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    PER2 period circadian regulator 2 [ Homo sapiens (human) ]

    Gene ID: 8864, updated on 19-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Variants in the circadian clock genes PER2 and PER3 associate with familial sleep phase disorders.

    Variants in the circadian clock genes PER2 and PER3 associate with familial sleep phase disorders.
    Plavc L, Skubic C, Dolenc Grošelj L, Rozman D.

    08/30/2024
    Hierarchical and scaffolded phosphorylation of two degrons controls PER2 stability.

    Hierarchical and scaffolded phosphorylation of two degrons controls PER2 stability.
    Francisco JC, Virshup DM., Free PMC Article

    07/17/2024
    Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells.

    Phosphorylation of DNA-binding domains of CLOCK-BMAL1 complex for PER-dependent inhibition in circadian clock of mammalian cells.
    Otobe Y, Jeong EM, Ito S, Shinohara Y, Kurabayashi N, Aiba A, Fukada Y, Kim JK, Yoshitane H., Free PMC Article

    06/12/2024
    Transcription Repression of CRY2 via PER2 Interaction Promotes Adipogenesis.

    Transcription Repression of CRY2 via PER2 Interaction Promotes Adipogenesis.
    Li W, Xiong X, Kiperman T, Ma K., Free PMC Article

    02/15/2024
    Importance of Per2 in cardiac mitochondrial protection during stress.

    Importance of Per2 in cardiac mitochondrial protection during stress.
    Bhaskara M, Anjorin O, Yoniles A, Liu J, Wang M., Free PMC Article

    01/17/2024
    PER2 gene and its association with sleep-related disorders: A review.

    PER2 gene and its association with sleep-related disorders: A review.
    Pavithra S, Aich A, Chanda A, Zohra IF, Gawade P, Das RK.

    01/5/2024
    PER2 binding to HSP90 enhances immune response against oral squamous cell carcinoma by inhibiting IKK/NF-kappaB pathway and PD-L1 expression.

    PER2 binding to HSP90 enhances immune response against oral squamous cell carcinoma by inhibiting IKK/NF-κB pathway and PD-L1 expression.
    Zhang Z, Sun D, Tang H, Ren J, Yin S, Yang K., Free PMC Article

    11/7/2023
    A Three-Way Interaction of Sex, PER2 rs56013859 Polymorphism, and Family Maltreatment in Depressive Symptoms in Adolescents.

    A Three-Way Interaction of Sex, PER2 rs56013859 Polymorphism, and Family Maltreatment in Depressive Symptoms in Adolescents.
    Torres Soler C, Kanders SH, Rehn M, Olofsdotter S, Åslund C, Nilsson KW., Free PMC Article

    10/6/2023
    PER2 Promotes Odontoblastic/Osteogenic Differentiation of Dental Pulp Stem Cells by Modulating Mitochondrial Metabolism.

    PER2 Promotes Odontoblastic/Osteogenic Differentiation of Dental Pulp Stem Cells by Modulating Mitochondrial Metabolism.
    Huang W, Huang Q, He H, Huang F., Free PMC Article

    09/11/2023
    Insights into structure and activity relationship of clinically mutated PER1 and PER2 class A beta-lactamase enzymes.

    Insights into structure and activity relationship of clinically mutated PER1 and PER2 class A β-lactamase enzymes.
    Agarwal V, Yadav TC, Tiwari A, Varadwaj PK.

    06/15/2023
    PER2 integrates circadian disruption and pituitary tumorigenesis.

    PER2 integrates circadian disruption and pituitary tumorigenesis.
    Guo L, Cen H, Weng J, He Y, Guo X, He D, Liu K, Duan S, Yang J, Zhang X, Qin Z, Wan Y, Chen Z, Wu B., Free PMC Article

    05/30/2023
    Relationship between APOE, PER2, PER3 and OX2R Genetic Variants and Neuropsychiatric Symptoms in Patients with Alzheimer's Disease.

    Relationship between APOE, PER2, PER3 and OX2R Genetic Variants and Neuropsychiatric Symptoms in Patients with Alzheimer's Disease.
    Lozano-Tovar S, Rodríguez-Agudelo Y, Dávila-Ortiz de Montellano DJ, Pérez-Aldana BE, Ortega-Vázquez A, Monroy-Jaramillo N., Free PMC Article

    03/15/2023
    Transcription Factor EGR1 Regulates the Expression of the Clock Gene PER2 under IL-4 Stimulation in Human Keratinocytes.

    Transcription Factor EGR1 Regulates the Expression of the Clock Gene PER2 under IL-4 Stimulation in Human Keratinocytes.
    Yeo H, Ahn SS, Jung E, Lim Y, Lee YH, Shin SY.

