| N- and C-terminal Gln3-Tor1 interaction sites: one acting negatively and the other positively to regulate nuclear Gln3 localization. | N- and C-terminal Gln3-Tor1 interaction sites: one acting negatively and the other positively to regulate nuclear Gln3 localization.
Tate JJ, Rai R, De Virgilio C, Cooper TG., Free PMC Article | 09/25/2021 |
| Aminoacyl-tRNA quality control is required for efficient activation of the TOR pathway regulator Gln3p. | Aminoacyl-tRNA quality control is required for efficient activation of the TOR pathway regulator Gln3p.
Mohler K, Mann R, Kyle A, Reynolds N, Ibba M., Free PMC Article | 11/3/2018 |
| Performed a genome-wide screen in Saccharomyces cerevisiae to identify genes linked to high-fidelity DNA replication. Found URA7 or GLN3 inactivation had a role in imbalanced dNTP pools and increased mutagenesis. | Alterations in cellular metabolism triggered by URA7 or GLN3 inactivation cause imbalanced dNTP pools and increased mutagenesis.
Schmidt TT, Reyes G, Gries K, Ceylan CÜ, Sharma S, Meurer M, Knop M, Chabes A, Hombauer H., Free PMC Article | 05/5/2018 |
| two different ways in which intracellular Gln3 localization is regulated | Nuclear Gln3 Import Is Regulated by Nitrogen Catabolite Repression Whereas Export Is Specifically Regulated by Glutamine.
Rai R, Tate JJ, Shanmuganatham K, Howe MM, Nelson D, Cooper TG., Free PMC Article | 08/27/2016 |
| nuclear localization domains of GATA activator Gln3 are required for transcription of target genes, presumably through dephosphorylation | Nuclear localization domains of GATA activator Gln3 are required for transcription of target genes through dephosphorylation in Saccharomyces cerevisiae.
Numamoto M, Tagami S, Ueda Y, Imabeppu Y, Sasano Y, Sugiyama M, Maekawa H, Harashima S. | 07/30/2016 |
| we conclude that Siw14 functions upstream of Pph21 and Pph22 as an inhibitor of the phosphorylation and localization of Gln3, and that Sit4 acts independently of Siw14 | The protein phosphatase Siw14 controls caffeine-induced nuclear localization and phosphorylation of Gln3 via the type 2A protein phosphatases Pph21 and Pph22 in Saccharomyces cerevisiae.
Numamoto M, Sasano Y, Hirasaki M, Sugiyama M, Maekawa H, Harashima S. | 09/26/2015 |
| Rapamycin-dependent Gat1 and Gln3 binding to the Aro80 target promoters is not affected by tryptophan availability, suggesting that transactivation activity of Aro80 is not necessary for the recruitment of GATA factors. | Interplay of Aro80 and GATA activators in regulation of genes for catabolism of aromatic amino acids in Saccharomyces cerevisiae.
Lee K, Hahn JS. | 01/4/2014 |
| gln3 mutations dissociate responses to nitrogen limitation (nitrogen catabolite repression) and rapamycin inhibition of TorC1 | gln3 mutations dissociate responses to nitrogen limitation (nitrogen catabolite repression) and rapamycin inhibition of TorC1.
Rai R, Tate JJ, Nelson DR, Cooper TG., Free PMC Article | 04/6/2013 |
| Gln3, Gat1, and Ure2 respond to TorC1 and nitrogen availability via distinct regulatory pathways. | Alterations in the Ure2 αCap domain elicit different GATA factor responses to rapamycin treatment and nitrogen limitation.
Feller A, Georis I, Tate JJ, Cooper TG, Dubois E., Free PMC Article | 03/30/2013 |
| Nitrogen-responsive regulation of GATA protein family activators Gln3 and Gat1 occurs by two distinct pathways, one inhibited by rapamycin and the other by methionine sulfoximine. | Nitrogen-responsive regulation of GATA protein family activators Gln3 and Gat1 occurs by two distinct pathways, one inhibited by rapamycin and the other by methionine sulfoximine.
Georis I, Tate JJ, Cooper TG, Dubois E., Free PMC Article | 03/3/2012 |
| Ppz1 controls Gln3 localization by regulating its phosphorylation state in combination with Sat4 and Hal5. | Saccharomyces cerevisiae protein phosphatase Ppz1 and protein kinases Sat4 and Hal5 are involved in the control of subcellular localization of Gln3 by likely regulating its phosphorylation state.
Hirasaki M, Horiguchi M, Numamoto M, Sugiyama M, Kaneko Y, Nogi Y, Harashima S. | 05/14/2011 |
| the combination of Gln3 and Gcn4 results in the constitution of a hybrid modulator which elicits a novel transcriptional response, not evoked when these modulators act in a non-combinatorial fashion. | Gln3-Gcn4 hybrid transcriptional activator determines catabolic and biosynthetic gene expression in the yeast Saccharomyces cerevisiae.
