| Altered expression of anti-apoptotic protein Api5 affects breast tumorigenesis. | Altered expression of anti-apoptotic protein Api5 affects breast tumorigenesis.
Kuttanamkuzhi A, Panda D, Malaviya R, Gaidhani G, Lahiri M., Free PMC Article | 04/28/2023 |
| The gammadelta IEL effector API5 masks genetic susceptibility to Paneth cell death. | The γδ IEL effector API5 masks genetic susceptibility to Paneth cell death.
Matsuzawa-Ishimoto Y, Yao X, Koide A, Ueberheide BM, Axelrad JE, Reis BS, Parsa R, Neil JA, Devlin JC, Rudensky E, Dewan MZ, Cammer M, Blumberg RS, Ding Y, Ruggles KV, Mucida D, Koide S, Cadwell K., Free PMC Article | 10/29/2022 |
| DeSUMOylation of Apoptosis Inhibitor 5 by Avibirnavirus VP3 Supports Virus Replication. | DeSUMOylation of Apoptosis Inhibitor 5 by Avibirnavirus VP3 Supports Virus Replication.
Deng T, Hu B, Wang X, Yan Y, Zhou J, Lin L, Xu Y, Zheng X, Zhou J., Free PMC Article | 12/25/2021 |
| MicroRNA-224 modulates chemosensitivity of breast cancer cells to docetaxel by apoptosis inhibitor 5. | MicroRNA-224 modulates chemosensitivity of breast cancer cells to docetaxel by apoptosis inhibitor 5.
Zhang J, Lu Y, Zhang Y, Chen Y, Zhu W, Zhu H, Wu J, Tang J. | 12/18/2021 |
| Interplay between p300 and HDAC1 regulate acetylation and stability of Api5 to regulate cell proliferation. | Interplay between p300 and HDAC1 regulate acetylation and stability of Api5 to regulate cell proliferation.
Sharma VK, Lahiri M., Free PMC Article | 11/13/2021 |
| Evolution and Structure of API5 and Its Roles in Anti-Apoptosis. | Evolution and Structure of API5 and Its Roles in Anti-Apoptosis.
Chen M, Wu W, Liu D, Lv Y, Deng H, Gao S, Gu Y, Huang M, Guo X, Liu B, Zhao B, Pang Q. | 08/28/2021 |
| Regulation of mRNA export through API5 and nuclear FGF2 interaction. | Regulation of mRNA export through API5 and nuclear FGF2 interaction.
Bong SM, Bae SH, Song B, Gwak H, Yang SW, Kim S, Nam S, Rajalingam K, Oh SJ, Kim TW, Park S, Jang H, Lee BI., Free PMC Article | 09/12/2020 |
| study demonstrates that apoptosis inhibitor 5 is an endogenous and direct inhibitor of caspase-2. API5 protein directly binds to the caspase recruitment domain (CARD) of caspase-2 and impedes dimerization and activation of caspase-2. | Apoptosis inhibitor 5 is an endogenous inhibitor of caspase-2.
Imre G, Berthelet J, Heering J, Kehrloesser S, Melzer IM, Lee BI, Thiede B, Dötsch V, Rajalingam K., Free PMC Article | 01/27/2018 |
| Authors propose a proapoptotic role for NP in IAV pathogenesis, whereby it suppresses expression of antiapoptotic factor API5, thus potentiating the E2F1-dependent apoptotic pathway and ensuring viral replication. | Nucleoprotein of influenza A virus negatively impacts antiapoptotic protein API5 to enhance E2F1-dependent apoptosis and virus replication.
Mayank AK, Sharma S, Nailwal H, Lal SK., Free PMC Article | 09/17/2016 |
| Authors show that API5 increases the metastatic capacity of cervical cancer cells in vitro and in vivo via up-regulation of MMP-9. | Apoptosis Inhibitor 5 Increases Metastasis via Erk-mediated MMP expression.
Song KH, Kim SH, Noh KH, Bae HC, Kim JH, Lee HJ, Song J, Kang TH, Kim DW, Oh SJ, Jeon JH, Kim TW., Free PMC Article | 04/23/2016 |
| rs17684886 (ZNRF1) and rs599019 (COLEC12) are associated with diabetic retinopathy and rs6427247 (SCYL1BP1) and rs899036 (API5) are associated with severe diabetic retinopathy in Chinese patients with type 2 diabetes | Common variants in or near ZNRF1, COLEC12, SCYL1BP1 and API5 are associated with diabetic retinopathy in Chinese patients with type 2 diabetes.
Peng D, Wang J, Zhang R, Jiang F, Tang S, Chen M, Yan J, Sun X, Wang S, Wang T, Yan D, Bao Y, Hu C, Jia W. | 03/12/2016 |
| API5 overexpression promoted cell proliferation and colony formation in CaSki cancer cells, whereas API5 knockdown inhibited the both properties in HeLa cells; API5 expression is associated with pERK1/2 in a subset of cervical cancer patients and its expression predicts poor overall survival. | Apoptosis inhibitor-5 overexpression is associated with tumor progression and poor prognosis in patients with cervical cancer.
