| Huntingtin-associated protein 1 is a potential tumor suppressor for gastric cancer. | Huntingtin-associated protein 1 is a potential tumor suppressor for gastric cancer.
Qu YM, Chen A, Zhao X, Wang Z, Guo D, Shao SL, Tao YY, Li QJ, Wang MY, Ma WS. | 02/11/2023 |
| Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains. | Differential expression and roles of Huntingtin and Huntingtin-associated protein 1 in the mouse and primate brains.
Chen X, Sun Y, Chen L, Chen XS, Pan M, Zhang Y, Wang Q, Yang W, Yin P, He D, Guo X, Yang S, Zeng Y, Yan S, Li XJ, Li S. | 10/22/2022 |
| Efficient and crucial quality control of HAP1 cell ploidy status. | Efficient and crucial quality control of HAP1 cell ploidy status.
Beigl TB, Kjosås I, Seljeseth E, Glomnes N, Aksnes H., Free PMC Article | 10/16/2021 |
| Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway. | Sequential dynein effectors regulate axonal autophagosome motility in a maturation-dependent pathway.
Cason SE, Carman PJ, Van Duyne C, Goldsmith J, Dominguez R, Holzbaur ELF., Free PMC Article | 10/9/2021 |
| The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C. | The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C.
Twelvetrees AE, Lesept F, Holzbaur ELF, Kittler JT., Free PMC Article | 07/25/2020 |
| Acute lymphoblastic leukemia patient leukemic cells with reduced HAP1 levels exhibit resistance to l-asparaginase. | HAP1 loss confers l-asparaginase resistance in ALL by downregulating the calpain-1-Bid-caspase-3/12 pathway.
Lee JK, Kang S, Wang X, Rosales JL, Gao X, Byun HG, Jin Y, Fu S, Wang J, Lee KY., Free PMC Article | 01/18/2020 |
| HAP1 is differentially expressed in the human gastrointestinal tract and is down-regulated in pancreatic adenocarcinoma. | Expression and Localization of Huntingtin-Associated Protein 1 (HAP1) in the Human Digestive System.
Li T, Li S, Gao X, Cai Q, Li XJ., Free PMC Article | 11/23/2019 |
| HAP1 is expressed in endocrine cells of the human gut. | Huntingtin-associated protein 1: Eutherian adaptation from a TRAK-like protein, conserved gene promoter elements, and localization in the human intestine.
Lumsden AL, Young RL, Pezos N, Keating DJ., Free PMC Article | 08/12/2017 |
| data fully support that HAP1 is a GKAP, anchoring specifically to the cGMP-dependent protein kinase isoform Ibeta, and provide further evidence that also PKG spatiotemporal signaling is largely controlled by anchoring proteins | Huntingtin-associated protein 1 (HAP1) is a cGMP-dependent kinase anchoring protein (GKAP) specific for the cGMP-dependent protein kinase Iβ isoform.
Corradini E, Burgers PP, Plank M, Heck AJ, Scholten A., Free PMC Article | 07/4/2015 |
| The -141 T > G polymorphism, but not the 1349 T > G polymorphism, may have protective effects for lung cancer. | Evaluating the association of polymorphisms in the HAP1 gene with lung cancer risk: a meta-analysis.
Wang W, Yan H, Zhang Q, Song W, Li H, Xu J. | 04/18/2015 |
| HAP1 gene expression is related to the radiosensitivity of breast cancer cells and may play an important role in the regulation of cellular radiosensitivity | HAP1 gene expression is associated with radiosensitivity in breast cancer cells.
Wu J, Zhang JY, Yin L, Wu JZ, Guo WJ, Wu JF, Chen M, Xia YY, Tang JH, Ma YC, He X. | 03/21/2015 |
| Overexpression of HAP1 reduced in vitro cell growth in breast cancer cell lines. | Huntingtin-associated protein 1: a potential biomarker of breast cancer.
Zhu L, Song X, Tang J, Wu J, Ma R, Cao H, Ji M, Jing C, Wang Z. | 03/8/2014 |
| The results of this study found no association was found between the HAP1 T441M polymorphism and the age at onset of Huntington's disease . | Age at onset in Huntington's disease: replication study on the association of HAP1.
Karadima G, Dimovasili C, Koutsis G, Vassilopoulos D, Panas M. | 05/4/2013 |
| The results of this study suggested that HAP1 co-localizes and associates with APP in physiological conditions of mouse and human brain. | Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons.
Yang GZ, Yang M, Lim Y, Lu JJ, Wang TH, Qi JG, Zhong JH, Zhou XF. | 11/3/2012 |
| WT HTT regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1). | Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.
