Low expression of PDLIM4 is associated with growth and invasion of ovarian cancer. | PDZ and LIM domain protein 4 suppresses the growth and invasion of ovarian cancer cells via inactivation of STAT3 signaling. Jia Y, Shi H, Cao Y, Feng W, Li M, Li X. | 11/2/2019 |
Our study provides supportive evidence for the contribution of PDLIM4 gene polymorphisms to the susceptibility to osteoporotic fracture and suggests that rs270611 and rs3900945 are genetic risk factors, while rs366512 might be a genetic protective factor against osteoporotic fracture in elderly Han individuals. | Associations between polymorphisms of the PDLIM4 gene and susceptibility to osteoporotic fracture in an elderly population of Han Chinese. Chen J, Hong Z, Zhao C, Bi Q, Qiu B., Free PMC Article | 07/27/2019 |
The levels of the EDNRB, HJURP and p60/CAF-1 proteins were strongly associated with overall survival in high-grade gliomas patients (p<0.001, p<0.001 and p=0.002, respectively), whereas the one of PDLI4 was not (P=0.11). | Prognostic significance of EDN/RB, HJURP, p60/CAF-1 and PDLI4, four new markers in high-grade gliomas. de Tayrac M, Saikali S, Aubry M, Bellaud P, Boniface R, Quillien V, Mosser J., Free PMC Article | 06/14/2014 |
Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancers was associated with clinical characteristics, but only RASSF1A methylation was associated with time to first recurrence and overall survival. | Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome. Xu J, Shetty PB, Feng W, Chenault C, Bast RC Jr, Issa JP, Hilsenbeck SG, Yu Y., Free PMC Article | 01/26/2013 |
Actin cytoskeleton remodeling by the alternatively spliced isoform of PDLIM4/RIL protein. | Actin cytoskeleton remodeling by the alternatively spliced isoform of PDLIM4/RIL protein. Guryanova OA, Drazba JA, Frolova EI, Chumakov PM., Free PMC Article | 10/1/2011 |
Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle. | Reversion-induced LIM interaction with Src reveals a novel Src inactivation cycle. Zhang Y, Tu Y, Zhao J, Chen K, Wu C., Free PMC Article | 01/21/2010 |
PDLIM4 may function as a tumor suppressor, involved in the control of cell proliferation by associating with actin in prostate cancer cells. | PDLIM4, an actin binding protein, suppresses prostate cancer cell growth. Vanaja DK, Grossmann ME, Cheville JC, Gazi MH, Gong A, Zhang JS, Ajtai K, Burghardt TP, Young CY., Free PMC Article | 01/21/2010 |
several genes that are known to be regulated by DNA methylation were up-regulated dramatically by integrin alpha6beta4 expression, including S100A4, FST, PDLIM4, CAPG, and Nkx2.2. | Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin. Chen M, Sinha M, Luxon BA, Bresnick AR, O'Connor KL., Free PMC Article | 01/21/2010 |
Results showed that the hypermethylation of PDLIM4 gene could be used as a sensitive molecular tool in detection of prostate. | PDLIM4 repression by hypermethylation as a potential biomarker for prostate cancer. Vanaja DK, Ballman KV, Morlan BW, Cheville JC, Neumann RM, Lieber MM, Tindall DJ, Young CY. | 01/21/2010 |
Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesHigh-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. Yerges LM, Klei L, Cauley JA, Roeder K, Kammerer CM, Moffett SP, Ensrud KE, Nestlerode CS, Marshall LM, Hoffman AR, Lewis C, Lang TF, Barrett-Connor E, Ferrell RE, Orwoll ES, Zmuda JM, MrOS Research Group. Genetic association study for RSV bronchiolitis in infancy at the 5q31 cytokine cluster. Forton JT, Rowlands K, Rockett K, Hanchard N, Herbert M, Kwiatkowski DP, Hull J. Association of genetic variation of the RIL gene, encoding a PDZ-LIM domain protein and localized in 5q31.1, with low bone mineral density in adult Japanese women. Omasu F, Ezura Y, Kajita M, Ishida R, Kodaira M, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Orimo H, Emi M, Omasu F, Ezura Y, Kajita M, Ishida R, Kodaira M, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Orimo H, Emi M. | 03/13/2008 |
RIL methylation is a marker of adverse prognosis independent of chromosome 5 and 7 deletions. | RIL, a LIM gene on 5q31, is silenced by methylation in cancer and sensitizes cancer cells to apoptosis. Boumber YA, Kondo Y, Chen X, Shen L, Gharibyan V, Konishi K, Estey E, Kantarjian H, Garcia-Manero G, Issa JP. | 01/21/2010 |
Ril modulates actin stress fiber turnover and enhances the association with actinin and actins. | The PDZ-LIM protein RIL modulates actin stress fiber turnover and enhances the association of alpha-actinin with F-actin. Vallenius T, Scharm B, Vesikansa A, Luukko K, Schäfer R, Mäkelä TP. | 01/21/2010 |
RIL and its variant sequences may be an important determinant of osteoporosis | Association of genetic variation of the RIL gene, encoding a PDZ-LIM domain protein and localized in 5q31.1, with low bone mineral density in adult Japanese women. Omasu F, Ezura Y, Kajita M, Ishida R, Kodaira M, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Orimo H, Emi M, Omasu F, Ezura Y, Kajita M, Ishida R, Kodaira M, Yoshida H, Suzuki T, Hosoi T, Inoue S, Shiraki M, Orimo H, Emi M. | 01/21/2010 |