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    RIPK1 receptor interacting serine/threonine kinase 1 [ Homo sapiens (human) ]

    Gene ID: 8737, updated on 10-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The deubiquitinating protein OTUD6B promotes lung adenocarcinoma progression by stabilizing RIPK1.

    The deubiquitinating protein OTUD6B promotes lung adenocarcinoma progression by stabilizing RIPK1.
    Yang M, Wei Y, He X, Xia C., Free PMC Article

    10/10/2024
    ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy.

    ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy.
    Wang YM, Tang H, Tang YJ, Liu J, Yin YF, Tang YL, Feng YG, Gu HF., Free PMC Article

    10/1/2024
    The role of autophagy in RIP1 mediated cell death and intestinal inflammation.

    The role of autophagy in RIP1 mediated cell death and intestinal inflammation.
    Lee YM, Vucic D.

    09/23/2024
    Sirt1 Deficiency Promotes Age-Related AF Through Enhancing Atrial Necroptosis by Activation of RIPK1 Acetylation.

    Sirt1 Deficiency Promotes Age-Related AF Through Enhancing Atrial Necroptosis by Activation of RIPK1 Acetylation.
    Jin X, Zhang Y, Zhou Y, Luo Y, Han X, Gao Y, Yu H, Duan Y, Shi L, Wu Y, Li Y.

    08/14/2024
    A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death.

    A RIPK1-specific PROTAC degrader achieves potent antitumor activity by enhancing immunogenic cell death.
    Mannion J, Gifford V, Bellenie B, Fernando W, Ramos Garcia L, Wilson R, John SW, Udainiya S, Patin EC, Tiu C, Smith A, Goicoechea M, Craxton A, Moraes de Vasconcelos N, Guppy N, Cheung KJ, Cundy NJ, Pierrat O, Brennan A, Roumeliotis TI, Benstead-Hume G, Alexander J, Muirhead G, Layzell S, Lyu W, Roulstone V, Allen M, Baldock H, Legrand A, Gabel F, Serrano-Aparicio N, Starling C, Guo H, Upton J, Gyrd-Hansen M, MacFarlane M, Seddon B, Raynaud F, Roxanis I, Harrington K, Haider S, Choudhary JS, Hoelder S, Tenev T, Meier P.,

    08/6/2024
    TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers.

    TAK1 inhibition leads to RIPK1-dependent apoptosis in immune-activated cancers.
    Damhofer H, Tatar T, Southgate B, Scarneo S, Agger K, Shlyueva D, Uhrbom L, Morrison GM, Hughes PF, Haystead T, Pollard SM, Helin K., Free PMC Article

    05/2/2024
    RIPK3 and RIPK1 gene expression in pterygium: unveiling molecular insights into pathogenesis.

    RIPK3 and RIPK1 gene expression in pterygium: unveiling molecular insights into pathogenesis.
    Divandari M, Javadifar A, Moghadam AB, Janatabadi AA.

    05/1/2024
    Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2.

    Simultaneous substrate and ubiquitin modification recognition by bispecific antibodies enables detection of ubiquitinated RIP1 and RIP2.
    Goncharov T, Kőműves LG, Kist M, Castellanos ER, Witt A, Fedorova AV, Izrael-Tomasevic A, Yu K, Keir M, Matsumoto ML, Vucic D.

    01/29/2024
    Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis.

    Elevated peripheral levels of receptor-interacting protein kinase 1 (RIPK1) and IL-8 as biomarkers of human amyotrophic lateral sclerosis.
    Wei J, Li M, Ye Z, Hu X, He X, Wang J, Chen G, Zou C, Xu D, Zhang H, Yuan J, Zha Y., Free PMC Article

    12/20/2023
    Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IkappaBalpha axis in liver inflammation.

    Caspase 6 promotes innate immune activation by functional crosstalk between RIPK1-IκBα axis in liver inflammation.
    Lin Y, Sheng M, Qin H, Zhang P, Wang C, Fu W, Meng X, Wang D, Hou Y., Free PMC Article

    11/28/2023
    RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD.

    RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD.
    Van Eeckhoutte HP, Donovan C, Kim RY, Conlon TM, Ansari M, Khan H, Jayaraman R, Hansbro NG, Dondelinger Y, Delanghe T, Beal AM, Geddes B, Bertin J, Vanden Berghe T, De Volder J, Maes T, Vandenabeele P, Vanaudenaerde BM, Deforce D, Škevin S, Van Nieuwerburgh F, Verhamme FM, Joos GF, Idrees S, Schiller HB, Yildirim AÖ, Faiz A, Bertrand MJM, Brusselle GG, Hansbro PM, Bracke KR.

    08/11/2023
    O-GlcNAcylation of RIPK1 rescues red blood cells from necroptosis.

    O-GlcNAcylation of RIPK1 rescues red blood cells from necroptosis.
    Seo J, Kim Y, Ji S, Kim HB, Jung H, Yi EC, Lee YH, Shin I, Yang WH, Cho JW., Free PMC Article

    07/3/2023
    IKK-mediated TRAF6 and RIPK1 interaction stifles cell death complex assembly leading to the suppression of TNF-alpha-induced cell death.