Keryer G, Pineda JR, Liot G, Kim J, Dietrich P, Benstaali C, Smith K, Cordelières FP, Spassky N, Ferrante RJ, Dragatsis I, Saudou F., Free PMC Article | 01/7/2012 |
| HAP1/stigmoid body interacts with the normal ataxin-3 through Josephin domain | Interaction of ataxin-3 with huntingtin-associated protein 1 through Josephin domain.
Takeshita Y, Fujinaga R, Kokubu K, Islam MN, Jahan MR, Yanai A, Kakizuka A, Shinoda K. | 10/8/2011 |
| sortilin stabilizes the proBDNF.HAP1 complex | Precursor of brain-derived neurotrophic factor (proBDNF) forms a complex with Huntingtin-associated protein-1 (HAP1) and sortilin that modulates proBDNF trafficking, degradation, and processing.
Yang M, Lim Y, Li X, Zhong JH, Zhou XF., Free PMC Article | 07/2/2011 |
| ADORA2A, but not HAP1 or OGG1, may have a role in age at onset in Huntington's disease | Age at onset in Huntington's disease: replication study on the associations of ADORA2A, HAP1 and OGG1.
Taherzadeh-Fard E, Saft C, Wieczorek S, Epplen JT, Arning L, Taherzadeh-Fard E, Saft C, Wieczorek S, Epplen JT, Arning L. | 01/22/2011 |
| REVIEW: function of HAP1 | Huntingtin associated protein 1 and its functions.
Wu LL, Zhou XF., Free PMC Article | 09/13/2010 |
| HAP1 may participate in axonal transport and activity-dependent release of pro-BDNF by interacting with the BDNF prodomain. | Huntingtin-associated protein-1 interacts with pro-brain-derived neurotrophic factor and mediates its transport and release.
Wu LL, Fan Y, Li S, Li XJ, Zhou XF., Free PMC Article | 03/15/2010 |
| REST/NRSF, dynactin p150(Glued), huntingtin, HAP1, and RILP form a complex involved in the translocation of REST/NRSF into the nucleus and HAP1 controls REST/NRSF cellular localization in neurons | Huntingtin regulates RE1-silencing transcription factor/neuron-restrictive silencer factor (REST/NRSF) nuclear trafficking indirectly through a complex with REST/NRSF-interacting LIM domain protein (RILP) and dynactin p150 Glued.
Shimojo M., Free PMC Article | 01/21/2010 |
| Study provides genetic and functional evidence that the M441-HAP1 polymorphism modifies the age-at-onset of Huntington's disease . | Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease.
Metzger S, Rong J, Nguyen HP, Cape A, Tomiuk J, Soehn AS, Propping P, Freudenberg-Hua Y, Freudenberg J, Tong L, Li SH, Li XJ, Riess O, Metzger S, Rong J, Nguyen HP, Cape A, Tomiuk J, Soehn AS, Propping P, Freudenberg-Hua Y, Freudenberg J, Tong L, Li SH, Li XJ, Riess O. | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesAge at onset in Huntington's disease: replication study on the associations of ADORA2A, HAP1 and OGG1.
Taherzadeh-Fard E, Saft C, Wieczorek S, Epplen JT, Arning L, Taherzadeh-Fard E, Saft C, Wieczorek S, Epplen JT, Arning L. Huntingtin-associated protein-1 is a modifier of the age-at-onset of Huntington's disease.
Metzger S, Rong J, Nguyen HP, Cape A, Tomiuk J, Soehn AS, Propping P, Freudenberg-Hua Y, Freudenberg J, Tong L, Li SH, Li XJ, Riess O, Metzger S, Rong J, Nguyen HP, Cape A, Tomiuk J, Soehn AS, Propping P, Freudenberg-Hua Y, Freudenberg J, Tong L, Li SH, Li XJ, Riess O. A polymorphism in the protease-like domain of apolipoprotein(a) is associated with severe coronary artery disease.
Luke MM, Kane JP, Liu DM, Rowland CM, Shiffman D, Cassano J, Catanese JJ, Pullinger CR, Leong DU, Arellano AR, Tong CH, Movsesyan I, Naya-Vigne J, Noordhof C, Feric NT, Malloy MJ, Topol EJ, Koschinsky ML, Devlin JJ, Ellis SG. | 03/13/2008 |
| The combination of siRNA, the SB transposon, and an accurate transgenic mouse model may permit evaluation of this approach in preventing the pathogenesis associated with expression of mutant Htt. | Sleeping Beauty-mediated down-regulation of huntingtin expression by RNA interference.
Chen ZJ, Kren BT, Wong PY, Low WC, Steer CJ. | 01/21/2010 |