Klionsky DJ., Free PMC Article | 07/23/2022 |
| Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation. | Multilayered regulation of autophagy by the Atg1 kinase orchestrates spatial and temporal control of autophagosome formation.
Schreiber A, Collins BC, Davis C, Enchev RI, Sedra A, D'Antuono R, Aebersold R, Peter M., Free PMC Article | 02/19/2022 |
| Vacuolar protein Tag1 and Atg1-Atg13 regulate autophagy termination during persistent starvation in S. cerevisiae. | Vacuolar protein Tag1 and Atg1-Atg13 regulate autophagy termination during persistent starvation in S. cerevisiae.
Kira S, Noguchi M, Araki Y, Oikawa Y, Yoshimori T, Miyahara A, Noda T. | 07/24/2021 |
| Function of the SNARE Ykt6 on autophagosomes requires the Dsl1 complex and the Atg1 kinase complex. | Function of the SNARE Ykt6 on autophagosomes requires the Dsl1 complex and the Atg1 kinase complex.
Gao J, Kurre R, Rose J, Walter S, Fröhlich F, Piehler J, Reggiori F, Ungermann C., Free PMC Article | 05/1/2021 |
| Here, the authors discover a novel mechanism for the PAS targeting of Atg12-Atg5-Atg16, which is mediated by the interaction of Atg12 with the Atg1 kinase complex that serves as a scaffold for pre-autophagosomal structure organization. | Two distinct mechanisms target the autophagy-related E3 complex to the pre-autophagosomal structure.
Harada K, Kotani T, Kirisako H, Sakoh-Nakatogawa M, Oikawa Y, Kimura Y, Hirano H, Yamamoto H, Ohsumi Y, Nakatogawa H., Free PMC Article | 03/21/2020 |
| Data show that phosphorylation by Atg1 inhibits Atg4 at autophagosome formation sites. | Atg4 proteolytic activity can be inhibited by Atg1 phosphorylation.
Sánchez-Wandelmer J, Kriegenburg F, Rohringer S, Schuschnig M, Gómez-Sánchez R, Zens B, Abreu S, Hardenberg R, Hollenstein D, Gao J, Ungermann C, Martens S, Kraft C, Reggiori F., Free PMC Article | 12/9/2017 |
| The article shows how selective autophagy is tightly regulated in space and time to prevent aberrant Atg1 kinase activation and autophagy induction. | Two Independent Pathways within Selective Autophagy Converge to Activate Atg1 Kinase at the Vacuole.
Torggler R, Papinski D, Brach T, Bas L, Schuschnig M, Pfaffenwimmer T, Rohringer S, Matzhold T, Schweida D, Brezovich A, Kraft C. | 09/9/2017 |
| Atg1 complex provide insights into assembly and regulatory mechanisms | Molecular interactions of the Saccharomyces cerevisiae Atg1 complex provide insights into assembly and regulatory mechanisms.
Chew LH, Lu S, Liu X, Li FK, Yu AY, Klionsky DJ, Dong MQ, Yip CK., Free PMC Article | 04/23/2016 |
| In vitro studies show that Atg1 kinase is activated by selective autophagy targets in yeast requiring the Atg11 scaffold. | Receptor-Bound Targets of Selective Autophagy Use a Scaffold Protein to Activate the Atg1 Kinase.
Kamber RA, Shoemaker CJ, Denic V., Free PMC Article | 11/7/2015 |
| These results lead to a model for autophagy initiation in which Atg1 and Atg13 are tightly associated with one another and assemble transiently into the pentameric Atg1 complex during starvation. | Assembly and dynamics of the autophagy-initiating Atg1 complex.
Stjepanovic G, Davies CW, Stanley RE, Ragusa MJ, Kim DJ, Hurley JH., Free PMC Article | 11/22/2014 |
| The Atg1 kinase acts early in autophagy by regulating the outgrowth of autophagosomal membranes. | Early steps in autophagy depend on direct phosphorylation of Atg9 by the Atg1 kinase.
Papinski D, Schuschnig M, Reiter W, Wilhelm L, Barnes CA, Maiolica A, Hansmann I, Pfaffenwimmer T, Kijanska M, Stoffel I, Lee SS, Brezovich A, Lou JH, Turk BE, Aebersold R, Ammerer G, Peter M, Kraft C., Free PMC Article | 05/10/2014 |
| Atg1, Atg8 and the Atg16-Atg12-Atg5 complex were present at both the VICS and the cup-shaped IM. | Fine mapping of autophagy-related proteins during autophagosome formation in Saccharomyces cerevisiae.
Suzuki K, Akioka M, Kondo-Kakuta C, Yamamoto H, Ohsumi Y. | 11/16/2013 |
| Findings show that Ypt1/Rab1 infindings show that Ypt1/Rab1 interacts with Atg1/Ulk1 in yeast and mammalian cells. | Ypt1 recruits the Atg1 kinase to the preautophagosomal structure.
Wang J, Menon S, Yamasaki A, Chou HT, Walz T, Jiang Y, Ferro-Novick S., Free PMC Article | 08/31/2013 |
| mutations in the Atg1 AIM cause a significant defect in autophagy, without affecting the functions of Atg1 implicated in triggering autophagosome formation | The autophagy-related protein kinase Atg1 interacts with the ubiquitin-like protein Atg8 via the Atg8 family interacting motif to facilitate autophagosome formation.
Nakatogawa H, Ohbayashi S, Sakoh-Nakatogawa M, Kakuta S, Suzuki SW, Kirisako H, Kondo-Kakuta C, Noda NN, Yamamoto H, Ohsumi Y., Free PMC Article | 11/3/2012 |
| An Atg13 protein-mediated self-association of the Atg1 protein kinase is important for the induction of autophagy. | An Atg13 protein-mediated self-association of the Atg1 protein kinase is important for the induction of autophagy.
Yeh YY, Shah KH, Herman PK., Free PMC Article | 10/22/2011 |
| findings suggest that the direct control of the Atg1 complex by Tor complex1 induces autophagy. | Tor directly controls the Atg1 kinase complex to regulate autophagy.
Kamada Y, Yoshino K, Kondo C, Kawamata T, Oshiro N, Yonezawa K, Ohsumi Y., Free PMC Article | 02/15/2010 |
| Data show that Atg1, PKA directly phosphorylates Atg13 in a Tor-dependent manner. | The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy.
Stephan JS, Yeh YY, Ramachandran V, Deminoff SJ, Herman PK., Free PMC Article | 01/21/2010 |
| Atg1 kinase activity affects the dynamics of protein movement at the phagophore assembly site involved in Atg protein cycling. | The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae.
Cheong H, Nair U, Geng J, Klionsky DJ., Free PMC Article | 01/21/2010 |
| Atg1 plays a structural role for efficient recruitment of Atg proteins to the pre-autophagosomal structure, which is mediated by interaction with Atg13 and Atg17. | Dual role of Atg1 in regulation of autophagy-specific PAS assembly in Saccharomyces cerevisiae.
Cheong H, Klionsky DJ. | 01/21/2010 |
| Atg17-Atg13 complex formation plays an important role in normal autophagosome formation via binding to and activating the Atg1 kinase. | Atg17 functions in cooperation with Atg1 and Atg13 in yeast autophagy.
Kabeya Y, Kamada Y, Baba M, Takikawa H, Sasaki M, Ohsumi Y., Free PMC Article | 01/21/2010 |