| Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast. | Protein phosphatase 2A (PP2A) promotes anaphase entry after DNA replication stress in budding yeast.
Haluska C, Jin F, Wang Y., Free PMC Article | 03/26/2022 |
| Here, we show that Rts1 is required for the proportional relationship between cell size and growth rate during mitosis. Moreover, nutrients and Rts1 influence the duration and extent of growth in mitosis via Wee1 and Pds1/securin, two conserved regulators of mitotic progression. | A Conserved PP2A Regulatory Subunit Enforces Proportional Relationships Between Cell Size and Growth Rate.
Leitao RM, Jasani A, Talavara RA, Pham A, Okobi QJ, Kellogg DR., Free PMC Article | 02/15/2020 |
| Swe1 and the Polo-like kinase Cdc5 control the balance between phosphorylated and unphosphorylated forms of Mih1, which is, in turn, important for mitotic spindle elongation. | Swe1 and Mih1 regulate mitotic spindle dynamics in budding yeast via Bik1.
Raspelli E, Facchinetti S, Fraschini R. | 12/7/2019 |
| Moreover, the authors show that high levels of histones promote Swe1(WEE1) stabilisation thereby triggering the phosphorylation and inhibition of Cdc28(CDK1) through a mechanism different of the canonical DNA damage response. | High levels of histones promote whole-genome-duplications and trigger a Swe1(WEE1)-dependent phosphorylation of Cdc28(CDK1).
Maya Miles D, Peñate X, Sanmartín Olmo T, Jourquin F, Muñoz Centeno MC, Mendoza M, Simon MN, Chavez S, Geli V., Free PMC Article | 06/1/2019 |
| strict temporal regulation of M-phase cyclin-dependent kinase (CDK; M-CDK) is important for polarity establishment and morphogenesis. Cells with premature M-CDK activity caused by loss of checkpoint kinase Swe1 failed to polarize and underwent anaphase without budding. Mutants with increased Swe1-dependent M-CDK inhibition showed additional or more penetrant phenotypes in RTG than mitosis | Prolonged cyclin-dependent kinase inhibition results in septin perturbations during return to growth and mitosis.
Gihana GM, Musser TR, Thompson O, Lacefield S., Free PMC Article | 05/25/2019 |
| Wee1 distinguishes spindle pole bodies to guide their pattern of age-dependent segregation. | Budding yeast Wee1 distinguishes spindle pole bodies to guide their pattern of age-dependent segregation.
Lengefeld J, Hotz M, Rollins M, Baetz K, Barral Y. | 09/23/2017 |
| Swe1 kinase perceives alterations in sphingolipid (SL) homeostasis, activates SL synthesis, and may thus represent the missing regulatory link that controls the SL rheostat during the cell cycle | Regulation of Sphingolipid Biosynthesis by the Morphogenesis Checkpoint Kinase Swe1.
Chauhan N, Han G, Somashekarappa N, Gable K, Dunn T, Kohlwein SD., Free PMC Article | 06/28/2016 |
| propose a model by which TG-derived sphingolipids are required to activate the protein phosphatase 2A (PP2A(Cdc55)) to attenuate Swe1 phosphorylation | Morphogenesis checkpoint kinase Swe1 is the executor of lipolysis-dependent cell-cycle progression.
Chauhan N, Visram M, Cristobal-Sarramian A, Sarkleti F, Kohlwein SD., Free PMC Article | 05/16/2015 |
| Swe1 regulation by Cdc14 allows proper coordination of spindle elongation with mitotic progression. | Budding yeast Swe1 is involved in the control of mitotic spindle elongation and is regulated by Cdc14 phosphatase during mitosis.
Raspelli E, Cassani C, Chiroli E, Fraschini R., Free PMC Article | 04/11/2015 |
| Transition from meiotic prophase to mitosis requires modulation of Cdk1 activity to coordinate cell-cycle events. Swe1 prevents formation of multinucleate cells by restraining M phase CDK activity to allow bud formation prior to nuclear division. | Cdk1 modulation ensures the coordination of cell-cycle events during the switch from meiotic prophase to mitosis.
Tsuchiya D, Lacefield S. | 04/26/2014 |
| Data indicate that Swe1p degradation following osmotic shock. | Feedback control of Swe1p degradation in the yeast morphogenesis checkpoint.
King K, Kang H, Jin M, Lew DJ., Free PMC Article | 09/21/2013 |
| Here we show that the budding yeast Wee1 kinase, Swe1, also restrains the metaphase-to-anaphase transition by preventing Cdk1 phosphorylation and activation of the mitotic form of the anaphase-promoting complex/cyclosome (APC(Cdc20)). | A Wee1 checkpoint inhibits anaphase onset.
Lianga N, Williams EC, Kennedy EK, Doré C, Pilon S, Girard SL, Deneault JS, Rudner AD., Free PMC Article | 08/31/2013 |
| Degradation, but not tethering, of Swe1p depends on Hsl1p and Hsl7p interaction. | Roles of Hsl1p and Hsl7p in Swe1p degradation: beyond septin tethering.
