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    RUNX2 RUNX family transcription factor 2 [ Homo sapiens (human) ]

    Gene ID: 860, updated on 5-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Polymorphisms in the Runx2 and osteocalcin genes affect BMD in postmenopausal women: a systematic review and meta-analysis.

    Polymorphisms in the Runx2 and osteocalcin genes affect BMD in postmenopausal women: a systematic review and meta-analysis.
    Sanyal S, Rajput S, Sadhukhan S, Rajender S, Mithal A, Chattopadhyay N.

    04/4/2024
    METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells through IGF2BP1-Mediated Regulation of Runx2 Stability.

    METTL3 Promotes Osteogenic Differentiation of Human Periodontal Ligament Stem Cells through IGF2BP1-Mediated Regulation of Runx2 Stability.
    Sun X, Meng X, Piao Y, Dong S, Dong Q., Free PMC Article

    03/14/2024
    A synthetic, closed-looped gene circuit for the autonomous regulation of RUNX2 activity during chondrogenesis.

    A synthetic, closed-looped gene circuit for the autonomous regulation of RUNX2 activity during chondrogenesis.
    Kaur G, Wu B, Murali S, Lanigan T, Coleman RM.,

    02/28/2024
    Keratocystoma: A Distinctive Salivary Gland Neoplasm Characterized by RUNX2 Rearrangements.

    Keratocystoma: A Distinctive Salivary Gland Neoplasm Characterized by RUNX2 Rearrangements.
    Bishop JA, Nakaguro M, Urano M, Yamamoto Y, Utsumi Y, Li R, Weinreb I, Nagashima Y, Gangahar C, Yamashiro K, Hashimoto K, Rooper LM, Carlile B, Wang RC, Gagan J, Nagao T.

    02/22/2024
    Scopolamine regulates the osteogenic differentiation of human periodontal ligament stem cells through lactylation modification of RUNX2 protein.

    Scopolamine regulates the osteogenic differentiation of human periodontal ligament stem cells through lactylation modification of RUNX2 protein.
    Wu Y, Gong P., Free PMC Article

    02/20/2024
    RUNX2 prompts triple negative breast cancer drug resistance through TGF-beta pathway regulating breast cancer stem cells.

    RUNX2 prompts triple negative breast cancer drug resistance through TGF-β pathway regulating breast cancer stem cells.
    Lv F, Si W, Xu X, He X, Wang Y, Li Y, Li F., Free PMC Article

    02/14/2024
    Circ_0027885 sponges miR-203-3p to regulate RUNX2 expression and alleviates osteoporosis progression.

    Circ_0027885 sponges miR-203-3p to regulate RUNX2 expression and alleviates osteoporosis progression.
    Fang S, Cao D, Wu Z, Chen J, Huang Y, Shen Y, Gao Z., Free PMC Article

    01/17/2024
    Differences of RUNX2 gene promoter methylation and transcription level in ankylosing spondylitis.

    Differences of RUNX2 gene promoter methylation and transcription level in ankylosing spondylitis.
    Wang F, Chen Y, Kong J, Xu S, Xu S, Shuai Z, Cai G, Pan F.

    12/14/2023
    RUNX2 promotes the suppression of osteoblast function and enhancement of osteoclast activity by multiple myeloma cells.

    RUNX2 promotes the suppression of osteoblast function and enhancement of osteoclast activity by multiple myeloma cells.
    Huang B, Liu H, Chan S, Liu J, Gu J, Chen M, Kuang L, Li X, Zhang X, Li J., Free PMC Article

    10/26/2023
    Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB - GRB2/ERK/RUNX2 pathway.

    Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB - GRB2/ERK/RUNX2 pathway.
    Tang Y, Yang K, Liu Q, Ma Y, Zhu H, Tang K, Geng C, Xie J, Zhuo D, Wu W, Jin L, Xiao W, Wang J, Zhu Q, Liu J., Free PMC Article

    10/12/2023
    Glutathione limits RUNX2 oxidation and degradation to regulate bone formation.

    Glutathione limits RUNX2 oxidation and degradation to regulate bone formation.
    Hu G, Yu Y, Sharma D, Pruett-Miller SM, Ren Y, Zhang GF, Karner CM., Free PMC Article

    08/25/2023
    HnRNP A1 Suppresses the Odontogenic Differentiation and the Inclusion of RUNX2 Exon 5 of Dental Mesenchymal Cells.

    HnRNP A1 Suppresses the Odontogenic Differentiation and the Inclusion of RUNX2 Exon 5 of Dental Mesenchymal Cells.
    Zhang Y, Huang J, Yan L, Jia R, Guo J.

    08/3/2023
    Functional consequences of C-terminal mutations in RUNX2.

    Functional consequences of C-terminal mutations in RUNX2.
    Thaweesapphithak S, Theerapanon T, Rattanapornsompong K, Intarak N, Kanpittaya P, Trachoo V, Porntaveetus T, Shotelersuk V., Free PMC Article

    08/2/2023
    Impact of genetic variations in the WNT family members and RUNX2 on dental and skeletal maturation: a cross-sectional study.

