| Downregulation of ABCC3 activates MAPK signaling through accumulation of deoxycholic acid in colorectal cancer cells. | Downregulation of ABCC3 activates MAPK signaling through accumulation of deoxycholic acid in colorectal cancer cells.
Sato Y, Kobayashi M, Ohira M, Funayama R, Maekawa M, Karasawa H, Kashiwagi R, Aoyama Y, Mano N, Ohnuma S, Unno M, Nakayama K., Free PMC Article | 07/8/2024 |
| SMARCA4 (BRG1) activates ABCC3 transcription to promote hepatocellular carcinogenesis. | SMARCA4 (BRG1) activates ABCC3 transcription to promote hepatocellular carcinogenesis.
Liu H, Yue L, Hong W, Zhou J. | 06/7/2024 |
| Association Study of SLCO1B3 and ABCC3 Genetic Variants in Gallstone Disease. | Association Study of SLCO1B3 and ABCC3 Genetic Variants in Gallstone Disease.
Banach B, Modrzejewski A, Juzyszyn Z, Kurzawski M, Sroczynski T, Pawlik A., Free PMC Article | 05/7/2022 |
| The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes. | The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes.
Seborova K, Kloudova-Spalenkova A, Koucka K, Holy P, Ehrlichova M, Wang C, Ojima I, Voleska I, Daniel P, Balusikova K, Jelinek M, Kovar J, Rob L, Hruda M, Mrhalova M, Soucek P, Vaclavikova R., Free PMC Article | 02/5/2022 |
| Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line. | Effect of bile acids on the expression of MRP3 and MRP4: An In vitro study in HepG2 cell line.
Pérez-Pineda SI, Baylón-Pacheco L, Espíritu-Gordillo P, Tsutsumi V, Rosales-Encina JL. | 02/5/2022 |
| CircABCC3 knockdown inhibits glioblastoma cell malignancy by regulating miR-770-5p/SOX2 axis through PI3K/AKT signaling pathway. | CircABCC3 knockdown inhibits glioblastoma cell malignancy by regulating miR-770-5p/SOX2 axis through PI3K/AKT signaling pathway.
Zhang H, Xu W. | 01/22/2022 |
| Prevalence of ABCC3-1767G/A polymorphism among patients with antiretroviral-associated hepatotoxicity. | Prevalence of ABCC3-1767G/A polymorphism among patients with antiretroviral-associated hepatotoxicity.
Singh H, Lata S, Choudhari R, Dhole TN., Free PMC Article | 03/27/2021 |
| ABCC3 is a novel target for the treatment of pancreatic cancer. | ABCC3 is a novel target for the treatment of pancreatic cancer.
Adamska A, Ferro R, Lattanzio R, Capone E, Domenichini A, Damiani V, Chiorino G, Akkaya BG, Linton KJ, De Laurenzi V, Sala G, Falasca M. | 07/11/2020 |
| Low expression of MRP3 is associated with Hepatocellular Carcinoma and in Cholangiocarcinoma. | Immunohistochemical Assessment of the Expression of Biliary Transportation Proteins MRP2 and MRP3 in Hepatocellular Carcinoma and in Cholangiocarcinoma.
Cirqueira CS, Felipe-Silva AS, Wakamatsu A, Marins LV, Rocha EC, de Mello ES, Alves VAF. | 04/4/2020 |
| OATPB1/B3 and MRP3 immunohistochemistry and signal intensity on hepatobiliary phase Gd-EOB-DTPA-enhanced MRI can help to stratify hepatocellular adenoma according to their risk of malignant transformation. | OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd-EOB-DTPA uptake and correlates with risk of malignancy.
Sciarra A, Schmidt S, Pellegrinelli A, Maggioni M, Dondossola D, Pasquier J, Cigala C, Tosi D, Halkic N, Bulfamante G, Viale G, Bosari S, Balabaud C, Bioulac-Sage P, Sempoux C. | 01/11/2020 |
| The glucuronides of inactive androgens, androsterone glucuronide and etiocholanolone glucuronide were preferentially transported by MRP3, whereas the glucuronides of active androgens, Testosterone glucuronide and dihydrotestosterone glucuronide were mainly transported by MRP2 in liver. | Major glucuronide metabolites of testosterone are primarily transported by MRP2 and MRP3 in human liver, intestine and kidney.
Li CY, Basit A, Gupta A, Gáborik Z, Kis E, Prasad B., Free PMC Article | 11/23/2019 |
| CGI may function as an enhancer of the transcription of ABCC3. | Interindividual Differences in the Expression of ATP-Binding Cassette and Solute Carrier Family Transporters in Human Skin: DNA Methylation Regulates Transcriptional Activity of the Human ABCC3 Gene.
Takechi T, Hirota T, Sakai T, Maeda N, Kobayashi D, Ieiri I. | 11/10/2018 |
| Data suggest that inhibition of sirtuin 1 and sirtuin 2 in hepatocellular carcinoma cells (a) impairs cell survival and cell migration and (b) down-regulates expression of P-glycoprotein and MRP3 (ATP binding cassette subfamily C member 3). | Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines.
