| METTL3 Promotes Osteosarcoma Metastasis via an m6A-dependent Epigenetic Activity of CBX4. | METTL3 Promotes Osteosarcoma Metastasis via an m6A-dependent Epigenetic Activity of CBX4.
Huo XS, Lu D, Chen DG, Ye M, Wang XW, Shang FS. | 04/3/2024 |
| Long Noncoding RNA SNHG5 Induces the NF-kappaB Pathway by Regulating miR-181c-5p/CBX4 Axis to Promote the Progression of Non-Small Cell Lung Cancer. | Long Noncoding RNA SNHG5 Induces the NF-κB Pathway by Regulating miR-181c-5p/CBX4 Axis to Promote the Progression of Non-Small Cell Lung Cancer.
Kang S, Ou C, Yan A, Zhu K, Xue R, Zhang Y, Lai J. | 01/11/2023 |
| MicroRNA-6838-5p suppresses the self-renewal and metastasis of human liver cancer stem cells through downregulating CBX4 expression and inactivating ERK signaling. | MicroRNA-6838-5p suppresses the self-renewal and metastasis of human liver cancer stem cells through downregulating CBX4 expression and inactivating ERK signaling.
Dou Z, Lu F, Hu J, Wang H, Li B, Li X. | 12/10/2022 |
| MiR-507 inhibits the progression of gastric carcinoma via targeting CBX4-mediated activation of Wnt/beta-catenin and HIF-1alpha pathways. | MiR-507 inhibits the progression of gastric carcinoma via targeting CBX4-mediated activation of Wnt/β-catenin and HIF-1α pathways.
Fang X, Pan A. | 09/10/2022 |
| Chromobox homolog 4 overexpression inhibits TNF-alpha-induced matrix catabolism and senescence by suppressing activation of the NF-kappaB signaling pathway in nucleus pulposus cells. | Chromobox homolog 4 overexpression inhibits TNF-α-induced matrix catabolism and senescence by suppressing activation of the NF-κB signaling pathway in nucleus pulposus cells.
Zhang Y, Li S, Hong J, Yan J, Huang Z, Wu J, Deng Z, Qin T, Xu K, Ye W., Free PMC Article | 07/30/2022 |
| CBX4 Regulates Long-Form Thymic Stromal Lymphopoietin-mediated Airway Inflammation through SUMOylation in House Dust Mite-induced Asthma. | CBX4 Regulates Long-Form Thymic Stromal Lymphopoietin-mediated Airway Inflammation through SUMOylation in House Dust Mite-induced Asthma.
Liang S, Zhou Z, Zhou Z, Liu J, Huang W, Dong H, Zou F, Zhao H, Yu C, Cai S. | 06/11/2022 |
| CBX4-dependent regulation of HDAC3 nuclear translocation reduces Bmp2-induced osteoblastic differentiation and calcification in adamantinomatous craniopharyngioma. | CBX4-dependent regulation of HDAC3 nuclear translocation reduces Bmp2-induced osteoblastic differentiation and calcification in adamantinomatous craniopharyngioma.
Yan X, Kang D, Lin Y, Qi S, Jiang C., Free PMC Article | 04/23/2022 |
| CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts. | CBX4 Regulates Replicative Senescence of WI-38 Fibroblasts.
Chen YH, Zhang X, Ko KY, Hsueh MF, Kraus VB., Free PMC Article | 03/26/2022 |
| The predictive potential of genetic single nucleotide polymorphisms in CBX4 for hepatocellular carcinoma survival. | The predictive potential of genetic single nucleotide polymorphisms in CBX4 for hepatocellular carcinoma survival.
Zhu XY, Huang MJ, Su QY, Wang XZ, Wang J, Long QQ, Wu XM, Huang XY, Yao JG, Long XD. | 01/22/2022 |
| Long intergenic noncoding RNA00265 promotes proliferation of gastric cancer via the microRNA-144-3p/Chromobox 4 axis. | Long intergenic noncoding RNA00265 promotes proliferation of gastric cancer via the microRNA-144-3p/Chromobox 4 axis.
Yang Z, OuYang X, Zheng L, Dai L, Luo W., Free PMC Article | 11/13/2021 |
| Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/beta-catenin pathway. | Chromobox 4 facilitates tumorigenesis of lung adenocarcinoma through the Wnt/β-catenin pathway.
Wang Z, Fang Z, Chen G, Liu B, Xu J, Li F, Li F, Liu H, Zhang H, Sun Y, Tian G, Chen H, Xu G, Zhang L, Hu L, Ji H., Free PMC Article | 10/16/2021 |
| CBX4 promotes the proliferation and metastasis via regulating BMI-1 in lung cancer. | CBX4 promotes the proliferation and metastasis via regulating BMI-1 in lung cancer.
Hu C, Zhang Q, Tang Q, Zhou H, Liu W, Huang J, Liu Y, Wang Q, Zhang J, Zhou M, Sheng F, Lai W, Tian J, Li G, Zhang R., Free PMC Article | 05/15/2021 |
| Circular RNA hsa_circ_0008039 promotes proliferation, migration and invasion of breast cancer cells through upregulating CBX4 via sponging miR-515-5p. | Circular RNA hsa_circ_0008039 promotes proliferation, migration and invasion of breast cancer cells through upregulating CBX4 via sponging miR-515-5p.
