| Low tension recruits the yeast Aurora B protein Ipl1 to centromeres in metaphase. | Low tension recruits the yeast Aurora B protein Ipl1 to centromeres in metaphase.
Edgerton HD, Mukherjee S, Johansson M, Bachant J, Gardner MK, Clarke DJ., Free PMC Article | 08/22/2023 |
| Structure of the Ndc80 complex and its interactions at the yeast kinetochore-microtubule interface. | Structure of the Ndc80 complex and its interactions at the yeast kinetochore-microtubule interface.
Zahm JA, Jenni S, Harrison SC., Free PMC Article | 03/10/2023 |
| Killing two birds with one stone: how budding yeast Mps1 controls chromosome segregation and spindle assembly checkpoint through phosphorylation of a single kinetochore protein. | Killing two birds with one stone: how budding yeast Mps1 controls chromosome segregation and spindle assembly checkpoint through phosphorylation of a single kinetochore protein.
Benzi G, Piatti S. | 06/5/2021 |
| These results give important insight into how Aurora B disrupts kinetochore-microtubule interaction in a tension-dependent manner to promote chromosome bi-orientation. | Aurora B-INCENP Localization at Centromeres/Inner Kinetochores Is Required for Chromosome Bi-orientation in Budding Yeast.
García-Rodríguez LJ, Kasciukovic T, Denninger V, Tanaka TU., Free PMC Article | 05/16/2020 |
| While ubiquitylation likely regulates Ipl1 protein stability via the canonical proteasomal degradation pathway, a non-canonical ubiquitin-dependent pathway maintains normal Glc7 localization and activity. | New ubiquitin-dependent mechanisms regulating the Aurora B-protein phosphatase 1 balance in Saccharomyces cerevisiae.
Ravindran R, Polk P, Robinson LC, Tatchell K. | 11/30/2019 |
| The authors show that the Ndc80 complex can simultaneously bind and bridge across two Dam1 complex rings through a tripartite interaction, each component of which is regulated by Aurora B kinase. | The Ndc80 complex bridges two Dam1 complex rings.
Kim JO, Zelter A, Umbreit NT, Bollozos A, Riffle M, Johnson R, MacCoss MJ, Asbury CL, Davis TN., Free PMC Article | 02/10/2018 |
| Decatenation and condensation defects lead to spindle stabilization during cytokinesis, allowing bridge detection by Aurora B. | The Aurora-B-dependent NoCut checkpoint prevents damage of anaphase bridges after DNA replication stress.
Amaral N, Vendrell A, Funaya C, Idrissi FZ, Maier M, Kumar A, Neurohr G, Colomina N, Torres-Rosell J, Geli MI, Mendoza M. | 06/3/2017 |
| Shedding is regulated by the conserved protein kinase Ipl1/Aurora-B and promotes the subsequent assembly of a kinetochore. | Ipl1/Aurora-B is necessary for kinetochore restructuring in meiosis I in Saccharomyces cerevisiae.
Meyer RE, Chuong HH, Hild M, Hansen CL, Kinter M, Dawson DS., Free PMC Article | 06/11/2016 |
| increase in Aurora B activity causes premature collapse of the mitotic spindle by promoting instability of the spindle midzone. | Increased Aurora B activity causes continuous disruption of kinetochore-microtubule attachments and spindle instability.
Muñoz-Barrera M, Monje-Casas F., Free PMC Article | 04/25/2015 |
| Ipl1-dependent phosphorylation of Sli15 therefore inhibits its association with microtubules both in vivo and in vitro and may negatively regulate the tension checkpoint mechanism. | Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae.
Makrantoni V, Corbishley SJ, Rachidi N, Morrice NA, Robinson DA, Stark MJ., Free PMC Article | 10/25/2014 |
| a novel and unexpected role for Aurora kinase in preventing the formation of spindles by Clb5-CDK (S-CDK) during meiotic prophase I | Ipl1/Aurora kinase suppresses S-CDK-driven spindle formation during prophase I to ensure chromosome integrity during meiosis.
Newnham L, Jordan PW, Carballo JA, Newcombe S, Hoffmann E., Free PMC Article | 09/6/2014 |
| protein phosphatase-1 and aurora protein kinase suppressors | Analysis of protein phosphatase-1 and aurora protein kinase suppressors reveals new aspects of regulatory protein function in Saccharomyces cerevisiae.
Ghosh A, Cannon JF., Free PMC Article | 03/1/2014 |
| We found that Aurora B phosphorylation of Dsn1 promotes the interaction between outer and inner kinetochore proteins in budding yeast. | The aurora B kinase promotes inner and outer kinetochore interactions in budding yeast.