    10/15/2022
    Per2 Expression Regulates the Spatial Working Memory of Mice through DRD1-PKA-CREB Signaling.

    Per2 Expression Regulates the Spatial Working Memory of Mice through DRD1-PKA-CREB Signaling.
    Kim M, Custodio RJ, Lee HJ, Sayson LV, Ortiz DM, Kim BN, Kim HJ, Cheong JH.

    06/11/2022
    Circadian Period 2 (Per2) downregulate inhibitor of differentiation 3 (Id3) expression via PTEN/AKT/Smad5 axis to inhibits glioma cell proliferation.

    Circadian Period 2 (Per2) downregulate inhibitor of differentiation 3 (Id3) expression via PTEN/AKT/Smad5 axis to inhibits glioma cell proliferation.
    Zhang Y, Hu X, Li H, Yao J, Yang P, Lan Y, Xia H., Free PMC Article

    05/28/2022
    IL-1beta induces changes in expression of core circadian clock components PER2 and BMAL1 in primary human chondrocytes through the NMDA receptor/CREB and NF-kappaB signalling pathways.

    IL-1β induces changes in expression of core circadian clock components PER2 and BMAL1 in primary human chondrocytes through the NMDA receptor/CREB and NF-κB signalling pathways.
    Alhilali M, Hearn JI, Rong J, Jain L, Bolam SM, Monk AP, Munro JT, Dalbeth N, Poulsen RC.

    04/9/2022
    PER2: a potential molecular marker for hematological malignancies.

    PER2: a potential molecular marker for hematological malignancies.
    Jiang H, Yang X, Mi M, Wei X, Wu H, Xin Y, Sun C.

    02/26/2022
    Period circadian regulator 2 suppresses drug resistance to cisplatin by PI3K/AKT pathway and improves chronochemotherapeutic efficacy in cervical cancer.

    Period circadian regulator 2 suppresses drug resistance to cisplatin by PI3K/AKT pathway and improves chronochemotherapeutic efficacy in cervical cancer.
    Wang Z, Li F, He S, Zhao L, Wang F.

    12/11/2021
    Expression of HO1 and PER2 can predict the incidence of delirium in trauma patients with concomitant brain injury.

    Expression of HO1 and PER2 can predict the incidence of delirium in trauma patients with concomitant brain injury.
    Steimer M, Kaiser S, Ulbrich F, Kalbhenn J, Bürkle H, Schallner N., Free PMC Article

    11/6/2021
    Dopamine adjusts the circadian gene expression of Per2 and Per3 in human dermal fibroblasts from ADHD patients.

    Dopamine adjusts the circadian gene expression of Per2 and Per3 in human dermal fibroblasts from ADHD patients.
    Faltraco F, Palm D, Uzoni A, Borchert L, Simon F, Tucha O, Thome J., Free PMC Article

    10/23/2021
    Association of PER2 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus.

    Association of PER2 gene single nucleotide polymorphisms with genetic susceptibility to systemic lupus erythematosus.
    Dan YL, Zhao CN, Mao YM, Wu Q, He YS, Hu YQ, Xiang K, Yang XK, Sam NB, Wu GC, Pan HF.

    10/9/2021
    Targeting circadian PER2 as therapy in myocardial ischemia and reperfusion injury.

    Targeting circadian PER2 as therapy in myocardial ischemia and reperfusion injury.
    Oyama Y, Walker LA, Eckle T., Free PMC Article

    10/2/2021
    PER2 C111G polymorphism, cognitive reserve and cognition in subjective cognitive decline and mild cognitive impairment: a 10-year follow-up study.

    PER2 C111G polymorphism, cognitive reserve and cognition in subjective cognitive decline and mild cognitive impairment: a 10-year follow-up study.
    Bessi V, Giacomucci G, Mazzeo S, Bagnoli S, Padiglioni S, Balestrini J, Tomaiuolo G, Piaceri I, Carraro M, Bracco L, Sorbi S, Nacmias B.

    08/21/2021
    Comparing expression levels of PERIOD genes PER1, PER2 and PER3 in chronic insomnia patients and medical staff working in the night shift.

    Comparing expression levels of PERIOD genes PER1, PER2 and PER3 in chronic insomnia patients and medical staff working in the night shift.
    Emeklİ R, İsmaİloğullari S, Bayram A, Akalin H, Tuncel G, Dündar M.

    08/14/2021
    For whom the circadian clock ticks? Investigation of PERIOD and CLOCK gene variants in bipolar disorder.

    For whom the circadian clock ticks? Investigation of PERIOD and CLOCK gene variants in bipolar disorder.
    Yegin Z, Sarisoy G, Erguner Aral A, Koc H.

    08/7/2021
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