| Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts. | Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts.
Du X, Zang C, Wang Q., Free PMC Article | 03/13/2024 |
| [Cyclin A1 affects the invasion, metastasis, and prognosis of hepatocellular carcinoma]. | [Cyclin A1 affects the invasion, metastasis, and prognosis of hepatocellular carcinoma].
Ma YR, Yang Q, Li H, Song JZ, Zhou X, Xiang FG. | 12/1/2023 |
| Histone methyltransferase EZH2 epigenetically affects CCNA1 expression in acute myeloid leukemia. | Histone methyltransferase EZH2 epigenetically affects CCNA1 expression in acute myeloid leukemia.
Yang X, Wan M, Yu F, Wu X. | 04/9/2022 |
| The combined detection of Amphiregulin, Cyclin A1 and DDX20/Gemin3 expression predicts aggressive forms of oral squamous cell carcinoma. | The combined detection of Amphiregulin, Cyclin A1 and DDX20/Gemin3 expression predicts aggressive forms of oral squamous cell carcinoma.
Bourova-Flin E, Derakhshan S, Goudarzi A, Wang T, Vitte AL, Chuffart F, Khochbin S, Rousseaux S, Aminishakib P., Free PMC Article | 12/18/2021 |
| CCNA1 gene as a potential diagnostic marker in papillary thyroid cancer. | CCNA1 gene as a potential diagnostic marker in papillary thyroid cancer.
da Silva RM, Santos JN, Uno M, Chammas R, Kulcsar MAV, Sant'Anna LB, Canevari RA. | 09/4/2021 |
| Deubiquitinating enzyme inhibitor alleviates cyclin A1-mediated proteasome inhibitor tolerance in mixed-lineage leukemia. | Deubiquitinating enzyme inhibitor alleviates cyclin A1-mediated proteasome inhibitor tolerance in mixed-lineage leukemia.
Ge M, Xu Q, Kang T, Li D, Wang R, Chen Z, Xie S, Wang W, Liu H., Free PMC Article | 06/19/2021 |
| Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells. | Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells.
Akaike Y, Chibazakura T., Free PMC Article | 02/2/2021 |
| Expression and prognosis of CyclinA and CDK2 in patients with advanced cervical cancer after chemotherapy. | Expression and prognosis of CyclinA and CDK2 in patients with advanced cervical cancer after chemotherapy.
Gao Y, Wang H, Zhong A, Yu T. | 01/23/2021 |
| Value of CCNA1 promoter methylation in triaging ASC-US cytology. | Value of CCNA1 promoter methylation in triaging ASC-US cytology.
Oranratanaphan S, Kobwitaya K, Termrungruanglert W, Triratanachat S, Kitkumthorn N, Mutirangura A., Free PMC Article | 12/5/2020 |
| immunopeptidome of HeLa cells transfected with Cyclin A1 and HLA-A*02:01 revealed six Cyclin A1-derived HLA ligands | Cancer testis antigen Cyclin A1 harbors several HLA-A*02:01-restricted T cell epitopes, which are presented and recognized in vivo.
Teck AT, Urban S, Quass P, Nelde A, Schuster H, Letsch A, Busse A, Walz JS, Keilholz U, Ochsenreither S., Free PMC Article | 07/4/2020 |
| Study found the WT1 and CCNA1 mRNA levels to be elevated in bone marrow samples from pediatric acute promyelocytic leukemia patients (APL), and varied in pediatric acute lymphocytic leukemia (ALL) patients. The examination of the CCNA1 promoter identified potential canonical WT1 binding sites within the 3kb region upstream of the transcription start site. | WT1 regulates cyclin A1 expression in K562 cells.
Pandey S, Moazam M, Ghimirey N, Kuerbitz SJ, Fraizer GC. | 02/29/2020 |
| LINC00304 can significantly promote CCNA1 expression in PCa cells. | Androgen-responsive lncRNA LINC00304 promotes cell cycle and proliferation via regulating CCNA1.
Zhang P, Lu Y, Kong Z, Zhang Y, Fu F, Su X, Huang Y, Wan X, Li Y. | 01/25/2020 |
| DUB3 functions as a novel cyclin A regulator through maintaining cyclin A stability. | Deubiquitinase DUB3 Regulates Cell Cycle Progression via Stabilizing Cyclin A for Proliferation of Non-Small Cell Lung Cancer Cells.
Hu B, Deng T, Ma H, Liu Y, Feng P, Wei D, Ling N, Li L, Qiu S, Zhang L, Peng B, Liu J, Ye M., Free PMC Article | 11/30/2019 |
| Thus, Cyclin A/Cdk1 phosphorylation primes MYPT1 for Plk1 binding. These data demonstrate cross-regulation between Cyclin A/Cdk1-dependent and Plk1-dependent phosphorylation of substrates during mitosis to ensure efficient correction of kinetochore microtubule attachment errors necessary for high mitotic fidelity. | Cyclin A/Cdk1 modulates Plk1 activity in prometaphase to regulate kinetochore-microtubule attachment stability.
