| SNHG3/WISP2 Axis Promotes Hela Cell Migration and Invasion via Activating Wnt/beta-Catenin Signaling. | SNHG3/WISP2 Axis Promotes Hela Cell Migration and Invasion via Activating Wnt/β-Catenin Signaling.
Xu D, Feng H, Ren Z, Li X, Jiang C, Chen Y, Liu L, Chen W, Cui Z, Cang S., Free PMC Article | 12/5/2023 |
| WISP2 downregulation inhibits the osteogenic differentiation of BMSCs in congenital scoliosis by regulating Wnt/beta-catenin pathway. | WISP2 downregulation inhibits the osteogenic differentiation of BMSCs in congenital scoliosis by regulating Wnt/β-catenin pathway.
Zheng Y, Shen P, Tong M, Li H, Ren C, Wu F, Li H, Yang H, Cai B, Du W, Zhao X, Yao S, Quan R. | 08/9/2023 |
| ERalpha prevents tumorigenesis of both liver and breast cancer cells through CCN5. | ERα prevents tumorigenesis of both liver and breast cancer cells through CCN5.
Zheng D, Bashir M, Li Z. | 07/27/2023 |
| Acetylation stabilizes the signaling protein WISP2 by preventing its degradation to suppress the progression of acute myeloid leukemia. | Acetylation stabilizes the signaling protein WISP2 by preventing its degradation to suppress the progression of acute myeloid leukemia.
Zhang H, Song W, Ma X, Yu M, Chen L, Tao Y., Free PMC Article | 04/6/2023 |
| LncRNA TRG-AS1 inhibits bone metastasis of breast cancer by the miR-877-5p/WISP2 axis. | LncRNA TRG-AS1 inhibits bone metastasis of breast cancer by the miR-877-5p/WISP2 axis.
Zhu J, Dai H, Li X, Guo L, Sun X, Zheng Z, Xu C. | 03/15/2023 |
| The carboxyl-terminal TSP1-homology domain is the biologically active effector peptide of matricellular protein CCN5 that counteracts profibrotic CCN2. | The carboxyl-terminal TSP1-homology domain is the biologically active effector peptide of matricellular protein CCN5 that counteracts profibrotic CCN2.
Zolfaghari S, Kaasbøll OJ, Monsen VT, Sredic B, Hagelin EMV, Attramadal H., Free PMC Article | 02/4/2023 |
| WISP-2 modulates the induction of inflammatory mediators and cartilage catabolism in chondrocytes. | WISP-2 modulates the induction of inflammatory mediators and cartilage catabolism in chondrocytes.
Ruiz-Fernández C, González-Rodríguez M, Abella V, Francisco V, Cordero-Barreal A, Ait Eldjoudi D, Farrag Y, Pino J, Conde-Aranda J, González-Gay MÁ, Mera A, Mobasheri A, García-Caballero L, Gándara-Cortés M, Lago F, Scotece M, Gualillo O. | 09/3/2022 |
| Matricellular Protein WISP2 Is an Endogenous Inhibitor of Collagen Linearization and Cancer Metastasis. | Matricellular Protein WISP2 Is an Endogenous Inhibitor of Collagen Linearization and Cancer Metastasis.
Janjanam J, Pano G, Wang R, Minden-Birkenmaier BA, Breeze-Jones H, Baker E, Garcin C, Clayton G, Shirinifard A, Zaske AM, Finkelstein D, Labelle M., Free PMC Article | 01/15/2022 |
| Dual roles of WISP2 in the progression of hepatocellular carcinoma: implications of the fibroblast infiltration into the tumor microenvironment. | Dual roles of WISP2 in the progression of hepatocellular carcinoma: implications of the fibroblast infiltration into the tumor microenvironment.
Jia Q, Zhang Y, Xu B, Liao X, Bu Y, Xu Z, Duan X, Zhang Q., Free PMC Article | 01/8/2022 |
| Protective effect of estrogen receptors (ERalpha/beta) against the intervertebral disc degeneration involves activating CCN5 via the promoter. | Protective effect of estrogen receptors (ERα/β) against the intervertebral disc degeneration involves activating CCN5 via the promoter.
Song MX, Ma XX, Wang C, Wang Y, Sun C, Xu DR, Zhu K, Li GH, Zhao H, Zhang C. | 01/8/2022 |
| WISP2/IGF1 promotes the survival of DSCs and impairs the cytotoxicity of decidual NK cells. | WISP2/IGF1 promotes the survival of DSCs and impairs the cytotoxicity of decidual NK cells.
Shi JW, Yang HL, Lai ZZ, Shen HH, Qin XY, Qiu XM, Wang Y, Wu JN, Li MQ. | 01/8/2022 |
| WISP2 promotes cell proliferation via targeting ERK and YAP in ovarian cancer cells. | WISP2 promotes cell proliferation via targeting ERK and YAP in ovarian cancer cells.
Shi ZQ, Chen ZY, Han Y, Zhu HY, Lyu MD, Zhang H, Zhang Y, Yang LQ, Pan WW., Free PMC Article | 05/29/2021 |
| CCN5 inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma cells. | CCN5 inhibits proliferation and promotes apoptosis of oral squamous cell carcinoma cells.
