Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis. | Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis. Kanai S, Fujiwara H, Mizuno S, Kishikawa T, Nakatsuka T, Hamada T, Tanaka M, Arita J, Nakai Y, Isayama H, Kasuga M, Tateishi R, Tateishi K, Ushiku T, Hasegawa K, Koike K, Fujishiro M. | 02/1/2024 |
MIF promotes Th17 cell differentiation in Hashimoto's thyroiditis by binding HVEM and activating NF-kappaB signaling pathway. | MIF promotes Th17 cell differentiation in Hashimoto's thyroiditis by binding HVEM and activating NF-κB signaling pathway. Liu Z, Li Z, Yan G, Lin C, Luo Y, Ye Y, Zeng X, Yao J. | 11/10/2023 |
Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1[-] stem cell-like T cells over PD-1[+] T cells curbing tumor progression. | Genetic deletion of HVEM in a leukemia B cell line promotes a preferential increase of PD-1(-) stem cell-like T cells over PD-1(+) T cells curbing tumor progression. Del Rio ML, de Juan CY, Roncador G, Caleiras E, Álvarez-Esteban R, Pérez-Simón JA, Rodriguez-Barbosa JI., Free PMC Article | 08/10/2023 |
Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2. | Tumor Cell-Intrinsic BTLA Receptor Inhibits the Proliferation of Tumor Cells via ERK1/2. Cheng TY, Liu YJ, Yan H, Xi YB, Duan LQ, Wang Y, Zhang TT, Gu YM, Wang XD, Wu CX, Gao S., Free PMC Article | 01/14/2023 |
BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM. | BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM. Battin C, Leitner J, Waidhofer-Söllner P, Grabmeier-Pfistershammer K, Olive D, Steinberger P., Free PMC Article | 10/8/2022 |
The role of the BTLA-HVEM complex in the pathogenesis of autoimmune diseases. | The role of the BTLA-HVEM complex in the pathogenesis of autoimmune diseases. Wojciechowicz K, Spodzieja M, Lisowska KA, Wardowska A. | 06/18/2022 |
Clinical Significance of BTLA and HVEM Expression on Circulating CD4(+) T and CD8(+) T Cells in Chronic Hepatitis B Virus Infection. | Clinical Significance of BTLA and HVEM Expression on Circulating CD4(+) T and CD8(+) T Cells in Chronic Hepatitis B Virus Infection. Song HF, Chen XJ, Tang PJ, Xu P, Huang ZY, Wang XF. | 05/21/2022 |
HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160. | HVEM structures and mutants reveal distinct functions of binding to LIGHT and BTLA/CD160. Liu W, Chou TF, Garrett-Thomson SC, Seo GY, Fedorov E, Ramagopal UA, Bonanno JB, Wang Q, Kim K, Garforth SJ, Kakugawa K, Cheroutre H, Kronenberg M, Almo SC., Free PMC Article | 01/1/2022 |
Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype. | Frequent mutated B2M, EZH2, IRF8, and TNFRSF14 in primary bone diffuse large B-cell lymphoma reflect a GCB phenotype. de Groen RAL, van Eijk R, Böhringer S, van Wezel T, Raghoo R, Ruano D, Jansen PM, Briaire-de Bruijn I, de Groot FA, Kleiverda K, Te Boome L, Terpstra V, Levenga H, Nicolae A, Posthuma EFM, Focke-Snieders I, Hardi L, den Hartog WCE, Bohmer LH, Hogendoorn PCW, van den Berg A, Diepstra A, Nijland M, Lugtenburg PJ, Kersten MJ, Pals ST, Veelken H, Bovée JVMG, Cleven AHG, Vermaat JSP., Free PMC Article | 11/6/2021 |
Redesigning HVEM Interface for Selective Binding to LIGHT, BTLA, and CD160. | Redesigning HVEM Interface for Selective Binding to LIGHT, BTLA, and CD160. Shrestha R, Garrett-Thomson SC, Liu W, Almo SC, Fiser A., Free PMC Article | 10/16/2021 |
The Analysis of PTPN6 for Bladder Cancer: An Exploratory Study Based on TCGA. | The Analysis of PTPN6 for Bladder Cancer: An Exploratory Study Based on TCGA. Shen C, Liu J, Wang J, Yang X, Niu H, Wang Y., Free PMC Article | 04/3/2021 |
Fragments of gD Protein as Inhibitors of BTLA/HVEM Complex Formation-Design, Synthesis, and Cellular Studies. | Fragments of gD Protein as Inhibitors of BTLA/HVEM Complex Formation-Design, Synthesis, and Cellular Studies. Kuncewicz K, Battin C, Sieradzan A, Karczyńska A, Orlikowska M, Wardowska A, Pikuła M, Steinberger P, Rodziewicz-Motowidło S, Spodzieja M., Free PMC Article | 03/6/2021 |
HVEM/HIF-1alpha promoted proliferation and inhibited apoptosis of ovarian cancer cells under hypoxic microenvironment conditions. | HVEM/HIF-1α promoted proliferation and inhibited apoptosis of ovarian cancer cells under hypoxic microenvironment conditions. Duan L, Tao J, Yang X, Ye L, Wu Y, He Q, Duan Y, Chen L, Zhu J., Free PMC Article | 11/21/2020 |
BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection. | BTLA/HVEM Signaling: Milestones in Research and Role in Chronic Hepatitis B Virus Infection. Yu X, Zheng Y, Mao R, Su Z, Zhang J., Free PMC Article | 08/13/2020 |
High TNFRSF14 expression is associated with Colorectal Liver Metastasis. | Significance of Herpesvirus Entry Mediator Expression in Human Colorectal Liver Metastasis. Sasaki Y, Hokuto D, Inoue T, Nomi T, Yoshikawa T, Matsuo Y, Koyama F, Sho M. | 03/7/2020 |
