| Kernel machine SNP set analysis finds the association of BUD13, ZPR1, and APOA5 variants with metabolic syndrome in Tehran Cardio-metabolic Genetics Study. | Kernel machine SNP set analysis finds the association of BUD13, ZPR1, and APOA5 variants with metabolic syndrome in Tehran Cardio-metabolic Genetics Study.
Masjoudi S, Sedaghati-Khayat B, Givi NJ, Bonab LNH, Azizi F, Daneshpour MS., Free PMC Article | 11/13/2021 |
| The ZPR1 genotype predicts myocardial infarction in patients with familial hypercholesterolemia. | The ZPR1 genotype predicts myocardial infarction in patients with familial hypercholesterolemia.
Paquette M, Fantino M, Bernard S, Baass A. | 09/18/2021 |
| Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD Severity in Patients with Hypertriglyceridemia. | Implication between Genetic Variants from APOA5 and ZPR1 and NAFLD Severity in Patients with Hypertriglyceridemia.
Esteve-Luque V, Padró-Miquel A, Fanlo-Maresma M, Corbella E, Corbella X, Pintó X, Candás-Estébanez B., Free PMC Article | 05/8/2021 |
| ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy. | ZPR1 prevents R-loop accumulation, upregulates SMN2 expression and rescues spinal muscular atrophy.
Kannan A, Jiang X, He L, Ahmad S, Gangwani L., Free PMC Article | 08/22/2020 |
| provide genetic and molecular evidence that a homozygous missense mutation in ZPR1 is associated with a rare and recognizable multisystem syndrome | A ZPR1 mutation is associated with a novel syndrome of growth restriction, distinct craniofacial features, alopecia, and hypoplastic kidneys.
Ito YA, Smith AC, Kernohan KD, Pena IA, Ahmed A, McDonell LM, Beaulieu C, Bulman DE, Smidt A, Sawyer SL, Care4Rare Canada Consortium, Dyment DA, Boycott KM, Clericuzio CL. | 11/2/2019 |
| Identification of a relationship between a genetic variant in CETP and ZNF259 gene with coronary artery disease (CAD) and CAD and lipid profile, respectively. Further investigation in a larger population may help to investigate the value of emerging marker as a risk stratification marker in CAD and its risk factors. | There is an association between a genetic polymorphism in the ZNF259 gene involved in lipid metabolism and coronary artery disease.
Mirhafez SR, Avan A, Khatamianfar S, Ghasemi F, Moohebati M, Ebrahimi M, Ghazizadeh H, Ghayour-Mobarhan M, Pasdar A. | 06/22/2019 |
| Results suggest that ZPR1 plays an important role in the etiology of type 2 diabetes mellitus, and this gene might be involved in abnormal glucose metabolism. | Two-stage association study to identify the genetic susceptibility of a novel common variant of rs2075290 in ZPR1 to type 2 diabetes.
Guan F, Niu Y, Zhang T, Liu S, Ma L, Qi T, Feng J, Zuo H, Li G, Liu X, Wang S., Free PMC Article | 07/21/2018 |
| When the inter-dependence between alleles was examined using conditional models, five loci on BUD13, ZNF259, and ApoA5 showed possible independent associations. | Multiple susceptibility loci at chromosome 11q23.3 are associated with plasma triglyceride in East Asians.
Gombojav B, Lee SJ, Kho M, Song YM, Lee K, Sung J., Free PMC Article | 10/29/2016 |
| Single nucleotide polymorphisms (Rs964184, rs3317316, rs6589566) of ZNF259 protein did not increase the risk of CHD in the Chinese population. | Effects of Polymorphisms in APOA4-APOA5-ZNF259-BUD13 Gene Cluster on Plasma Levels of Triglycerides and Risk of Coronary Heart Disease in a Chinese Han Population.
