| Forkhead transcription factor Fkh1: insights into functional regulatory domains crucial for recruitment of Sin3 histone deacetylase complex. | Forkhead transcription factor Fkh1: insights into functional regulatory domains crucial for recruitment of Sin3 histone deacetylase complex.
Aref R, Sanad MNME, Schüller HJ., Free PMC Article | 09/4/2021 |
| Data indicate the role of the principal mitotic cyclin gene CLB2 at the end of S phase. | Genetic Evidence for Roles of Yeast Mitotic Cyclins at Single-Stranded Gaps Created by DNA Replication.
Signon L., Free PMC Article | 10/13/2018 |
| Our observations suggest that both APC(Cdh1) and SCF(Cdc4)-dependent proteolysis of Clb6 at the G1/S border are crucial for multiple cell cycle regulated events including proper expression of Clb2, the G1/S and G2/M cell cycle transitions and for proper completion of cell division at mitotic exit. | The anaphase-promoting complex works together with the SCF complex for proteolysis of the S-phase cyclin Clb6 during the transition from G1 to S phase.
Wu SY, Kuan VJ, Tzeng YW, Schuyler SC, Juang YL. | 09/23/2017 |
| Cdk1 and multiple cyclins become highly enriched at DSBs and that the recruitment of Cdk1 and cyclins Clb2 and Clb5 ensures optimal Fun30 phosphorylation and checkpoint activation. | Enrichment of Cdk1-cyclins at DNA double-strand breaks stimulates Fun30 phosphorylation and DNA end resection.
Chen X, Niu H, Yu Y, Wang J, Zhu S, Zhou J, Papusha A, Cui D, Pan X, Kwon Y, Sung P, Ira G., Free PMC Article | 08/27/2016 |
| Size control seems to be exerted twice, where the G2/M control affects bud size through bud-localized translation of CLB2 mRNA, explaining the dependence of the S-G2-M duration on nutrients. | Bud-Localization of CLB2 mRNA Can Constitute a Growth Rate Dependent Daughter Sizer.
Spiesser TW, Kühn C, Krantz M, Klipp E., Free PMC Article | 01/16/2016 |
| Models for the functional interactions of mitotic cyclin Clb2, Sgs1 and Exo1 with replication fork stabilization are proposed. | The analysis of S. cerevisiae cells deleted for mitotic cyclin Clb2 reveals a novel requirement of Sgs1 DNA helicase and Exonuclease 1 when replication forks break in the presence of alkylation damage.
Signon L, Simon MN. | 06/20/2015 |
| The essential role of nuclear Clb2 is in both survival and adaptation to the DNA damage checkpoint, illustrating a spatially distinct dual function of this mitotic cyclin in the response to DNA damage. | Spatially distinct functions of Clb2 in the DNA damage response.
Machu C, Eluère R, Signon L, Simon MN, de La Roche Saint-André C, Bailly E., Free PMC Article | 01/17/2015 |
| Study discovered a pathway that links starvation to control of CLB2 mRNA stability and M phase delay. Dbf2 phosphorylates and activates the arginine methyltransferase Hmt1. In turn, Hmt1 methylates hnRNPs, promoting their nuclear localization, their cotranscriptional association with CLB2 mRNA, and the stability of CLB2 mRNA. | A nutrient-responsive pathway that determines M phase timing through control of B-cyclin mRNA stability.
Messier V, Zenklusen D, Michnick SW. | 08/3/2013 |
| inactivation of the negative regulatory system by deletion of the HIR1 gene relieved the dependence of HTA1-HTB1 transcription on the mitotic Clb1/Cb2 cyclins | The mitotic Clb cyclins are required to alleviate HIR-mediated repression of the yeast histone genes at the G1/S transition.
Amin AD, Dimova DK, Ferreira ME, Vishnoi N, Hancock LC, Osley MA, Prochasson P., Free PMC Article | 05/5/2012 |
| We found that the transcriptional cofactor Swi6p and activator Swi4p, as well as the G(2)/M-specific cyclin Clb2p, are required in a microtubule-destabilizing environment | Cell cycle regulators interact with pathways that modulate microtubule stability in Saccharomyces cerevisiae.
Shohat-Tal A, Eshel D., Free PMC Article | 03/31/2012 |
| These observations differentiate the functions of CLB1, CLB2, and CLB3 at mitotic exit.Actin ring formation is disrupted by deletion of CLB2 in cdc14-arrested cells | Functions of the mitotic B-type cyclins CLB1, CLB2, and CLB3 at mitotic exit antagonized by the CDC14 phosphatase.
Tzeng YW, Huang JN, Schuyler SC, Wu CH, Juang YL. | 12/31/2011 |
| Clb2/Cdc28 drives spindle pole separation by direct phosphorylation of Kip1 and Cin8. | B-cyclin/CDKs regulate mitotic spindle assembly by phosphorylating kinesins-5 in budding yeast.
