| GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells. | GITR Ligation Improves Anti-PD1-Mediated Restoration of Human MMR-Proficient Colorectal Carcinoma Tumor-Derived T Cells.
Rakké YS, Campos Carrascosa L, van Beek AA, de Ruiter V, van Gemerden RS, Doukas M, Doornebosch PG, Vermaas M, Ter Borg S, van der Harst E, Coene PPLO, Kliffen M, Grünhagen DJ, Verhoef C, IJzermans JNM, Kwekkeboom J, Sprengers D., Free PMC Article | 12/31/2022 |
| DNA Methylation and mRNA Expression of OX40 (TNFRSF4) and GITR (TNFRSF18, AITR) in Head and Neck Squamous Cell Carcinoma Correlates With HPV Status, Mutational Load, an Interferon-gamma Signature, Signatures of Immune Infiltrates, and Survival. | DNA Methylation and mRNA Expression of OX40 (TNFRSF4) and GITR (TNFRSF18, AITR) in Head and Neck Squamous Cell Carcinoma Correlates With HPV Status, Mutational Load, an Interferon-γ Signature, Signatures of Immune Infiltrates, and Survival.
Loick SM, Fröhlich A, Gabrielpillai J, Franzen A, Vogt TJ, Dietrich J, Wiek C, Scheckenbach K, Strieth S, Landsberg J, Dietrich D. | 04/16/2022 |
| Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis. | Glucocorticoid induced TNF receptor family-related protein (GITR) - A novel driver of atherosclerosis.
Bosmans LA, Shami A, Atzler D, Weber C, Gonçalves I, Lutgens E. | 04/2/2022 |
| Phenotypic Changes of PD-1 and GITR in T Cells Are Associated With Hepatitis B Surface Antigen Seroclearance. | Phenotypic Changes of PD-1 and GITR in T Cells Are Associated With Hepatitis B Surface Antigen Seroclearance.
Liu F, Zhang S, Wong DK, Huang FY, Cheung KS, Mak LY, Fung J, Yuen MF, Seto WK. | 02/5/2022 |
| GITR Promotes the Polarization of TFH-Like Cells in Helicobacter pylori-Positive Gastritis. | GITR Promotes the Polarization of TFH-Like Cells in Helicobacter pylori-Positive Gastritis.
Ming S, Yin H, Li X, Gong S, Zhang G, Wu Y., Free PMC Article | 12/25/2021 |
| Interleukin 3-induced GITR promotes the activation of human basophils. | Interleukin 3-induced GITR promotes the activation of human basophils.
Hong L, Tang Y, Pan S, Xu M, Shi Y, Gao S, Sui C, He C, Zheng K, Tang R, Shi Z, Wang Q, Wang H. | 11/27/2021 |
| Experimental Medicine Study to Measure Immune Checkpoint Receptors PD-1 and GITR Turnover Rates In Vivo in Humans. | Experimental Medicine Study to Measure Immune Checkpoint Receptors PD-1 and GITR Turnover Rates In Vivo in Humans.
Lassman ME, Chappell DL, McAvoy T, Cheng A, de Alwis DP, Pruitt SK, Laterza OF, Li C, Stoch A, Mayawala K. | 09/11/2021 |
| Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans. | Glucocorticoid-induced tumour necrosis factor receptor family-related protein (GITR) drives atherosclerosis in mice and is associated with an unstable plaque phenotype and cerebrovascular events in humans.
Shami A, Atzler D, Bosmans LA, Winkels H, Meiler S, Lacy M, van Tiel C, Ta Megens R, Nitz K, Baardman J, Kusters P, Seijkens T, Buerger C, Janjic A, Riccardi C, Edsfeldt A, Monaco C, Daemen M, de Winther MPJ, Nilsson J, Weber C, Gerdes N, Gonçalves I, Lutgens E., Free PMC Article | 07/10/2021 |
| GITR shapes humoral immunity by controlling the balance between follicular T helper cells and regulatory T follicular cells. | GITR shapes humoral immunity by controlling the balance between follicular T helper cells and regulatory T follicular cells.
Oja AE, Brasser G, Slot E, van Lier RAW, Pascutti MF, Nolte MA. | 05/22/2021 |
| Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. | Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions.
Wang F, Chau B, West SM, Kimberlin CR, Cao F, Schwarz F, Aguilar B, Han M, Morishige W, Bee C, Dollinger G, Rajpal A, Strop P., Free PMC Article | 03/13/2021 |
| Characterization and Comparison of GITR Expression in Solid Tumors. | Characterization and Comparison of GITR Expression in Solid Tumors.
Vence L, Bucktrout SL, Fernandez Curbelo I, Blando J, Smith BM, Mahne AE, Lin JC, Park T, Pascua E, Sai T, Chaparro-Riggers J, Subudhi SK, Scutti JB, Higa MG, Zhao H, Yadav SS, Maitra A, Wistuba II, Allison JP, Sharma P., Free PMC Article | 09/12/2020 |
| This work demonstrates abnormal changes in Helios(+) Tregs and soluble GITR in myasthenia gravis, as well as direct regulation of Helios by GITR in the context of Tregulatory cells. | Soluble glucocorticoid-induced tumor necrosis factor receptor regulates Helios expression in myasthenia gravis.