Dumitru AMG, Rusin SF, Clark AEM, Kettenbach AN, Compton DA., Free PMC Article | 07/7/2018 |
| Cyclin A1 functions as an oncogene that controls proliferative and survival activities in tumourigenesis and chemoresistance of ovarian cancer. | Cyclin A1 expression and paclitaxel resistance in human ovarian cancer cells.
Huang KC, Yang J, Ng MC, Ng SK, Welch WR, Muto MG, Berkowitz RS, Ng SW., Free PMC Article | 08/5/2017 |
| In the bone marrow, cyclin A1 and aromatase enhanced local bone marrow-releasing factors, including androgen receptor, estrogen and matrix metalloproteinase MMP9 and promoted the metastatic growth of prostate cancer cells | Cyclin A1 and P450 Aromatase Promote Metastatic Homing and Growth of Stem-like Prostate Cancer Cells in the Bone Marrow.
Miftakhova R, Hedblom A, Semenas J, Robinson B, Simoulis A, Malm J, Rizvanov A, Heery DM, Mongan NP, Maitland NJ, Allegrucci C, Persson JL. | 03/4/2017 |
| The data showed that E7 induced CCNA1 methylation by forming a complex with Dnmt1 at the CCNA1 promoter, resulting in the subsequent reduction of expression in cancers. | Human papillomavirus type 16 E7 oncoprotein mediates CCNA1 promoter methylation.
Chalertpet K, Pakdeechaidan W, Patel V, Mutirangura A, Yanatatsaneejit P., Free PMC Article | 02/20/2016 |
| DNA methylation status of key cell-cycle regulators such as CDKNA2/p16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors. | DNA methylation status of key cell-cycle regulators such as CDKNA2/p16 and CCNA1 correlates with treatment response to doxorubicin and 5-fluorouracil in locally advanced breast tumors.
Klajic J, Busato F, Edvardsen H, Touleimat N, Fleischer T, Bukholm I, Børresen-Dale AL, Lønning PE, Tost J, Kristensen VN. | 11/21/2015 |
| Cyclin A1 immunoexpression is of potential utility in predicting disease progression in patients with pT1 urothelial carcinomas of the bladder | Cyclin A1 expression predicts progression in pT1 urothelial carcinoma of bladder: a tissue microarray study of 149 patients treated by transurethral resection.
Munari E, Chaux A, Maldonado L, Compérat E, Varinot J, Bivalacqua TJ, Hoque MO, Netto GJ. | 09/26/2015 |
| HS3ST2 and CCNA1 genes may play important roles in HPV-induced cervical cancer and patients with specific hypermethylated genes may have a greater risk of progressing to invasive cervical cancer. | Methylation in the promoters of HS3ST2 and CCNA1 genes is associated with cervical cancer in Uygur women in Xinjiang.
Zuo Q, Zheng W, Zhang J, Pan Z, Liu Y, Long H, Fan P, Guo C, Li F, Shao R. | 08/29/2015 |
| CCNA1 promoter methylation is associated with cervical squamous intraepithelial lesions. | CCNA1 promoter methylation: a potential marker for grading Papanicolaou smear cervical squamous intraepithelial lesions.
Chujan S, Kitkumthorn N, Siriangkul S, Mutirangura A. | 06/27/2015 |
| High CCNA1 expression is associated with nasopharyngeal carcinoma. | Elucidating the roles of miR-372 in cell proliferation and apoptosis of nasopharyngeal carcinoma TW01 cells.
Tan JK, Tan EL, Gan SY. | 04/18/2015 |
| Mutations in genes such as AKT2, CCNA1, MAP3K4, and TGFBR1, were associated significantly with Epstein-Barr-positive gastric tumors, compared with EBV-negative tumors. | Integrative identification of Epstein-Barr virus-associated mutations and epigenetic alterations in gastric cancer.
Liang Q, Yao X, Tang S, Zhang J, Yau TO, Li X, Tang CM, Kang W, Lung RW, Li JW, Chan TF, Xing R, Lu Y, Lo KW, Wong N, To KF, Yu C, Chan FK, Sung JJ, Yu J. | 02/7/2015 |
| Promoter reporter assays with a series of deletion constructs determined that the DNA element from -102 to -96 bp of the cyclin A1 promoter is responsible for PITX2-induced gene expression. | Cyclin A1 is a transcriptional target of PITX2 and overexpressed in papillary thyroid carcinoma.
Liu Y, Huang Y, Zhu GZ. | 10/4/2014 |
| presents CCNA1 and TIMP3 hypermethylation as a helpful tool to identify HNSCC subjects at risk of developing second primary carcinomas | TIMP3 and CCNA1 hypermethylation in HNSCC is associated with an increased incidence of second primary tumors.
Rettori MM, de Carvalho AC, Longo AL, de Oliveira CZ, Kowalski LP, Carvalho AL, Vettore AL., Free PMC Article | 09/27/2014 |