| Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling. | Cholesterol-dependent dynamic changes in the conformation of the type 1 cholecystokinin receptor affect ligand binding and G protein coupling.
Harikumar KG, Zhao P, Cary BP, Xu X, Desai AJ, Dong M, Mobbs JI, Toufaily C, Furness SGB, Christopoulos A, Belousoff MJ, Wootten D, Sexton PM, Miller LJ., Free PMC Article | 08/1/2024 |
| Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. | Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity.
Mobbs JI, Belousoff MJ, Harikumar KG, Piper SJ, Xu X, Furness SGB, Venugopal H, Christopoulos A, Danev R, Wootten D, Thal DM, Miller LJ, Sexton PM., Free PMC Article | 10/2/2021 |
| Photodynamic Activation of Cholecystokinin 1 Receptor with Different Genetically Encoded Protein Photosensitizers and from Varied Subcellular Sites. | Photodynamic Activation of Cholecystokinin 1 Receptor with Different Genetically Encoded Protein Photosensitizers and from Varied Subcellular Sites.
Li Y, Cui ZJ., Free PMC Article | 09/11/2021 |
| CCK1R may play a role differing from CCK2R in colon carcinogenesis, nuclear CCK1R represents a potential biomarker for poor prognosis. | Expression of cholecystokinin receptors in colon cancer and the clinical correlation in Taiwan.
Huang BP, Lin CH, Chen YC, Kao SH. | 02/18/2017 |
| Study shows downregulation of CCKAR gene expression in A1/A1 genotype of gallstone disease patients as compared with control with significant variation in its expression pattern in relation to polymorphism. | Polymorphism and Expression Profile of Cholecystokinin Type A Receptor in Relation to Gallstone Disease Susceptibility.
Kazmi HR, Chandra A, Nigam J, Baghel K, Srivastava M, Maurya SS, Parmar D. | 01/28/2017 |
| Our study showed significantly higher expression of CCKAR and down regulation of CCKBR in pancreatic cancer as compared to control while CCKBR/GR was detected in majority of stomach cancer samples. Thus, our study suggests that CCK and Gs receptors may have diagnostic and therapeutic implications. | Heterogeneous expression of cholecystokinin and gastrin receptor in stomach and pancreatic cancer: An immunohistochemical study.
Rai R, Kim JJ, Tewari M, Shukla HS. | 12/24/2016 |
| The neurotransmitter cholecystokinin (CCK), along with its receptors, CCKAR and CCKBR, have been previously associated with psychiatric disorders, suggesting that variants near these genes may play a role in the pre-pulse/startle response in this cohort | Variants Near CCK Receptors are Associated With Electrophysiological Responses to Pre-pulse Startle Stimuli in a Mexican American Cohort.
Norden-Krichmar TM, Gizer IR, Phillips E, Wilhelmsen KC, Schork NJ, Ehlers CL., Free PMC Article | 10/22/2016 |
| CCK-AR polymorphism is protective against functional dyspepsia. | Functional dyspepsia is associated with GNβ3 C825T and CCK-AR T/C polymorphism.
Singh R, Mittal B, Ghoshal UC. | 10/1/2016 |
| There is functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development. | Functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development.
Nishimura S, Bilgüvar K, Ishigame K, Sestan N, Günel M, Louvi A., Free PMC Article | 01/16/2016 |
| CCK binding modulates the contractile function of the lower esophageal sphincter through differential binding to the CCK-A receptor on the sling and clasp fibers | Investigation of cholecystokinin receptors in the human lower esophageal sphincter.
Liu JF, Zhang J, Liu XB, Drew PA., Free PMC Article | 04/18/2015 |
| Age related differential expression of CCKAR in GBC may suggest two possible variants of the disease in this endemic belt. | Differential expression of cholecystokinin A receptor in gallbladder cancer in the young and elderly suggests two subsets of the same disease?
Kazmi HR, Chandra A, Baghel K, Singh A, Nigam J, Parmar D, Mahdi AA, Goel SK, Kumar S., Free PMC Article | 03/21/2015 |
| Y140A mutation within a cholesterol-binding motif results in ligand binding and activity characteristics similar to wild type CCK1R. in a high cholesterol environment | A type 1 cholecystokinin receptor mutant that mimics the dysfunction observed for wild type receptor in a high cholesterol environment.
Desai AJ, Harikumar KG, Miller LJ., Free PMC Article | 10/18/2014 |
| The findings suggest that variants in the CCKAR gene may influence the risk of gallbladder cancer in women. | Variants in CCK and CCKAR genes to susceptibility to biliary tract cancers and stones: a population-based study in Shanghai, China.
