| IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating beta1-integrin via FAK and MRTF/SRF. | IQGAP1 and NWASP promote human cancer cell dissemination and metastasis by regulating β1-integrin via FAK and MRTF/SRF.
Cerutti C, Lucotti S, Menendez ST, Reymond N, Garg R, Romero IA, Muschel R, Ridley AJ. | 04/30/2024 |
| Neural Wiskott-Aldrich syndrome protein (N-WASP) promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2. | Neural Wiskott-Aldrich syndrome protein (N-WASP) promotes distant metastasis in pancreatic ductal adenocarcinoma via activation of LOXL2.
Kim HS, Lee YS, Dong SM, Kim HJ, Lee DE, Kang HW, Kim MJ, Park JS., Free PMC Article | 04/4/2024 |
| Polo-like kinase 1 promotes Cdc42-induced actin polymerization for asymmetric division in oocytes. | Polo-like kinase 1 promotes Cdc42-induced actin polymerization for asymmetric division in oocytes.
Yuen WS, Zhang QH, Bourdais A, Adhikari D, Halet G, Carroll J., Free PMC Article | 03/10/2023 |
| nWASP Inhibition Increases Wound Healing via TrKb/PLCgamma Signalling. | nWASP Inhibition Increases Wound Healing via TrKb/PLCγ Signalling.
Frugtniet BA, Ruge F, Sanders AJ, Owen S, Harding KG, Jiang WG, Martin TA., Free PMC Article | 03/1/2023 |
| Compound heterozygous variants in Wiskott-Aldrich syndrome like (WASL) gene segregating in a family with early onset Parkinson's disease. | Compound heterozygous variants in Wiskott-Aldrich syndrome like (WASL) gene segregating in a family with early onset Parkinson's disease.
Kumar S, Abbas MM, Govindappa ST, Muthane UB, Behari M, Pandey S, Juyal RC, Thelma BK. | 01/1/2022 |
| FCHSD2 cooperates with CDC42 and N-WASP to regulate cell protrusion formation. | FCHSD2 cooperates with CDC42 and N-WASP to regulate cell protrusion formation.
Zhai X, Shen Y, Zhang X, Li T, Lu Q, Xu Z. | 01/1/2022 |
| Chlamydia trachomatis TmeA Directly Activates N-WASP To Promote Actin Polymerization and Functions Synergistically with TarP during Invasion. | Chlamydia trachomatis TmeA Directly Activates N-WASP To Promote Actin Polymerization and Functions Synergistically with TarP during Invasion.
Keb G, Ferrell J, Scanlon KR, Jewett TJ, Fields KA., Free PMC Article | 09/11/2021 |
| Loss of Wasl improves pancreatic cancer outcome. | Loss of Wasl improves pancreatic cancer outcome.
Hidalgo-Sastre A, Desztics J, Dantes Z, Schulte K, Ensarioglu HK, Bassey-Archibong B, Öllinger R, Engleiter T, Rayner L, Einwächter H, Daniel JM, Altaee ASA, Steiger K, Lesina M, Rad R, Reichert M, von Figura G, Siveke JT, Schmid RM, Lubeseder-Martellato C., Free PMC Article | 05/22/2021 |
| TRPV4 activates the Cdc42/N-wasp pathway to promote glioblastoma invasion by altering cellular protrusions. | TRPV4 activates the Cdc42/N-wasp pathway to promote glioblastoma invasion by altering cellular protrusions.
Yang W, Wu PF, Ma JX, Liao MJ, Xu LS, Yi L., Free PMC Article | 01/9/2021 |
| The Chlamydia trachomatis secreted effector TmeA hijacks the N-WASP-ARP2/3 actin remodeling axis to facilitate cellular invasion. | The Chlamydia trachomatis secreted effector TmeA hijacks the N-WASP-ARP2/3 actin remodeling axis to facilitate cellular invasion.
Faris R, McCullough A, Andersen SE, Moninger TO, Weber MM., Free PMC Article | 10/24/2020 |
| Together, these data support a model wherein TNK2, WASL, and NCK1 comprise a pathway important for the entry of multiple picornaviruses. | Entry by multiple picornaviruses is dependent on a pathway that includes TNK2, WASL, and NCK1.
Jiang H, Leung C, Tahan S, Wang D., Free PMC Article | 05/9/2020 |
| N-WASP has an early tumour suppressive role in APC-induced intestinal carcinogenesis. | Loss of N-WASP drives early progression in an Apc model of intestinal tumourigenesis.
Morris HT, Fort L, Spence HJ, Patel R, Vincent DF, Park JH, Snapper SB, Carey FA, Sansom OJ, Machesky LM., Free PMC Article | 10/26/2019 |
| N-WASP positively regulates demarcation membrane system development and proplatelet formation, and the Src family kinases in association with CDC42 regulate proplatelet formation through N-WASP | The cell division control protein 42-Src family kinase-neural Wiskott-Aldrich syndrome protein pathway regulates human proplatelet formation.
Palazzo A, Bluteau O, Messaoudi K, Marangoni F, Chang Y, Souquere S, Pierron G, Lapierre V, Zheng Y, Vainchenker W, Raslova H, Debili N. | 12/30/2017 |
| By using VCA nanobodiess, study shows the influence of N-WASps VCA domain in invadopodium formation and extracellular matrix degradation | VCA nanobodies target N-WASp to reduce invadopodium formation and functioning.
