| miR-146a-3p as a potential novel therapeutic by targeting MBD2 to mediate Th17 differentiation in Th17 predominant neutrophilic severe asthma. | miR-146a-3p as a potential novel therapeutic by targeting MBD2 to mediate Th17 differentiation in Th17 predominant neutrophilic severe asthma.
Duan W, Huang J, Wasti B, Chen Z, Yuan Y, He Y, Li D, Jia J, Liu S, Liu Y, Ma L, Zeng Q, Zhu L, Li J, Zhang X, Xiang X., Free PMC Article | 10/5/2023 |
| Hsa-miR-221-3p promotes proliferation and migration in HER2-positive breast cancer cells by targeting LASS2 and MBD2. | Hsa-miR-221-3p promotes proliferation and migration in HER2-positive breast cancer cells by targeting LASS2 and MBD2.
Shao X, Zheng Y, Huang Y, Li G, Zou W, Shi L. | 12/17/2022 |
| Densely methylated DNA traps Methyl-CpG-binding domain protein 2 but permits free diffusion by Methyl-CpG-binding domain protein 3. | Densely methylated DNA traps Methyl-CpG-binding domain protein 2 but permits free diffusion by Methyl-CpG-binding domain protein 3.
Leighton GO, Irvin EM, Kaur P, Liu M, You C, Bhattaram D, Piehler J, Riehn R, Wang H, Pan H, Williams DC Jr., Free PMC Article | 11/19/2022 |
| Blockade of Mbd2 by siRNA-loaded liposomes protects mice against OVA-induced allergic airway inflammation via repressing M2 macrophage production. | Blockade of Mbd2 by siRNA-loaded liposomes protects mice against OVA-induced allergic airway inflammation via repressing M2 macrophage production.
Wu GR, Zhou M, Wang Y, Zhou Q, Zhang L, He L, Zhang S, Yu Q, Xu Y, Zhao J, Xiong W, Wang CY., Free PMC Article | 10/1/2022 |
| Silencing of MBD2 and EZH2 inhibits the proliferation of colorectal carcinoma cells by rescuing the expression of SFRP. | Silencing of MBD2 and EZH2 inhibits the proliferation of colorectal carcinoma cells by rescuing the expression of SFRP.
Xie Y, Wang F, Yu J, Zhang J, Liu Y, Li M, Qi J., Free PMC Article | 01/22/2022 |
| GATA zinc finger domain-containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with beta-thalassaemia through impaired formation of methyl-binding domain protein 2 (MBD2)-containing nucleosome remodelling and deacetylation (NuRD) complex. | GATA zinc finger domain-containing protein 2A (GATAD2A) deficiency reactivates fetal haemoglobin in patients with β-thalassaemia through impaired formation of methyl-binding domain protein 2 (MBD2)-containing nucleosome remodelling and deacetylation (NuRD) complex.
Liang Y, Zhang X, Liu Y, Wang L, Ye Y, Tan X, Pu J, Zhang Q, Bao X, Wei X, Li D, Kurita R, Nakamura Y, Li D, Xu X. | 10/2/2021 |
| Hypoxia-Induced Suppression of Alternative Splicing of MBD2 Promotes Breast Cancer Metastasis via Activation of FZD1. | Hypoxia-Induced Suppression of Alternative Splicing of MBD2 Promotes Breast Cancer Metastasis via Activation of FZD1.
Liu Z, Sun L, Cai Y, Shen S, Zhang T, Wang N, Wu G, Ma W, Li ST, Suo C, Hao Y, Jia WD, Semenza GL, Gao P, Zhang H. | 05/22/2021 |
| The topology of chromatin-binding domains in the NuRD deacetylase complex. | The topology of chromatin-binding domains in the NuRD deacetylase complex.
Millard CJ, Fairall L, Ragan TJ, Savva CG, Schwabe JWR., Free PMC Article | 01/16/2021 |
| Upregulated exosomal miR-221/222 promotes cervical cancer via repressing methyl-CpG-binding domain protein 2. | Upregulated exosomal miR-221/222 promotes cervical cancer via repressing methyl-CpG-binding domain protein 2.
Pan ZX, Zhang XY, Chen SR, Li CZ. | 09/19/2020 |
| The HERV-E clone 4-1 also takes part in disease pathogenesis of SLE through miR-302d/Methyl-CpG binding domain protein 2 (MBD2)/DNA hypomethylation and IL-17 signaling via its 3'LTR. | Increased HERV-E clone 4-1 expression contributes to DNA hypomethylation and IL-17 release from CD4(+) T cells via miR-302d/MBD2 in systemic lupus erythematosus.
Wang X, Zhao C, Zhang C, Mei X, Song J, Sun Y, Wu Z, Shi W., Free PMC Article | 09/12/2020 |
| LOC105369748 was shown to promote MBD2 expression through competitively binding to microRNA(miR)-5095 in hepatocellular carcinoma. | Silencing of a novel lncRNA LOC105369748 suppresses the progression of hepatocellular carcinoma by sponging miR-5095 from MBD2.
E C, Li C, Li H, Yang J. | 05/30/2020 |
| our results demonstrate that mCG-binding arginine fingers embedded into a conserved structural fold are essential structural features for MBD2/3s binding to methylated DNA among metazoans. | Structural analyses reveal that MBD3 is a methylated CG binder.
Liu K, Lei M, Wu Z, Gan B, Cheng H, Li Y, Min J. | 05/23/2020 |
| Low MBD2 expression is associated with metastasis in Lung Adenocarcinoma. | Methyl-CpG Binding Domain Protein 2 Inhibits the Malignant Characteristic of Lung Adenocarcinoma through the Epigenetic Modulation of 10 to 11 Translocation 1 and miR-200s.
