| Biochemical and Biophysical Characterization of the Caveolin-2 Interaction with Membranes and Analysis of the Protein Structural Alteration by the Presence of Cholesterol. | Biochemical and Biophysical Characterization of the Caveolin-2 Interaction with Membranes and Analysis of the Protein Structural Alteration by the Presence of Cholesterol.
Gorospe B, Moura JJG, Gutierrez-Merino C, Samhan-Arias AK., Free PMC Article | 01/7/2023 |
| Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis. | Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis.
Bai R, Rebelo A, Kleeff J, Sunami Y., Free PMC Article | 12/11/2021 |
| A genetic variant conferred high expression of CAV2 promotes pancreatic cancer progression and associates with poor prognosis. | A genetic variant conferred high expression of CAV2 promotes pancreatic cancer progression and associates with poor prognosis.
Zhu Y, Tian J, Peng X, Wang X, Yang N, Ying P, Wang H, Li B, Li Y, Zhang M, Cai Y, Lu Z, Niu S, Li Y, Zhong R, Chang J, Miao X. | 11/13/2021 |
| Association of the CAV1-CAV2 locus with normal-tension glaucoma in Chinese and Japanese. | Association of the CAV1-CAV2 locus with normal-tension glaucoma in Chinese and Japanese.
Lu SY, Rong SS, Wu Z, Huang C, Matsushita K, Ng TK, Leung CKS, Kawashima R, Usui S, Tam POS, Tsujikawa M, Young AL, Zhang M, Wiggs JL, Nishida K, Tham CC, Pang CP, Chen LJ. | 09/25/2021 |
| Caveolin proteins electrochemical oxidation and interaction with cholesterol. | Caveolin proteins electrochemical oxidation and interaction with cholesterol.
Fernandes IPG, Oliveira-Brett AM. | 12/19/2020 |
| Genetic prediction models for primary open-angle glaucoma: translational research. | Genetic prediction models for primary open-angle glaucoma: translational research.
Chen LJ, Pang CP, Tham CCY, Leung CKS. | 09/12/2020 |
| No differences were observed for genotype and allele distributions in relation to rs4236601 in the CAV1/CAV2 region. The association of rs2157719 (CDKN2B-AS1) with the primary open angle glaucoma (POAG) phenotype corroborates previously published results, reinforcing the importance of this variant in POAG etiology. | Investigation of CAV1/CAV2 rs4236601 and CDKN2B-AS1 rs2157719 in primary open-angle glaucoma patients from Brazil.
Nunes HF, Ananina G, Costa VP, Zanchin NIT, de Vasconcellos JPC, de Melo MB. | 03/16/2019 |
| MiR-29a was negatively correlated with both MUC16 expression and serum CA125 levels. | MiR-29a, targeting caveolin 2 expression, is responsible for limitation of pancreatic cancer metastasis in patients with normal level of serum CA125.
Liang C, Shi S, Meng Q, Liang D, Hua J, Qin Y, Zhang B, Xu J, Ni Q, Yu X. | 02/23/2019 |
| Cav-2beta isoform yielded by alternative translation initiation desensitizes insulin receptor (IR) via dephosphorylation by PTP1B, and subsequent endocytosis and lysosomal degradation of IR, causing insulin resistance. | Alternative translation initiation of Caveolin-2 desensitizes insulin signaling through dephosphorylation of insulin receptor by PTP1B and causes insulin resistance.
Kwon H, Jang D, Choi M, Lee J, Jeong K, Pak Y. | 12/22/2018 |
| Results verified the presence of transcript III of cav-2 for the first time, but no protein associated was found. Also, a decreasing trend of cav-2 (transcripts I and II) were observed in tumoral tissues especially in stages I and II and seem to be associated with the incidence and promotion of breast cancer, especially in the initial stages of breast cancer. | The diversity in the expression profile of caveolin II transcripts, considering its new transcript in breast cancer.
Ariana M, Arabi N, Pornour M, Vaseghi H, Ganji SM, Alivand MR, Salari M, Akbari ME. | 10/20/2018 |
| stromal expression of CAV1 in primary tumors was not associated with clinical outcome whereas the stromal expression of especially CAV2 in the metastatic lymph nodes could be associated with lung cancer pathogenesis. | Stromal Caveolin-1 and Caveolin-2 Expression in Primary Tumors and Lymph Node Metastases.
Gerstenberger W, Wrage M, Kettunen E, Pantel K, Anttila S, Steurer S, Wikman H., Free PMC Article | 10/6/2018 |
| this study confirmed the association of rs4236601 with primary open-angle glaucoma in different Chinese cohorts, and also found a common single-nucleotide polymorphism rs3801994 of diverse associations with primary open-angle glaucoma between Chinese and Japanese | Ethnic specific association of the CAV1/CAV2 locus with primary open-angle glaucoma.
Rong SS, Chen LJ, Leung CK, Matsushita K, Jia L, Miki A, Chiang SW, Tam PO, Hashida N, Young AL, Tsujikawa M, Zhang M, Wang N, Nishida K, Pang CP., Free PMC Article | 05/19/2018 |
| High CAV2 expression is associated with lung cancer. | Integrated quantitative proteomic and transcriptomic analysis of lung tumor and control tissue: a lung cancer showcase.
Tenzer S, Leidinger P, Backes C, Huwer H, Hildebrandt A, Lenhof HP, Wesse T, Franke A, Meese E, Keller A., Free PMC Article | 01/27/2018 |
| A-type lamin-dependent Caveolin-2 homo-oligomerization in the inner nuclear membrane microdomain is a precondition for pY19-Caveolin-2-mediated insulin-response epigenetic activation at the nuclear periphery. | A-type lamin-dependent homo-oligomerization for pY19-Caveolin-2 to function as an insulin-response epigenetic regulator.
