| Hypoxia-induced ALKBH5 aggravates synovial aggression and inflammation in rheumatoid arthritis by regulating the m6A modification of CH25H. | Hypoxia-induced ALKBH5 aggravates synovial aggression and inflammation in rheumatoid arthritis by regulating the m6A modification of CH25H.
Fan D, Geng Q, Wang B, Wang X, Xia Y, Yang L, Zhang Q, Deng T, Xu Y, Zhao H, Liu B, Lu C, Gu X, Xiao C. | 03/18/2024 |
| Expression Pattern of Cholesterol 25-Hydroxylase and Serum Level of 25-Hydroxycholesterol and Relevant Inflammatory Cytokines in Patients with Varying Disease Severity of COVID-19. | Expression Pattern of Cholesterol 25-Hydroxylase and Serum Level of 25-Hydroxycholesterol and Relevant Inflammatory Cytokines in Patients with Varying Disease Severity of COVID-19.
Roozbehani M, Razizadeh MH, Keyvani H, Nejati F, Soleymani S, Mousavizadeh L. | 11/18/2023 |
| Research progress on the mechanism of cholesterol-25-hydroxylase in intestinal immunity. | Research progress on the mechanism of cholesterol-25-hydroxylase in intestinal immunity.
Zhong G, He C, Wang S, Lin C, Li M., Free PMC Article | 09/28/2023 |
| The role of cholesterol 25-hydroxylase in viral infections: Mechanisms and implications. | The role of cholesterol 25-hydroxylase in viral infections: Mechanisms and implications.
Yousefi P, Gholami A, Mehrjo M, Razizadeh MH, Akhavan M, Karampoor S, Tabibzadeh A. | 09/28/2023 |
| Involvement of CCL2 and CH25H Genes and TNF signaling pathways in mast cell activation and pathogenesis of chronic spontaneous urticaria. | Involvement of CCL2 and CH25H Genes and TNF signaling pathways in mast cell activation and pathogenesis of chronic spontaneous urticaria.
Fang X, Weng Y, Zheng X., Free PMC Article | 09/6/2023 |
| Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells. | Tumor-Suppressive and Immune-Stimulating Roles of Cholesterol 25-hydroxylase in Pancreatic Cancer Cells.
McBrearty N, Cho C, Chen J, Zahedi F, Peck AR, Radaelli E, Assenmacher CA, Pavlak C, Devine A, Yu P, Lu Z, Zhang H, Li J, Pitarresi JR, Astsaturov I, Cukierman E, Rustgi AK, Stanger BZ, Rui H, Fuchs SY., Free PMC Article | 03/6/2023 |
| Cholesterol 25-hydroxylase expression following immune activation in response to SARS-CoV-2 infection. | Cholesterol 25-hydroxylase expression following immune activation in response to SARS-CoV-2 infection.
Davidson J, Rotondo D. | 07/17/2021 |
| Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes. | Cholesterol 25-hydroxylase (CH25H) as a promoter of adipose tissue inflammation in obesity and diabetes.
Russo L, Muir L, Geletka L, Delproposto J, Baker N, Flesher C, O'Rourke R, Lumeng CN., Free PMC Article | 07/10/2021 |
| we observed that cAMP-dependent transcription factor (ATF3) weakly binds to the CH25H promoter, suggesting cooperation with STAT1. However, ZIKV-induced CH25H was independent of type I interferon. These findings provide important information for understanding how the Zika virus induces innate inflammatory responses and promotes the expression of anti-viral CH25H protein. | IL-1β/TNF-α/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in Zika virus-infected human macrophages.
Magoro T, Dandekar A, Jennelle LT, Bajaj R, Lipkowitz G, Angelucci AR, Bessong PO, Hahn YS., Free PMC Article | 05/9/2020 |
| Overexpression of both human and murine CH25H inhibited rabies virus (RABV) infection in HEK-293T cells. | Cholesterol 25-hydroxylase suppresses rabies virus infection by inhibiting viral entry.