Hebbrecht T, Van Audenhove I, Zwaenepoel O, Verhelle A, Gettemans J., Free PMC Article | 10/21/2017 |
| Recruitment of Paxillin, Cdc42 and N-WASP is necessary for cell adhesion, migration and invasion induced by Estradiol in breast cancer cells. | Paxillin, a novel controller in the signaling of estrogen to FAK/N-WASP/Arp2/3 complex in breast cancer cells.
Shortrede JE, Uzair ID, Neira FJ, Flamini MI, Sanchez AM. | 09/30/2017 |
| Results suggest that local invasiveness of ameloblastoma is dependent upon the migratory potential of its tumour cells as defined by their distribution of cortactin, N-WASP and WIP in correlation with F-actin cytoskeletal dynamics. | Invadopodia proteins, cortactin, N-WASP and WIP differentially promote local invasiveness in ameloblastoma.
Siar CH, Rahman ZA, Tsujigiwa H, Mohamed Om Alblazi K, Nagatsuka H, Ng KH. | 09/23/2017 |
| This suggests that TOCA1 binding to Cdc42 is an early step in the Cdc42-dependent pathways that govern actin dynamics, and the differential binding affinities of the effectors facilitate a handover from TOCA1 to N-WASP, which can then drive recruitment of the actin-modifying machinery. | Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES.
Watson JR, Fox HM, Nietlispach D, Gallop JL, Owen D, Mott HR., Free PMC Article | 12/17/2016 |
| the Cdc42/Nwasp/stress fibers/YAP signal pathway may potentially play an important role in regulating podocyte apoptosis. Maintaining necessary Cdc42 would be one potent way to prevent proteinuria kidney diseases. | Cdc42 deficiency induces podocyte apoptosis by inhibiting the Nwasp/stress fibers/YAP pathway.
Huang Z, Zhang L, Chen Y, Zhang H, Zhang Q, Li R, Ma J, Li Z, Yu C, Lai Y, Lin T, Zhao X, Zhang B, Ye Z, Liu S, Wang W, Liang X, Liao R, Shi W., Free PMC Article | 11/19/2016 |
| Low GAS7C increases cancer cell motility by promoting N-WASP/FAK/F-actin cytoskeleton dynamics. It also enhances beta-catenin stability via hnRNP U/beta-TrCP complex formation. | Growth-arrest-specific 7C protein inhibits tumor metastasis via the N-WASP/FAK/F-actin and hnRNP U/β-TrCP/β-catenin pathways in lung cancer.
Tseng RC, Chang JW, Mao JS, Tsai CD, Wu PC, Lin CJ, Lu YL, Liao SY, Cheng HC, Hsu HS, Wang YC., Free PMC Article | 11/12/2016 |
| This suggests that N-WASP's failure to compensate for WASP in rescuing chemotaxis could be due to the absence of this I30 region. | Molecular difference between WASP and N-WASP critical for chemotaxis of T-cells towards SDF-1α.
Jain N, Thanabalu T., Free PMC Article | 08/20/2016 |
| RTVP-1 regulates glioma cell spreading, migration and invasion and that these effects are mediated via interaction with N-WASP and by interfering with the inhibitory effect of hnRNPK on the function of this protein. | RTVP-1 regulates glioma cell migration and invasion via interaction with N-WASP and hnRNPK.
Ziv-Av A, Giladi ND, Lee HK, Cazacu S, Finniss S, Xiang C, Pauker MH, Barda-Saad M, Poisson L, Brodie C., Free PMC Article | 05/28/2016 |
| Nck was the most potent activator of N-WASP-driven actin assembly. | Allosteric N-WASP activation by an inter-SH3 domain linker in Nck.
Okrut J, Prakash S, Wu Q, Kelly MJ, Taunton J., Free PMC Article | 03/19/2016 |
| our results reveal a novel role for N-WASP in remodeling EC junctions, which is critical for monolayer integrity and function. | Role of N-WASP in Endothelial Monolayer Formation and Integrity.
Mooren OL, Kim J, Li J, Cooper JA., Free PMC Article | 10/24/2015 |
| Tir-Intimin interaction recruits the Nck adaptor to a Tir tyrosine phosphorylated residue where it activates neural Wiskott-Aldrich syndrome protein (N-WASP). | Nck adaptors, besides promoting N-WASP mediated actin-nucleation activity at pedestals, influence the cellular levels of enteropathogenic Escherichia coli Tir effector.
Nieto-Pelegrin E, Kenny B, Martinez-Quiles N., Free PMC Article | 08/8/2015 |
| These results support a role for N-WASP in amphiphysin-2-dependent nuclear positioning and triad organization and in centronuclear myopathy and myotonic dystrophy pathophysiology. | N-WASP is required for Amphiphysin-2/BIN1-dependent nuclear positioning and triad organization in skeletal muscle and is involved in the pathophysiology of centronuclear myopathy.
Falcone S, Roman W, Hnia K, Gache V, Didier N, Lainé J, Auradé F, Marty I, Nishino I, Charlet-Berguerand N, Romero NB, Marazzi G, Sassoon D, Laporte J, Gomes ER., Free PMC Article | 06/27/2015 |