Pei YF, Xu XN, Wang ZF, Wang FW, Wu WD, Geng JF, Liu XQ. | 02/15/2020 |
| MBD2_v2 expression is induced by obesity and drives triple-negative breast cancer cell tumorigenicity. | Obesity-induced MBD2_v2 expression promotes tumor-initiating triple-negative breast cancer stem cells.
Teslow EA, Mitrea C, Bao B, Mohammad RM, Polin LA, Dyson G, Purrington KS, Bollig-Fischer A., Free PMC Article | 12/7/2019 |
| we conclude that disruption of MBD2 can inhibit the proliferation of CML-BP cells in vivo and in vitro. Given the striking effect in CML blast crisis cell lines, we believe that targeting MBD2 could be a candidate therapeutic strategy for CML-BP patients. | Deletion of MBD2 inhibits proliferation of chronic myeloid leukaemia blast phase cells.
Cheng L, Tang Y, Chen X, Zhao L, Liu S, Ma Y, Wang N, Zhou K, Zhou J, Zhou M., Free PMC Article | 08/17/2019 |
| IL-6 treatment downregulated wild-type TP53 protein and induced mRNA and protein expression of the epigenetic reader methyl CpG binding domain protein 2 (MBD2), specifically the alternative mRNA splicing variant MBD2_v2. | Exogenous IL-6 induces mRNA splice variant MBD2_v2 to promote stemness in TP53 wild-type, African American PCa cells.
Teslow EA, Bao B, Dyson G, Legendre C, Mitrea C, Sakr W, Carpten JD, Powell I, Bollig-Fischer A., Free PMC Article | 06/1/2019 |
| In Notch1-driven T-cell acute lymphoblastic leukemia (T-ALL), MBD2 was required for the progression and maintenance of leukemia. The results define essential roles for MBD2 in lymphopoiesis and T-ALL and suggest MBD2 as a candidate therapeutic target in T-ALL. | MBD2 Ablation Impairs Lymphopoiesis and Impedes Progression and Maintenance of T-ALL.
Zhou M, Zhou K, Cheng L, Chen X, Wang J, Wang XM, Zhang Y, Yu Q, Zhang S, Wang D, Huang L, Huang M, Ma D, Cheng T, Wang CY, Yuan W, Zhou J. | 03/23/2019 |
| Suggest that reduced MBD2 expression could contribute to chronic airway inflammation in COPD. | Reduced MBD2 expression enhances airway inflammation in bronchial epithelium in COPD.
Zeng Z, Li M, Chen J, Li Q, Ning Q, Zhao J, Xu Y, Xie J, Yu J., Free PMC Article | 09/22/2018 |
| knockdown of MBD2 by siRNA attenuated vancomycin-induced apoptosis, caspase activity, and the expression of BAX and cleaved caspase 3. | MBD2 upregulates miR-301a-5p to induce kidney cell apoptosis during vancomycin-induced AKI.
Wang J, Li H, Qiu S, Dong Z, Xiang X, Zhang D., Free PMC Article | 06/9/2018 |
| CpG and methylation-dependent DNA binding and dynamics of the MBD2 protein at the single-molecule level have been reported. | CpG and methylation-dependent DNA binding and dynamics of the methylcytosine binding domain 2 protein at the single-molecule level.
Pan H, Bilinovich SM, Kaur P, Riehn R, Wang H, Williams DC Jr., Free PMC Article | 10/14/2017 |
| Results show that MBD2 mediates epigenetic silencing of Htra1. | Epigenetic silencing of serine protease HTRA1 drives polyploidy.
Schmidt N, Irle I, Ripkens K, Lux V, Nelles J, Johannes C, Parry L, Greenow K, Amir S, Campioni M, Baldi A, Oka C, Kawaichi M, Clarke AR, Ehrmann M., Free PMC Article | 10/7/2017 |
| MBD2 has a critical role in 'rewriting' the cancer methylome at specific regulatory regions. | Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer.
Stirzaker C, Song JZ, Ng W, Du Q, Armstrong NJ, Locke WJ, Statham AL, French H, Pidsley R, Valdes-Mora F, Zotenko E, Clark SJ. | 09/2/2017 |
| MBD2 expression was elevated in HCC tissue, which suggesting MBD2 as a candidate prognostic marker of HCC. | MBD2 as a novel marker associated with poor survival of patients with hepatocellular carcinoma after hepatic resection.
Liu W, Wang N, Lu M, Du XJ, Xing BC., Free PMC Article | 04/8/2017 |
| downregulation of miR-221 inhibits cell migration and invasion at least partially through targeting MBD2 in the human OSCC cell line UM1. | Downregulation of miR-221 Inhibits Cell Migration and Invasion through Targeting Methyl-CpG Binding Domain Protein 2 in Human Oral Squamous Cell Carcinoma Cells.
He S, Lai R, Chen D, Yan W, Zhang Z, Liu Z, Ding X, Chen Y., Free PMC Article | 10/22/2016 |
| Specifically, methyl-CpG-binding domain protein 2 (MBD2) is revealed to be recruited to DNA damage sites after laser microirradiation, which was mediated through MBD domain and MBD2 C-terminus. | iTRAQ-based chromatin proteomic screen reveals CHD4-dependent recruitment of MBD2 to sites of DNA damage.
Sun Y, Yang Y, Shen H, Huang M, Wang Z, Liu Y, Zhang H, Tang TS, Guo C. | 07/16/2016 |