Xu HL, Hsing AW, Vogtmann E, Chu LW, Cheng JR, Gao J, Tan YT, Wang BS, Shen MC, Gao YT., Free PMC Article | 04/26/2014 |
| A significant association of the cholecystokinin-A receptor (CCKAR) gene variation rs1800857 and language lateralization, is reported. | Cholecystokinin A receptor (CCKAR) gene variation is associated with language lateralization.
Ocklenburg S, Arning L, Gerding WM, Epplen JT, Güntürkün O, Beste C., Free PMC Article | 07/13/2013 |
| The results showed that three individual haplotypes of CCKAR were strongly associated with increased risk of schizophrenia. | Investigation of allelic heterogeneity of the CCK-A receptor gene in paranoid schizophrenia.
Zheng C, Fu Q, Shen Y, Xu Q. | 04/13/2013 |
| Data suggest that CCK-1R expression is up-regulated in kidney tubules (but not in glomeruli) in patients with diabetic nephropathy; increased expression of CCK-1R in tubules appears to be biomarker of severity of proteinuria in these patients. | Expression of cholecystokinin-1 receptor is correlated with proteinuria in human diabetic nephropathy.
Wang M, Xie R, Liu R, Jia X, Bao Y, Liu X. | 04/6/2013 |
| data may suggest that the TM3 CRAC cholesterol-binding motif could be responsible for the cholesterol sensitivity of the CCK1R. | Differential sensitivity of types 1 and 2 cholecystokinin receptors to membrane cholesterol.
Potter RM, Harikumar KG, Wu SV, Miller LJ., Free PMC Article | 04/14/2012 |
| CCKAR expression was significantly increased in gallbladder cancer compared to gallstone disease. | Expression profile of cholecystokinin type-A receptor in gallbladder cancer and gallstone disease.
Rai R, Tewari M, Kumar M, Singh TB, Shukla HS. | 12/10/2011 |
| Data indicate that the Homo-Phe derivative 2 (VL-0797) enhanced 12-fold the affinity for the rat CCK(1)-R affinity and 15-fold for the human CCK(1)-R relative to the reference compound 12 (VL-0395). | New anthranilic acid based antagonists with high affinity and selectivity for the human cholecystokinin receptor 1 (hCCK1-R).
Pavan MV, Lassiani L, Berti F, Stefancich G, Ciogli A, Gasparrini F, Mennuni L, Ferrari F, Escrieut C, Marco E, Makovec F, Fourmy D, Varnavas A. | 12/10/2011 |
| An association is not found between cholecystokinin A receptor polymorphisms and antipsychotic induced weight gain in schizophrenia patients. | Association study of polymorphisms in cholecystokinin gene and its receptors with antipsychotic induced weight gain in schizophrenia patients.
Tiwari AK, Rodgers JB, Sicard M, Zai CC, Likhodi O, Freeman N, Meltzer HY, Lieberman JA, Kennedy JL, Müller DJ. | 11/19/2011 |
| LPS can up-regulate the expression of CCK-AR and CCK-BR mRNA in vascular endothelial cells. | [The expression of cholecystokinin-octapeptide receptor in vascular endothelial cells induced by lipopolysaccharide].
Ping J, Gu ZY, Gao F, Cong B, Ling YL. | 11/6/2010 |
| Impaired muscle contraction in gallbladders with cholesterol stones is due to high caveolar levels of cholesterol that inhibits CAV-3 generation; cholesterol increases the caveolar sequestration of CAV-3 and CCK-1R. | Effects of cholesterol on CCK-1 receptors and caveolin-3 proteins recycling in human gallbladder muscle.
Cong P, Pricolo V, Biancani P, Behar J., Free PMC Article | 09/27/2010 |
| a 2-marker haplotype (rs1800855/rs1800857) in the CCKAR gene protected women against PD (P=0.004). In addition, we found two novel rare missense variations in the CCKBR gene (Lys329Asn and Pro446Leu) in two and one patient, respectively | Gene variations in the cholecystokinin system in patients with panic disorder.
Koefoed P, Woldbye DP, Hansen TO, Hansen ES, Knudsen GM, Bolwig TG, Rehfeld JF. | 08/23/2010 |
| an intron 1 polymorphism in the cholecystokinin A receptor gene is associated with schizophrenia in males | An intron 1 polymorphism in the cholecystokinin-A receptor gene associated with schizophrenia in males.
Koefoed P, Hansen TV, Woldbye DP, Werge T, Mors O, Hansen T, Jakobsen KD, Nordentoft M, Wang A, Bolwig TG, Rehfeld JF. | 02/15/2010 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database.
Allen NC, Bagade S, McQueen MB, Ioannidis JP, Kavvoura FK, Khoury MJ, Tanzi RE, Bertram L. | 12/2/2009 |