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    ADAM19 ADAM metallopeptidase domain 19 [ Homo sapiens (human) ]

    Gene ID: 8728, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    ADAM19 and TUBB1 Correlate with Tumor Infiltrating Immune Cells and Predicts Prognosis in Osteosarcoma.

    ADAM19 and TUBB1 Correlate with Tumor Infiltrating Immune Cells and Predicts Prognosis in Osteosarcoma.
    Wang J, Gong M, Xiong Z, Zhao Y, Xing D.

    03/9/2023
    Human umbilical cord mesenchymal stem cell-derived exosomal miR-335-5p attenuates the inflammation and tubular epithelial-myofibroblast transdifferentiation of renal tubular epithelial cells by reducing ADAM19 protein levels.

    Human umbilical cord mesenchymal stem cell-derived exosomal miR-335-5p attenuates the inflammation and tubular epithelial-myofibroblast transdifferentiation of renal tubular epithelial cells by reducing ADAM19 protein levels.
    Qiu Z, Zhong Z, Zhang Y, Tan H, Deng B, Meng G., Free PMC Article

    08/6/2022
    MiR-874-3p suppresses cell proliferation and invasion by targeting ADAM19 in nasopharyngeal carcinoma.

    MiR-874-3p suppresses cell proliferation and invasion by targeting ADAM19 in nasopharyngeal carcinoma.
    Feng X, Xue H, Guo S, Chen Y, Zhang X, Tang X.

    03/26/2022
    Synovial mesenchymal stem cell-derived exosomal miR-320c enhances chondrogenesis by targeting ADAM19.

    Synovial mesenchymal stem cell-derived exosomal miR-320c enhances chondrogenesis by targeting ADAM19.
    Kong R, Gao J, Zhang J, Ji L, Yu Y, Zhang L, Zhao D.

    02/26/2022
    MicroRNA-874-3p/ADAM (A Disintegrin and Metalloprotease) 19 Mediates Macrophage Activation and Renal Fibrosis After Acute Kidney Injury.

    MicroRNA-874-3p/ADAM (A Disintegrin and Metalloprotease) 19 Mediates Macrophage Activation and Renal Fibrosis After Acute Kidney Injury.
    Wang J, Nie W, Xie X, Bai M, Ma Y, Jin L, Xiao L, Shi P, Yang Y, Jose PA, Armando I, Chen J, Lin W, Han F.

    01/15/2022
    Comparison of ADAM19 and CUEDC2 expression in EHCC and their clinicopathological significance.

    Comparison of ADAM19 and CUEDC2 expression in EHCC and their clinicopathological significance.
    Xu S, Huang S, Li D, Zou Q, Yuan Y, Yang Z.

    10/16/2021
    The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer.

    The elevated transcription of ADAM19 by the oncohistone H2BE76K contributes to oncogenic properties in breast cancer.
    Kang TZE, Zhu L, Yang D, Ding D, Zhu X, Wan YCE, Liu J, Ramakrishnan S, Chan LL, Chan SY, Wang X, Gan H, Han J, Ishibashi T, Li Q, Chan KM., Free PMC Article

    08/28/2021
    Circular RNA has_circ_0000034 accelerates retinoblastoma advancement through the miR-361-3p/ADAM19 axis.

    Circular RNA has_circ_0000034 accelerates retinoblastoma advancement through the miR-361-3p/ADAM19 axis.
    Jiang Y, Xiao F, Wang L, Wang T, Chen L.

    07/17/2021
    ADAM19 hypermethylation was associated with more advanced gastric neoplasm (GC) as stage IV.

    Analysis of the clinical significance of DNA methylation in gastric cancer based on a genome-wide high-resolution array.
    Fang WL, Chen MH, Huang KH, Chang SC, Lin CH, Chao Y, Lo SS, Li AF, Wu CW, Shyr YM., Free PMC Article

    08/1/2020
    3 SNPs (rs4329505 and rs4845626 in interleukin 6 receptor [IL6R] and rs1422794 in a disintegrin and metalloproteinase domain 19 [ADAM19]) were associated with a lower risk of suffering the most severe stages of the disease.

    Genetic Variants in IL6R and ADAM19 are Associated with COPD Severity in a Mexican Mestizo Population.
    Pérez-Rubio G, Silva-Zolezzi I, Fernández-López JC, Camarena Á, Velázquez-Uncal M, Morales-Mandujano F, Hernández-Zenteno Rde J, Flores-Trujillo F, Sánchez-Romero C, Velázquez-Montero A, Espinosa de Los Monteros C, Sansores RH, Ramírez-Venegas A, Falfán-Valencia R.

    12/9/2017
    ADAM19 is a protective factor for human prostate cancer. Further, this study suggests that upregulation of ADAM19 expression could be of therapeutic potential in human prostate cancer.

