| IL-6 Up-Regulates Expression of LIM-Domain Only Protein 4 in Psoriatic Keratinocytes through Activation of the MEK/ERK/NF-kappaB Pathway. | IL-6 Up-Regulates Expression of LIM-Domain Only Protein 4 in Psoriatic Keratinocytes through Activation of the MEK/ERK/NF-κB Pathway.
Tu Z, Wei W, Zeng F, Wang W, Zhang Y, Zhang Y, Zhou F, Cai C, Zhang S, Zhou H. | 04/25/2024 |
| CircLDLR Promotes Papillary Thyroid Carcinoma Tumorigenicity by Regulating miR-637/LMO4 Axis. | CircLDLR Promotes Papillary Thyroid Carcinoma Tumorigenicity by Regulating miR-637/LMO4 Axis.
Jiang YM, Liu W, Jiang L, Chang H., Free PMC Article | 03/19/2022 |
| MicroRNA-139-5p Alleviates High Glucose-Triggered Human Retinal Pigment Epithelial Cell Injury by Targeting LIM-Only Factor 4. | MicroRNA-139-5p Alleviates High Glucose-Triggered Human Retinal Pigment Epithelial Cell Injury by Targeting LIM-Only Factor 4.
Shao K, Chen G, Xia L, Chen C, Huang S., Free PMC Article | 03/5/2022 |
| Research and Clinical Significance of the Differentially Expressed Genes TP63 and LMO4 in Human Immunodeficiency Virus-Related Penile Squamous Cell Carcinoma. | Research and Clinical Significance of the Differentially Expressed Genes TP63 and LMO4 in Human Immunodeficiency Virus-Related Penile Squamous Cell Carcinoma.
Xue W, Zheng X, Hu X, Zhang Y., Free PMC Article | 10/23/2021 |
| Long noncoding RNA SNHG1 promotes breast cancer progression by regulation of LMO4. | Long non‑coding RNA SNHG1 promotes breast cancer progression by regulation of LMO4.
Xiong X, Feng Y, Li L, Yao J, Zhou M, Zhao P, Huang F, Zeng L, Yuan L., Free PMC Article | 02/6/2021 |
| LMO4 appears to mediate IL-23-related responses in psoriatic keratinocytes and is a potential therapeutic target in psoriasis. | LMO4 Is a Disease-Provocative Transcription Coregulator Activated by IL-23 in Psoriatic Keratinocytes.
Tu Z, Zhang S, Zhou G, Zhou L, Xiang Q, Chen Q, Zhao P, Zhan H, Zhou H, Sun L. | 05/18/2019 |
| Lmo4 participates in the regulation of lung epithelial cell proliferation but is not essential for tumor progression. | The LIM-domain only protein 4 contributes to lung epithelial cell proliferation but is not essential for tumor progression.
Holik AZ, Filby CE, Pasquet J, Viitaniemi K, Ciciulla J, Sutherland KD, Asselin-Labat ML., Free PMC Article | 04/2/2016 |
| LMO4 appears to form a hub in protein-protein interaction networks, linking numerous pathways within cells. | The structure of an LIM-only protein 4 (LMO4) and Deformed epidermal autoregulatory factor-1 (DEAF1) complex reveals a common mode of binding to LMO4.
Joseph S, Kwan AH, Stokes PH, Mackay JP, Cubeddu L, Matthews JM., Free PMC Article | 07/4/2015 |
| Clim2, in a complex with LMO4, supports mammary stem cells by directly targeting the Fgfr2 promoter in basal cells to increase its expression | The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis.
Salmans ML, Yu Z, Watanabe K, Cam E, Sun P, Smyth P, Dai X, Andersen B., Free PMC Article | 02/14/2015 |
| Existence of a region in the lateral portion of the mammalian cochlea that is competent to make an organ of Corti is demonstrated in the absence of LMO4 function. | LMO4 functions as a negative regulator of sensory organ formation in the mammalian cochlea.
Deng M, Luo XJ, Pan L, Yang H, Xie X, Liang G, Huang L, Hu F, Kiernan AE, Gan L., Free PMC Article | 09/27/2014 |
| Low LMO4 mRNA levels were associated with response to erlotinib in non-small-cell lung cancer. | BRCA1, LMO4, and CtIP mRNA expression in erlotinib-treated non-small-cell lung cancer patients with EGFR mutations.
Karachaliou N, Costa C, Gimenez-Capitan A, Molina-Vila MA, Bertran-Alamillo J, Mayo C, Massuti B, Majem M, Carcereny E, Moran T, Sanchez JJ, Viteri S, Gasco A, Wannesson L, Souglakos J, Jimeno J, Rosell R, Spanish Lung Cancer Group. | 08/3/2013 |
| oncoprotein HBXIP is able to activate the transcriptional coregulatory protein LMO4 through transcription factor Sp1 in promotion of proliferation of breast cancer cells. | The oncoprotein HBXIP activates transcriptional coregulatory protein LMO4 via Sp1 to promote proliferation of breast cancer cells.