    Impact of genetic variations in the WNT family members and RUNX2 on dental and skeletal maturation: a cross-sectional study.
    Bitencourt Reis CL, Nakane Matsumoto MA, Baratto-Filho F, Scariot R, Sasso Stuani MB, Lourenço Romano F, Della Coletta R, Silva Barroso de Oliveira D, Proff P, Kirschneck C, Calvano Küchler E., Free PMC Article

    07/10/2023
    Long non-coding RNA SNHG5 promotes osteogenic differentiation of human periodontal ligament stem cells via mediating miR-23b-3p/Runx2 axis.

    Long non‑coding RNA SNHG5 promotes osteogenic differentiation of human periodontal ligament stem cells via mediating miR‑23b‑3p/Runx2 axis.
    Sun X, Li Z, Dong S, Dong Q., Free PMC Article

    06/24/2023
    LncRNA HCG18 Promotes Osteosarcoma Cells Proliferation, Migration, and Invasion in by Regulating miR-34a/RUNX2 Pathway.

    LncRNA HCG18 Promotes Osteosarcoma Cells Proliferation, Migration, and Invasion in by Regulating miR-34a/RUNX2 Pathway.
    Chen YP, Zhang DX, Cao Q, He CK.

    06/23/2023
    Long non-coding RNA MALAT1 sponges miR-30c to promote the calcification of human vascular smooth muscle cells by regulating Runx2.

    Long non-coding RNA MALAT1 sponges miR-30c to promote the calcification of human vascular smooth muscle cells by regulating Runx2.
    Gong Y, Zhong Q, Xia Y, Wen Y, Gan H., Free PMC Article

    05/19/2023
    Crosstalk between protein kinase C alpha and transforming growth factor beta signaling mediated by Runx2 in intestinal epithelial cells.

    Crosstalk between protein kinase C α and transforming growth factor β signaling mediated by Runx2 in intestinal epithelial cells.
    Li X, Kaur N, Albahrani M, Karpf AR, Black AR, Black JD., Free PMC Article

    05/17/2023
    RUNX2 and Cancer.

    RUNX2 and Cancer.
    Lin TC., Free PMC Article

    06/20/2023
    Heterozygous pathogenic variants involving CBFB cause a new skeletal disorder resembling cleidocranial dysplasia.

    Heterozygous pathogenic variants involving CBFB cause a new skeletal disorder resembling cleidocranial dysplasia.
    Beyltjens T, Boudin E, Revencu N, Boeckx N, Bertrand M, Schütz L, Haack TB, Weber A, Biliouri E, Vinkšel M, Zagožen A, Peterlin B, Pai S, Telegrafi A, Henderson LB, Ells C, Turner L, Wuyts W, Van Hul W, Hendrickx G, Mortier GR., Free PMC Article

    04/26/2023
    Complement Cross Talks With H-K-ATPase to Upregulate Runx2 in Human Aortic Valve Interstitial Cells.

    Complement Cross Talks With H-K-ATPase to Upregulate Runx2 in Human Aortic Valve Interstitial Cells.
    Deng XS, Meng X, Fullerton D, Stone M, Iguidbashian J, Jaggers J., Free PMC Article

    04/1/2023
    RUNX2 interacts with SCD1 and activates Wnt/beta-catenin signaling pathway to promote the progression of clear cell renal cell carcinoma.

    RUNX2 interacts with SCD1 and activates Wnt/β-catenin signaling pathway to promote the progression of clear cell renal cell carcinoma.
    Song X, Liu J, Liu B, Piao C, Kong C, Li Z., Free PMC Article

    03/23/2023
    BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer's patients' iPSCs in senescence-related conditions.

    BMP4-SMAD1/5/9-RUNX2 pathway activation inhibits neurogenesis and oligodendrogenesis in Alzheimer's patients' iPSCs in senescence-related conditions.
    Nakatsu D, Kunishige R, Taguchi Y, Shinozaki-Narikawa N, Osaka K, Yokomizo K, Ishida M, Takei S, Yamasaki S, Hagiya K, Hattori K, Tsukamoto T, Murata M, Kano F., Free PMC Article

    03/22/2023
    Abnormal mechanical stress on bicuspid aortic valve induces valvular calcification and inhibits Notch1/NICD/Runx2 signal.

    Abnormal mechanical stress on bicuspid aortic valve induces valvular calcification and inhibits Notch1/NICD/Runx2 signal.
    Li G, Shen N, Deng H, Wang Y, Kong G, Shi J, Dong N, Deng C., Free PMC Article

    03/16/2023
    Extracellular PPM1A promotes mineralization of osteoblasts differentiation in ankylosing spondylitis via the FOXO1A-RUNX2 pathway.

    Extracellular PPM1A promotes mineralization of osteoblasts differentiation in ankylosing spondylitis via the FOXO1A-RUNX2 pathway.
    Weon S, Jo S, Nam B, Choi SH, Park YS, Kim YG, Kim TH., Free PMC Article

    03/7/2023
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