Hernández H, Aranda C, Riego L, González A. | 03/12/2011 |
| GAAC is a major effector of the TOR pathway, with Gcn4p and Gln3p each inducing a similar number of genes during rapamycin treatment | Integration of general amino acid control and target of rapamycin (TOR) regulatory pathways in nitrogen assimilation in yeast.
Staschke KA, Dey S, Zaborske JM, Palam LR, McClintick JN, Pan T, Edenberg HJ, Wek RC., Free PMC Article | 06/28/2010 |
| Gln3 and Gat1 localizations are controlled by two different regulatory pathways | Distinct phosphatase requirements and GATA factor responses to nitrogen catabolite repression and rapamycin treatment in Saccharomyces cerevisiae.
Tate JJ, Georis I, Dubois E, Cooper TG., Free PMC Article | 06/28/2010 |
| The phosphorylation of Put3p appears to influence the association of Gat1p, but not Gln3p, to the PUT1 promoter. | Mutation of a phosphorylatable residue in Put3p affects the magnitude of rapamycin-induced PUT1 activation in a Gat1p-dependent manner.
Leverentz MK, Campbell RN, Connolly Y, Whetton AD, Reece RJ., Free PMC Article | 01/21/2010 |
| there is a role for Golgi-to-endosome vesicular trafficking in TORC1-controlled nuclear translocation of Gln3 | Nuclear translocation of Gln3 in response to nutrient signals requires Golgi-to-endosome trafficking in Saccharomyces cerevisiae.
Puria R, Zurita-Martinez SA, Cardenas ME., Free PMC Article | 01/21/2010 |
| Tor pathway control of the nitrogen-responsive DAL5 gene bifurcates at the level of Gln3 and Gat1 regulation in Saccharomyces cerevisiae | Tor pathway control of the nitrogen-responsive DAL5 gene bifurcates at the level of Gln3 and Gat1 regulation in Saccharomyces cerevisiae.
Georis I, Tate JJ, Cooper TG, Dubois E., Free PMC Article | 01/21/2010 |
| Siw14 controls the intracellular localization of Gln3 in combination with Npr1, and one of the causes for the caffeine sensitivity of the Deltasiw14 disruptant was an accumulation of dephosphorylated Gln3 in the nucleus. | Protein phosphatase Siw14 controls intracellular localization of Gln3 in cooperation with Npr1 kinase in Saccharomyces cerevisiae.
Hirasaki M, Kaneko Y, Harashima S. | 01/21/2010 |
| the connection between Gln3 localization and Npr1 is indirect, arising from the influence of Npr1 on the ability of cells to utilize ammonia as a repressive nitrogen source. | Ammonia-specific regulation of Gln3 localization in Saccharomyces cerevisiae by protein kinase Npr1.
Tate JJ, Rai R, Cooper TG., Free PMC Article | 01/21/2010 |
| Gln3-mediated transcription activated by nitrogen signal transduction is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae | Transduction of the nitrogen signal activating Gln3-mediated transcription is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae.
Feller A, Boeckstaens M, Marini AM, Dubois E. | 01/21/2010 |
| in the absence of urmylation, nuclear/cytosolic shuffling of both Nil1 and Gln3 transcriptional factors is altered, ultimately leading to inability to repress GAP1 gene | Urmylation controls Nil1p and Gln3p-dependent expression of nitrogen-catabolite repressed genes in Saccharomyces cerevisiae.
Rubio-Texeira M. | 01/21/2010 |
| Sit4 activity masked nitrogen source-dependent changes in Gln3-Myc(13) phosphorylation which were clearly visible when SIT4 was deleted. | Saccharomyces cerevisiae Sit4 phosphatase is active irrespective of the nitrogen source provided, and Gln3 phosphorylation levels become nitrogen source-responsive in a sit4-deleted strain.
Tate JJ, Feller A, Dubois E, Cooper TG., Free PMC Article | 01/21/2010 |
| Rtg1/3p, Gln3p, and Gat1p can be differentially regulated through different nutrient-sensing pathways, such as TOR and retrograde signaling, and by multiple factors, such as Lst8p, which is suggested to have a role in connecting the RTG and TOR pathways | Retrograde response to mitochondrial dysfunction is separable from TOR1/2 regulation of retrograde gene expression.
Giannattasio S, Liu Z, Thornton J, Butow RA. | 01/21/2010 |
| Gln3 localization in Saccharomyces cerevisiae is separable from and can overwhelm nitrogen source regulation | Stress-responsive Gln3 localization in Saccharomyces cerevisiae is separable from and can overwhelm nitrogen source regulation.
Tate JJ, Cooper TG., Free PMC Article | 01/21/2010 |
| role in regulation of invertase activity and SUC2 expression | Gln3p and Nil1p regulation of invertase activity and SUC2 expression in Saccharomyces cerevisiae.
Oliveira EM, Mansure JJ, Bon EP. | 01/21/2010 |