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    CPNE3 copine 3 [ Homo sapiens (human) ]

    Gene ID: 8895, updated on 5-May-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    YAP1-CPNE3 positive feedback pathway promotes gastric cancer cell progression.

    YAP1-CPNE3 positive feedback pathway promotes gastric cancer cell progression.
    Li X, Zhong H, Shi Q, Ruan R, Huang C, Wen Q, Zeng S, Xia Y, Zeng Q, Xiong J, Wang S, Chen J, Lei W, Deng J., Free PMC Article

    03/19/2024
    [High expression of CPNE3 correlates with poor long-term prognosis of gastric cancer by inhibiting cell apoptosis via activating PI3K/AKT signaling].

    [High expression of CPNE3 correlates with poor long-term prognosis of gastric cancer by inhibiting cell apoptosis via activating PI3K/AKT signaling].
    Duan T, Zhang Z, Shi J, Xiao L, Yang J, Yin L, Zhang X, Geng Z, Lu G., Free PMC Article

    02/8/2024
    Upregulation of CPNE3 suppresses invasion, migration and proliferation of glioblastoma cells through FAK pathway inactivation.

    Upregulation of CPNE3 suppresses invasion, migration and proliferation of glioblastoma cells through FAK pathway inactivation.
    Shi D, Lin B, Lai J, Li K, Feng Y.

    11/27/2021
    CPNE3 moderates the association between anxiety and working memory.

    CPNE3 moderates the association between anxiety and working memory.
    Chen C, Wang Z, Chen C, Xue G, Lu S, Liu H, Dong Q, Zhang M., Free PMC Article

    10/23/2021
    Patients who have low CPNE3 expression in peripheral blood are more likely to suffer from AMI than those with stable CAD. Low expression of CPNE3 gene serves as an potential independent risk factor of AMI.

    Low CPNE3 expression is associated with risk of acute myocardial infarction: A feasible genetic marker of acute myocardial infarction in patients with stable coronary artery disease.
    Tan B, Liu L, Yang Y, Liu Q, Yang L, Meng F., Free PMC Article

    03/14/2020
    Exosomal CPNE3 levels are associated with the tumor extent and may serve as a diagnostic biomarker in colorectal cancer patients.

    Circulating exosomal CPNE3 as a diagnostic and prognostic biomarker for colorectal cancer.
    Sun B, Li Y, Zhou Y, Ng TK, Zhao C, Gan Q, Gu X, Xiang J.

    12/7/2019
    upregulation of EMP1 significantly increases cancer cell migration that leads to tumor metastasis

    Epithelial membrane protein 1 promotes tumor metastasis by enhancing cell migration via copine-III and Rac1.
    Ahmat Amin MKB, Shimizu A, Zankov DP, Sato A, Kurita S, Ito M, Maeda T, Yoshida T, Sakaue T, Higashiyama S, Kawauchi A, Ogita H., Free PMC Article

    02/23/2019
    CPNE3(high) is an adverse prognostic biomarker for acute myeloid leukemia.

    High expression of CPNE3 predicts adverse prognosis in acute myeloid leukemia.
    Fu L, Fu H, Qiao J, Pang Y, Xu K, Zhou L, Wu Q, Li Z, Ke X, Xu K, Shi J., Free PMC Article

    10/21/2017
    Copine3 binding to ErbB2 increases when Jab1 is overexpressed in SKBr3 breast cancer cells. Copine3 and Jab1 binding regulates the ErbB2 signaling pathway.

    Direct binding of Copine3 with Jab1 activates downstream ErbB2 signaling and motility in SKBr3 breast cancer cells.
    Choi HY, Park N, Na JB, Ko ES, Park JY, Yoo JC.

    10/22/2016
    our results indicate that CPNE3 could play a critical role in NSCLC metastasis.

    Quantitative proteomic analysis identifies CPNE3 as a novel metastasis-promoting gene in NSCLC.
    Lin HC, Zhang FL, Geng Q, Yu T, Cui YQ, Liu XH, Li J, Yan MX, Liu L, He XH, Li JJ, Yao M.

    02/22/2014
    This study demonistrated that dysregulation of cpne3 3'UTR in brain of patient with schizophrenia.

    Transcriptomic analysis of postmortem brain identifies dysregulated splicing events in novel candidate genes for schizophrenia.
    Cohen OS, Mccoy SY, Middleton FA, Bialosuknia S, Zhang-James Y, Liu L, Tsuang MT, Faraone SV, Glatt SJ., Free PMC Article

    05/11/2013
    Data suggest that Copine-III is a novel player in the regulation of ErbB2-dependent cancer cell motility.

    Copine-III interacts with ErbB2 and promotes tumor cell migration.
    Heinrich C, Keller C, Boulay A, Vecchi M, Bianchi M, Sack R, Lienhard S, Duss S, Hofsteenge J, Hynes NE.

    05/3/2010
    Susceptibility genes CPNE3, IL16 and CDH13 with moderate effects associated with susceptibility to prostate cancer.

    Multiple loci identified in a genome-wide association study of prostate cancer.
    Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, Yu K, Chatterjee N, Welch R, Hutchinson A, Crenshaw A, Cancel-Tassin G, Staats BJ, Wang Z, Gonzalez-Bosquet J, Fang J, Deng X, Berndt SI, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cussenot O, Valeri A, Andriole GL, Crawford ED, Tucker M, Gerhard DS, Fraumeni JF Jr, Hoover R, Hayes RB, Hunter DJ, Chanock SJ, Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, Yu K, Chatterjee N, Welch R, Hutchinson A, Crenshaw A, Cancel-Tassin G, Staats BJ, Wang Z, Gonzalez-Bosquet J, Fang J, Deng X, Berndt SI, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cussenot O, Valeri A, Andriole GL, Crawford ED, Tucker M, Gerhard DS, Fraumeni JF Jr, Hoover R, Hayes RB, Hunter DJ, Chanock SJ.

    01/21/2010
    Genome-wide association study of gene-disease association. (HuGE Navigator)

    Multiple loci identified in a genome-wide association study of prostate cancer.
    Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, Yu K, Chatterjee N, Welch R, Hutchinson A, Crenshaw A, Cancel-Tassin G, Staats BJ, Wang Z, Gonzalez-Bosquet J, Fang J, Deng X, Berndt SI, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cussenot O, Valeri A, Andriole GL, Crawford ED, Tucker M, Gerhard DS, Fraumeni JF Jr, Hoover R, Hayes RB, Hunter DJ, Chanock SJ, Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, Yu K, Chatterjee N, Welch R, Hutchinson A, Crenshaw A, Cancel-Tassin G, Staats BJ, Wang Z, Gonzalez-Bosquet J, Fang J, Deng X, Berndt SI, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cussenot O, Valeri A, Andriole GL, Crawford ED, Tucker M, Gerhard DS, Fraumeni JF Jr, Hoover R, Hayes RB, Hunter DJ, Chanock SJ.

    04/3/2008
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