| Regulation of sphingolipid synthesis by the G1/S transcription factor Swi4. | Regulation of sphingolipid synthesis by the G1/S transcription factor Swi4.
Matos GS, Madeira JB, Fernandes CM, Dasilva D, Masuda CA, Del Poeta M, Montero-Lomelí M., Free PMC Article | 09/18/2021 |
| TORC1 regulates G1/S transition and cell proliferation via the E2F homologs MBF and SBF in yeast. | TORC1 regulates G1/S transition and cell proliferation via the E2F homologs MBF and SBF in yeast.
Morshed S, Shibata T, Naito K, Miyasato K, Takeichi Y, Takuma T, Tasnin MN, Ushimaru T. | 02/13/2021 |
| methionine influx triggers Art1 translocation to the plasma membrane (PM), followed by Ppz-mediated dephosphorylation which promotes cargo recognition at the PM. | Methionine triggers Ppz-mediated dephosphorylation of Art1 to promote cargo-specific endocytosis.
Lee S, Ho HC, Tumolo JM, Hsu PC, MacGurn JA., Free PMC Article | 02/29/2020 |
| Authors show that a functionally similar ART sorting signal is also required for the endocytosis of a second Art1-dependent cargo, Can1, suggesting a common mechanism for recognition of Art1 substrates. | Identification of the endocytic sorting signal recognized by the Art1-Rsp5 ubiquitin ligase complex.
Guiney EL, Klecker T, Emr SD., Free PMC Article | 09/23/2017 |
| expression of mutated Swi4(S159A) protein in the GG104-Swi4Delta strain did not restore the transient G1 arrest induced by PKA activation, suggesting that Swi4 phosphorylation by PKA regulates CLN1 gene expression and G1/S phase transition. | The transcription factor Swi4 is target for PKA regulation of cell size at the G1 to S transition in Saccharomyces cerevisiae.
Amigoni L, Colombo S, Belotti F, Alberghina L, Martegani E., Free PMC Article | 05/21/2016 |
| Swi4/Swi6 (SBF) factor binding at HO follows a temporal cascade, with SBF bound at upstream regulatory sequence (URS2-L) serving to relay a signal from URS1 to the SBF sites in URS2-R that ultimately activate gene expression. | Spatiotemporal cascade of transcription factor binding required for promoter activation.
Yarrington RM, Rudd JS, Stillman DJ., Free PMC Article | 04/18/2015 |
| We found that the transcriptional cofactor Swi6p and activator Swi4p, as well as the G(2)/M-specific cyclin Clb2p, are required in a microtubule-destabilizing environment | Cell cycle regulators interact with pathways that modulate microtubule stability in Saccharomyces cerevisiae.
Shohat-Tal A, Eshel D., Free PMC Article | 03/31/2012 |
| Study shows that Npr1 inhibits the activity of Art1, an arrestin-like adaptor protein that promotes endocytosis by targeting the Rsp5 ubiquitin ligase to specific plasma membrane cargoes. | TORC1 regulates endocytosis via Npr1-mediated phosphoinhibition of a ubiquitin ligase adaptor.
MacGurn JA, Hsu PC, Smolka MB, Emr SD. | 01/28/2012 |
| The dimeric complex of Mpk1 binds to a Swi4 recognition site in the FKS2 promoter.[Mpk1, Swi4, FKS2] | Transcriptional reporters for genes activated by cell wall stress through a non-catalytic mechanism involving Mpk1 and SBF.
Kim KY, Levin DE., Free PMC Article | 11/27/2010 |
| Data show that phosphorylation of Ser423 specifically blocked SBF activation by preventing Mpk1 association with Swi4, revealing a novel mechanism for regulating MAPK target specificity. | Mechanism of Mpk1 mitogen-activated protein kinase binding to the Swi4 transcription factor and its regulation by a novel caffeine-induced phosphorylation.
Truman AW, Kim KY, Levin DE., Free PMC Article | 01/21/2010 |
| Identified the cell cycle-regulated SBF protein complex(Swi4/Swi6) as required for H3K79 dimethylation. | Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation.
Schulze JM, Jackson J, Nakanishi S, Gardner JM, Hentrich T, Haug J, Johnston M, Jaspersen SL, Kobor MS, Shilatifard A., Free PMC Article | 01/21/2010 |
| propose a model in which phosphorylated Mpk1 or Mlp1 forms a dimeric complex with Swi4 that is competent to associate with the FKS2 promoter | Yeast Mpk1 mitogen-activated protein kinase activates transcription through Swi4/Swi6 by a noncatalytic mechanism that requires upstream signal.
Kim KY, Truman AW, Levin DE., Free PMC Article | 01/21/2010 |
| Deletion of Swi4 enhances transcription, suggesting that Swi4 can also function as transcriptional repressor. | High functional overlap between MluI cell-cycle box binding factor and Swi4/6 cell-cycle box binding factor in the G1/S transcriptional program in Saccharomyces cerevisiae.
Bean JM, Siggia ED, Cross FR., Free PMC Article | 01/21/2010 |
| binding of the Swi4/Swi6 (SBF) transcription factors to an evolutionarily conserved site within the recombination enhancer | Cell cycle-dependent regulation of Saccharomyces cerevisiae donor preference during mating-type switching by SBF (Swi4/Swi6) and Fkh1.
Coïc E, Sun K, Wu C, Haber JE., Free PMC Article | 01/21/2010 |
| the binding site for Xbp1 is present in the target genes of Swi4 and Mbp1 and is conserved phylogenetically | Identification of target genes of a yeast transcriptional repressor.
Mai B, Breeden LL. | 01/21/2010 |