King K, Jin M, Lew D., Free PMC Article | 05/11/2013 |
| PP2A(Cdc55) sets a threshold that limits activation of Wee1, thereby allowing a low constant level of Cdk1 activity to escape Wee1 inhibition in early mitosis. | A phosphatase threshold sets the level of Cdk1 activity in early mitosis in budding yeast.
Harvey SL, Enciso G, Dephoure N, Gygi SP, Gunawardena J, Kellogg DR., Free PMC Article | 02/11/2012 |
| Swe1 is stabilized, restrained at the bud neck, and hyperphosphorylated in dma1Delta dma2Delta cells subjected to DNA replication stress | Budding yeast Dma1 and Dma2 participate in regulation of Swe1 levels and localization.
Raspelli E, Cassani C, Lucchini G, Fraschini R., Free PMC Article | 12/17/2011 |
| Cdk1 and SUMO regulate Swe1 stability | Cdk1 and SUMO regulate Swe1 stability.
Simpson-Lavy KJ, Brandeis M., Free PMC Article | 07/9/2011 |
| growth defects in cells lacking SLA2 are associated with a cell cycle delay that is influenced by Swe1, a morphogenesis checkpoint kinase | SLA2 mutations cause SWE1-mediated cell cycle phenotypes in Candida albicans and Saccharomyces cerevisiae.
Gale CA, Leonard MD, Finley KR, Christensen L, McClellan M, Abbey D, Kurischko C, Bensen E, Tzafrir I, Kauffman S, Becker J, Berman J., Free PMC Article | 04/19/2010 |
| Swe1(Wee1) phosphorylates a conserved tyrosine residue in the N domain of Hsp90. | Swe1Wee1-dependent tyrosine phosphorylation of Hsp90 regulates distinct facets of chaperone function.
Mollapour M, Tsutsumi S, Donnelly AC, Beebe K, Tokita MJ, Lee MJ, Lee S, Morra G, Bourboulia D, Scroggins BT, Colombo G, Blagg BS, Panaretou B, Stetler-Stevenson WG, Trepel JB, Piper PW, Prodromou C, Pearl LH, Neckers L., Free PMC Article | 04/12/2010 |
| Results suggest that that Cdc5 promotes Cdc14 release primarily by stimulating the degradation of Swe1, the inhibitory kinase for mitotic Cdk. | The molecular function of the yeast polo-like kinase Cdc5 in Cdc14 release during early anaphase.
Liang F, Jin F, Liu H, Wang Y., Free PMC Article | 01/21/2010 |
| Isc1p as an upstream regulator of Swe1p levels and stability and Cdc28-Tyr-19 phosphorylation, in effect signaling recovery from the effects of genotoxic stress and allowing G(2)/M progression. | Hydroxyurea sensitivity reveals a role for ISC1 in the regulation of G2/M.
Matmati N, Kitagaki H, Montefusco D, Mohanty BK, Hannun YA., Free PMC Article | 01/21/2010 |
| shuttling of Swe1p between nucleus and cytoplasm serves to couple cytoplasmic stress to nuclear cyclin/CDK inhibition | Nucleocytoplasmic trafficking of G2/M regulators in yeast.
Keaton MA, Szkotnicki L, Marquitz AR, Harrison J, Zyla TR, Lew DJ., Free PMC Article | 01/21/2010 |
| a phenyl hydroquinone-induced G(2)/M transition checkpoint that is activated by the Hog1-Swe1 pathway plays a role in the development of aneuploidy. | Phenyl hydroquinone, an Ames test-negative carcinogen, induces Hog1-dependent stress response signaling.
Yamamoto A, Nunoshiba T, Umezu K, Enomoto T, Yamamoto K. | 01/21/2010 |
| Swe1 may competitively inhibit Clb2-Cdc28 interactions with substrates, in addition to its well-known function as a regulator of CDK activity through tyrosine phosphorylation. | Identification of Clb2 residues required for Swe1 regulation of Clb2-Cdc28 in Saccharomyces cerevisiae.
Hu F, Gan Y, Aparicio OM., Free PMC Article | 01/21/2010 |
| Rad53 shows genetic interactions with septin ring pathway components, and, along with other checkpoint proteins, controls the timely degradation of Swe1 during replication stress, thereby facilitating proper bud growth. | Checkpoint proteins control morphogenetic events during DNA replication stress in Saccharomyces cerevisiae.
Enserink JM, Smolka MB, Zhou H, Kolodner RD., Free PMC Article | 01/21/2010 |
| Swe1p responds to cytoskeletal perturbation, not bud size, in S. cerevisiae. | Swe1p responds to cytoskeletal perturbation, not bud size, in S. cerevisiae.
McNulty JJ, Lew DJ. | 01/21/2010 |