Sun S, Cui Z, Yan T, Wu J, Liu Z. | 11/21/2020 |
| Our findings suggest that activation of WISP2 could be a useful therapeutic strategy for the treatment of esophageal squamous cell carcinoma | WISP2 exhibits its potential antitumor activity via targeting ERK and E-cadherin pathways in esophageal cancer cells.
Chai DM, Qin YZ, Wu SW, Ma L, Tan YY, Yong X, Wang XL, Wang ZP, Tao YS., Free PMC Article | 06/15/2019 |
| The authors show that, in triple-negative-breast cancer (TNBC) cells enriched with tumor initiating cells, CCN5 significantly blocks cellular growth via apoptosis, reversing epithelial-mesenchymal-transition-signaling and impairing mammosphere formation, thereby blocking the tumor-forming ability and invasive capacity of these cells. | Deficiency of CCN5/WISP-2-Driven Program in breast cancer Promotes Cancer Epithelial cells to mesenchymal stem cells and Breast Cancer growth.
Das A, Dhar K, Maity G, Sarkar S, Ghosh A, Haque I, Dhar G, Banerjee S, Banerjee SK., Free PMC Article | 09/8/2018 |
| by analyzing different estrogen receptor-alpha(ER-a)-positive and ER-a-negative breast cancer cell lines, we defined the role of CCN5 in the leptin-mediated regulation of growth and invasive capacity. | Leptin-induced ER-α-positive breast cancer cell viability and migration is mediated by suppressing CCN5-signaling via activating JAK/AKT/STAT-pathway.
Haque I, Ghosh A, Acup S, Banerjee S, Dhar K, Ray A, Sarkar S, Kambhampati S, Banerjee SK., Free PMC Article | 08/18/2018 |
| CCN3 (Nov) and CCN5 (WISP2) are novel substrates of MMP14. | Degradomic and yeast 2-hybrid inactive catalytic domain substrate trapping identifies new membrane-type 1 matrix metalloproteinase (MMP14) substrates: CCN3 (Nov) and CCN5 (WISP2).
Butler GS, Connor AR, Sounni NE, Eckhard U, Morrison CJ, Noël A, Overall CM. | 01/6/2018 |
| Results show that WISP2 and beta-catenin were more highly expressed in gastric cancer tissues and seem to correlate with early stage or without metastasis. | Clinical Correlation Between WISP2 and β-Catenin in Gastric Cancer.
Li L, Cui Y, Ji JF, Jiang WG. | 09/9/2017 |
| Studies indicate that the CYR61 CTGF NOV matricellular proteins (CCN family of proteins) comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6 and have been identified in various types of cancer. | Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review).
Li J, Ye L, Owen S, Weeks HP, Zhang Z, Jiang WG., Free PMC Article | 09/17/2016 |
| Report opposing effects of CCN2 and CCN5 on fibroblast proliferation and transdifferentiation induced by TGF-beta. | CCN2 and CCN5 exerts opposing effect on fibroblast proliferation and transdifferentiation induced by TGF-β.
Xu H, Li P, Liu M, Liu C, Sun Z, Guo X, Zhang Y. | 04/16/2016 |
| Serum WISP2 correlated directly with fatty acid binding protein 4. Serum SFRP5 did not differ between obese (n=32) vs. nonobese (n=25) PCOS women, but reference women had lower SFRP5 (p<5x10(-6) as compared to both PCOS groups). | Roles of circulating WNT-signaling proteins and WNT-inhibitors in human adiposity, insulin resistance, insulin secretion, and inflammation.
Almario RU, Karakas SE. | 09/26/2015 |
| Activation of CCN5 may have the therapeutic potential to kill triple-negative breast cancer. | CCN5/WISP-2 promotes growth arrest of triple-negative breast cancer cells through accumulation and trafficking of p27(Kip1) via Skp2 and FOXO3a regulation.
Haque I, Banerjee S, De A, Maity G, Sarkar S, Majumdar M, Jha SS, McGragor D, Banerjee SK. | 08/29/2015 |
| WISP2 has a role in regulating tumor cell susceptibility through EMT by inducing the TGF-beta signaling pathway, KLF-4 expression and miR-7 inhibition. | Targeting WNT1-inducible signaling pathway protein 2 alters human breast cancer cell susceptibility to specific lysis through regulation of KLF-4 and miR-7 expression.
Akalay I, Tan TZ, Kumar P, Janji B, Mami-Chouaib F, Charpy C, Vielh P, Larsen AK, Thiery JP, Sabbah M, Chouaib S. | 07/4/2015 |
| The obtained results indicate that the changes in gene expression in bone marrow progenitor cells can be involved into space flight-induced osteopenia. | [The effects of simulated microgravity on the pattern of gene expression in human bone marrow mesenchymal stem cells under osteogenic differentiation].
Gershovich PM, Gershovich IuG, Buravkova LB. | 01/3/2015 |
| overexpression of FGFBP1 or loss of WISP-2 expression is closely related to the metastasis, invasion and poor prognosis of gallbladder cancer. | A comparative study of clinicopathological significance, FGFBP1, and WISP-2 expression between squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder.
Yang Z, Yang Z, Zou Q, Yuan Y, Li J, Li D, Liang L, Zeng G, Chen S. | 12/20/2014 |