| Positively charged patch at the carboxyl terminus of Fis1p is required for both membrane insertion and organelle specificity. | Evidence for Amino Acid Snorkeling from a High-Resolution, In Vivo Analysis of Fis1 Tail-Anchor Insertion at the Mitochondrial Outer Membrane.
Keskin A, Akdoğan E, Dunn CD., Free PMC Article | 06/3/2017 |
| Fis1-E78A at lower expression levels recruits Dnm1 into mitochondrial punctate structures but fails to support normal fission. Thus, Fis1 makes multiple interactions that support Dnm1 puncta formation and may be essential after this step, supporting a revised model for assembly of the mitochondrial fission machinery. | A Targeted Mutation Identified through pKa Measurements Indicates a Postrecruitment Role for Fis1 in Yeast Mitochondrial Fission.
Koppenol-Raab M, Harwig MC, Posey AE, Egner JM, MacKenzie KR, Hill RB., Free PMC Article | 05/20/2017 |
| The lifespan extension caused by deletion of FIS1 is mainly due to a defect in peroxisome fission and not caused by a block in mitochondrial fragmentation. | Inhibition of peroxisome fission, but not mitochondrial fission, increases yeast chronological lifespan.
Lefevre SD, Kumar S, van der Klei IJ., Free PMC Article | 03/5/2016 |
| 1.75 A resolution crystal structure of the Fis1 cytoplasmic domain from Saccharomyces cerevisiae is reported which adopts a tetratricopeptide-repeat fold | The 1.75 Å resolution structure of fission protein Fis1 from Saccharomyces cerevisiae reveals elusive interactions of the autoinhibitory domain.
Tooley JE, Khangulov V, Lees JP, Schlessman JL, Bewley MC, Heroux A, Bosch J, Hill RB., Free PMC Article | 02/25/2012 |
| Charcot-Marie-Tooth-related gene GDAP1 complements cell cycle delay at G2/M phase in Saccharomyces cerevisiae fis1 gene-defective cells | Charcot-Marie-Tooth-related gene GDAP1 complements cell cycle delay at G2/M phase in Saccharomyces cerevisiae fis1 gene-defective cells.
Estela A, Pla-Martín D, Sánchez-Piris M, Sesaki H, Palau F., Free PMC Article | 12/10/2011 |
| NMR measurements sensitive to dynamics occurring on a wide range of time scales (picoseconds to minutes) were used to assess whether the Fis1 arm is dynamic. | Evidence for conformational heterogeneity of fission protein Fis1 from Saccharomyces cerevisiae.
Picton LK, Casares S, Monahan AC, Majumdar A, Hill RB., Free PMC Article | 01/21/2010 |
| Deletion of the FIS1 gene in yeast consistently results in acquisition of a secondary mutation that confers sensitivity to cell death. | Fis1 deficiency selects for compensatory mutations responsible for cell death and growth control defects.
Cheng WC, Teng X, Park HK, Tucker CM, Dunham MJ, Hardwick JM., Free PMC Article | 01/21/2010 |
| findings show that Dnm1p-dependent peroxisome fission requires Fis1p, Caf4p and Mdv1p; association of Caf4p and Mdv1p with peroxisomes relies on Fis1p | Dnm1p-dependent peroxisome fission requires Caf4p, Mdv1p and Fis1p.
Motley AM, Ward GP, Hettema EH., Free PMC Article | 01/21/2010 |
| reveal how Fis1 recruits the mitochondrial fission complex and will facilitate efforts to manipulate mitochondrial fission | Structural basis for recruitment of mitochondrial fission complexes by Fis1.
Zhang Y, Chan DC., Free PMC Article | 01/21/2010 |
| Refinement against the (13)C' T(1)/T(2) improved the overall quality of the yeast Fis1 structure, as evaluated by cross-validation against the residual dipolar coupling as well as the (15)N relaxation data. | Refinement of protein structure against non-redundant carbonyl 13C NMR relaxation.
Tjandra N, Suzuki M, Chang SL. | 01/21/2010 |
| Dnm1p dimers are initially recruited to the membrane via interaction with Mdv1p.Fis1p complexes | Dimeric Dnm1-G385D interacts with Mdv1 on mitochondria and can be stimulated to assemble into fission complexes containing Mdv1 and Fis1.
Bhar D, Karren MA, Babst M, Shaw JM. | 01/21/2010 |
| Ethanol-induced cell death in yeast is Fis1-mediated apoptosis. | Ethanol-induced death in yeast exhibits features of apoptosis mediated by mitochondrial fission pathway.
Kitagaki H, Araki Y, Funato K, Shimoi H. | 01/21/2010 |
| the N terminus of Fis1 is a prerequisite to recruit Mdv1 to facilitate mitochondrial fission | Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission.
Suzuki M, Neutzner A, Tjandra N, Youle RJ. | 01/21/2010 |
| Data suggest that Caf4p and Fis1, but not Mdv1, play a role in determining the polarized localization of those Dnm1p clusters that are not immediately involved in the mitochondrial fission process. | Fis1p and Caf4p, but not Mdv1p, determine the polar localization of Dnm1p clusters on the mitochondrial surface.
Schauss AC, Bewersdorf J, Jakobs S. | 01/21/2010 |