Fu Q, Tang X, Chen J, Su L, Zhang M, Wang L, Jing J, Zhou L., Free PMC Article | 06/28/2016 |
| ZNF259 variants were associated with elevated Metabolic Syndrome risk in a Han Chinese population from the Jilin province of Northeastern China | Zinc Finger Protein 259 (ZNF259) Polymorphisms are Associated with the Risk of Metabolic Syndrome in a Han Chinese Population.
Wu Y, Yu S, Wang S, Shi J, Xu Z, Zhang Q, Fu Y, Qi Y, Liu J, Fu R, Kou C, Yaqin Y. | 10/3/2015 |
| Single nucleotide polymorphism zinc finger protein 259 gene is associated with hyperlipidaemia. | Association of the variants in the BUD13-ZNF259 genes and the risk of hyperlipidaemia.
Aung LH, Yin RX, Wu DF, Wang W, Liu CW, Pan SL., Free PMC Article | 04/18/2015 |
| Significant linkage disequilibria were noted among ZNF259, BUD13 and MLXIPL SNPs and serum lipid levels. | Association between the MLX interacting protein-like, BUD13 homolog and zinc finger protein 259 gene polymorphisms and serum lipid levels.
Aung LH, Yin RX, Wu JZ, Wu DF, Wang W, Li H., Free PMC Article | 02/28/2015 |
| These findings suggest that the association between ZNF259 rs2075290 SNP and serum lipid levels might have ethnic- and/or sex-specificity. | Sex-specific association of the zinc finger protein 259 rs2075290 polymorphism and serum lipid levels.
Aung LH, Yin RX, Wu DF, Wang W, Wu JZ, Liu CW., Free PMC Article | 11/22/2014 |
| Novel APOA5-ZNF259 haplotype manifesting sex-dependent effects on elevation of the TG:HDL-C ratio as well as the increased risk for metabolic syndrome. | Effects of apolipoprotein A5 haplotypes on the ratio of triglyceride to high-density lipoprotein cholesterol and the risk for metabolic syndrome in Koreans.
Cha S, Yu H, Park AY, Song KH., Free PMC Article | 08/30/2014 |
| genetic polymorphism at the loci is associated with Factor VII and fibrinogen levels, and with plasma viscosity | Gene-centric association signals for haemostasis and thrombosis traits identified with the HumanCVD BeadChip.
Gaunt TR, Zabaneh D, Shah S, Guyatt A, Ladroue C, Kumari M, Drenos F, Shah T, Talmud PJ, Casas JP, Lowe G, Rumley A, Lawlor DA, Kivimaki M, Whittaker J, Hingorani AD, Humphries SE, Day IN., Free PMC Article | 07/19/2014 |
| Significant associations of two SNPs (rs964184 and rs12286037) from ZNF259 with triglyceride levels in an Asian Indian cohort. | A replication study of GWAS-derived lipid genes in Asian Indians: the chromosomal region 11q23.3 harbors loci contributing to triglycerides.
Braun TR, Been LF, Singhal A, Worsham J, Ralhan S, Wander GS, Chambers JC, Kooner JS, Aston CE, Sanghera DK., Free PMC Article | 09/22/2012 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease.
Anderson JL, Horne BD, Camp NJ, Muhlestein JB, Hopkins PN, Cannon-Albright LA, Mower CP, Park JJ, Clarke JL, Nicholas ZP, McKinney JT, Carlquist JF., Free PMC Article | 12/5/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association study of Lp-PLA(2) activity and mass in the Framingham Heart Study.
Suchindran S, Rivedal D, Guyton JR, Milledge T, Gao X, Benjamin A, Rowell J, Ginsburg GS, McCarthy JJ., Free PMC Article | 06/30/2010 |
| ZPR1 deficiency causes disruption of survival motor neurons and histone gene-specific transcription factor NPAT localization within the nucleus, blocks S phase progression, and arrests cells in both the G1 and G2 phases of the cell cycle. | Deficiency of the zinc finger protein ZPR1 causes defects in transcription and cell cycle progression.
Gangwani L. | 01/21/2010 |