Cho H, Chung JY, Song KH, Noh KH, Kim BW, Chung EJ, Ylaya K, Kim JH, Kim TW, Hewitt SM, Kim JH., Free PMC Article | 04/11/2015 |
| miR-143 and miR-145 and the predicted target proteins API5, ERK5, K-RAS, and IRS-1 display regional differences in expression in the colon | Tumor suppressors miR-143 and miR-145 and predicted target proteins API5, ERK5, K-RAS, and IRS-1 are differentially expressed in proximal and distal colon.
Pekow J, Meckel K, Dougherty U, Butun F, Mustafi R, Lim J, Crofton C, Chen X, Joseph L, Bissonnette M., Free PMC Article | 03/28/2015 |
| Negative regulation of API-5 expression by miR-1 was demonstrated to promote apoptosis of HepG2 cells. | MicroRNA-1 promotes apoptosis of hepatocarcinoma cells by targeting apoptosis inhibitor-5 (API-5).
Li D, Liu Y, Li H, Peng JJ, Tan Y, Zou Q, Song XF, Du M, Yang ZH, Tan Y, Zhou JJ, Xu T, Fu ZQ, Feng JQ, Cheng P, chen T, Wei D, Su XM, Liu HY, Qi ZC, Tang LJ, Wang T, Guo X, Hu YH, Zhang T. | 02/21/2015 |
| API5 acts as an immune escape gene in tumors by rendering them resistant to apoptosis triggered by tumor antigen-specific T cells. | API5 confers tumoral immune escape through FGF2-dependent cell survival pathway.
Noh KH, Kim SH, Kim JH, Song KH, Lee YH, Kang TH, Han HD, Sood AK, Ng J, Kim K, Sonn CH, Kumar V, Yee C, Lee KM, Kim TW., Free PMC Article | 10/18/2014 |
| Low miR-224 and high API5 expression correlated with worse survival of glioblastoma patients. | MiR-224 expression increases radiation sensitivity of glioblastoma cells.
Upraity S, Kazi S, Padul V, Shirsat NV. | 08/30/2014 |
| Api5, even if not physically interacting with E2F1, contributes positively to E2F1 transcriptional activity by increasing E2F1 binding to its target promoters. | Api5 contributes to E2F1 control of the G1/S cell cycle phase transition.
Garcia-Jove Navarro M, Basset C, Arcondéguy T, Touriol C, Perez G, Prats H, Lacazette E., Free PMC Article | 03/8/2014 |
| structure and function of API5 | Helical repeat structure of apoptosis inhibitor 5 reveals protein-protein interaction modules.
Han BG, Kim KH, Lee SJ, Jeong KC, Cho JW, Noh KH, Kim TW, Kim SJ, Yoon HJ, Suh SW, Lee S, Lee BI., Free PMC Article | 09/22/2012 |
| The prognostic significance of the genes casein kinase 2 alpha subunit (CSNK2A1), anti-apoptosis clone-11 (AAC-11), and tumor metastasis suppressor NME1 in completely resected non-small cell lung cancer (NSCLC) patients, was analysed. | Gene expression levels of CSNK1A1 and AAC-11, but not NME1, in tumor tissues as prognostic factors in NSCLC patients.
Wang Z, Liu H, Liu B, Ma W, Xue X, Chen J, Zhou Q. | 11/6/2010 |
| we infer that Pim-2 could activate API-5 to inhibit the apoptosis of liver cells, and NF-kappaB is the key regulator | Pim-2 activates API-5 to inhibit the apoptosis of hepatocellular carcinoma cells through NF-kappaB pathway.
Ren K, Zhang W, Shi Y, Gong J. | 08/23/2010 |
| The authors report here that AAC-11, a survival protein whose expression prevents apoptosis that occurs on deprivation of growth factors, physiologically binds to Acinus and prevents Acinus-mediated DNA fragmentation. | The antiapoptotic protein AAC-11 interacts with and regulates Acinus-mediated DNA fragmentation.
Rigou P, Piddubnyak V, Faye A, Rain JC, Michel L, Calvo F, Poyet JL., Free PMC Article | 01/21/2010 |
| define a true in vivo target of miR-224 and reaffirm the important role of miRNAs in the dysregulation of cellular processes that may ultimately lead to tumorigenesis | Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target.
Wang Y, Lee AT, Ma JZ, Wang J, Ren J, Yang Y, Tantoso E, Li KB, Ooi LL, Tan P, Lee CG. | 01/21/2010 |
| Apoptosis inhibitor-5/antiapoptosis clone-11 (Api5/Aac11) is a critical determinant of dE2F1-induced apoptosis in vivo and in vitro. | Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo.
Morris EJ, Michaud WA, Ji JY, Moon NS, Rocco JW, Dyson NJ., Free PMC Article | 01/21/2010 |