| EGCG regulates CTR1 expression through its pro-oxidative property in non-small-cell lung cancer cells. | EGCG regulates CTR1 expression through its pro-oxidative property in non-small-cell lung cancer cells.
Chen A, Jiang P, Zeb F, Wu X, Xu C, Chen L, Feng Q. | 03/13/2021 |
| IGF1R prognosticates prolonged survival in HGSOC patients, possibly due to its positive correlation with hCtr1 | IGF1R predicts better survival in high-grade serous epithelial ovarian cancer patients and correlates with hCtr1 levels.
Deo A, Chaudhury S, Kannan S, Rekhi B, Maheshwari A, Gupta S, Ray P. | 03/21/2020 |
| Rho0 cells demonstrated loss of Sco1, resulting in copper deficiency by lowering copper transporter 1 abundance, via mechanism involving increased turnover due to ubiquitination. These findings reveal that a Sco1-dependent mitochondrial signal regulates cellular cisplatin import and cytotoxicity. | Low Ctr1p, due to lack of Sco1p results in lowered cisplatin uptake and mediates insensitivity of rho0 yeast to cisplatin.
Bodiga S, Vemuri PK, Bodiga VL. | 05/18/2019 |
| Expression of the human copper transporter 1 in SOD1G37R transgenic ALS mice increases copper levels in the spinal cord and restores SOD1 activity. | The accumulation of enzymatically inactive cuproenzymes is a CNS-specific phenomenon of the SOD1(G37R) mouse model of ALS and can be restored by overexpressing the human copper transporter hCTR1.
Hilton JB, Kysenius K, White AR, Crouch PJ. | 02/23/2019 |
| Several biological properties of the GST-hNdCTR1 fusion protein were assessed. It was demonstrated that in cells, the protein was prone to oligomerization, formed inclusion bodies and displayed no toxicity. Treatment of E. coli cells with copper and silver ions reduced cell viability in a dose- and time-dependent manner | The Extracellular Domain of Human High Affinity Copper Transporter (hNdCTR1), Synthesized by E. coli Cells, Chelates Silver and Copper Ions In Vivo.
Sankova TP, Orlov IA, Saveliev AN, Kirilenko DA, Babich PS, Brunkov PN, Puchkova LV., Free PMC Article | 07/21/2018 |
| 11 single-nucleotide polymorphisms (SNPs) in CTR1, CTR2, ATP7A, and ATP7B were genotyped in these patients. | Association between polymorphisms in CTR1, CTR2, ATP7A, and ATP7B and platinum resistance in epithelial ovarian cancer.
Li T, Peng J, Zeng F, Zhang K, Liu J, Li X, Ouyang Q, Wang G, Wang L, Liu Z, Liu Y. | 11/18/2017 |
| Polymorphism at CTR1 rs12686377 may be associated with toxicity from platinum-based regimens. | Impact of the Copper Transporter Protein 1 (CTR1) Polymorphism on Adverse Events among Advanced NonSmall Cell Lung Cancer Patients Treated with a Carboplatin/Gemcitabine Regimen.
Kumpiro S, Sriuranpong V, Areepium N. | 02/4/2017 |
| findings show that beta-elemene can block the reduction of CTR1 resulting from oxaliplatin treatment, and therefore has a synergistic anti-hepatocellular carcinoma effect with oxaliplatin by enhancing cellular uptake of oxaliplatin. | β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1.
Li X, Lin Z, Zhang B, Guo L, Liu S, Li H, Zhang J, Ye Q., Free PMC Article | 12/31/2016 |
| The transition metal ion homeostasis was disrupted in ctr1Delta300 overexpressing strains combined with a transcriptional remodeling of cellular processes. | Overexpression of ctr1Δ300, a high-affinity copper transporter with deletion of the cytosolic C-terminus in Saccharomyces cerevisiae under excess copper, leads to disruption of transition metal homeostasis and transcriptional remodelling of cellular processes.
Schuller A, Auffermann G, Zoschke K, Schmidt U, Ostermann K, Rödel G. | 11/2/2013 |
| Deletion of the MAC1 and CTR1 genes involved in copper ion homeostasis exhibited freeze-thaw sensitivity, suggesting that copper ion homeostasis is required for freeze-thaw tolerance. | Insufficiency of copper ion homeostasis causes freeze-thaw injury of yeast cells as revealed by indirect gene expression analysis.
Takahashi S, Ando A, Takagi H, Shima J., Free PMC Article | 02/8/2010 |
| conformational changes in the cytosolic tail of yeast Ctr1 by copper sensing within this domain lead to the inhibition of Ctr1-mediated copper transport | Copper transport activity of yeast Ctr1 is down-regulated via its C terminus in response to excess copper.
Wu X, Sinani D, Kim H, Lee J., Free PMC Article | 01/21/2010 |
| Targeting of Ctr1p into the endocytic downregulation pathway with delivery to the vacuole clearly requires Rsp5p and ubiquitinylation of Ctr1p. | Regulation of copper-dependent endocytosis and vacuolar degradation of the yeast copper transporter, Ctr1p, by the Rsp5 ubiquitin ligase.
Liu J, Sitaram A, Burd CG. | 01/21/2010 |
| functional roles for structural remodeling of the Ctr1 multimeric complex in copper transport and suggest distinct mechanisms employed by Ctr1 for copper and cisplatin transport. | Distinct mechanisms for Ctr1-mediated copper and cisplatin transport.
Sinani D, Adle DJ, Kim H, Lee J. | 01/21/2010 |