Li Y, Yang S, Li Z, Meng H, Jin W, Yang H, Yin W., Free PMC Article | 06/20/2020 |
| Agonistic targeting of GITR can enhance functionality of HCC TIL. | GITR ligation enhances functionality of tumor-infiltrating T cells in hepatocellular carcinoma.
van Beek AA, Zhou G, Doukas M, Boor PPC, Noordam L, Mancham S, Campos Carrascosa L, van der Heide-Mulder M, Polak WG, Ijzermans JNM, Pan Q, Heirman C, Mahne A, Bucktrout SL, Bruno MJ, Sprengers D, Kwekkeboom J., Free PMC Article | 12/7/2019 |
| GITR cosignal in ILC2s controls allergic lung inflammation. | GITR cosignal in ILC2s controls allergic lung inflammation.
Nagashima H, Okuyama Y, Fujita T, Takeda T, Motomura Y, Moro K, Hidaka T, Omori K, Sakurai T, Machiyama T, Ndhlovu LC, Riccardi C, So T, Ishii N. | 08/3/2019 |
| Authors demonstrate that GITR engagement of activated, but not naive, ILC2s improves glucose homeostasis, resulting in both protection against insulin resistance onset and amelioration of established insulin- resistance. | Costimulation of type-2 innate lymphoid cells by GITR promotes effector function and ameliorates type 2 diabetes.
Galle-Treger L, Sankaranarayanan I, Hurrell BP, Howard E, Lo R, Maazi H, Lewis G, Banie H, Epstein AL, Hu P, Rehan VK, Gilliland FD, Allayee H, Soroosh P, Sharpe AH, Akbari O., Free PMC Article | 04/13/2019 |
| The increased expression of FOXP3, CTLA-4 and GITR represent higher activity of Treg cells. | Overexpression of Regulatory T Cell-Related Markers (FOXP3, CTLA-4 and GITR) by Peripheral Blood Mononuclear Cells from Patients with Breast Cancer.
Khalife E, Khodadadi A, Talaeizadeh A, Rahimian L, Nemati M, Jafarzadeh A., Free PMC Article | 03/30/2019 |
| HTLV-1 infection can modify the expression of main functional transcription factors, FOXP3 and GITR | Evaluation of T Regulatory Lymphocytes Transcription Factors in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) Patients.
Ghezeldasht SA, Sadeghian H, Azarpazhooh MR, Shamsian SAA, Rafatpanah H, Mahmoodi M, Rezaee SA. | 09/9/2017 |
| a novel molecular mechanism by which MBD4 inhibits GITR expression in a DNMT1-dependent manner | DNMT1 cooperates with MBD4 to inhibit the expression of Glucocorticoid-induced TNFR-related protein in human T cells.
Wang S, Li Y, Zhu F, Lin F, Luo X, Zhao B, Zhang P, Li D, Gao Y, Liang R, Liu L, Tsun A, Yuan X, Wu K, Li B. | 08/19/2017 |
| Aberrant expression of GITR may contribute to systemic lupus erithematosus pathogenesis. Glucocorticoid may achieve its therapeutic effect partly by inducing GITR expression on Tresps rather than Tregs, which initiates the apoptosis of Tresp cells in SLE patients. | Aberrant GITR expression on different T cell subsets and the regulation by glucocorticoid in systemic lupus erythematosus.
Sun J, Yu N, Li X, Wang L, Pan Y, Li X, Tao J, Chen Z, Wang G. | 01/14/2017 |
| GITR expression can enhance the sensitivity to Bortezomib by inhibiting Bortezomib-induced NF-kappaB activation. | Expression of GITR Enhances Multiple Myeloma Cell Sensitivity to Bortezomib.
Zhao Y, Zhang K, Li G, Zhang X, Shi D., Free PMC Article | 02/27/2016 |
| GITR is a crucial player in differentiation of thymic regulatory T cells and expansion of regulatory T cells, including both thymic regulatory T cells and peripheral regulatory T cells. | Glucocorticoid-induced tumour necrosis factor receptor-related protein: a key marker of functional regulatory T cells.
Ronchetti S, Ricci E, Petrillo MG, Cari L, Migliorati G, Nocentini G, Riccardi C., Free PMC Article | 02/6/2016 |
| Data may suggest a key role of regulatory GITR+CD25 low/-CD4+ T cells subset in the modulation of the abnormal immune response in lupus erythematosus (SLE) patients. | Expansion of regulatory GITR+CD25 low/-CD4+ T cells in systemic lupus erythematosus patients.
Nocentini G, Alunno A, Petrillo MG, Bistoni O, Bartoloni E, Caterbi S, Ronchetti S, Migliorati G, Riccardi C, Gerli R., Free PMC Article | 08/15/2015 |
| results suggest that the GITR rs3753348 polymorphism may be involved in the development and susceptibility of CWP. | GITR promoter polymorphism contributes to risk of coal workers' pneumoconiosis: a case-control study from China.
Wu B, Ji X, Han R, Han L, Wang T, Yang J, Zhu B, Ni C. | 08/1/2015 |
| these results show a higher susceptibility to apoptosis in patients' versus controls' T(reg) cells, suggesting that GITR is a T(reg)-cell marker that would be primarily involved in T(reg)-cell survival rather than in their suppressor function. | Low frequency of GITR+ T cells in ex vivo and in vitro expanded Treg cells from type 1 diabetic patients.
Xufré C, Costa M, Roura-Mir C, Codina-Busqueta E, Usero L, Pizarro E, Obiols G, Jaraquemada D, Martí M. | 04/19/2014 |
| Our findings indicate the possible involvement of GITR-GITRL pathway in the pathogenesis of pSS. | Correlation of increased blood levels of GITR and GITRL with disease severity in patients with primary Sjögren's syndrome.
Gan X, Feng X, Gu L, Tan W, Sun X, Lv C, Zhang M., Free PMC Article | 02/22/2014 |