| PIWIL1 interacting RNA piR-017061 inhibits pancreatic cancer growth via regulating EFNA5. | PIWIL1 interacting RNA piR-017061 inhibits pancreatic cancer growth via regulating EFNA5.
Xie J, Xing S, Shen BY, Chen HT, Sun B, Wang ZT, Wang JW, Lu XX. | 08/7/2021 |
| Pirin is a nuclear redox-sensitive modulator of autophagy-dependent ferroptosis. | Pirin is a nuclear redox-sensitive modulator of autophagy-dependent ferroptosis.
Hu N, Bai L, Dai E, Han L, Kang R, Li H, Tang D. | 04/24/2021 |
| PIR promotes tumorigenesis of breast cancer by upregulating cell cycle activator E2F1. | PIR promotes tumorigenesis of breast cancer by upregulating cell cycle activator E2F1.
Suleman M, Chen A, Ma H, Wen S, Zhao W, Lin D, Wu G, Li Q., Free PMC Article | 09/5/2020 |
| miR-455-5p/PIR axis contributed to cancer cell aggressiveness. | Pirin: a potential novel therapeutic target for castration-resistant prostate cancer regulated by miR-455-5p.
Arai T, Kojima S, Yamada Y, Sugawara S, Kato M, Yamazaki K, Naya Y, Ichikawa T, Seki N., Free PMC Article | 12/21/2019 |
| Data suggest that only the Fe(III) form of pirin [not the Fe(II) form] enhances affinity of binding between p65 and DNA in the pirin-p65-DNA supramolecular complex. (pirin = quercetin 2,3-dioxygenase; p65 = RELA proto-oncogene NF-kappaB subunit) | Redox-Specific Allosteric Modulation of the Conformational Dynamics of κB DNA by Pirin in the NF-κB Supramolecular Complex.
Adeniran C, Hamelberg D. | 10/7/2017 |
| Pirin regulates E-cadherin independently of Bcl3-Slug signaling. | Pirin regulates epithelial to mesenchymal transition independently of Bcl3-Slug signaling.
Komai K, Niwa Y, Sasazawa Y, Simizu S. | 05/2/2015 |
| The NRF2 transcription factor binds to this element in vivo and drives the basal PIR expression. | Basal PIR expression in HeLa cells is driven by NRF2 via evolutionary conserved antioxidant response element.
Brzóska K, Stępkowski TM, Kruszewski M., Free PMC Article | 11/8/2014 |
| Pirin is a newly identified binding partner of EAF2/U19 capable of down-regulating EAF2/U19 protein and alleviating its inhibition of prostate cancer cell survival/proliferation. | Pirin down-regulates the EAF2/U19 protein and alleviates its growth inhibition in prostate cancer cells.
Qiao Z, Wang D, Hahn J, Ai J, Wang Z., Free PMC Article | 03/15/2014 |
| Data indicate that the R-shaped area composes the interface for pirin-NF-kappaB binding that is responsible for modulation of NF-kappaB's DNA-binding properties. | Pirin is an iron-dependent redox regulator of NF-κB.
Liu F, Rehmani I, Esaki S, Fu R, Chen L, de Serrano V, Liu A., Free PMC Article | 08/31/2013 |
| pirin may have a relevant role in melanoma progression. | Pirin inhibits cellular senescence in melanocytic cells.
Licciulli S, Luise C, Scafetta G, Capra M, Giardina G, Nuciforo P, Bosari S, Viale G, Mazzarol G, Tonelli C, Lanfrancone L, Alcalay M., Free PMC Article | 08/27/2011 |
| knockdown of pirin or treatment with the small molecule inhibited melanoma cell migration | A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.
Miyazaki I, Simizu S, Okumura H, Takagi S, Osada H. | 10/23/2010 |
| This study aimed to examine genetic variations in the PIR gene by a comprehensive tagging method and its sex-specific effects on bone mineral density and osteoporotic risk. | Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese.
Tang NL, Liao CD, Ching JK, Suen EW, Chan IH, Orwoll E, Ho SC, Chan FW, Kwok AW, Kwok T, Woo J, Leung PC, Tang NL, Liao CD, Ching JK, Suen EW, Chan IH, Orwoll E, Ho SC, Chan FW, Kwok AW, Kwok T, Woo J, Leung PC. | 05/3/2010 |
| An abnormal pattern of PIR sub-cellular localization is a characteristic feature of a subset of melanomas, and suggest it may represent a marker associated with disease progression. | Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches.
Licciulli S, Luise C, Zanardi A, Giorgetti L, Viale G, Lanfrancone L, Carbone R, Alcalay M., Free PMC Article | 05/3/2010 |
| Pirin downregulation is a feature of acute myeloid leukemia and leads to impairment of terminal myeloid differentiation. | Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation.
Licciulli S, Cambiaghi V, Scafetta G, Gruszka AM, Alcalay M. | 03/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese.
Tang NL, Liao CD, Ching JK, Suen EW, Chan IH, Orwoll E, Ho SC, Chan FW, Kwok AW, Kwok T, Woo J, Leung PC, Tang NL, Liao CD, Ching JK, Suen EW, Chan IH, Orwoll E, Ho SC, Chan FW, Kwok AW, Kwok T, Woo J, Leung PC. | 12/2/2009 |
| First report of enzymatic activity for any member of the Pirin family which may be an important connection to their roles in transcriptional regulation. | Structural and biochemical analysis reveal pirins to possess quercetinase activity.
Adams M, Jia Z. | 01/21/2010 |
| x-ray crystallography of of human pirin shows that it is an iron-binding nuclear protein and transcription cofactor | Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor.
Pang H, Bartlam M, Zeng Q, Miyatake H, Hisano T, Miki K, Wong LL, Gao GF, Rao Z. | 01/21/2010 |