    IKK-mediated TRAF6 and RIPK1 interaction stifles cell death complex assembly leading to the suppression of TNF-α-induced cell death.
    Lee CS, Hwang G, Nam YW, Hwang CH, Song J., Free PMC Article

    06/13/2023
    RIPK1-dependent necroptosis promotes vasculogenic mimicry formation via eIF4E in triple-negative breast cancer.

    RIPK1-dependent necroptosis promotes vasculogenic mimicry formation via eIF4E in triple-negative breast cancer.
    Li F, Sun H, Yu Y, Che N, Han J, Cheng R, Zhao N, Guo Y, Huang C, Zhang D., Free PMC Article

    05/31/2023
    RNF31 promotes tumorigenesis via inhibiting RIPK1 kinase-dependent apoptosis.

    RNF31 promotes tumorigenesis via inhibiting RIPK1 kinase-dependent apoptosis.
    Zhang J, Tu H, Zheng Z, Zhao X, Lin X.

    05/12/2023
    Upregulation of RIPK1 implicates in HEK 293T cell death upon transient transfection of A53T-alpha-synuclein.

    Upregulation of RIPK1 implicates in HEK 293T cell death upon transient transfection of A53T-α-synuclein.
    Meshkini F, Moradi A, Hosseinkhani S.

    02/22/2023
    Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1.

    Human ZBP1 induces cell death-independent inflammatory signaling via RIPK3 and RIPK1.
    Peng R, Wang CK, Wang-Kan X, Idorn M, Kjaer M, Zhou FY, Fiil BK, Timmermann F, Orozco SL, McCarthy J, Leung CS, Lu X, Bagola K, Rehwinkel J, Oberst A, Maelfait J, Paludan SR, Gyrd-Hansen M., Free PMC Article

    12/24/2022
    RIPK1 mutations causing infantile-onset IBD with inflammatory and fistulizing features.

    RIPK1 mutations causing infantile-onset IBD with inflammatory and fistulizing features.
    Sultan M, Adawi M, Kol N, McCourt B, Adawi I, Baram L, Tal N, Werner L, Lev A, Snapper SB, Barel O, Konnikova L, Somech R, Shouval DS., Free PMC Article

    12/10/2022
    Characterization of Novel Pathogenic Variants Leading to Caspase-8 Cleavage-Resistant RIPK1-Induced Autoinflammatory Syndrome.

    Characterization of Novel Pathogenic Variants Leading to Caspase-8 Cleavage-Resistant RIPK1-Induced Autoinflammatory Syndrome.
    Tapiz I Reula AJ, Cochino AV, Martins AL, Angosto-Bazarra D, de Landazuri IO, Mensa-Vilaró A, Cabral M, Baroja-Mazo A, Baños MC, Lobato-Salinas Z, Fabregat V, Plaza S, Yagüe J, Casals F, Oliva B, Figueiredo AE, Pelegrín P, Aróstegui JI., Free PMC Article

    11/26/2022
    Dengue virus downregulates TNFR1- and TLR3-stimulated NF-kappaB activation by targeting RIPK1.

    Dengue virus downregulates TNFR1- and TLR3-stimulated NF-κB activation by targeting RIPK1.
    Udawatte DJ, Lang DM, Currier JR, Medin CL, Rothman AL., Free PMC Article

    11/5/2022
    RIPK1 and RIPK3 regulate TNFalpha-induced beta-cell death in concert with caspase activity.

    RIPK1 and RIPK3 regulate TNFα-induced β-cell death in concert with caspase activity.
    Contreras CJ, Mukherjee N, Branco RCS, Lin L, Hogan MF, Cai EP, Oberst AA, Kahn SE, Templin AT., Free PMC Article

    10/15/2022
    Hsa_circ_0010729 regulates H2O2-induced myocardial injury by regulating miR-1184/RIPK1 axis.

    Hsa_circ_0010729 regulates H(2)O(2)-induced myocardial injury by regulating miR-1184/RIPK1 axis.
    Wang L, Su H, Liu W.

    09/17/2022
    [Autoinflammatory diseases associated with RIPK1 mutations: A review of the literature].", trans "Revue de la litterature sur les maladies auto-inflammatoires associees aux mutations du gene RIPK1.

    [Autoinflammatory diseases associated with RIPK1 mutations: A review of the literature].
    Parentelli AS, Picard C, Boursier G, Melki I, Belot A, Smahi A, Georgin-Lavialle S.

    09/10/2022
    ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-kappaB.

    ANKRD13a controls early cell-death checkpoint by interacting with RIP1 independent of NF-κB.
    Won M, Park KA, Kim S, Ju E, Ko Y, Yoo H, Ro H, Lee J, Oh J, Lee EG, Kim SY, Nam SW, Shen HM, Yeo MK, Kim JM, Hur GM., Free PMC Article

    06/18/2022
    Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3(+) and CD8(+) T cell density and predict prognosis in hepatocellular carcinoma.

    Necroptosis-driving genes RIPK1, RIPK3 and MLKL-p are associated with intratumoral CD3(+) and CD8(+) T cell density and predict prognosis in hepatocellular carcinoma.
    Nicolè L, Sanavia T, Cappellesso R, Maffeis V, Akiba J, Kawahara A, Naito Y, Radu CM, Simioni P, Serafin D, Cortese G, Guido M, Zanus G, Yano H, Fassina A., Free PMC Article

    05/14/2022
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