Chee MK, Haase SB., Free PMC Article | 09/6/2010 |
| The inhibition of mitotic exit in budding yeast using graded levels of stable mitotic cyclin (Clb2), is investigated. | Analysis of the mitotic exit control system using locked levels of stable mitotic cyclin.
Drapkin BJ, Lu Y, Procko AL, Timney BL, Cross FR., Free PMC Article | 05/31/2010 |
| transcription factors for CLB2 are involved in the cell wall integrity checkpoint system and suggest that there are multiple regulation pathways of the checkpoint. | Transcription factors of M-phase cyclin CLB2 in the yeast cell wall integrity checkpoint.
Sekiya M, Nogami S, Ohya Y. | 02/8/2010 |
| Cells expressing partially stable Clb2 were particularly sensitive to different stresses, possibly due to reduced Sic1 levels. | APC/CCdh1 specific degradation of Hsl1 and Clb2 is required for proper stress responses of S. cerevisiae.
Simpson-Lavy KJ, Sajman J, Zenvirth D, Brandeis M. | 01/21/2010 |
| Swe1 may competitively inhibit Clb2-Cdc28 interactions with substrates, in addition to its well-known function as a regulator of CDK activity through tyrosine phosphorylation. | Identification of Clb2 residues required for Swe1 regulation of Clb2-Cdc28 in Saccharomyces cerevisiae.
Hu F, Gan Y, Aparicio OM., Free PMC Article | 01/21/2010 |
| The inactivation of the Sin3 histone deacetylase complex bypasses the essential role of Ndd1 in cell cycle progression. Sin3 and its catalytic subunit Rpd3 associate with the CLB2 promoter during the G1 phase of the cell cycle. | Activation of the G2/M-specific gene CLB2 requires multiple cell cycle signals.
Veis J, Klug H, Koranda M, Ammerer G., Free PMC Article | 01/21/2010 |
| functional antagonism between Rot1 and Clb2 is supported by genetic and biochemical data, which indicate that Rot1 is implicated in Clb2 protein degradation | Rot1 plays an antagonistic role to Clb2 in actin cytoskeleton dynamics throughout the cell cycle.
Juanes MA, Queralt E, Bañó MC, Igual JC. | 01/21/2010 |
| SIC1-0P (all nine phosphorylation sites mutated) was lethal when combined with deletion of CLB2, CLB3, or CLB5; failure of Sic1 phosphorylation and proteolysis imposes a variable cell cycle delay and extreme sensitivity to B-type cyclin dosage | Phosphorylation of the Sic1 inhibitor of B-type cyclins in Saccharomyces cerevisiae is not essential but contributes to cell cycle robustness.
Cross FR, Schroeder L, Bean JM., Free PMC Article | 01/21/2010 |
| The subcellular localization of the mitotic cyclin Clb2 is one of the key determinants of its biological function. | Compartmentalization of the functions and regulation of the mitotic cyclin Clb2 in S. cerevisiae.
Eluère R, Offner N, Varlet I, Motteux O, Signon L, Picard A, Bailly E, Simon MN. | 01/21/2010 |
| cytoplasmic Clb2is required for timely inactivation of Swe1 at the G2/M transition, and bud morphogenesis. | Cytoplasmic Clb2 is required for timely inactivation of the mitotic inhibitor Swe1 and normal bud morphogenesis in Saccharomyces cerevisiae.
Hood-DeGrenier JK, Boulton CN, Lyo V. | 01/21/2010 |
| development of a model to generate biochemical predictions for Clb2 levels, asynchronous as well as through the cell cycle, as the Clb2 overexpression threshold is approached | Quantitative characterization of a mitotic cyclin threshold regulating exit from mitosis.
Cross FR, Schroeder L, Kruse M, Chen KC., Free PMC Article | 01/21/2010 |
| Clb2-Cdk1 possessed higher intrinsic kinase activity than Clb5-Cdk1, enabling efficient phosphorylation of a broad range of mitotic Cdk1 targets | Cyclin specificity in the phosphorylation of cyclin-dependent kinase substrates.
Loog M, Morgan DO. | 01/21/2010 |
| results show that the FEAR network acts in part by stimulating phosphorylation of Net1 by Clb-Cdk, which directly weakens the interaction of Cdc14 with Net1, allowing for Cdc14 activation and mitotic exit | Phosphorylation by cyclin B-Cdk underlies release of mitotic exit activator Cdc14 from the nucleolus.
Azzam R, Chen SL, Shou W, Mah AS, Alexandru G, Nasmyth K, Annan RS, Carr SA, Deshaies RJ. | 01/21/2010 |
| CDK interaction with the amino-terminal domain of Cdc6 is mediated by the cyclin subunit Clb2 | Phosphorylation-dependent binding of mitotic cyclins to Cdc6 contributes to DNA replication control.
Mimura S, Seki T, Tanaka S, Diffley JF. | 01/21/2010 |