Kwon H, Lee J, Jeong K, Jang D, Choi M, Pak Y. | 07/1/2017 |
| CAV-1 and -2 have roles in progression of prostate neoplasms | Significant Association of Caveolin-1 and Caveolin-2 with Prostate Cancer Progression.
Sugie S, Mukai S, Yamasaki K, Kamibeppu T, Tsukino H, Kamoto T. | 09/17/2016 |
| Caveolin-2 expression is necessary for the control of E2-dependent cellular proliferation of MCF-7 cells. | Modulation of 17β-Estradiol Signaling on Cellular Proliferation by Caveolin-2.
Totta P, Gionfra F, Busonero C, Acconcia F. | 07/16/2016 |
| variant in CAV2 is associated with increased age-of-onset of P. aeruginosa airway infection in cystic fibrosis cohort. | Exome Sequencing of Phenotypic Extremes Identifies CAV2 and TMC6 as Interacting Modifiers of Chronic Pseudomonas aeruginosa Infection in Cystic Fibrosis.
Emond MJ, Louie T, Emerson J, Chong JX, Mathias RA, Knowles MR, Rieder MJ, Tabor HK, Nickerson DA, Barnes KC, NHLBI GO Exome Sequencing Project, Go L, Gibson RL, Bamshad MJ., Free PMC Article | 06/11/2016 |
| The minor allele G of rs17588172 in the CAV1-CAV2 locus is associated with decreased expression of CAV1 and CAV2 in some tissues, marginally with intraocular pressure elevation, and consequently with increased susceptibility to high-tension glaucoma. | Expression-associated polymorphisms of CAV1-CAV2 affect intraocular pressure and high-tension glaucoma risk.
Kim S, Kim K, Heo DW, Kim JS, Park CK, Kim CS, Kang C., Free PMC Article | 04/23/2016 |
| Results present initial characterization of key proteins Cav2 and CFL1 as cellular factors that colocalize with M in viral inclusions and filaments and ZNF502 protein which appears to interact with RSV M in the nucleus. | New host factors important for respiratory syncytial virus (RSV) replication revealed by a novel microfluidics screen for interactors of matrix (M) protein.
Kipper S, Hamad S, Caly L, Avrahami D, Bacharach E, Jans DA, Gerber D, Bajorek M., Free PMC Article | 12/5/2015 |
| The implication of the caveolin genes, CAV1/CAV2, as a common genetic factor influencing both IOP variations and POAG may provide new insights of the underlying mechanism leading to glaucoma and glaucomatous visual field loss. | Exome array analysis identifies CAV1/CAV2 as a susceptibility locus for intraocular pressure.
Chen F, Klein AP, Klein BE, Lee KE, Truitt B, Klein R, Iyengar SK, Duggal P., Free PMC Article | 03/7/2015 |
| This meta-analysis suggests that rs4236601[A] is associated with increased risk for POAG in Caucasian and Asian populations. | Association of single-nucleotide polymorphism rs4236601 near caveolin 1 and 2 with primary open-angle glaucoma: a meta-analysis.
Huang W, Wang W, Zhou M, Zhang X. | 02/14/2015 |
| CAV1/CAV2 SNPs were associated significantly with primary open-angle glaucoma overall, particularly among women. | Association of CAV1/CAV2 genomic variants with primary open-angle glaucoma overall and by gender and pattern of visual field loss.
Loomis SJ, Kang JH, Weinreb RN, Yaspan BL, Cooke Bailey JN, Gaasterland D, Gaasterland T, Lee RK, Lichter PR, Budenz DL, Liu Y, Realini T, Friedman DS, McCarty CA, Moroi SE, Olson L, Schuman JS, Singh K, Vollrath D, Wollstein G, Zack DJ, Brilliant M, Sit AJ, Christen WG, Fingert J, Kraft P, Zhang K, Allingham RR, Pericak-Vance MA, Richards JE, Hauser MA, Haines JL, Pasquale LR, Wiggs JL., Free PMC Article | 03/29/2014 |
| Our findings did not correspond with previous positive results, suggesting that CAV1-CAV2 variants studied in the present study are not important risk factors for Normal Tension Glaucoma. | Association study of genetic variants on chromosome 7q31 with susceptibility to normal tension glaucoma in a Japanese population.
Kato T, Meguro A, Nomura E, Uemoto R, Nomura N, Ota M, Kashiwagi K, Mabuchi F, Iijima H, Kawase K, Yamamoto T, Nakamura M, Negi A, Sagara T, Nishida T, Inatani M, Tanihara H, Aihara M, Araie M, Fukuchi T, Abe H, Higashide T, Sugiyama K, Kanamoto T, Kiuchi Y, Iwase A, Chin S, Ohno S, Inoko H, Mizuki N., Free PMC Article | 02/8/2014 |
| This study does not support an association between CAV2 variation and kidney transplant survival. | Comprehensive investigation of the caveolin 2 gene: resequencing and association for kidney transplant outcomes.
McCaughan JA, Duffy S, O'Hagan T, Courtney AE, Borrows R, Conlon PJ, Maxwell AP, McKnight AJ., Free PMC Article | 12/21/2013 |
| The combination of the expression of the genes for PPARgamma, STMN1 and CAV2 was significantly predictive for early recurrence of non-muscle-invasive bladder cancer | Identification of a three-gene expression signature of early recurrence in non-muscle-invasive urothelial cell carcinoma of the bladder.
Dubosq F, Ploussard G, Soliman H, Turpin E, Latil A, Desgrandchamps F, de The H, Mongiat-Artus P. | 07/27/2013 |