Yue L, Li L, Liu F, Hu N, Zhang W, Bai X, Li Y, Zhang Y, Fu L, Zhang X, Ye L., Free PMC Article | 06/22/2013 |
| Data suggest that overexpression of LMO4 may disrupt some of the normal tumour suppressor activities of CtIP, thereby contributing to breast cancer progression. | Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour suppressor CtIP/RBBP8.
Stokes PH, Liew CW, Kwan AH, Foo P, Barker HE, Djamirze A, O'Reilly V, Visvader JE, Mackay JP, Matthews JM. | 05/25/2013 |
| the association of high levels of LMO4 with aggressive neuroblastomas is dependent on LMO4 regulation of cadherin expression and hence, tumor invasiveness | LMO4 is an essential cofactor in the Snail2-mediated epithelial-to-mesenchymal transition of neuroblastoma and neural crest cells.
Ferronha T, Rabadán MA, Gil-Guiñon E, Le Dréau G, de Torres C, Martí E., Free PMC Article | 04/13/2013 |
| LMO4 is a direct target of p53 and inhibits p53-mediated proliferative inhibition of breast cancer cells through interacting p53 | LMO4 inhibits p53-mediated proliferative inhibition of breast cancer cells through interacting p53.
Zhou X, Sang M, Liu W, Gao W, Xing E, Lü W, Xu Y, Fan X, Jing S, Shan B. | 11/24/2012 |
| LMO4 is over-expressed in highly invasive rhabdomyosarcoma, alveolar cells | Differential expression of invasion promoting genes in childhood rhabdomyosarcoma.
Armeanu-Ebinger S, Bonin M, Häbig K, Poremba C, Koscielniak E, Godzinski J, Warmann SW, Fuchs J, Seitz G. | 08/27/2011 |
| LMO4 expression in squamous cell carcinoma of the anterior tongue | LMO4 expression in squamous cell carcinoma of the anterior tongue.
Kwong RA, Scarlett CJ, Kalish LH, Cole IE, Kench JG, Sum EY, Musgrove EA, Henshall SM, Lindeman GJ, Biankin AV, Visvader JE, Sutherland RL. | 07/16/2011 |
| data indicate that LMO4 has similar cellular effects in normal mammary epithelial cells and breast cancer cells, and also provide direct evidence for the idea that normal development and carcinogenesis share conserved molecular mechanisms | Repression of Lim only protein 4-activated transcription inhibits proliferation and induces apoptosis of normal mammary epithelial cells and breast cancer cells.
Tian Y, Wang N, Lu Z. | 10/23/2010 |
| LMO4 protects neurons from ischemic brain injury, in part through its requirement as an essential cofactor of PPAR gamma | Rescue of neurons from ischemic injury by peroxisome proliferator-activated receptor-gamma requires a novel essential cofactor LMO4.
Schock SC, Xu J, Duquette PM, Qin Z, Lewandowski AJ, Rai PS, Thompson CS, Seifert EL, Harper ME, Chen HH., Free PMC Article | 04/15/2010 |
| LMO4 is a novel cell cycle regulator with a key role in mediating ErbB2-induced proliferation, a hallmark of ErbB2-positive disease. | LMO4 is an essential mediator of ErbB2/HER2/Neu-induced breast cancer cell cycle progression.
Montañez-Wiscovich ME, Seachrist DD, Landis MD, Visvader J, Andersen B, Keri RA., Free PMC Article | 01/21/2010 |
| Lmo4 expression coincides with the timing of the development of the somatosensory barrel field. | Transcription factor Lmo4 defines the shape of functional areas in developing cortices and regulates sensorimotor control.
Huang Z, Kawase-Koga Y, Zhang S, Visvader J, Toth M, Walsh CA, Sun T., Free PMC Article | 01/21/2010 |
| Results suggested that LMO4 is overexpressed at late stages in carcinogenesis of pancreatic cancer. | LIM only 4 is overexpressed in late stage pancreas cancer.
Yu J, Ohuchida K, Nakata K, Mizumoto K, Cui L, Fujita H, Yamaguchi H, Egami T, Kitada H, Tanaka M., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesCase-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder.
Ribasés M, Bosch R, Hervás A, Ramos-Quiroga JA, Sánchez-Mora C, Bielsa A, Gastaminza X, Guijarro-Domingo S, Nogueira M, Gómez-Barros N, Kreiker S, Gross-Lesch S, Jacob CP, Lesch KP, Reif A, Johansson S, Plessen KJ, Knappskog PM, Haavik J, Estivill X, Casas M, Bayés M, Cormand B. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A. | 11/5/2008 |
| In this study, patients whose tumours exhibited high LMO4 expression had a significant survival advantage following operative resection | Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma.
Murphy NC, Scarlett CJ, Kench JG, Sum EY, Segara D, Colvin EK, Susanto J, Cosman PH, Lee CS, Musgrove EA, Sutherland RL, Lindeman GJ, Henshall SM, Visvader JE, Biankin AV., Free PMC Article | 01/21/2010 |
| These findings reveal a novel complex between BRCA1, LMO4, and CtIP and indicate a role for LMO4 as a repressor of BRCA1 activity in breast tissue. | The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity.
Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE. | 01/21/2010 |