| Decidual stromal cells-derived exosomes incurred insufficient migration and invasion of trophoblast by disturbing of beta-TrCP-mediated snail ubiquitination and degradation in unexplained recurrent spontaneous abortion. | Decidual stromal cells-derived exosomes incurred insufficient migration and invasion of trophoblast by disturbing of β-TrCP-mediated snail ubiquitination and degradation in unexplained recurrent spontaneous abortion.
Xiong M, Wang Q, Zhang X, Wen L, Zhao A., Free PMC Article | 01/16/2024 |
| Sequence variants in DLX5, HOXD13 and 445 kb-microduplication surrounding BTRC cause split-hand/foot malformation in three different families. | Sequence variants in DLX5, HOXD13 and 445 kb-microduplication surrounding BTRC cause split-hand/foot malformation in three different families.
Abdullah, Hussain S, Ji W, Khan H, Mis EK, Mushtaq R, Chodhary M, Raza MH, Jan A, Ullah I, Khokha MK, Lakhani SA, Ahmad W. | 01/3/2024 |
| Exosomal GPT2 derived from triple-negative breast cancer cells promotes metastasis by activating BTRC. | Exosomal GPT2 derived from triple-negative breast cancer cells promotes metastasis by activating BTRC.
Cui M, Peng J, Zhou Y, Wang X, Cui D., Free PMC Article | 07/25/2023 |
| Ubiquitin E3 ligase beta-TrCP negatively regulates surface protein of hepatitis B virus. | Ubiquitin E3 ligase β-TrCP negatively regulates surface protein of hepatitis B virus.
Tu W, Liu J, Qian F, Zhu L, Li M, Zheng H, Zhu C. | 03/30/2023 |
| Pan-cancer analysis of FBXW family with potential implications in prognosis and immune infiltration. | Pan-cancer analysis of FBXW family with potential implications in prognosis and immune infiltration.
Huang T, OuYang X, Li J, Shi B, Shan Z, Shi Z, Yang Z., Free PMC Article | 01/14/2023 |
| circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR. | circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR.
Ding F, Lu L, Wu C, Pan X, Liu B, Zhang Y, Wang Y, Wu W, Yan B, Zhang Y, Yu XY, Li Y., Free PMC Article | 12/10/2022 |
| The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and beta-TrCP-NRF2 interactions in cancer chemoresistance. | The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and β-TrCP-NRF2 interactions in cancer chemoresistance.
Srivastava R, Fernández-Ginés R, Encinar JA, Cuadrado A, Wells G. | 10/22/2022 |
| WBP2 promotes BTRC mRNA stability to drive migration and invasion in triple-negative breast cancer via NF-kappaB activation. | WBP2 promotes BTRC mRNA stability to drive migration and invasion in triple-negative breast cancer via NF-κB activation.
Lim YX, Lin H, Chu T, Lim YP., Free PMC Article | 04/2/2022 |
| The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation. | The transcript ENST00000444125 of lncRNA LINC01503 promotes cancer stem cell properties of glioblastoma cells via reducing FBXW1 mediated GLI2 degradation.
Wei P, Jiang J, Xiao M, Zeng M, Liu X, Zhao B, Chen F. | 02/12/2022 |
| FBXW8 regulates G1 and S phases of cell cycle progression by restricting beta-TrCP1 function. | FBXW8 regulates G1 and S phases of cell cycle progression by restricting β-TrCP1 function.
Islam S, Dutta P, Chopra K, Rapole S, Chauhan R, Santra MK. | 10/2/2021 |
| Mutual regulation between beta-TRCP mediated REST protein degradation and Kv1.3 expression controls vascular smooth muscle cell phenotype switch. | Mutual regulation between β-TRCP mediated REST protein degradation and Kv1.3 expression controls vascular smooth muscle cell phenotype switch.
Ye M, Guo X, Wang H, Wang Y, Qian X, Deng H, Wang W, Yang S, Ni Q, Chen J, Lv L, Zhao Y, Xue G, Li Y, Zhang L. | 08/14/2021 |
| MiR-135a-5p promotes the migration and invasion of trophoblast cells in preeclampsia by targeting beta-TrCP. | MiR-135a-5p promotes the migration and invasion of trophoblast cells in preeclampsia by targeting β-TrCP.
Wu D, Shi L, Hong L, Chen X, Cen H. | 08/14/2021 |
| beta-Trcp and CK1delta-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma. | β-Trcp and CK1δ-mediated degradation of LZTS2 activates PI3K/AKT signaling to drive tumorigenesis and metastasis in hepatocellular carcinoma.
Lu Y, Li X, Liu H, Xue J, Zeng Z, Dong X, Zhang T, Wu G, Yang K, Xu S., Free PMC Article | 07/31/2021 |
| The characteristics and roles of beta-TrCP1/2 in carcinogenesis. | The characteristics and roles of β-TrCP1/2 in carcinogenesis.