expression of BTLA and its ligand HVEM, the proportion of T lymphocytes and the expression of BTLA on the surface of gammadelta T cells in patients with chronic myelomonocytic leukemia are reduced | [Expression and Significance of BTLA and Its Ligand HVEM in Patients with Chronic Myelomonocytic Leukemia]. Li C, Geng SX, Li MM, Su F, Chen XM, Deng CX, Huang X, Lai PL, Weng JY, DU X. | 02/22/2020 |
HVEM expression on CD3+ cells increases after trauma. Patients developing secondary infections have less circulating HVEM+CD3+. This implies HVEM signaling in lymphocytes plays a role in maintaining host defense to infection in after trauma. | Herpes Virus Entry Mediator (HVEM): A Novel Potential Mediator of Trauma-Induced Immunosuppression. Wakeley ME, Shubin NJ, Monaghan SF, Gray CC, Ayala A, Heffernan DS., Free PMC Article | 02/15/2020 |
we have shown that soluble Fc-disabled HVEM-(Fc*) augments NK cell activation, IFN-gamma production, and cytotoxicity of NK cells without inducing NK cell fratricide by promoting cross-talk between NK cells and monocytes without Fc receptor-induced effects | Soluble Fc-Disabled Herpes Virus Entry Mediator Augments Activation and Cytotoxicity of NK Cells by Promoting Cross-Talk between NK Cells and Monocytes. Meng Q, Zaidi AK, Sedy J, Bensussan A, Popkin DL., Free PMC Article | 01/11/2020 |
These data provide the first evidence of overexpression of LIGHT and its receptors HVEM and LT beta receptor in systemic sclerosis and suggest that the LIGHT axis might contribute to the pathogenesis of systemic sclerosis. | Increased expression of the TNF superfamily member LIGHT/TNFSF14 and its receptors (HVEM and LTßR) in patients with systemic sclerosis. Gindzienska-Sieskiewicz E, Distler O, Reszec J, Jordan S, Bielecki P, Sieskiewicz A, Sulik A, Lukasik M, Bielecki M, Kowal K, Kowal-Bielecka O. | 01/11/2020 |
Our data highlights the importance of HVEM in the development of GBM and as a potential molecular target in combination with current immune checkpoint blockades for treatment of GBM. | Immune checkpoint molecule herpes virus entry mediator is overexpressed and associated with poor prognosis in human glioblastoma. Han MZ, Wang S, Zhao WB, Ni SL, Yang N, Kong Y, Huang B, Chen AJ, Li XG, Wang J, Wang DH., Free PMC Article | 11/30/2019 |
HVEM was found to have a significant negative correlation with PD-L1 expression. | The immune checkpoint, HVEM may contribute to immune escape in non-small cell lung cancer lacking PD-L1 expression. Ren S, Tian Q, Amar N, Yu H, Rivard CJ, Caldwell C, Ng TL, Tu M, Liu Y, Gao D, Ellison K, Suda K, Rozeboom L, Rivalland G, Mitchell P, Zhou C, Hirsch FR. | 09/7/2019 |
the BTLA-TNFRSF14 immune modulation pathway seems to play a role in the pathobiology and prognosis of FL. | High TNFRSF14 and low BTLA are associated with poor prognosis in Follicular Lymphoma and in Diffuse Large B-cell Lymphoma transformation. Carreras J, Lopez-Guillermo A, Kikuti YY, Itoh J, Masashi M, Ikoma H, Tomita S, Hiraiwa S, Hamoudi R, Rosenwald A, Leich E, Martinez A, Roncador G, Villamor N, Colomo L, Perez P, Tsuji NM, Campo E, Nakamura N., Free PMC Article | 04/20/2019 |
LIGHT signaling through HVEM in epidermal keratinocytes directly induced proliferation and periostin expression, and both keratinocyte-specific deletion of HVEM or antibody blocking of LIGHT-HVEM interactions after disease onset prevented expression of periostin and limited atopic dermatitis symptoms. | LIGHT-HVEM signaling in keratinocytes controls development of dermatitis. Herro R, Shui JW, Zahner S, Sidler D, Kawakami Y, Kawakami T, Tamada K, Kronenberg M, Croft M., Free PMC Article | 04/13/2019 |
Data suggest that both HVEM and UL144 bind a common epitope of BTLA, whether engaged in trans or in cis; these studies were conducted in cell lines representing B-lymphocytes, T-lymphocytes, and natural killer cells. (HVEM = human herpes virus entry mediator; UL144 = membrane glycoprotein UL144 of Human herpesvirus 5; BTLA = human B- and T-lymphocyte attenuator) | A herpesvirus entry mediator mutein with selective agonist action for the inhibitory receptor B and T lymphocyte attenuator. Šedý JR, Balmert MO, Ware BC, Smith W, Nemčovičova I, Norris PS, Miller BR, Aivazian D, Ware CF., Free PMC Article | 11/17/2018 |
our data suggested that the BTLA/HVEM pathway contributes to peripheral T cell suppression in hepatocellular carcinoma patients | Distinct Changes of BTLA and HVEM Expressions in Circulating CD4(+) and CD8(+) T Cells in Hepatocellular Carcinoma Patients. Liu J, Li J, He M, Zhang GL, Zhao Q., Free PMC Article | 11/10/2018 |