| The Polo kinase Cdc5 is regulated at multiple levels in the adaptation response to telomere dysfunction. | The Polo kinase Cdc5 is regulated at multiple levels in the adaptation response to telomere dysfunction.
Coutelier H, Ilioaia O, Le Peillet J, Hamon M, D'Amours D, Teixeira MT, Xu Z., Free PMC Article | 01/21/2023 |
| The N-Terminal Region of the Polo Kinase Cdc5 Is Required for Downregulation of the Meiotic Recombination Checkpoint. | The N-Terminal Region of the Polo Kinase Cdc5 Is Required for Downregulation of the Meiotic Recombination Checkpoint.
González-Arranz S, Acosta I, Carballo JA, Santos B, San-Segundo PA., Free PMC Article | 01/8/2022 |
| Polo kinase recruitment via the constitutive centromere-associated network at the kinetochore elevates centromeric RNA. | Polo kinase recruitment via the constitutive centromere-associated network at the kinetochore elevates centromeric RNA.
Ólafsson G, Thorpe PH., Free PMC Article | 09/26/2020 |
| we confirmed that this release indeed accompanies the dissociation of acetylated Smc3 as well as Rec8 from meiotic chromosomes during late prophase-I. This release requires, in addition to PLK, the cohesin regulator, Wapl (Rad61/Wpl1 in yeast), and Dbf4-dependent Cdc7 kinase (DDK) | Meiosis-specific prophase-like pathway controls cleavage-independent release of cohesin by Wapl phosphorylation.
Challa K, Fajish V G, Shinohara M, Klein F, Gasser SM, Shinohara A., Free PMC Article | 03/16/2019 |
| Cdc5 interacts with cohesin in vivo, and cohesin is required for association of Cdc5 at centromeric chromatin. Cohesin removal from centromeric chromatin requires Cdc5 but removal at distal chromosomal arm sites does not. Results define a novel role for Cdc5 in regulating removal of centromeric cohesins and faithful chromosome segregation. | Polo kinase Cdc5 associates with centromeres to facilitate the removal of centromeric cohesin during mitosis.
Mishra PK, Ciftci-Yilmaz S, Reynolds D, Au WC, Boeckmann L, Dittman LE, Jowhar Z, Pachpor T, Yeh E, Baker RE, Hoyt MA, D'Amours D, Bloom K, Basrai MA., Free PMC Article | 08/12/2017 |
| budding yeast Plk1, Cdc5, is pre-deposited onto cohesin engaged in cohesion on chromosome arms in G2/M phase cells. The Cdc5-cohesin association is mediated by direct interaction between the polo-box domain of Cdc5 and Scc1 phosphorylated at multiple sites in its middle region. | Physical Association of Saccharomyces cerevisiae Polo-like Kinase Cdc5 with Chromosomal Cohesin Facilitates DNA Damage Response.
Pakchuen S, Ishibashi M, Takakusagi E, Shirahige K, Sutani T., Free PMC Article | 05/6/2017 |
| Polo kinase Cdc5 mediates centrosome-dependent bypass of the DNA damage checkpoint. | Centrosome-Dependent Bypass of the DNA Damage Checkpoint by the Polo Kinase Cdc5.
Ratsima H, Serrano D, Pascariu M, D'Amours D. | 12/17/2016 |
| Small N-terminal regions of both Cdc20 (RxxL-type D box) and Cdc5 (KEN motif) were identified as transferable degradation domains (degrons) that mediated efficient targeting by APC/C-Cdh1 (anaphase-promoting complex/cyclosome-Cdh1). | Insights into the cellular mechanism of the yeast ubiquitin ligase APC/C-Cdh1 from the analysis of in vivo degrons.
Arnold L, Höckner S, Seufert W., Free PMC Article | 10/31/2015 |
| Cin8 mutants lacking critical CDK phosphorylation sites suppress the requirement for Cdc14 and Cdc5 in anaphase spindle elongation. | FEAR-mediated activation of Cdc14 is the limiting step for spindle elongation and anaphase progression.
Roccuzzo M, Visintin C, Tili F, Visintin R. | 05/2/2015 |
| Misregulated expression of Cdc5 causes increased mitotic crossover frequency. | Cell-cycle kinases coordinate the resolution of recombination intermediates with chromosome segregation.
Matos J, Blanco MG, West SC. | 02/1/2014 |
| Despite CDC5's central role in meiosis I, the protein kinase is dispensable during meiosis II and does not even phosphorylate its meiosis I targets during the second meiotic division | Polo kinase Cdc5 is a central regulator of meiosis I.
Attner MA, Miller MP, Ee LS, Elkin SK, Amon A., Free PMC Article | 11/23/2013 |
| Premature activation of the Cdk1/Cdc5/Mus81 pathway induces crossover-associated chromosome translocations and precocious processing of damage-bypass sister chromatid junction intermediates. | Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossover.