Huang FJ, Dang JQ, Zhang S, Cheng ZY. | 03/20/2021 |
| SUMO E3 ligase CBX4 regulates hTERT-mediated transcription of CDH1 and promotes breast cancer cell migration and invasion. | SUMO E3 ligase CBX4 regulates hTERT-mediated transcription of CDH1 and promotes breast cancer cell migration and invasion.
Sanyal S, Mondal P, Sen S, Sengupta Bandyopadhyay S, Das C. | 02/27/2021 |
| Chromobox homolog 4 (CBX4) is overexpressed in osteosarcoma cell lines and tissues. CBX4 promotes metastasis by transcriptionally up-regulating Runx2 via the recruitment of GCN5 to the Runx2 promoter. The phosphorylation of CBX4 at T437 by casein kinase 1alpha (CK1alpha) facilitates its ubiquitination at both K178 and K280 and subsequent degradation by CHIP, and this phosphorylation of CBX4 could be reduced by TNFalpha. | Targeting the CK1α/CBX4 axis for metastasis in osteosarcoma.
Wang X, Qin G, Liang X, Wang W, Wang Z, Liao D, Zhong L, Zhang R, Zeng YX, Wu Y, Kang T., Free PMC Article | 05/30/2020 |
| role of CBX4 in maintaining cellular homeostasis in mesenchymal stem cells | Maintenance of Nucleolar Homeostasis by CBX4 Alleviates Senescence and Osteoarthritis.
Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J, Tang F, Liu GH. | 05/23/2020 |
| This is the evidence supporting the interaction between GRM4 and CBX4, which could inhibit the malignant behavior of osteosarcoma cells through the GRM4/CBX4/HIF-1alpha signaling pathway | GRM4 inhibits the proliferation, migration, and invasion of human osteosarcoma cells through interaction with CBX4.
Zhang Z, Li N, Wei X, Chen B, Zhang Y, Zhao Y, Hu X, Hou S. | 03/7/2020 |
| findings suggest that CBX4 rs2289728 and CBX7 rs139394 are protective SNPs against HCC. The two SNPs may reduce the risk of HCC while suppressing the expression of CBX4 and CBX7. | Single Nucleotide Polymorphisms of CBX4 and CBX7 Decrease the Risk of Hepatocellular Carcinoma.
Tan C, Bei C, Zhu X, Zhang Y, Qin L, Tan S., Free PMC Article | 12/14/2019 |
| Results identify a modifying enzyme for Prdm16, and they demonstrate a central role of Cbx4 in the control of Prdm16 stability and white fat browning. | Cbx4 Sumoylates Prdm16 to Regulate Adipose Tissue Thermogenesis.
Chen Q, Huang L, Pan D, Zhu LJ, Wang YX., Free PMC Article | 09/14/2019 |
| CBX4 is up-regulated in breast cancer tissues and while its over-expression promotes cell proliferation, its knockdown suppresses cell proliferation in breast cancer cells. Furthermore, CBX4 mediates miR-129-5p-induced inhibition of cell proliferation and negatively correlates with the expression of miR-129-5p expression. | miR-129-5p suppresses breast cancer proliferation by targeting CBX4.
Meng R, Fang J, Yu Y, Hou LK, Chi JR, Chen AX, Zhao Y, Cao XC. | 07/6/2019 |
| Data suggest that CBX4 expression is up-regulated in breast cancer and is correlated with unfavorable overall survival; CBX4 promotes cell growth and migration via transcriptionally suppressing expression of miR137 to trigger Notch1 signaling pathway. (CBX4 = chromobox homolog 4; miR137 = microRNA 137; Notch1 = neurogenic locus notch homolog protein-1) | CBX4 exhibits oncogenic activities in breast cancer via Notch1 signaling.
Zeng JS, Zhang ZD, Pei L, Bai ZZ, Yang Y, Yang H, Tian QH. | 11/3/2018 |
| Data show that USP26 interacts with PRC1 components chromobox (CBX)-containing proteins CBX4 and CBX6. | USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components.
Ning B, Zhao W, Qian C, Liu P, Li Q, Li W, Wang RF., Free PMC Article | 12/9/2017 |
| Data show that SUMO E3 ligase CBX4 sumoylates subpopulation of CtIP to regulate recruitment to breaks and resection. | DNA end resection requires constitutive sumoylation of CtIP by CBX4.
Soria-Bretones I, Cepeda-García C, Checa-Rodriguez C, Heyer V, Reina-San-Martin B, Soutoglou E, Huertas P., Free PMC Article | 11/18/2017 |
| provide evidence to show that CBX4 may serve as a tumor suppressor in colorectal carcinoma by recruiting HDAC3 to the Runx2 promoter to impede Runx2 expression | CBX4 Suppresses Metastasis via Recruitment of HDAC3 to the Runx2 Promoter in Colorectal Carcinoma.
Wang X, Li L, Wu Y, Zhang R, Zhang M, Liao D, Wang G, Qin G, Xu RH, Kang T. | 07/29/2017 |
| Cbx4 is an independent prognostic factor for HCC patients, and the patients with high Cbx4 expression should receive postoperative TACE treatment to improve their survival | Prognostic significance of Cbx4 expression and its beneficial effect for transarterial chemoembolization in hepatocellular carcinoma.
Jiao HK, Xu Y, Li J, Wang W, Mei Z, Long XD, Chen GQ., Free PMC Article | 12/5/2015 |