| eIF3f Mediates SGOC Pathway Reprogramming by Enhancing Deubiquitinating Activity in Colorectal Cancer. | eIF3f Mediates SGOC Pathway Reprogramming by Enhancing Deubiquitinating Activity in Colorectal Cancer.
Pan Q, Yu F, Jin H, Zhang P, Huang X, Peng J, Xie X, Li X, Ma N, Wei Y, Wen W, Zhang J, Zhang B, Yu H, Xiao Y, Liu RY, Liu Q, Meng X, Lee MH., Free PMC Article | 09/29/2023 |
| EIF3F-related neurodevelopmental disorder: refining the phenotypic and expanding the molecular spectrum. | EIF3F-related neurodevelopmental disorder: refining the phenotypic and expanding the molecular spectrum.
Hüffmeier U, Kraus C, Reuter MS, Uebe S, Abbott MA, Ahmed SA, Rawson KL, Barr E, Li H, Bruel AL, Faivre L, Tran Mau-Them F, Botti C, Brooks S, Burns K, Ward DI, Dutra-Clarke M, Martinez-Agosto JA, Lee H, Nelson SF, UCLA California Center for Rare Disease, Zacher P, Abou Jamra R, Klöckner C, McGaughran J, Kohlhase J, Schuhmann S, Moran E, Pappas J, Raas-Rothschild A, Sacoto MJG, Henderson LB, Palculict TB, Mullegama SV, Zghal Elloumi H, Reich A, Schrier Vergano SA, Wahl E, Reis A, Zweier C., Free PMC Article | 08/28/2021 |
| Study discovered a role of EIF3F-STAT3 interaction in the genetic control of cell migration and metastasis in human lung adenocarcinoma. EIF3F promotes lung cancer cell metastasis in vivo by regulating a cluster of 34 metastasis-promoting genes including Snail2. The interaction between EIF3F and STAT3 controlled the EIF3F-mediated increase in Snail2 expression and cellular invasion. | Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.
Esteves P, Dard L, Brillac A, Hubert C, Sarlak S, Rousseau B, Dumon E, Izotte J, Bonneu M, Lacombe D, Dupuy JW, Amoedo N, Rossignol R., Free PMC Article | 06/20/2020 |
| results underscore the importance of estrogen-ERalpha-mediated control of eIF3f expression for the proliferation and survival of ER-positive breast cancer cells. These findings may provide rationale for the development of new therapies to treat ER-positive breast cancer. | Estrogen receptor α promotes protein synthesis by fine-tuning the expression of the eukaryotic translation initiation factor 3 subunit f (eIF3f).
Cuesta R, Berman AY, Alayev A, Holz MK., Free PMC Article | 05/4/2019 |
| The overexpression of eIF3f suppressed Akt and ERK signaling and subsequently depleted CLU expression. In addition, eIF3F stabilized p53, which increased the expression of p21 and Bax. | eIF3f reduces tumor growth by directly interrupting clusterin with anti-apoptotic property in cancer cells.
Lee JY, Kim HJ, Rho SB, Lee SH., Free PMC Article | 02/18/2017 |
| eIF3f/alpha adrenergic receptor interaction | The eukaryotic translation initiation factor 3f (eIF3f) interacts physically with the alpha 1B-adrenergic receptor and stimulates adrenoceptor activity.
Gutiérrez-Fernández MJ, Higareda-Mendoza AE, Gómez-Correa CA, Pardo-Galván MA., Free PMC Article | 01/30/2016 |
| Decreased expression of eukaryotic initiation factor 3f is associated with gastric cancer. | Decreased expression of eukaryotic initiation factor 3f is an adverse prognostic factor for stage I-III gastric cancer.
Li G, Wang N, Sun C, Li B., Free PMC Article | 02/7/2015 |
| eIF3f may play an important role in recurrence. | Expression of eukaryotic initiation factor 3f is associated with prognosis in gastric carcinomas.
Cheng Y, Jia C, Li G, Li H. | 12/20/2014 |
| findings established a new mechanism of rRNA decay regulation mediated by hnRNP K/eIF3f and suggest that the tumor suppressive function of eIF3f may link to impaired rRNA degradation and translation | The tumor suppressive role of eIF3f and its function in translation inhibition and rRNA degradation.
Wen F, Zhou R, Shen A, Choi A, Uribe D, Shi J., Free PMC Article | 08/4/2012 |
| catalytically inactive forms of eIF3f as well as shRNAs targeting eIF3f repress Notch activation in a coculture assay, showing that eIF3f is a new positive regulator of the Notch pathway | The translation initiation factor 3f (eIF3f) exhibits a deubiquitinase activity regulating Notch activation.
Moretti J, Chastagner P, Gastaldello S, Heuss SF, Dirac AM, Bernards R, Masucci MG, Israël A, Brou C., Free PMC Article | 02/5/2011 |
| eIF3f mediates restriction of HIV-1 expression through a set of factors that includes eIF3f, the SR protein 9G8, and the cyclin-dependent kinase 11 (CDK11). | HIV-1 mRNA 3' end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8.
Valente ST, Gilmartin GM, Venkatarama K, Arriagada G, Goff SP., Free PMC Article | 01/21/2010 |
| eIF3f may inhibit translation by increasing the binding to the eIF3 complex during apoptosis. | Phosphorylation of the eukaryotic initiation factor 3f by cyclin-dependent kinase 11 during apoptosis.
Shi J, Hershey JW, Nelson MA., Free PMC Article | 01/21/2010 |
| eIF3f specifically interferes with the 3' end processing of HIV-1 mRNAs | Inhibition of HIV-1 replication by eIF3f.
Valente ST, Gilmartin GM, Mott C, Falkard B, Goff SP., Free PMC Article | 01/21/2010 |
| demonstrated a statistically significant decrease of the eIF3f gene copy number in melanoma compared with normal tissues with a tumor/normal ratio of 0.52 | Loss of the eukaryotic initiation factor 3f in melanoma.
Doldan A, Chandramouli A, Shanas R, Bhattacharyya A, Leong SP, Nelson MA, Shi J., Free PMC Article | 01/21/2010 |
| Loss of EIF3F in pancreatic cancer is reported. | Loss of the eukaryotic initiation factor 3f in pancreatic cancer.
Doldan A, Chandramouli A, Shanas R, Bhattacharyya A, Cunningham JT, Nelson MA, Shi J., Free PMC Article | 01/21/2010 |