| Single-cell transcriptomics reveals the intra-tumoral heterogeneity and SQSTM1/P62 and Wnt/beta-catenin mediated epithelial to mesenchymal transition and stemness of triple-negative breast cancer. | Single-cell transcriptomics reveals the intra-tumoral heterogeneity and SQSTM1/P62 and Wnt/β-catenin mediated epithelial to mesenchymal transition and stemness of triple-negative breast cancer.
Shome R, Sen P, Sarkar S, Ghosh SS. | 05/29/2024 |
| Dual-specificity kinase DYRK3 phosphorylates p62 at the Thr-269 residue and promotes melanoma progression. | Dual-specificity kinase DYRK3 phosphorylates p62 at the Thr-269 residue and promotes melanoma progression.
Lee YH, Yoon AR, Yun CO, Chung KC., Free PMC Article | 05/13/2024 |
| Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62. | Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62.
Krause M, Samolej J, Yakimovich A, Kriston-Vizi J, Huttunen M, Lara-Reyna S, Frickel EM, Mercer J., Free PMC Article | 05/9/2024 |
| circRNA_SLC8A1 promotes the survival of mycobacterium tuberculosis in macrophages by upregulating expression of autophagy-related protein SQSTM1/p62 to activate the NF-kappaB pathway. | circRNA_SLC8A1 promotes the survival of mycobacterium tuberculosis in macrophages by upregulating expression of autophagy-related protein SQSTM1/p62 to activate the NF-κB pathway.
Li Z, Gao Y, Zhang B, Dong W, Xi Y, Li Y, Cui J., Free PMC Article | 03/5/2024 |
| Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction. | Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction.
Feng J, Li Y, Zhang Y, Sun S, Sun J, Xu Q, Ji X, Liu Y, Wan Q., Free PMC Article | 03/1/2024 |
| Nuclear-cytoplasmic translocation of SQSTM1/p62 protein enhances ESCC cell migration and invasion by stabilizing EPLIN expression. | Nuclear-cytoplasmic translocation of SQSTM1/p62 protein enhances ESCC cell migration and invasion by stabilizing EPLIN expression.
Liu Z, Yang LY, Hao JJ, Zhang N, Fan ZL, Cai HQ, Cai Y, Wei WQ, Zhang Y, Wang MR. | 02/4/2024 |
| SQSTM1/p62 inhibition impairs pro-survival signaling in hypoxic human dendritic cells. | SQSTM1/p62 inhibition impairs pro-survival signaling in hypoxic human dendritic cells.
Coppola F, Monaci S, Falsini A, Aldinucci C, Filippi I, Rossi D, Carraro F, Naldini A. | 01/17/2024 |
| Distal myopathy due to digenic inheritance of TIA1 and SQSTM1 variants in two unrelated Spanish patients. | Distal myopathy due to digenic inheritance of TIA1 and SQSTM1 variants in two unrelated Spanish patients.
Bermejo-Guerrero L, de Fuenmayor Fernández-de la Hoz CP, González-Quereda L, Segarra-Casas A, Nedkova V, Gallano P, Martín-Jiménez P, Hernández-Laín A, Olivé M, Arteche-López A, Domínguez-González C. | 12/21/2023 |
| TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2. | TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.
Yu T, Yang X, Fu Q, Liang J, Wu X, Sheng J, Chen Y, Xiao L, Wu Y, Nie D, You X, Mai H, Chen K, Hu S. | 12/5/2023 |
| Cancer-associated fibroblasts-derived CXCL12 enhances immune escape of bladder cancer through inhibiting P62-mediated autophagic degradation of PDL1. | Cancer-associated fibroblasts-derived CXCL12 enhances immune escape of bladder cancer through inhibiting P62-mediated autophagic degradation of PDL1.
Zhang Z, Yu Y, Zhang Z, Li D, Liang Z, Wang L, Chen Y, Liang Y, Niu H., Free PMC Article | 12/1/2023 |
| The role of p62 in cell death and survival of 5-fluorouracil and oxaliplatin-resistant colorectal cancer cells. | The role of p62 in cell death and survival of 5-fluorouracil and oxaliplatin-resistant colorectal cancer cells.
Zitkute V, Jasinevicius A, Vaitiekaite G, Kukcinaviciute E, Aleksandraviciute B, Eidenaite E, Sudeikis L, Jonusiene V, Sasnauskiene A. | 11/25/2023 |
| USP13 deubiquitinates p62/SQSTM1 to induce autophagy and Nrf2 release for activating antioxidant response genes. | USP13 deubiquitinates p62/SQSTM1 to induce autophagy and Nrf2 release for activating antioxidant response genes.