    Genetic and cellular studies highlight that A Disintegrin and Metalloproteinase 19 is a protective biomarker in human prostate cancer.
    Hoyne G, Rudnicka C, Sang QX, Roycik M, Howarth S, Leedman P, Schlaich M, Candy P, Matthews V., Free PMC Article

    12/17/2016
    these findings suggested that miR-145 functions as a tumor suppressor in RB by directly targeting ADAM19 in retinoblastoma cells

    MiR-145 suppressed human retinoblastoma cell proliferation and invasion by targeting ADAM19.
    Sun Z, Zhang A, Jiang T, Du Z, Che C, Wang F., Free PMC Article

    10/29/2016
    miR-30c inhibited colon cancer cells via targeting ADAM19.

    Role of microRNA-30c targeting ADAM19 in colorectal cancer.
    Zhang Q, Yu L, Qin D, Huang R, Jiang X, Zou C, Tang Q, Chen Y, Wang G, Wang X, Gao X., Free PMC Article

    12/19/2015
    four suggestive loci (PAX3, CCRN4L, PIGQ, and ADAM19)determinants of disease progression in Alzheimer's disease.

    Genetic determinants of disease progression in Alzheimer's disease.
    Wang X, Lopez OL, Sweet RA, Becker JT, DeKosky ST, Barmada MM, Demirci FY, Kamboh MI., Free PMC Article

    07/25/2015
    ADAM19 rs1422795 and HTR4 rs11168048 are associated with pulmonary function.

    ADAM19 and HTR4 variants and pulmonary function: Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Targeted Sequencing Study.
    London SJ, Gao W, Gharib SA, Hancock DB, Wilk JB, House JS, Gibbs RA, Muzny DM, Lumley T, Franceschini N, North KE, Psaty BM, Kovar CL, Coresh J, Zhou Y, Heckbert SR, Brody JA, Morrison AC, Dupuis J., Free PMC Article

    04/4/2015
    MiR-153 has a role in inhibiting migration and invasion of human non-small-cell lung cancer by targeting ADAM19

    MiR-153 inhibits migration and invasion of human non-small-cell lung cancer by targeting ADAM19.
    Shan N, Shen L, Wang J, He D, Duan C.

    03/21/2015
    ADAM19 was upregulated in patients with ulcerative colitis and, to a lesser extent, in patients with Crohn's disease compared with normal controls. In contrast, ADAM9 and ADAM10 expression did not differ between patients with IBD and controls.

    High expression of the "A Disintegrin And Metalloprotease" 19 (ADAM19), a sheddase for TNF-α in the mucosa of patients with inflammatory bowel diseases.
    Franzè E, Caruso R, Stolfi C, Sarra M, Cupi ML, Ascolani M, Sedda S, Antenucci C, Ruffa A, Caprioli F, MacDonald TT, Pallone F, Monteleone G.

    08/31/2013
    Prorenin receptor is mainly localized in the subcellular organelles, such as the endoplasmic reticulum and Golgi apparatus, and the prorenin receptor is cleaved by ADAM19 in the Golgi, resulting in two fragments.

    The (pro)renin receptor is cleaved by ADAM19 in the Golgi leading to its secretion into extracellular space.
    Yoshikawa A, Aizaki Y, Kusano K, Kishi F, Susumu T, Iida S, Ishiura S, Nishimura S, Shichiri M, Senbonmatsu T.

    09/17/2011
    Single nucleotide polymorphisms in ADAM19 gene is associated with lymphoma.

    Polymorphisms in integrin genes and lymphoma risk.
    Shen M, Zheng T, Lan Q, Zhang Y, Hosgood HD 3rd, Zahm SH, Holford TR, Leaderer B, Yeager M, Yuenger J, Chanock S, Rothman N., Free PMC Article

    08/20/2011
    These findings suggest that ADAM19 autolysis is activated by lipopolysaccharide and that ADAM19 promotes the secretion of CRIP2.

    ADAM19 autolysis is activated by LPS and promotes non-classical secretion of cysteine-rich protein 2.
    Tanabe C, Hotoda N, Sasagawa N, Futai E, Komano H, Ishiura S.

    07/19/2010
    Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)

    Polymorphisms in innate immunity genes and risk of childhood leukemia.
    Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D., Free PMC Article

    06/30/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles

    Risk of meningioma and common variation in genes related to innate immunity.
    Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD.

    Common variation in genes related to innate immunity and risk of adult glioma.
    Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ.

    06/30/2010
    ADAM19 correlates with the progress and prognosis of endometrial carcinoma.

    [Expression and clinical significance of ADAM19 in endometrial carcinoma].
    Ou Qz, Zhang Y, Yu L, Dong Y, Zhu C, Liao Qp.

    05/31/2010
    ADAM19 may participate in the coordinated regulation of human trophoblast cell behaviors during the process of placentation.

    Dynamic change of Adamalysin 19 (ADAM19) in human placentas and its effects on cell invasion and adhesion in human trophoblastic cells.
    Zhao M, Qiu W, Li Y, Sang QA, Wang Y.

    05/3/2010
    Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator)

    Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.
    Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD, Franceschini N, van Durme YM, Chen TH, Barr RG, Schabath MB, Couper DJ, Brusselle GG, Psaty BM, van Duijn CM, Rotter JI, Uitterlinden AG, Hofman A, Punjabi NM, Rivadeneira F, Morrison AC, Enright PL, North KE, Heckbert SR, Lumley T, Stricker BH, O'Connor GT, London SJ., Free PMC Article

    01/20/2010
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