Yuan Y, Wang Z, Tian B, Zhou M, Fu ZF, Zhao L. | 11/30/2019 |
| Limited analysis of leukocytes from melanoma patients is suggestive of an association between the loss of CH25H and poor disease outcome. CH25H acts to restrict tumor-derived extracellular vesicles uptake and limit the education of healthy cells to promote metastases. | An Interferon-Driven Oxysterol-Based Defense against Tumor-Derived Extracellular Vesicles.
Ortiz A, Gui J, Zahedi F, Yu P, Cho C, Bhattacharya S, Carbone CJ, Yu Q, Katlinski KV, Katlinskaya YV, Handa S, Haas V, Volk SW, Brice AK, Wals K, Matheson NJ, Antrobus R, Ludwig S, Whiteside TL, Sander C, Tarhini AA, Kirkwood JM, Lehner PJ, Guo W, Rui H, Minn AJ, Koumenis C, Diehl JA, Fuchs SY., Free PMC Article | 10/19/2019 |
| The CH25H rs13500 polymorphism is associated with an increased Alzheimer's disease (AD) risk in the Turkish population and co-occurrence of CH25H 'T' and APOE epsilon4 alleles is a strong risk factor for AD. Based on our overall results, it can be concluded that CH25H might have a role in the pathogenesis of AD together with, and independently from APOE | Association between selected cholesterol-related gene polymorphisms and Alzheimer's disease in a Turkish cohort.
Guven G, Vurgun E, Bilgic B, Hanagasi H, Gurvit H, Ozer E, Lohmann E, Erginel-Unaltuna N. | 09/14/2019 |
| We examined whether 25HC restricts infection by mammalian reovirus. Results suggest that 25HC inhibits the efficiency of cellular entry of reovirus virions, which may require specific endosomal membrane dynamics for efficient membrane penetration. | 25-Hydroxycholesterol Production by the Cholesterol-25-Hydroxylase Interferon-Stimulated Gene Restricts Mammalian Reovirus Infection.
Doms A, Sanabria T, Hansen JN, Altan-Bonnet N, Holm GH., Free PMC Article | 09/15/2018 |
| We detected Cholesterol 25-hydroxylase, the enzyme responsible for 25-HC production, in human spermatozoa at the level of the neck and the post acrosomal area. Upon incubation with spermatozoa, 25-HC induced calcium and cholesterol transients in connection with the acrosomal reaction. | Mass spectrometry profiling of oxysterols in human sperm identifies 25-hydroxycholesterol as a marker of sperm function.
Zerbinati C, Caponecchia L, Puca R, Ciacciarelli M, Salacone P, Sebastianelli A, Pastore A, Palleschi G, Petrozza V, Porta N, Rago R, Carbone A, Iuliano L., Free PMC Article | 12/2/2017 |
| Exome analysis in 212 multiple sclerosis and 14 neuromyelitis optica patients identified a rare CH25H p.Q17H mutation in two NMO patients of Asian ancestry. In addition, association analysis of common CH25H variants. | Analysis of CH25H in multiple sclerosis and neuromyelitis optica.
Forwell AL, Bernales CQ, Ross JP, Yee IM, Encarnacion M, Lee JD, Sadovnick AD, Traboulsee AL, Vilariño-Güell C., Free PMC Article | 06/28/2016 |
| Infection with HCV causes up-regulation of interferon-inducible CH25H in vivo. | Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation.
Anggakusuma, Romero-Brey I, Berger C, Colpitts CC, Boldanova T, Engelmann M, Todt D, Perin PM, Behrendt P, Vondran FW, Xu S, Goffinet C, Schang LM, Heim MH, Bartenschlager R, Pietschmann T, Steinmann E. | 11/28/2015 |
| These results demonstrate that CH25H constitutes a primary innate response against hepatitis C virus infection through regulating host lipid metabolism. | Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection.
Xiang Y, Tang JJ, Tao W, Cao X, Song BL, Zhong J., Free PMC Article | 08/29/2015 |
| Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons. | Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons.
Park K, Scott AL., Free PMC Article | 01/8/2011 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.
