| The diverging role of CDC14B: from mitotic exit in yeast to cell fate control in humans. | The diverging role of CDC14B: from mitotic exit in yeast to cell fate control in humans.
Partscht P, Schiebel E., Free PMC Article | 08/17/2023 |
| CDC14B is a favorable biomarker for recurrence and prognosis of GBM. | CDC14B is a favorable biomarker for recurrence and prognosis of GBM.
Zhu C, Zhao Y, Zheng W. | 03/31/2023 |
| Downregulation of CDC14B in 5218 breast cancer patients: A novel prognosticator for triple-negative breast cancer. | Downregulation of CDC14B in 5218 breast cancer patients: A novel prognosticator for triple-negative breast cancer.
Li JD, Chen G, Wu M, Huang Y, Tang W. | 08/21/2021 |
| Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression. | Human cells lacking CDC14A and CDC14B show differences in ciliogenesis but not in mitotic progression.
Partscht P, Uddin B, Schiebel E. | 08/7/2021 |
| MiR-1247-5p Functions as a Tumor Suppressor in Human Astroglioma Cells by Targeting CDC14B. | MiR-1247-5p Functions as a Tumor Suppressor in Human Astroglioma Cells by Targeting CDC14B.
Liu Q, Dong Z, Chen T. | 02/6/2021 |
| miR-1225 targets CDC14B 3'-UTR and recovery of CDC14B expression counteracted the suppressive influence of miR-1225 on laryngeal cancer cells | MicroRNA-1225-5p acts as a tumor-suppressor in laryngeal cancer via targeting CDC14B.
Sun P, Zhang D, Huang H, Yu Y, Yang Z, Niu Y, Liu J. | 10/5/2019 |
| The authors found a significant association between the localization of RET mutations and the expression of three genes: NNAT (suggested to be a tumour suppressor gene), CDC14B (involved in cell cycle control) and NTRK3 (tyrosine receptor kinase that undergoes rearrangement in papillary thyroid cancer) in patients with medullary thyroid cancer. | Differences in the transcriptome of medullary thyroid cancer regarding the status and type of RET gene mutations.
Oczko-Wojciechowska M, Swierniak M, Krajewska J, Kowalska M, Kowal M, Stokowy T, Wojtas B, Rusinek D, Pawlaczek A, Czarniecka A, Szpak-Ulczok S, Gawlik T, Chmielik E, Tyszkiewicz T, Nikiel B, Lange D, Jarzab M, Wiench M, Jarzab B., Free PMC Article | 10/27/2018 |
| hCdc14B promotes reactivation of rDNA transcription by dephosphorylating TAFI110. SIRT1 becomes transiently enriched in nucleoli at the onset of mitosis. SIRT1 deacetylates TAFI68 destabilizing SL1 binding to the rDNA promoter | Cooperative Action of Cdk1/cyclin B and SIRT1 Is Required for Mitotic Repression of rRNA Synthesis.
Voit R, Seiler J, Grummt I., Free PMC Article | 04/9/2016 |
| CDC14B expression is downregulated in clear cell renal carinoma, suggesting its role in renal carcinogenesis | Loss of CDC14B expression in clear cell renal cell carcinoma: meta-analysis of microarray data sets.
Kim Y, Choi JW, Lee JH, Kim YS. | 05/3/2014 |
| CDC (cell division cycle) 14A/B phosphatases associate with KIBRA, and CDK1-non-phosphorylatable KIBRA has greatly reduced interaction with CDC14B. | Phospho-regulation of KIBRA by CDK1 and CDC14 phosphatase controls cell-cycle progression.
Ji M, Yang S, Chen Y, Xiao L, Zhang L, Dong J. | 11/17/2012 |
| studies have revealed a novel interplay between Chk1 kinase and Cdc14B phosphatase involving radiation-induced nucleolar shuttling to facilitate error-free cell cycle progression and prevent genomic instability | The DNA damage effector Chk1 kinase regulates Cdc14B nucleolar shuttling during cell cycle progression.
Peddibhotla S, Wei Z, Papineni R, Lam MH, Rosen JM, Zhang P., Free PMC Article | 09/3/2011 |
| Cdc14B-dependent modulation of Cdc25 phosphatase and Cdk1/cyclin B activity is linked to correct chromosome segregation and bipolar spindle formation, processes that are required for proper progression through mitosis and maintenance of genomic stability. | Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity.
Tumurbaatar I, Cizmecioglu O, Hoffmann I, Grummt I, Voit R., Free PMC Article | 09/3/2011 |
| human HCT116, and human telomerase reverse transcription-immortalized retinal pigment epithelial cells deleted for Cdc14B are DNA damage checkpoint proficient and arrest efficiently in G2 in response to irradiation. | Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair.
Mocciaro A, Berdougo E, Zeng K, Black E, Vagnarelli P, Earnshaw W, Gillespie D, Jallepalli P, Schiebel E., Free PMC Article | 07/5/2010 |
| In response to genotoxic stress in G2, the phosphatase Cdc14B translocates from the nucleolus to the nucleoplasm and induces the activation of the ubiquitin ligase APC/C(Cdh1), with the consequent degradation of Plk1, a prominent mitotic kinase. | The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint.
Bassermann F, Frescas D, Guardavaccaro D, Busino L, Peschiaroli A, Pagano M., Free PMC Article | 01/21/2010 |
| Our findings reveal substantial divergence in mitotic regulation between yeast and mammalian cells, as the latter possess efficient mechanisms for completing late M-phase events in the absence of a nucleolar Cdc14-related phosphatase. | The nucleolar phosphatase Cdc14B is dispensable for chromosome segregation and mitotic exit in human cells.
Berdougo E, Nachury MV, Jackson PK, Jallepalli PV. | 01/21/2010 |
| Results suggest a potential function for Cdc14B phosphatase in maintaining the fidelity of centrosome duplication cycle. | Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication.
Wu J, Cho HP, Rhee DB, Johnson DK, Dunlap J, Liu Y, Wang Y., Free PMC Article | 01/21/2010 |
| CDC14B is a novel microtubule-bundling and -stabilizing protein, whose regulated subcellular localization may help modulate spindle and microtubule dynamics in mitosis. | The dual-specificity phosphatase CDC14B bundles and stabilizes microtubules.
Cho HP, Liu Y, Gomez M, Dunlap J, Tyers M, Wang Y., Free PMC Article | 01/21/2010 |
| hCdc14A and hCdc14B have functional homology to S. pombe Cdc25 and flp1 | Functional homology among human and fission yeast Cdc14 phosphatases.
Vázquez-Novelle MD, Esteban V, Bueno A, Sacristán MP. | 01/21/2010 |
| Cdc14B is critical for the maintenance of proper nuclear structure. | Visualization of a highly organized intranuclear network of filaments in living mammalian cells.
Nalepa G, Harper JW. | 01/21/2010 |