| The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes. | The microglial innate immune protein PGLYRP1 mediates neuroinflammation and consequent behavioral changes.
Bhusal A, Kim JH, Kim SC, Hwang EM, Ryu H, Ali MS, Park SC, Lee WH, Suk K. | 04/1/2024 |
| Value of gingival crevicular fluid TREM-1, PGLYRP1, and IL-1beta levels during menopause. | Value of gingival crevicular fluid TREM-1, PGLYRP1, and IL-1β levels during menopause.
Yakar N, Emingil G, Türedi A, Şahin Ç, Köse T, Bostanci N, Silbereisen A. | 09/13/2023 |
| Association of peptidoglycan recognition protein 1 to post-myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study. | Association of peptidoglycan recognition protein 1 to post-myocardial infarction and periodontal inflammation: A subgroup report from the PAROKRANK (Periodontal Disease and the Relation to Myocardial Infarction) study.
Rathnayake N, Gustafsson A, Sorsa T, Norhammar A, Bostanci N, PAROKRANK Steering Committee., Free PMC Article | 10/1/2022 |
| N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor. | N-Terminal Peptide of PGLYRP1/Tag7 Is a Novel Ligand for TREM-1 Receptor.
Sharapova TN, Ivanova OK, Romanova EA, Sashchenko LP, Yashin DV., Free PMC Article | 06/11/2022 |
| TNF upregulates peptidoglycan recognition protein 1 in esophageal cancer cells to clear the path to its signaling: Making the ""enemy"" a friend. | TNF upregulates peptidoglycan recognition protein 1 in esophageal cancer cells to clear the path to its signaling: Making the "enemy" a friend.
Cui X, Chang Z, Dang T, Meng J, Wang P, Wu J, Chai J. | 04/30/2022 |
| Circulating PGLYRP1 Levels as a Potential Biomarker for Coronary Artery Disease and Heart Failure. | Circulating PGLYRP1 Levels as a Potential Biomarker for Coronary Artery Disease and Heart Failure.
Han Y, Hua S, Chen Y, Yang W, Zhao W, Huang F, Qiu Z, Yang C, Jiang J, Su X, Yang K, Jin W. | 12/11/2021 |
| Cytokines TNFalpha, IFNgamma and IL-2 Are Responsible for Signal Transmission from the Innate Immunity Protein Tag7 (PGLYRP1) to Cytotoxic Effector Lymphocytes. | Cytokines TNFα, IFNγ and IL-2 Are Responsible for Signal Transmission from the Innate Immunity Protein Tag7 (PGLYRP1) to Cytotoxic Effector Lymphocytes.
Sharapova TN, Romanova EA, Ivanova OK, Sashchenko LP, Yashin DV., Free PMC Article | 07/10/2021 |
| Inhibition of Chlamydial Infection by CRISPR/Cas9-SAM Mediated Enhancement of Human Peptidoglycan Recognition Proteins Gene Expression in HeLa Cells. | Inhibition of Chlamydial Infection by CRISPR/Cas9-SAM Mediated Enhancement of Human Peptidoglycan Recognition Proteins Gene Expression in HeLa Cells.
Bobrovsky PA, Moroz VD, Lavrenova VN, Manuvera VA, Lazarev VN. | 07/10/2021 |
| A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis. | A human secretome library screen reveals a role for Peptidoglycan Recognition Protein 1 in Lyme borreliosis.
Gupta A, Arora G, Rosen CE, Kloos Z, Cao Y, Cerny J, Sajid A, Hoornstra D, Golovchenko M, Rudenko N, Munderloh U, Hovius JW, Booth CJ, Jacobs-Wagner C, Palm NW, Ring AM, Fikrig E., Free PMC Article | 02/13/2021 |
| Regulation of Salivary Peptidoglycan Recognition Protein 1 in Adolescents. | Regulation of Salivary Peptidoglycan Recognition Protein 1 in Adolescents.
Raivisto T, Heikkinen AM, Silbereisen A, Kovanen L, Ruokonen H, Tervahartiala T, Haukka J, Sorsa T, Bostanci N. | 01/16/2021 |
| The modulation of the TREM-1/PGLYRP1/MMP-8 axis in peri-implant diseases. | The modulation of the TREM-1/PGLYRP1/MMP-8 axis in peri-implant diseases.
Teixeira MKS, Lira-Junior R, Lourenço EJV, Telles DM, Boström EA, Figueredo CM, Bostanci N. | 08/22/2020 |
| Smoking might have a suppressive effect on GCF PGRP-1 levels in chronic periodontitis (CP). Initial periodontal therapy is effective in decreasing GCF PGRP-1 levels in both smokers and non-smokers with CP. | The effect of smoking on gingival crevicular fluid peptidoglycan recognition protein-1 level following initial periodontal therapy in chronic periodontitis.
Karsiyaka Hendek M, Kisa U, Olgun E. | 01/25/2020 |
| High PGLYRP1 expression is associated with rheumatoid arthritis. | Serum PGLYRP‑1 is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis.
Luo Q, Li X, Zhang L, Yao F, Deng Z, Qing C, Su R, Xu J, Guo Y, Huang Z, Li J. | 06/1/2019 |
| It was found that the incubation of lymphocytes with Tag7 for 3 days promotes the appearance of cytotoxic NK cells that are active against a number of tumor cell lines. | Innate Immune Protein Tag7 Stimulates the Appearance of Cytotoxic NK Cells after Incubation with Lymphocytes.
