| Human testis-specific Y-encoded protein-like protein 5 is a histone H3/H4-specific chaperone that facilitates histone deposition in vitro. | Human testis-specific Y-encoded protein-like protein 5 is a histone H3/H4-specific chaperone that facilitates histone deposition in vitro.
Dalui S, Dasgupta A, Adhikari S, Das C, Roy S., Free PMC Article | 09/17/2022 |
| TSPYL5 activates endoplasmic reticulum stress to inhibit cell proliferation, migration and invasion in colorectal cancer. | TSPYL5 activates endoplasmic reticulum stress to inhibit cell proliferation, migration and invasion in colorectal cancer.
Huang C, He C, Ruan P, Zhou R., Free PMC Article | 05/8/2021 |
| TSPYL5, a novel angiogenic regulator, plays a key role in maintaining endothelial integrity and function. | TSPYL5-mediated inhibition of p53 promotes human endothelial cell function.
Na HJ, Yeum CE, Kim HS, Lee J, Kim JY, Cho YS. | 04/4/2020 |
| PML depletion suppressed POT1 poly-ubiquitination, suggesting an interplay between USP7 and PML to trigger POT1 degradation in TSPYL5-depleted ALT(+) cells. We demonstrate that ALT telomeres need to be protected from POT1 degradation in ALT-associated PML bodies and identify TSPYL5 as an ALT(+) cancer-specific therapeutic target. | TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1.
Episkopou H, Diman A, Claude E, Viceconte N, Decottignies A. | 01/18/2020 |
| The expression of spermatogenic phenotypes of TSPY1 defects is independent of variations in TSPYL1 and TSPYL5 in the Han Chinese population. | Spermatogenic phenotype of testis-specific protein, Y-encoded, 1 (TSPY1) dosage deficiency is independent of variations in TSPY-like 1 (TSPYL1) and TSPY-like 5 (TSPYL5): a case-control study in a Han Chinese population.
Yang X, Leng X, Tu W, Liu Y, Xu J, Pei X, Ma Y, Yang D, Yang Y. | 09/8/2018 |
| Transcriptome analysis of MUC16 KD showed a downregulation (P = 0.005) of TSPYL5 gene, which encodes for a testis-specific Y-like protein...Also, MUC16 overexpression induced cisplatin and gemcitabine resistance by downregulation of p53 | MUC16 Regulates TSPYL5 for Lung Cancer Cell Growth and Chemoresistance by Suppressing p53.
Lakshmanan I, Salfity S, Seshacharyulu P, Rachagani S, Thomas A, Das S, Majhi PD, Nimmakayala RK, Vengoji R, Lele SM, Ponnusamy MP, Batra SK, Ganti AK., Free PMC Article | 04/14/2018 |
| More advanced tumor tissues had an inverse correlation between methylation and TSPYL5 gene or protein expression. TSPYL5 may play a role in sensitivity to chemotherapy likely by modulating pleiotropic protein such as CDKN1A. | Testis specific Y-like 5: gene expression, methylation and implications for drug sensitivity in prostate carcinoma.
Kumar SR, Bryan JN, Esebua M, Amos-Landgraf J, May TJ., Free PMC Article | 03/3/2018 |
| Increasing the expression of TSPYL5 in HT29 cells or inhibiting miR-19-5p promotes apoptosis of HT29 cells. | miR-19-5p Enhances Tumorigenesis in Human Colorectal Cancer Cells by Targeting TSPYL5.
Huang C, Luo H. | 01/20/2018 |
| Overexpression of miR-629 promoted the cell ability of migration and invasion and reduced ovarian cancer cell apoptosis. In addition, elevated cancer inhibition ability of TSPYL5 induced by the miR-629 inhibitor was significantly blocked by inhibition of TSPYL5. | Knockdown of miR-629 Inhibits Ovarian Cancer Malignant Behaviors by Targeting Testis-Specific Y-Like Protein 5.
Shao L, Shen Z, Qian H, Zhou S, Chen Y. | 12/23/2017 |
| TSPYL5 overexpression is associated with Down syndrome. | Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression.
Lu J, Mccarter M, Lian G, Esposito G, Capoccia E, Delli-Bovi LC, Hecht J, Sheen V., Free PMC Article | 08/19/2017 |
| Suggest that hypermethylation of ACP1, BMP4, and TSPYL5 are common events in HCC and could be used as potentially detectable biomarkers in HCC tissues. | Hypermethylation of ACP1, BMP4, and TSPYL5 in Hepatocellular Carcinoma and Their Potential Clinical Significance.
Qiu X, Hu B, Huang Y, Deng Y, Wang X, Zheng F. | 05/14/2016 |
| TSPYL5 knockdown decreased, and overexpression increased aromatase (CYP19A1) expression through the skin/adipose (I.4) promoter. | TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression.
Liu M, Ingle JN, Fridley BL, Buzdar AU, Robson ME, Kubo M, Wang L, Batzler A, Jenkins GD, Pietrzak TL, Carlson EE, Goetz MP, Northfelt DW, Perez EA, Williard CV, Schaid DJ, Nakamura Y, Weinshilboum RM., Free PMC Article | 09/14/2013 |
| Data identify TSPYL5 as a suppressor of p53 function through its interaction with USP7. | TSPYL5 suppresses p53 levels and function by physical interaction with USP7.
Epping MT, Meijer LA, Krijgsman O, Bos JL, Pandolfi PP, Bernards R. | 03/5/2011 |
| This study provides the first demonstration that TSPYL5 modulates cell growth and sensitization of cells to the detrimental effects of damaging agents via regulation of p21(WAF1/Cip1) and PTEN/AKT pathway. | TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21(WAF1/Cip1) and PTEN/AKT pathway.
Kim EJ, Lee SY, Kim TR, Choi SI, Cho EW, Kim KC, Kim IG. | 03/29/2010 |
| aberrant methylation at a CpG island of TSPYL5 may play an important role in development of gastric cancers | Gene silencing of TSPYL5 mediated by aberrant promoter methylation in gastric cancers.
Jung Y, Park J, Bang YJ, Kim TY. | 01/21/2010 |