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    YBX3 Y-box binding protein 3 [ Homo sapiens (human) ]

    Gene ID: 8531, updated on 17-Jun-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The YBX3 RNA-binding protein posttranscriptionally controls SLC1A5 mRNA in proliferating and differentiating skeletal muscle cells.

    The YBX3 RNA-binding protein posttranscriptionally controls SLC1A5 mRNA in proliferating and differentiating skeletal muscle cells.
    Awad S, Skipper W, Vostrejs W, Ozorowski K, Min K, Pfuhler L, Mehta D, Cooke A., Free PMC Article

    02/27/2024
    M6A-mediated-upregulation of lncRNA BLACAT3 promotes bladder cancer angiogenesis and hematogenous metastasis through YBX3 nuclear shuttling and enhancing NCF2 transcription.

    M6A-mediated-upregulation of lncRNA BLACAT3 promotes bladder cancer angiogenesis and hematogenous metastasis through YBX3 nuclear shuttling and enhancing NCF2 transcription.
    Xie J, Zhang H, Wang K, Ni J, Ma X, Khoury CJ, Prifti V, Hoard B, Cerenzia EG, Yin L, Zhang H, Wang R, Zhuo D, Mao W, Peng B., Free PMC Article

    10/11/2023
    Identification of RNA-binding protein YBX3 as an oncogene in clear cell renal cell carcinoma.

    Identification of RNA-binding protein YBX3 as an oncogene in clear cell renal cell carcinoma.
    Wang C, You Z, He Y, Chen X., Free PMC Article

    07/12/2023
    Identification and verification of YBX3 and its regulatory gene HEIH as an oncogenic system: A multidimensional analysis in colon cancer.

    Identification and verification of YBX3 and its regulatory gene HEIH as an oncogenic system: A multidimensional analysis in colon cancer.
    Sun Y, Li Z, Wang W, Zhang X, Li W, Du G, Yin J, Xiao W, Yang H., Free PMC Article

    09/17/2022
    Knockdown of DNA-binding protein A enhances the chemotherapy sensitivity of colorectal cancer via suppressing the Wnt/beta-catenin/Chk1 pathway.

    Knockdown of DNA-binding protein A enhances the chemotherapy sensitivity of colorectal cancer via suppressing the Wnt/β-catenin/Chk1 pathway.
    Tong C, Qu K, Wang G, Liu R, Duan B, Wang X, Liu C.

    08/14/2021
    YB-3 substitutes YB-1 in global mRNA binding.

    YB-3 substitutes YB-1 in global mRNA binding.
    Lyabin DN, Eliseeva IA, Smolin EA, Doronin AN, Budkina KS, Kulakovskiy IV, Ovchinnikov LP., Free PMC Article

    05/1/2021
    Y-Box-Binding Protein 3 (YBX3) Restricts Influenza A Virus by Interacting with Viral Ribonucleoprotein Complex and Imparing its Function.

    Y-Box-Binding Protein 3 (YBX3) Restricts Influenza A Virus by Interacting with Viral Ribonucleoprotein Complex and Imparing its Function.
    Qin Z, Qu X, Lei L, Xu L, Pan Z.

    09/19/2020
    YBX3 binds within the 3' UTR of SLC7A5 to stabilize the transcript.

    The RNA-Binding Protein YBX3 Controls Amino Acid Levels by Regulating SLC mRNA Abundance.
    Cooke A, Schwarzl T, Huppertz I, Kramer G, Mantas P, Alleaume AM, Huber W, Krijgsveld J, Hentze MW.

    08/12/2020
    ZONAB is up-regulated in bladder cancer cell lines, which promotes invasion, demonstrating the important role it plays in tumorogenesis and cancer progression

    Zonula occludens-1 associated nucleic acid binding protein plays an invasion-promoting role in bladder cancer.
    Xu X, You K, Wu B.

    09/14/2019
    Authors examined, for the first time in a Turkish population, the association between protamine gene alleles (PRM1 c.-190C>A, PRM1 c.197G>T, and PRM2 c.248C>T), and YBX2 (c.187T>C and c.1095 + 16A>G) and male infertility.

    Genetic Polymorphisms in PRM1, PRM2, and YBX2 Genes are Associated with Male Factor Infertility.
    Aydos OSE, Hekmatshoar Y, Altınok B, Özkan T, Şakirağaoğlu O, Karadağ A, Kaplan F, Ilgaz S, Taşpınar M, Yükselen I, Sunguroğlu A, Aydos K.

    05/26/2018
    Data suggest that DNA binding protein A (dbpA) may be used as a therapeutic target in colorectal cancer (CRC).

    RNAi-mediated downregulation of DNA binding protein A inhibits tumorigenesis in colorectal cancer.
    Liu RT, Wang GR, Liu C, Qiu J, Yan LK, Li XJ, Wang XQ., Free PMC Article

    03/25/2017
    dbpA knockdown in SW620 cells altered the expression of carcinogenesis-associated genes in Colorectal cancer.