Sharapova TN, Romanova EA, Sashchenko LP, Gnuchev NV, Yashin DV. | 05/4/2019 |
| this study shows that Tag7 can induce the CD3+CD4+CD25+CD127+ cells with antitumor activity | Tag7 (PGLYRP1) Can Induce an Emergence of the CD3+CD4+CD25+CD127+ Cells with Antitumor Activity.
Sharapova TN, Romanova EA, Sashchenko LP, Yashin DV., Free PMC Article | 10/13/2018 |
| the results of this study provide evidence for a novel role of the Tag7 protein in the immune response | Innate Immunity Protein Tag7 Induces 3 Distinct Populations of Cytotoxic Cells That Use Different Mechanisms to Exhibit Their Antitumor Activity on Human Leukocyte Antigen-Deficient Cancer Cells.
Sharapova TN, Ivanova OK, Soshnikova NV, Romanova EA, Sashchenko LP, Yashin DV. | 07/28/2018 |
| Tag7 activates lymphocytes capable of Fasl-Fas-dependent contact killing of virus-infected cells. | Innate immunity protein Tag7 (PGRP-S) activates lymphocytes capable of Fasl-Fas-dependent contact killing of virus-infected cells.
Sharapova TN, Ivanova OK, Prasolov VS, Romanova EA, Sashchenko LP, Yashin DV. | 07/7/2018 |
| The interaction of Fas receptor with FasL leads to an activation of the Tag7-Hsp70 complex in the lymphocyte membrane fraction, and here FasL acts as a receptor that induces intracellular signaling in lymphocytes.An interaction of the MicA stress ligand with the NKG2D receptor is necessary for the release of this cytotoxic complex | FasL and the NKG2D receptor are required for the secretion of the Tag7/PGRP-S-Hsp70 complex by the cytotoxic CD8(+) lymphocytes.
Sashchenko LP, Romanova EA, Ivanova OK, Sharapova TN, Yashin DV. | 09/2/2017 |
| interaction of Tag7-Hsp70 with the TNFR1 receptor triggered a certain sequence of events: at first, it activated RIP1 kinase, and later on, increased intracellular concentration of capital ES, Cyrillicsmall a, Cyrillic(2+) ions and an activation of calpains, which led to the permeabilization of the lysosomal membranes | The Tag7-Hsp70 cytotoxic complex induces tumor cell necroptosis via permeabilisation of lysosomes and mitochondria.
Yashin DV, Romanova EA, Ivanova OK, Sashchenko LP. | 12/17/2016 |
| Tag7-Mts1 complex causes chemotactic migration of lymphocytes, with NK cells being a preferred target. | A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1.
Dukhanina EA, Lukyanova TI, Romanova EA, Guerriero V, Gnuchev NV, Georgiev GP, Yashin DV, Sashchenko LP., Free PMC Article | 09/17/2016 |
| Tag7, can bind to the TNFR1 receptor, thereby inhibiting the cytotoxic actions of the Tag7-Hsp70 complex and TNF-alpha, an acquired immunity cytokine. | Tag7 (PGLYRP1) in Complex with Hsp70 Induces Alternative Cytotoxic Processes in Tumor Cells via TNFR1 Receptor.
Yashin DV, Ivanova OK, Soshnikova NV, Sheludchenkov AA, Romanova EA, Dukhanina EA, Tonevitsky AG, Gnuchev NV, Gabibov AG, Georgiev GP, Sashchenko LP., Free PMC Article | 11/21/2015 |
| The role for PGLYRP1 as a TREM-1 activator provides a new mechanism by which bacteria can trigger myeloid cells, linking two known, but previously unrelated, pathways in innate immunity. | Cutting Edge: identification of neutrophil PGLYRP1 as a ligand for TREM-1.
Read CB, Kuijper JL, Hjorth SA, Heipel MD, Tang X, Fleetwood AJ, Dantzler JL, Grell SN, Kastrup J, Wang C, Brandt CS, Hansen AJ, Wagtmann NR, Xu W, Stennicke VW., Free PMC Article | 04/25/2015 |
| The association study in a discovery sample of 200 French trio families revealed a significant association with rheumatoid arthritis for one SNP, PGLYRP1-rs2041992 (p = 0.019). | Relationship between SNPs and expression level for candidate genes in rheumatoid arthritis.
Fodil M, Teixeira VH, Chaudru V, Hilliquin P, Bombardieri S, Balsa A, Westhovens R, Barrera P, Alves H, Migliorin P, Bardin T, Cornelis F, Boudjema A, Petit-Teixeira E. | 03/21/2015 |
| shown that HspBP1 binds Tag7 in the conditioned medium of tumor CSML0 cells, thereby preventing formation of the cytotoxic Tag7-Hsp70 complex | Extracellular HspBP1 inhibits formation of a cytotoxic Tag7-Hsp70 complex in vitro and in human serum.
Yashin DV, Dukhanina EA, Kabanova OD, Romanova EA, Lukyanova TI, Tonevitskii AG, Belogurov AA, Raynes DA, Sheludchenkov AA, Gnuchev NV, Guerriero V, Georgiev GP, Sashchenko LP. | 04/21/2012 |
| The PGRP-S promoter provides a useful reporter of M cell mucosal epithelium lineage commitment, corresponding to the expression of PGRP in M cells. | Convergent and divergent development among M cell lineages in mouse mucosal epithelium.
Wang J, Gusti V, Saraswati A, Lo DD., Free PMC Article | 01/14/2012 |