| These studies reveal an unexpected role of the axon guidance receptor UNC5A in fine-tuning ERalpha and EGFR signaling and the luminal progenitor status of hormone-sensitive breast cancers. Furthermore, UNC5A knockdown cells provide an ideal model system to investigate metastasis of ERalpha(+) breast cancers | Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis.
Padua MB, Bhat-Nakshatri P, Anjanappa M, Prasad MS, Hao Y, Rao X, Liu S, Wan J, Liu Y, McElyea K, Jacobsen M, Sandusky G, Althouse S, Perkins S, Nakshatri H., Free PMC Article | 05/11/2019 |
| The results suggest that netrin-1 promotes glioma cell proliferation by activating NF-kappaB signaling via UNC5A. | Netrin-1 promotes glioma growth by activating NF-κB via UNC5A.
Chen JY, He XX, Ma C, Wu XM, Wan XL, Xing ZK, Pei QQ, Dong XP, Liu DX, Xiong WC, Zhu XJ., Free PMC Article | 01/19/2019 |
| Such data indicate that cooperation between the UPR and UNC5A depletion as previously observed by ourselves in HCC patients samples may foster liver cancer development and growth. | Hepatocellular carcinoma-associated depletion of the netrin-1 receptor Uncoordinated Phenotype-5A (UNC5A) skews the hepatic unfolded protein response towards prosurvival outcomes.
Barnault R, Lahlali T, Plissonnier ML, Romero-López C, Laverdure N, Ducarouge B, Rivoire M, Mehlen P, Zoulim F, Parent R. | 02/24/2018 |
| UNC5A is capable of impeding autophagy and promoting HCV restriction through specific impact on virion infectivity, in a cell death-independent and DAPK-related manner. | Reciprocal antagonism between the netrin-1 receptor uncoordinated-phenotype-5A (UNC5A) and the hepatitis C virus.
Plissonnier ML, Lahlali T, Raab M, Michelet M, Romero-López C, Rivoire M, Strebhardt K, Durantel D, Levrero M, Mehlen P, Zoulim F, Parent R. | 12/9/2017 |
| FANCC interferes with UNC5A's functions in apoptosis and suggest that FANCC may participate in developmental processes through association with the dependence receptor UNC5A. | The Fanconi anemia group C protein interacts with uncoordinated 5A and delays apoptosis.
Huang F, Ben Aissa M, Magron A, Huard CC, Godin C, Lévesque G, Carreau M., Free PMC Article | 12/26/2015 |
| these data suggest an important role for UNC5A, a candidate tumor suppressor, in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer | DNA damage-inducible gene, UNC5A, functions as a tumor-suppressor in bladder cancer.
Zhu Y, Yu M, Chen Y, Wang Y, Wang J, Yang C, Bi J. | 10/11/2014 |
| UNC5A is a novel transcriptional target of p53 and plays a role in p53-dependent apoptosis | Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis.
Miyamoto Y, Futamura M, Kitamura N, Nakamura Y, Baba H, Arakawa H. | 11/27/2010 |
| Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article | 09/15/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| may represent tumor suppressor that inhibit tumor extension outside the region of netrin-1 availability by inducing apoptosis | The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.
Thiebault K, Mazelin L, Pays L, Llambi F, Joly MO, Scoazec JY, Saurin JC, Romeo G, Mehlen P., Free PMC Article | 01/21/2010 |
| UNC5 orthologues define a new mechanism for both the positive (induction) and negative (suppression) regulation of apoptosis in cancer cells (review) | Netrin-1 and its receptors in tumorigenesis.
Arakawa H. | 01/21/2010 |