| Spt4 promotes cellular senescence by activating non-coding RNA transcription in ribosomal RNA gene clusters. | Spt4 promotes cellular senescence by activating non-coding RNA transcription in ribosomal RNA gene clusters.
Yokoyama M, Sasaki M, Kobayashi T. | 02/11/2023 |
| Spt4 facilitates the movement of RNA polymerase II through the +2 nucleosomal barrier. | Spt4 facilitates the movement of RNA polymerase II through the +2 nucleosomal barrier.
Uzun Ü, Brown T, Fischl H, Angel A, Mellor J., Free PMC Article | 02/12/2022 |
| Opposite roles of transcription elongation factors Spt4/5 and Elf1 in RNA polymerase II transcription through B-form versus non-B DNA structures. | Opposite roles of transcription elongation factors Spt4/5 and Elf1 in RNA polymerase II transcription through B-form versus non-B DNA structures.
Xu J, Chong J, Wang D., Free PMC Article | 07/10/2021 |
| Dynamics of RNA polymerase II and elongation factor Spt4/5 recruitment during activator-dependent transcription. | Dynamics of RNA polymerase II and elongation factor Spt4/5 recruitment during activator-dependent transcription.
Rosen GA, Baek I, Friedman LJ, Joo YJ, Buratowski S, Gelles J., Free PMC Article | 02/13/2021 |
| Polo kinase recruitment via the constitutive centromere-associated network at the kinetochore elevates centromeric RNA. | Polo kinase recruitment via the constitutive centromere-associated network at the kinetochore elevates centromeric RNA.
Ólafsson G, Thorpe PH., Free PMC Article | 09/26/2020 |
| Suppression of the yeast elongation factor Spt4 ortholog reduces expanded SCA36 GGCCUG repeat aggregation and cytotoxicity. | Suppression of the yeast elongation factor Spt4 ortholog reduces expanded SCA36 GGCCUG repeat aggregation and cytotoxicity.
Furuta N, Tsukagoshi S, Hirayanagi K, Ikeda Y. | 08/13/2020 |
| Hog1 phosphorylates the Spt4 elongation factor at Thr42 and Ser43 and such phosphorylations are essential for the overall transcriptional response upon osmostress. | Regulation of transcription elongation in response to osmostress.
Silva A, Cavero S, Begley V, Solé C, Böttcher R, Chávez S, Posas F, de Nadal E., Free PMC Article | 12/30/2017 |
| Interactions between SPT4 and RNA Polymerase II | Relationships Between RNA Polymerase II Activity and Spt Elongation Factors to Spt- Phenotype and Growth in Saccharomyces cerevisiae.
Cui P, Jin H, Vutukuru MR, Kaplan CD., Free PMC Article | 12/9/2017 |
| Spt4/5 may be important to coordinate the mechanical movement of RNAPII through the nucleosome with co-transcriptional chromatin modifications during transcription. | The elongation factor Spt4/5 regulates RNA polymerase II transcription through the nucleosome.
Crickard JB, Lee J, Lee TH, Reese JC., Free PMC Article | 12/2/2017 |
| These findings attribute a new function to a domain of Spt4/5 that associates directly with RNAPII, making significant steps towards elucidating the mechanism behind transcriptional control by Spt4/5. | The yeast transcription elongation factor Spt4/5 is a sequence-specific RNA binding protein.
Blythe AJ, Yazar-Klosinski B, Webster MW, Chen E, Vandevenne M, Bendak K, Mackay JP, Hartzog GA, Vrielink A., Free PMC Article | 07/15/2017 |
| demonstrate that physical and genetic interactions exist between Hot1 and several proteins involved in transcriptional and posttranscriptional processes: for example, transcription co-activator Sub1 and elongation complex Spt4/5 | Hot1 factor recruits co-activator Sub1 and elongation complex Spt4/5 to osmostress genes.
Gomar-Alba M, Del Olmo M. | 07/1/2017 |
| This study demonstrates that the recruitment of the Saccharomyces cerevisiae Paf1 complex to active genes requires a domain of Rtf1 that directly interacts with the Spt4-Spt5 complex. | The recruitment of the Saccharomyces cerevisiae Paf1 complex to active genes requires a domain of Rtf1 that directly interacts with the Spt4-Spt5 complex.
Mayekar MK, Gardner RG, Arndt KM., Free PMC Article | 10/26/2013 |
| Study reports that transcription of genes containing long repeats of CAG or other trinucleotides located in either protein-coding or transcribed noncoding regions of templates is selectively facilitated by the actions of Spt4 | Spt4 is selectively required for transcription of extended trinucleotide repeats.
Liu CR, Chang CR, Chern Y, Wang TH, Hsieh WC, Shen WC, Chang CY, Chu IC, Deng N, Cohen SN, Cheng TH. | 04/7/2012 |
| Data provide evidence implicating the yeast DSIF complex (Spt4/5) and RNA polymerase II phosphorylation by Kin28 and Ctk1 in the recruitment of Rpd3S to active genes. | DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes.
Drouin S, Laramée L, Jacques PÉ, Forest A, Bergeron M, Robert F., Free PMC Article | 03/12/2011 |
| She2p interacts in vivo with the elongating forms of RNA polymerase II (pol II) via the transcription elongation factor Spt4-Spt5 | Cotranscriptional recruitment of She2p by RNA pol II elongation factor Spt4-Spt5/DSIF promotes mRNA localization to the yeast bud.
Shen Z, St-Denis A, Chartrand P., Free PMC Article | 09/20/2010 |
| one function of Spt4-Spt5 is to help RNA polymerase II overcome the repressive effects of these histone modifications and chromatin regulators on transcription | Histone H3K4 and K36 methylation, Chd1 and Rpd3S oppose the functions of Saccharomyces cerevisiae Spt4-Spt5 in transcription.
Quan TK, Hartzog GA., Free PMC Article | 04/12/2010 |
| Structural and evolutionary perspective of Spt4-Spt5 complex and suggests that it is an ancient, core component of the transcription elongation machinery. | Core structure of the yeast spt4-spt5 complex: a conserved module for regulation of transcription elongation.
Guo M, Xu F, Yamada J, Egelhofer T, Gao Y, Hartzog GA, Teng M, Niu L., Free PMC Article | 01/21/2010 |
| Spt4-Spt5 complex may help coordinate splicing with transcription under conditions that present kinetic challenges to spliceosome assembly or function | Analysis of a splice array experiment elucidates roles of chromatin elongation factor Spt4-5 in splicing.
Xiao Y, Yang YH, Burckin TA, Shiue L, Hartzog GA, Segal MR., Free PMC Article | 01/21/2010 |
| Absence of functional Spt4p leads to altered chromatin structure at the centromeric DNA and mislocalization of the mammalian CENP-A homolog Cse4p to noncentromeric loci | Functional roles for evolutionarily conserved Spt4p at centromeres and heterochromatin in Saccharomyces cerevisiae.
Crotti LB, Basrai MA., Free PMC Article | 01/21/2010 |
| data suggest that Spt4p, Spt5p, and, potentially, other regulators of Pol I transcription elongation play important roles in coupling rRNA transcription to its processing and ribosome assembly | RNA polymerase II elongation factors Spt4p and Spt5p play roles in transcription elongation by RNA polymerase I and rRNA processing.
Schneider DA, French SL, Osheim YN, Bailey AO, Vu L, Dodd J, Yates JR, Beyer AL, Nomura M., Free PMC Article | 01/21/2010 |