Szakal B, Branzei D., Free PMC Article | 06/22/2013 |
| Cdc5 induces the asymmetric distribution of Bfa1 to the bud-directed spindle pole body independently of Bfa1 GAP activity at anaphase. | Cdc5-dependent asymmetric localization of bfa1 fine-tunes timely mitotic exit.
Kim J, Luo G, Bahk YY, Song K., Free PMC Article | 06/30/2012 |
| Our results reveal a role for Cdc5 in meiotic checkpoint control by regulating Ndt80 function | The budding yeast polo-like kinase Cdc5 regulates the Ndt80 branch of the meiotic recombination checkpoint pathway.
Acosta I, Ontoso D, San-Segundo PA., Free PMC Article | 01/14/2012 |
| Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability. | Independent modulation of the kinase and polo-box activities of Cdc5 protein unravels unique roles in the maintenance of genome stability.
Ratsima H, Ladouceur AM, Pascariu M, Sauvé V, Salloum Z, Maddox PS, D'Amours D., Free PMC Article | 12/24/2011 |
| Data show that polo-like kinase Cdc5 first phosphorylates Hof1 to allow subsequent phosphorylation by Dbf2-Mob1. | Phosphorylation-dependent regulation of the F-BAR protein Hof1 during cytokinesis.
Meitinger F, Boehm ME, Hofmann A, Hub B, Zentgraf H, Lehmann WD, Pereira G., Free PMC Article | 06/18/2011 |
| Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction | Dbf4 regulates the Cdc5 Polo-like kinase through a distinct non-canonical binding interaction.
Chen YC, Weinreich M., Free PMC Article | 02/26/2011 |
| Cdc5 acts to attenuate the DNA damage checkpoint through loss of Rad53 hyperphosphorylation to allow cells to adapt to DNA damage. | CDC5 inhibits the hyperphosphorylation of the checkpoint kinase Rad53, leading to checkpoint adaptation.
Vidanes GM, Sweeney FD, Galicia S, Cheung S, Doyle JP, Durocher D, Toczyski DP., Free PMC Article | 07/12/2010 |
| Cdc5 override the Mec1/ATR checkpoint by acting at different steps of the signaling pathway. | Elevated levels of the polo kinase Cdc5 override the Mec1/ATR checkpoint in budding yeast by acting at different steps of the signaling pathway.
Donnianni RA, Ferrari M, Lazzaro F, Clerici M, Tamilselvan Nachimuthu B, Plevani P, Muzi-Falconi M, Pellicioli A., Free PMC Article | 03/15/2010 |
| Cdc5 is a novel regulator of the SUMO pathway and suggest the outlines of a broader circuitry in which Ulp2 and Cdc5 act in a mutually antagonistic fashion to modulate maintenance and dissolution of cohesion at centromeres. | The yeast SUMO isopeptidase Smt4/Ulp2 and the polo kinase Cdc5 act in an opposing fashion to regulate sumoylation in mitosis and cohesion at centromeres.
Baldwin ML, Julius JA, Tang X, Wang Y, Bachant J. | 01/21/2010 |
| Results suggest that that Cdc5 promotes Cdc14 release primarily by stimulating the degradation of Swe1, the inhibitory kinase for mitotic Cdk. | The molecular function of the yeast polo-like kinase Cdc5 in Cdc14 release during early anaphase.
Liang F, Jin F, Liu H, Wang Y., Free PMC Article | 01/21/2010 |
| Cdc7p-Dbf4p prevents inappropriate exit from mitosis by inhibiting Polo kinase and functions in the spindle position checkpoint. | Cdc7p-Dbf4p regulates mitotic exit by inhibiting Polo kinase.
Miller CT, Gabrielse C, Chen YC, Weinreich M., Free PMC Article | 01/21/2010 |
| Data demonstrate that Cdc5 directly phosphorylates all three regulatory subunits of the condensin complex in vivo and that this causes a hyperactivation of condensin DNA supercoiling activity. | Polo kinase regulates mitotic chromosome condensation by hyperactivation of condensin DNA supercoiling activity.
St-Pierre J, Douziech M, Bazile F, Pascariu M, Bonneil E, Sauvé V, Ratsima H, D'Amours D. | 01/21/2010 |
| Data show that Cdc5 interacts with Cdc14, that that this association is mediated by Cdc5's Polo-box domain, and that the Cdc5-Cdc14 association is direct. | The Polo-like kinase Cdc5 interacts with FEAR network components and Cdc14.
Rahal R, Amon A., Free PMC Article | 01/21/2010 |
| Cdh1 inactivation by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle | Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle.
Crasta K, Lim HH, Giddings TH Jr, Winey M, Surana U., Free PMC Article | 01/21/2010 |