Corneveaux JJ, Myers AJ, Allen AN, Pruzin JJ, Ramirez M, Engel A, Nalls MA, Chen K, Lee W, Chewning K, Villa SE, Meechoovet HB, Gerber JD, Frost D, Benson HL, O'Reilly S, Chibnik LB, Shulman JM, Singleton AB, Craig DW, Van Keuren-Jensen KR, Dunckley T, Bennett DA, De Jager PL, Heward C, Hardy J, Reiman EM, Huentelman MJ., Free PMC Article | 09/15/2010 |
| Meta-analysis of gene-disease association. (HuGE Navigator) | Assessment of Alzheimer's disease case-control associations using family-based methods.
Schjeide BM, McQueen MB, Mullin K, DiVito J, Hogan MF, Parkinson M, Hooli B, Lange C, Blacker D, Tanzi RE, Bertram L., Free PMC Article | 10/19/2008 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease.
Shibata N, Kawarai T, Lee JH, Lee HS, Shibata E, Sato C, Liang Y, Duara R, Mayeux RP, St George-Hyslop PH, Rogaeva E, Shibata N, Kawarai T, Lee JH, Lee HS, Shibata E, Sato C, Liang Y, Duara R, Mayeux RP, St George-Hyslop PH, Rogaeva E. | 03/13/2008 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (7) articlesIntermediate phenotypes identify divergent pathways to Alzheimer's disease.
Shulman JM, Chibnik LB, Aubin C, Schneider JA, Bennett DA, De Jager PL. Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease.
Thal DR, Papassotiropoulos A, Saido TC, Griffin WS, Mrak RE, Kölsch H, Del Tredici K, Attems J, Ghebremedhin E. Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study.
Laumet G, Chouraki V, Grenier-Boley B, Legry V, Heath S, Zelenika D, Fievet N, Hannequin D, Delepine M, Pasquier F, Hanon O, Brice A, Epelbaum J, Berr C, Dartigues JF, Tzourio C, Campion D, Lathrop M, Bertram L, Amouyel P, Lambert JC. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease.
Morgan AR, Turic D, Jehu L, Hamilton G, Hollingworth P, Moskvina V, Jones L, Lovestone S, Brayne C, Rubinsztein DC, Lawlor B, Gill M, O'Donovan MC, Owen MJ, Williams J. Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease.
Papassotiropoulos A, Lambert JC, Wavrant-De Vrièze F, Wollmer MA, von der Kammer H, Streffer JR, Maddalena A, Huynh KD, Wolleb S, Lutjohann D, Schneider B, Thal DR, Grimaldi LM, Tsolaki M, Kapaki E, Ravid R, Konietzko U, Hegi T, Pasch T, Jung H, Braak H, Amouyel P, Rogaev EI, Hardy J, Hock C, Nitsch RM. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, Hollingworth P, Jehu L, Foy C, Archer N, Hamilton G, Holmans P, Morris CM, Catanese J, Sninsky J, White TJ, Powell J, Hardy J, O'Donovan M, Lovestone S, Jones L, Morris JC, Thal L, Owen M, Williams J, Goate A. Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease.
Riemenschneider M, Mahmoodzadeh S, Eisele T, Klopp N, Schwarz S, Wagenpfeil S, Diehl J, Mueller U, Foerstl H, Illig T, Kurz A. | 03/13/2008 |
| Based on the results of genome-wide screens, along with biological studies, we selected three genes as candidates for AD risk factors: ATP-binding cassette transporter A1 (ABCA1), cholesterol 25-hydroxylase (CH25H) and cholesterol 24-hydroxylase (CH24H). | Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease.
Shibata N, Kawarai T, Lee JH, Lee HS, Shibata E, Sato C, Liang Y, Duara R, Mayeux RP, St George-Hyslop PH, Rogaeva E, Shibata N, Kawarai T, Lee JH, Lee HS, Shibata E, Sato C, Liang Y, Duara R, Mayeux RP, St George-Hyslop PH, Rogaeva E. | 01/21/2010 |