Lee B, Kim YH, Lee W, Choi HY, Lee J, Kim J, Mai DN, Jung SF, Kwak MS, Shin JS. | 11/6/2023 |
| The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy. | The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy.
Gallagher ER, Holzbaur ELF., Free PMC Article | 10/4/2023 |
| SQSTM1/p62 and Hepatic Mallory-Denk Body Formation in Alcohol-Associated Liver Disease. | SQSTM1/p62 and Hepatic Mallory-Denk Body Formation in Alcohol-Associated Liver Disease.
Qian H, Ding WX., Free PMC Article | 09/20/2023 |
| The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis. | The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis.
Hatanaka A, Nakada S, Matsumoto G, Satoh K, Aketa I, Watanabe A, Hirakawa T, Tsujita T, Waku T, Kobayashi A., Free PMC Article | 09/7/2023 |
| The sequestosome 1 protein: therapeutic vulnerabilities in ovarian cancer. | The sequestosome 1 protein: therapeutic vulnerabilities in ovarian cancer.
Nurzadeh M, Ghalandarpoor-Attar SM, Ghalandarpoor-Attar SN, Rabiei M. | 08/30/2023 |
| SQSTM1 is a therapeutic target for infection and sterile inflammation. | SQSTM1 is a therapeutic target for infection and sterile inflammation.
Tang D, Kang R. | 08/11/2023 |
| TFAM knockdown undermines SQSTM1 mRNA stability but retards autophagy flux and inhibits tumor cells proliferation under starvation conditions. | TFAM knockdown undermines SQSTM1 mRNA stability but retards autophagy flux and inhibits tumor cells proliferation under starvation conditions.
Jiang X, Xu Y, Yang J, Wang J, Gao L, Yu L. | 07/17/2023 |
| Impairment of autophagy promotes human conjunctival fibrosis and pterygium occurrence via enhancing the SQSTM1-NF-kappaB signaling pathway. | Impairment of autophagy promotes human conjunctival fibrosis and pterygium occurrence via enhancing the SQSTM1-NF-κB signaling pathway.
He Q, Cai Y, Huang J, He X, Han W, Chen W., Free PMC Article | 07/7/2023 |
| The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection. | The versatile defender: exploring the multifaceted role of p62 in intracellular bacterial infection.
Zhou Y, Hua S, Song L., Free PMC Article | 05/30/2023 |
| SQSTM1/p62 Knockout by Using the CRISPR/Cas9 System Inhibits Migration and Invasion of Hepatocellular Carcinoma. | SQSTM1/p62 Knockout by Using the CRISPR/Cas9 System Inhibits Migration and Invasion of Hepatocellular Carcinoma.
Lu J, Ding Y, Zhang W, Qi Y, Zhou J, Xu N, Zhang Y, Xie W., Free PMC Article | 05/24/2023 |
| Spitz Tumor With SQSTM1::NTRK2 Fusion: A Clinicopathological Study of 5 Cases. | Spitz Tumor With SQSTM1::NTRK2 Fusion: A Clinicopathological Study of 5 Cases.
Mansour B, Vanecek T, Kastnerova L, Nosek D, Kazakov DV, Donati M. | 04/20/2023 |
| MicroRNA-183-5p regulates TAR DNA-binding protein 43 neurotoxicity via SQSTM1/p62 in amyotrophic lateral sclerosis. | MicroRNA-183-5p regulates TAR DNA-binding protein 43 neurotoxicity via SQSTM1/p62 in amyotrophic lateral sclerosis.
Kim HC, Zhang Y, King PH, Lu L. | 03/20/2023 |
| p62/SQSTM1 in liver diseases: the usual suspect with multifarious identities. | p62/SQSTM1 in liver diseases: the usual suspect with multifarious identities.
Tan CT, Soh NJH, Chang HC, Yu VC. | 02/17/2023 |
| Analysis of microRNA expression profiles in exosomes derived from acute myeloid leukemia by p62 knockdown and effect on angiogenesis. | Analysis of microRNA expression profiles in exosomes derived from acute myeloid leukemia by p62 knockdown and effect on angiogenesis.
Li C, Long X, Liang P, Liu Z, Wang C, Hu R., Free PMC Article | 01/28/2023 |