Ceballos MP, Decándido G, Quiroga AD, Comanzo CG, Livore VI, Lorenzetti F, Lambertucci F, Chazarreta-Cifre L, Banchio C, Alvarez ML, Mottino AD, Carrillo MC. | 04/28/2018 |
| Data show that bladder cancer is associated with perturbed expression of MRP3 and BCRP. | Therapy-relevant aberrant expression of MRP3 and BCRP mRNA in TCC-/SCC-bladder cancer tissue of untreated patients.
Rady M, Mostageer M, Rohde J, Zaghloul A, Knüchel-Clarke R, Saad S, Attia D, Mahran L, Spahn-Langguth H. | 03/31/2018 |
| Histological subtype of epithelial ovarian cancer correlated with the expression of PgP, MRP1, and MRP3. The lowest level of Pgp and MRP1 expression was found in endometrioid ovarian cancers | [Expression of ATP-binding Cassette Proteins Pgp, MRP1, and MRP3 in Malignant and Benign Ovarian Lesions].
Sedláková I, Laco J, Tošner J, Špaček J. | 12/9/2017 |
| miR-148a-siRNA and rifampin inhibited estradiol upregulation of MRP3 expression. miR-148a may be involved in the estrogen induction in intrahepatic cholestasis of pregnancy via PXR signaling. MRP3 may be involved. | miR-148a-mediated estrogen-induced cholestasis in intrahepatic cholestasis of pregnancy: Role of PXR/MRP3.
Rao ZZ, Zhang XW, Ding YL, Yang MY., Free PMC Article | 09/16/2017 |
| ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children. | ABCC3 genetic variants are associated with postoperative morphine-induced respiratory depression and morphine pharmacokinetics in children.
Chidambaran V, Venkatasubramanian R, Zhang X, Martin LJ, Niu J, Mizuno T, Fukuda T, Meller J, Vinks AA, Sadhasivam S., Free PMC Article | 08/12/2017 |
| PXR is a potential biomarker for predicting outcome and activates MRP3 transcription by directly binding to its promoter resulting in an increased L-OHP efflux capacity, and resistance to L-OHP or platinum drugs in CRC. | Pregnane X receptor is associated with unfavorable survival and induces chemotherapeutic resistance by transcriptional activating multidrug resistance-related protein 3 in colorectal cancer.
Dong Y, Wang Z, Xie GF, Li C, Zuo WW, Meng G, Xu CP, Li JJ., Free PMC Article | 07/29/2017 |
| This study highlights the importance of ABCC3 transporters in drug resistance to chemotherapy in the context of breast cancer. | Role of the Drug Transporter ABCC3 in Breast Cancer Chemoresistance.
Balaji SA, Udupa N, Chamallamudi MR, Gupta V, Rangarajan A., Free PMC Article | 07/15/2017 |
| Wnt signaling regulates ABCC3 expression in colon cancer cells, with the ABCC3 locus being a target of the transcription factors TCF7L2 and beta-catenin. | Wnt-β-catenin signaling regulates ABCC3 (MRP3) transporter expression in colorectal cancer.
Kobayashi M, Funayama R, Ohnuma S, Unno M, Nakayama K., Free PMC Article | 02/18/2017 |
| ABCC3 is an important oncoprotein involved in glycolysis and drug resistance | Overexpression of ABCC3 promotes cell proliferation, drug resistance, and aerobic glycolysis and is associated with poor prognosis in urinary bladder cancer patients.
Liu X, Yao D, Liu C, Cao Y, Yang Q, Sun Z, Liu D. | 02/18/2017 |
| This report is the first to describe liver overexpression of Abcc3 during the cancer initiation, promotion, and progression periods in rat hepatocarcinogenesis model and in human hepatocellular carcinoma | The transmembrane transporter ABCC3 participates in liver cancer progression and is a potential biomarker.
Carrasco-Torres G, Fattel-Fazenda S, López-Alvarez GS, García-Román R, Villa-Treviño S, Vásquez-Garzón VR. | 01/28/2017 |
| High MRP expression is associated with sorafenib resistance in hepatocellular carcinoma. | MRP3 as a novel resistance factor for sorafenib in hepatocellular carcinoma.
Tomonari T, Takeishi S, Taniguchi T, Tanaka T, Tanaka H, Fujimoto S, Kimura T, Okamoto K, Miyamoto H, Muguruma N, Takayama T., Free PMC Article | 12/24/2016 |
| ABCC3 rs4148416 polymorphism was significantly associated with poor osteosarcoma response. | Quantitative Assessment of the Association between ABC Polymorphisms and Osteosarcoma Response: a Meta-analysis.
Chen X, Jiang M, Zhao RK, Gu GH. | 04/9/2016 |
| Data suggest that hepatic expression of MRP3 is up-regulated and canalicular localization of MRP2 is altered in pediatric patients with advanced nonalcoholic steatohepatitis; these alterations may be involved in changes observed in drug metabolism. | Altered regulation of hepatic efflux transporters disrupts acetaminophen disposition in pediatric nonalcoholic steatohepatitis.
Canet MJ, Merrell MD, Hardwick RN, Bataille AM, Campion SN, Ferreira DW, Xanthakos SA, Manautou JE, A-Kader HH, Erickson RP, Cherrington NJ., Free PMC Article | 01/30/2016 |