Akiyoshi B, Nelson CR, Biggins S., Free PMC Article | 02/15/2014 |
| phosphorylation of INCENP/Sli15 is required for activation of the kinase Aurora B/Ipl1 and can occur in trans. | Phosphorylation regulates kinase and microtubule binding activities of the budding yeast chromosomal passenger complex in vitro.
Cormier A, Drubin DG, Barnes G., Free PMC Article | 11/2/2013 |
| results suggest that activation of Aurora B kinase (Ipl1) by clustering either on chromatin or on microtubules is sufficient for chromosome biorientation | Tension sensing by Aurora B kinase is independent of survivin-based centromere localization.
Campbell CS, Desai A., Free PMC Article | 06/29/2013 |
| demonstrate that Rgd1p is phosphorylated by the Aurora B like kinase Ipl1 and observe that loss of Ipl1 function leads to a new Rgd1p distribution in a small part of the cell population | The Saccharomyces cerevisiae RhoGAP Rgd1 is phosphorylated by the Aurora B like kinase Ipl1.
Vieillemard A, Prouzet-Mauléon V, Hugues M, Lefebvre F, Mitteau R, Claverol S, Bonneu M, Crouzet M, Doignon F, Thoraval D. | 05/25/2013 |
| Ipl1 released these improper connections, whereas Mps1 triggered the formation of new force-generating microtubule attachments. | Mps1 and Ipl1/Aurora B act sequentially to correctly orient chromosomes on the meiotic spindle of budding yeast.
Meyer RE, Kim S, Obeso D, Straight PD, Winey M, Dawson DS., Free PMC Article | 03/9/2013 |
| The Ipl1/Aurora-dependent phosphorylation of Sli15 controls spindle function by excluding the CPC from spindle regions engaged in microtubule polymerization. | Ipl1/Aurora-dependent phosphorylation of Sli15/INCENP regulates CPC-spindle interaction to ensure proper microtubule dynamics.
Nakajima Y, Cormier A, Tyers RG, Pigula A, Peng Y, Drubin DG, Barnes G., Free PMC Article | 10/1/2011 |
| Cdc48-Shp1 promotes nuclear accumulation of Glc7 to counteract Ipl1 activity. | The AAA-ATPase Cdc48 and cofactor Shp1 promote chromosome bi-orientation by balancing Aurora B activity.
Cheng YL, Chen RH. | 09/6/2010 |
| the interaction between the Ndc80 and Dam1 complexes is abolished when the Dam1 complex is phosphorylated by the yeast aurora B kinase Ipl1. | Cooperation of the Dam1 and Ndc80 kinetochore complexes enhances microtubule coupling and is regulated by aurora B.
Tien JF, Umbreit NT, Gestaut DR, Franck AD, Cooper J, Wordeman L, Gonen T, Asbury CL, Davis TN., Free PMC Article | 07/5/2010 |
| We found that kinetochore-bound Ndc80 is phosphorylated on Ipl1 sites in vivo, but this phosphorylation is not essential.Instead, we show that additional Ipl1 targets contribute to segregation and the spindle checkpoint. | Analysis of Ipl1-mediated phosphorylation of the Ndc80 kinetochore protein in Saccharomyces cerevisiae.
Akiyoshi B, Nelson CR, Ranish JA, Biggins S., Free PMC Article | 02/22/2010 |
| Data propose that Aurora B/Ipl1-facilitated bi-orientation is stabilised in response to tension at kinetochores by dephosphorylation of Dam1, resulting in termination of kinetochore-microtubule attachment turnover. | Ipl1-dependent phosphorylation of Dam1 is reduced by tension applied on kinetochores.
Keating P, Rachidi N, Tanaka TU, Stark MJ., Free PMC Article | 02/8/2010 |
| Ipl1 coordinates changes to meiotic chromosome structure with resolution of crossovers and cell cycle progression at the end of meiotic prophase | Ipl1/Aurora B kinase coordinates synaptonemal complex disassembly with cell cycle progression and crossover formation in budding yeast meiosis.
Jordan P, Copsey A, Newnham L, Kolar E, Lichten M, Hoffmann E., Free PMC Article | 01/21/2010 |
| The budding Bim1p is regulated by Ipl1p-mediated multisite phosphorylation. Bim1p forms a stable complex with Ipl1p and is phosphorylated on a cluster of six Ser residues in the flexible linker connecting the calponin homology (CH) and EB1 domains. | Phosphoregulation of the budding yeast EB1 homologue Bim1p by Aurora/Ipl1p.
Zimniak T, Stengl K, Mechtler K, Westermann S., Free PMC Article | 01/21/2010 |
| Nbl1p colocalizes and copurifies with the chromosomal passenger complex | Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae.
Nakajima Y, Tyers RG, Wong CC, Yates JR 3rd, Drubin DG, Barnes G., Free PMC Article | 01/21/2010 |