| Pif1 Helicase Mediates Remodeling of Protein-Nucleic Acid Complexes by Promoting Dissociation of Sub1 from G-Quadruplex DNA and Cdc13 from G-Rich Single-Stranded DNA. | Pif1 Helicase Mediates Remodeling of Protein-Nucleic Acid Complexes by Promoting Dissociation of Sub1 from G-Quadruplex DNA and Cdc13 from G-Rich Single-Stranded DNA.
Chib S, Griffin WC, Gao J, Proffitt DR, Byrd AK, Raney KD., | 12/20/2023 |
| The Role of S. cerevisiae Sub1/PC4 in Transcription Elongation Depends on the C-Terminal Region and Is Independent of the ssDNA Binding Domain. | The Role of S. cerevisiae Sub1/PC4 in Transcription Elongation Depends on the C-Terminal Region and Is Independent of the ssDNA Binding Domain.
Collin A, González-Jiménez A, González-Jiménez MDC, Alfonso MJ, Calvo O., Free PMC Article | 11/5/2022 |
| Evolutionarily conserved role for Sub1 and PC4 in the maintenance of yeast and human genome stability has been summarized. (Review) | Sub1/PC4, a multifaceted factor: from transcription to genome stability.
Garavís M, Calvo O. | 06/23/2018 |
| Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA. | Yeast Sub1 and human PC4 are G-quadruplex binding proteins that suppress genome instability at co-transcriptionally formed G4 DNA.
Lopez CR, Singh S, Hambarde S, Griffin WC, Gao J, Chib S, Yu Y, Ira G, Raney KD, Kim N., Free PMC Article | 09/23/2017 |
| demonstrate that physical and genetic interactions exist between Hot1 and several proteins involved in transcriptional and posttranscriptional processes: for example, transcription co-activator Sub1 and elongation complex Spt4/5 | Hot1 factor recruits co-activator Sub1 and elongation complex Spt4/5 to osmostress genes.
Gomar-Alba M, Del Olmo M. | 07/1/2017 |
| demonstrate that purified Sub1 protein can protect DNA from oxidative damage in vitro, using the metal ion catalyzed oxidation assay | The Sub1 nuclear protein protects DNA from oxidative damage.
Yu L, Ma H, Ji X, Volkert MR., Free PMC Article | 11/5/2016 |
| This hypothesis was reinforced by the finding that inactivation of Sub1 transcription initiation factor, which is found predominantly in the regions of transcription initiation, leads to further increase in mutagenesis in the beginning of the genes. | Disruption of Transcriptional Coactivator Sub1 Leads to Genome-Wide Re-distribution of Clustered Mutations Induced by APOBEC in Active Yeast Genes.
Lada AG, Kliver SF, Dhar A, Polev DE, Masharsky AE, Rogozin IB, Pavlov YI., Free PMC Article | 04/30/2016 |
| results suggest that SUB1 acts as a negative regulator of sporulation. | SUB1 Plays a Negative Role during Starvation Induced Sporulation Program in Saccharomyces cerevisiae.
Gupta R, Sadhale PP, Vijayraghavan U., Free PMC Article | 04/16/2016 |
| Sub1, and its human homolog PC4, bind preferentially to G-quadruplexes | Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA.
Gao J, Zybailov BL, Byrd AK, Griffin WC, Chib S, Mackintosh SG, Tackett AJ, Raney KD., Free PMC Article | 01/2/2016 |
| Sub1 and Maf1 also exhibit an opposite role on yeast chronological life span | Sub1 and Maf1, two effectors of RNA polymerase III, are involved in the yeast quiescence cycle.
Acker J, Nguyen NT, Vandamme M, Tavenet A, Briand-Suleau A, Conesa C., Free PMC Article | 08/22/2015 |
| Differential requirement for SUB1 in chromosomal and plasmid double-strand DNA break repair. | Differential requirement for SUB1 in chromosomal and plasmid double-strand DNA break repair.
Yu L, Volkert MR., Free PMC Article | 10/19/2013 |
| Propose that Sub1 and RPA interact with the nontemplate strand of RNA polymerase II complexes during initiation and elongation, respectively. | Sub1 and RPA associate with RNA polymerase II at different stages of transcription.
Sikorski TW, Ficarro SB, Holik J, Kim T, Rando OJ, Marto JA, Buratowski S., Free PMC Article | 12/31/2011 |
| multiple roles for Sub1 in the regulation of RNA polymerase II C-terminal domain phosphorylation throughout the transcription cycle | Sub1 globally regulates RNA polymerase II C-terminal domain phosphorylation.
García A, Rosonina E, Manley JL, Calvo O., Free PMC Article | 11/6/2010 |
| Data showed that Sub1 was required for optimal Pol III gene transcription in exponentially growing cells. | Genome-wide location analysis reveals a role for Sub1 in RNA polymerase III transcription.
Tavenet A, Suleau A, Dubreuil G, Ferrari R, Ducrot C, Michaut M, Aude JC, Dieci G, Lefebvre O, Conesa C, Acker J., Free PMC Article | 01/21/2010 |
| during osmotic shock, Sub1 facilitates osmoresponse gene transcription by enhancing preinitiation complex formation | Sub1 functions in osmoregulation and in transcription by both RNA polymerases II and III.
Rosonina E, Willis IM, Manley JL., Free PMC Article | 01/21/2010 |
| the transcriptional co-activator Sub1 also has a role in transcriptional repression during transcription initiation in vivo. | Transcriptional repression of the IMD2 gene mediated by the transcriptional co-activator Sub1.
Koyama H, Sumiya E, Nagata M, Ito T, Sekimizu K. | 01/21/2010 |
| Sub1 influences and/or is sensitive to the phosphorylation status of elongating RNAP II. | The transcriptional coactivator PC4/Sub1 has multiple functions in RNA polymerase II transcription.
Calvo O, Manley JL., Free PMC Article | 01/21/2010 |
| glycogen synthesis in the absence of glycogenin may rely on an activated glycogen synthase and alternative primers whose synthesis may be controlled by TPS1 or under epigenetic silencing | Glycogen synthesis in the absence of glycogenin in the yeast Saccharomyces cerevisiae.
Torija MJ, Novo M, Lemassu A, Wilson W, Roach PJ, François J, Parrou JL. | 01/21/2010 |