    Gene expression profile analysis of dbpA knockdown in colorectal cancer cells.
    Liu R, Wang G, Liu C, Qiu J, Yan L, Li X, Wang X.

    02/4/2017
    In the prenatal brain, the cold shock domain protein A were found to be abundantly expressed in radial glial cells, neuroblasts and neurons.

    Differential distribution of Y-box-binding protein 1 and cold shock domain protein A in developing and adult human brain.
    Bernstein HG, Lindquist JA, Keilhoff G, Dobrowolny H, Brandt S, Steiner J, Bogerts B, Mertens PR.

    03/19/2016
    Stratification according to Fuhrman grade disclosed higher YBX3 expression levels.

    Validation of housekeeping gene and impact on normalized gene expression in clear cell renal cell carcinoma: critical reassessment of YBX3/ZONAB/CSDA expression.
    Dupasquier S, Delmarcelle AS, Marbaix E, Cosyns JP, Courtoy PJ, Pierreux CE., Free PMC Article

    09/13/2014
    We demonstrate that ZONAB promotes cell survival in response to proinflammatory, hyperosmotic, and cytotoxic stress and that stress-induced ZONAB activation involves the Rho regulator GEF-H1.

    Stress- and Rho-activated ZO-1-associated nucleic acid binding protein binding to p21 mRNA mediates stabilization, translation, and cell survival.
    Nie M, Balda MS, Matter K., Free PMC Article

    09/22/2012
    DbpA promoter was methylated in 37.7% of HCC samples.

    DNA binding protein A expression and methylation status in hepatocellular carcinoma and the adjacent tissue.
    Yasen M, Obulhasim G, Kajino K, Mogushi K, Mizushima H, Tanaka S, Tanaka H, Hino O, Arii S.

    07/7/2012
    In human skeletal muscle cells, CSDA was upregulated during hypoxia when cells were damaged and apoptosis was induced.

    Critical roles of cold shock domain protein A as an endogenous angiogenesis inhibitor in skeletal muscle.
    Saito Y, Nakagami H, Azuma N, Hirata S, Sanada F, Taniyama Y, Morishita R, Kaneda Y, Sasajima T.

    03/24/2012
    ZONAB is an important component of the mechanisms that sense epithelial density and participates in the complex transcriptional networks that regulate the switch between proliferation and differentiation

    ZONAB promotes proliferation and represses differentiation of proximal tubule epithelial cells.
    Lima WR, Parreira KS, Devuyst O, Caplanusi A, N'kuli F, Marien B, Van Der Smissen P, Alves PM, Verroust P, Christensen EI, Terzi F, Matter K, Balda MS, Pierreux CE, Courtoy PJ., Free PMC Article

    03/29/2010
    The expression of human DBPA was upregulated in gastric cancer tissues and cell lines. siRNA treatment successfully silenced DBPA expression.

    Upregulation of human DNA binding protein A (dbpA) in gastric cancer cells.
    Wang GR, Zheng Y, Che XM, Wang XY, Zhao JH, Wu KJ, Zeng J, Pan CE, He DL., Free PMC Article

    02/1/2010
    The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1.

    The symplekin/ZONAB complex inhibits intestinal cell differentiation by the repression of AML1/Runx1.
    Buchert M, Darido C, Lagerqvist E, Sedello A, Cazevieille C, Buchholz F, Bourgaux JF, Pannequin J, Joubert D, Hollande F.

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)

    Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    Trynka G, Zhernakova A, Romanos J, Franke L, Hunt KA, Turner G, Bruinenberg M, Heap GA, Platteel M, Ryan AW, de Kovel C, Holmes GK, Howdle PD, Walters JR, Sanders DS, Mulder CJ, Mearin ML, Verbeek WH, Trimble V, Stevens FM, Kelleher D, Barisani D, Bardella MT, McManus R, van Heel DA, Wijmenga C.

    04/1/2009
    ZONAB regulates the transcription of genes that are important for G1/S-phase progression and links tight junctions to the transcriptional control of key cell cycle regulators and epithelial cell differentiation.

    Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA.
    Sourisseau T, Georgiadis A, Tsapara A, Ali RR, Pestell R, Matter K, Balda MS., Free PMC Article

    01/21/2010
    human dbpA has a role in accelerating hepatocarcinogenesis

    Somatic mutation and SNP in the promoter of dbpA and human hepatocarcinogenesis.
    Hayashi J, Kajino K, Umeda T, Takano S, Arakawa Y, Kudo M, Hino O.

    01/21/2010
    identification of complexes, binding to the vascular endothelial growth factor mRNA 5'- and 3'-UTR, that contain cold shock domain and polypyrimidine tract binding RNA binding proteins

    A multi-protein complex containing cold shock domain (Y-box) and polypyrimidine tract binding proteins forms on the vascular endothelial growth factor mRNA. Potential role in mRNA stabilization.
    Coles LS, Bartley MA, Bert A, Hunter J, Polyak S, Diamond P, Vadas MA, Goodall GJ.

    01/21/2010
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