Bi Y, Cui D, Xiong X, Zhao Y. | 07/24/2021 |
| beta-TrCP1 promotes cell proliferation via TNF-dependent NF-kappaB activation in diffuse large B cell lymphoma. | β-TrCP1 promotes cell proliferation via TNF-dependent NF-κB activation in diffuse large B cell lymphoma.
Cai N, Chen Z, Huang Y, Shao S, Yu H, Wang Y, He S., Free PMC Article | 07/10/2021 |
| The cross talk of two family members of beta-TrCP in the regulation of cell autophagy and growth. | The cross talk of two family members of β-TrCP in the regulation of cell autophagy and growth.
Cui D, Dai X, Shu J, Ma Y, Wei D, Xiong X, Zhao Y., Free PMC Article | 07/3/2021 |
| Investigation of the role of beta-TrCP in growth hormone transduction defect (GHTD). | Investigation of the role of β-TrCP in growth hormone transduction defect (GHTD).
Kostopoulou E, Rojas Gil AP, Spiliotis BE. | 06/5/2021 |
| miR-193a-3p Promotes the Invasion, Migration, and Mesenchymal Transition in Glioma through Regulating BTRC. | miR-193a-3p Promotes the Invasion, Migration, and Mesenchymal Transition in Glioma through Regulating BTRC.
Zhou DD, Li HL, Liu W, Zhang LP, Zheng Q, Bai J, Hu YQ, Yin CG, Lv SJ, Zhang BG., Free PMC Article | 05/29/2021 |
| The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC. | The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC.
Guo W, Mu K, Zhang B, Sun C, Zhao L, Dong ZY, Cui Q., Free PMC Article | 03/27/2021 |
| Bergenin impedes the generation of extracellular matrix in glomerular mesangial cells and ameliorates diabetic nephropathy in mice by inhibiting oxidative stress via the mTOR/beta-TrcP/Nrf2 pathway. | Bergenin impedes the generation of extracellular matrix in glomerular mesangial cells and ameliorates diabetic nephropathy in mice by inhibiting oxidative stress via the mTOR/β-TrcP/Nrf2 pathway.
Qiao S, Liu R, Lv C, Miao Y, Yue M, Tao Y, Wei Z, Xia Y, Dai Y. | 09/5/2020 |
| CHK1 contains a beta-TrCP recognizable degron domain, which is phosphorylated by AMPK in response to glucose deprivation. | SCFβ-TrCP ubiquitinates CHK1 in an AMPK-dependent manner in response to glucose deprivation.
Ma Y, Cui D, Xiong X, Inuzuka H, Wei W, Sun Y, North BJ, Zhao Y., Free PMC Article | 12/21/2019 |
| Study findings identify beta-TrCP as an important negative regulator for upstream signaling of IkappaBalpha in lipopolysaccharide pathway, and therefore renew the understanding of the roles of beta-TrCP in regulating toll-like receptors inflammatory signaling. | β-TrCP Restricts Lipopolysaccharide (LPS)-Induced Activation of TRAF6-IKK Pathway Upstream of IκBα Signaling.
Liu J, Yuan Y, Xu J, Xiao K, Xu Y, Guo T, Zhang L, Wang J, Zheng H., Free PMC Article | 10/26/2019 |
| Beta transducin repeat-containing protein (beta-TrCP1) interacts with PERIOD2 (PER2) through conserved phosphoswitches i.e. SEP480 and SEP484 residues. | Interactive structural analysis of βTrCP1 and PER2 phosphoswitch binding through dynamics simulation assay.
Najumuddin, Fakhar M, Gul M, Rashid S. | 06/29/2019 |
| findings reveal that Akt activity determines the phosphorylation status of TBC1D7 at the phospho-switch Ser-124, which governs binding to either 14-3-3 or beta-TrCP2, resulting in increased or decreased stability of TBC1D7, respectively. | The tuberous sclerosis complex subunit TBC1D7 is stabilized by Akt phosphorylation-mediated 14-3-3 binding.
Madigan JP, Hou F, Ye L, Hu J, Dong A, Tempel W, Yohe ME, Randazzo PA, Jenkins LMM, Gottesman MM, Tong Y., Free PMC Article | 03/23/2019 |
| Study found that the F-box protein bTrCP binds a DSGmotif located within the N-terminus of STIL, and that mutation of this degron leads to STIL stabilization and consequent centriole overduplication. | The SKP1-Cullin-F-box E3 ligase βTrCP and CDK2 cooperate to control STIL abundance and centriole number.
Arquint C, Cubizolles F, Morand A, Schmidt A, Nigg EA., Free PMC Article | 03/16/2019 |