| Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore. | Ctf3/CENP-I provides a docking site for the desumoylase Ulp2 at the kinetochore.
Quan Y, Hinshaw SM, Wang PC, Harrison SC, Zhou H., Free PMC Article | 10/23/2021 |
| These results indicate that Ulp2 utilizes its dual substrate recognition to prevent hyper-sumoylation of Constitutive Centromere-Associated Network, ensuring accurate chromosome segregation during cell division. | Recruitment of the Ulp2 protease to the inner kinetochore prevents its hyper-sumoylation to ensure accurate chromosome segregation.
Suhandynata RT, Quan Y, Yang Y, Yuan WT, Albuquerque CP, Zhou H., Free PMC Article | 02/22/2020 |
| Results suggest sequential ubiquitin-histone and SUMO-histone modifications recruit Ulp2, which removes polySUMO chains and promotes RNAPII transcription elongation. | The Ulp2 SUMO protease promotes transcription elongation through regulation of histone sumoylation.
Ryu HY, Su D, Wilson-Eisele NR, Zhao D, López-Giráldez F, Hochstrasser M., Free PMC Article | 12/28/2019 |
| Aneuploidy allows rapid adaptation to Ulp2 loss, but long-term adaptation restores euploidy. | Distinct adaptive mechanisms drive recovery from aneuploidy caused by loss of the Ulp2 SUMO protease.
Ryu HY, López-Giráldez F, Knight J, Hwang SS, Renner C, Kreft SG, Hochstrasser M., Free PMC Article | 02/23/2019 |
| Binding to Csm1 regulates substrate specificity of the Ulp2 protease. | Binding to small ubiquitin-like modifier and the nucleolar protein Csm1 regulates substrate specificity of the Ulp2 protease.
de Albuquerque CP, Suhandynata RT, Carlson CR, Yuan WT, Zhou H., Free PMC Article | 02/9/2019 |
| Ulp2 promotes rDNA silencing by opposing STUbL-mediated degradation of silencing proteins | Recruitment of a SUMO isopeptidase to rDNA stabilizes silencing complexes by opposing SUMO targeted ubiquitin ligase activity.
Liang J, Singh N, Carlson CR, Albuquerque CP, Corbett KD, Zhou H., Free PMC Article | 10/7/2017 |
| Extra copies of ChrI and ChrXII appear quickly following loss of active Ulp2 and can be eliminated following reintroduction of ULP2, suggesting that aneuploidy is a reversible adaptive mechanism to counteract loss of the SUMO protease | Loss of the SUMO protease Ulp2 triggers a specific multichromosome aneuploidy.
Ryu HY, Wilson NR, Mehta S, Hwang SS, Hochstrasser M., Free PMC Article | 05/20/2017 |
| Ulp2 controls the dynamic range of SUMO chain lengths by trimming them from the distal ends | In Vitro Studies Reveal a Sequential Mode of Chain Processing by the Yeast SUMO (Small Ubiquitin-related Modifier)-specific Protease Ulp2.
Eckhoff J, Dohmen RJ., Free PMC Article | 08/8/2015 |
| mis-regulation is accompanied by a severe, recombination-dependent, block to chromosome segregation, revealing a critical role for Ulp2p in allowing sister chromatids to disjoin following HR DNA repair. | The SUMO isopeptidase Ulp2p is required to prevent recombination-induced chromosome segregation lethality following DNA replication stress.
Lee MT, Bakir AA, Nguyen KN, Bachant J., Free PMC Article | 07/30/2011 |
| C-terminal region of Ulp2 is phosphorylated during mitosis in a Cdc5-dependent manner. | The yeast SUMO isopeptidase Smt4/Ulp2 and the polo kinase Cdc5 act in an opposing fashion to regulate sumoylation in mitosis and cohesion at centromeres.
Baldwin ML, Julius JA, Tang X, Wang Y, Bachant J. | 01/21/2010 |
| The N-terminal domains is essential for Ulp2 function and is required for nuclear targeting. | Essential role of nuclear localization for yeast Ulp2 SUMO protease function.
Kroetz MB, Su D, Hochstrasser M., Free PMC Article | 01/21/2010 |
| This review shows how Ulp2 protein enables the successful completion of mitosis following DNA damage. | Ulp2 and the DNA damage response: desumoylation enables safe passage through mitosis.
Felberbaum R, Hochstrasser M. | 01/21/2010 |
| Data show that the SUMO protease Ulp2 is required for resumption of cell division following DNA damage-induced arrest in Saccharomyces cerevisiae, although it is not required for DNA double-strand break repair. | The Ulp2 SUMO protease is required for cell division following termination of the DNA damage checkpoint.
Schwartz DC, Felberbaum R, Hochstrasser M., Free PMC Article | 01/21/2010 |