| TM4SF5-mediated liver malignancy involves NK cell exhaustion-like phenotypes. | TM4SF5-mediated liver malignancy involves NK cell exhaustion-like phenotypes.
Sun H, Kim E, Ryu J, Lee H, Shin EA, Lee M, Lee H, Lee JH, Yoon JH, Song DG, Kim S, Lee JW., Free PMC Article | 01/22/2022 |
| TM4SF5 Knockout Protects Mice From Diet-Induced Obesity Partly by Regulating Autophagy in Adipose Tissue. | TM4SF5 Knockout Protects Mice From Diet-Induced Obesity Partly by Regulating Autophagy in Adipose Tissue.
Choi C, Son Y, Kim J, Cho YK, Saha A, Kim M, Im H, Kim K, Han J, Lee JW, Seong JK, Lee YH., Free PMC Article | 11/13/2021 |
| Tetraspanin TM4SF5 in hepatocytes negatively modulates SLC27A transporters during acute fatty acid supply. | Tetraspanin TM4SF5 in hepatocytes negatively modulates SLC27A transporters during acute fatty acid supply.
Park D, Kim E, Lee H, Shin EA, Lee H, Lee JW. | 09/25/2021 |
| N-terminus-independent activation of c-Src via binding to a tetraspan(in) TM4SF5 in hepatocellular carcinoma is abolished by the TM4SF5 C-terminal peptide application. | N-terminus-independent activation of c-Src via binding to a tetraspan(in) TM4SF5 in hepatocellular carcinoma is abolished by the TM4SF5 C-terminal peptide application.
Song HE, Lee Y, Kim E, Cho CY, Jung O, Lee D, Lee EG, Nam SH, Kang M, Macalino SJY, Kim JE, Jung JW, Kwon SW, Choi S, Lee JW., Free PMC Article | 08/21/2021 |
| SLAC2B-dependent microtubule acetylation regulates extracellular matrix-mediated intracellular TM4SF5 traffic to the plasma membranes. | SLAC2B-dependent microtubule acetylation regulates extracellular matrix-mediated intracellular TM4SF5 traffic to the plasma membranes.
Kim HJ, Kim E, Lee H, Jung JW, Kim JE, Pack CG, Lee JW. | 07/31/2021 |
| TM4SF5-mediated CD44v8-10 splicing variant promotes survival of type II alveolar epithelial cells during idiopathic pulmonary fibrosis. | TM4SF5-mediated CD44v8-10 splicing variant promotes survival of type II alveolar epithelial cells during idiopathic pulmonary fibrosis.
Kim JE, Kim HJ, Jung JW, Song DG, Park D, Lee H, Um H, Park J, Nam SH, Cho M, Lee JW., Free PMC Article | 09/12/2020 |
| Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling. | Transmembrane 4 L Six Family Member 5 Senses Arginine for mTORC1 Signaling.
Jung JW, Macalino SJY, Cui M, Kim JE, Kim HJ, Song DG, Nam SH, Kim S, Choi S, Lee JW. | 08/15/2020 |
| Data show that protein tyrosine phosphatase receptor type F (PTPRF) activity suppressed CD133/transmembrane 4L six family member 5 (TM4SF5)-mediated sphere growth. | CD133-induced TM4SF5 expression promotes sphere growth via recruitment and blocking of protein tyrosine phosphatase receptor type F (PTPRF).
Kim S, Cho CY, Lee D, Song DG, Kim HJ, Jung JW, Kim JE, Park D, Lee H, Um H, Park J, Choi Y, Kim Y, Nam SH, Lee JW. | 10/5/2019 |
| These results suggest that our novel antibody can be used to detect endogenous and recombinant TM4SF5, and that TM4SF5 may be a possible marker for the poor prognosis of patients with colorectal cancer | Production of an anti-TM4SF5 monoclonal antibody and its application in the detection of TM4SF5 as a possible marker of a poor prognosis in colorectal cancer.
Park BK, Park JY, Kim TH, Kim D, Wu G, Gautam A, Maharjan S, Lee SI, Lee Y, Kwon HJ, Choi KC. | 10/6/2018 |
| The review discusses the antifibrotic strategies that target TM4SF5 and its associated protein networks that regulate the intracellular signaling necessary for fibrotic functions of hepatocytes. | TM4SF5-Mediated Roles in the Development of Fibrotic Phenotypes.
Ryu J, Lee JW., Free PMC Article | 03/10/2018 |
| Replacement of the transmembrane 4 L six family protein TM4SF1 or TM4SF4 C-terminus with that of TM4SF5 increased spheroids growth, transwell migration, and invasive dissemination from spheroids in 3D collagen gels. | Differential regulation of cellular functions by the C-termini of transmembrane 4 L six family proteins in 2- or 3-dimensional environment.
Cheong JG, Song DG, Song HE, Berditchevski F, Nam SH, Jung JW, Kim HJ, Kim JE, Kim S, Ryu J, Cho CY, Lee KM, Lee JW., Free PMC Article | 08/19/2017 |
| TM4SF5-miR-4697-3P- CTD-2354A18.1 may play a key role in the pathogenesis of gastric cancer | TM4SF5-CTD-2354A18.1-miR-4697-3P may play a key role in the pathogenesis of gastric cancer.
Li DF, Yang MF, Shi SL, Du YL, Wang H, Zhou YL, Luo YL, Ren LL, Nie YQ. | 01/16/2016 |
| TM4SF5-positive tumors exhibited locally-increased CD44 expression, suggesting tumor cell differentiation | Self-renewal and circulating capacities of metastatic hepatocarcinoma cells required for collaboration between TM4SF5 and CD44.
Lee D, Lee JW., Free PMC Article | 12/26/2015 |
| TM4SF5 interacted with CD151, and caused the internalization of CD63 from the cell surface. | Correlations between transmembrane 4 L6 family member 5 (TM4SF5), CD151, and CD63 in liver fibrotic phenotypes and hepatic migration and invasive capacities.
Kang M, Ryu J, Lee D, Lee MS, Kim HJ, Nam SH, Song HE, Choi J, Lee GH, Kim TY, Lee H, Kim SJ, Ye SK, Kim S, Lee JW., Free PMC Article | 11/7/2015 |
| promotes self-renewal and circulating tumor cell properties | Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells.
Lee D, Na J, Ryu J, Kim HJ, Nam SH, Kang M, Jung JW, Lee MS, Song HE, Choi J, Lee GH, Kim TY, Chung JK, Park KH, Kim SH, Kim H, Seo H, Kim P, Youn H, Lee JW. | 08/8/2015 |
| TM4SF5-specific monoclonal antibody has a therapeutic effect against colon cancer. | Therapeutic effect of a TM4SF5-specific monoclonal antibody against colon cancer in a mouse model.
Kim YE, Kwon S, Wu G, Kim D, Park BK, Park JA, Choi KC, Kim DS, Kwon HJ, Lee Y., Free PMC Article | 06/27/2015 |
| TM4SF5 expression in SNU761 cells caused invasive extracellular matrix degradation negatively depending on IL-6/IL-6 receptor signaling. | Cross talk between the TM4SF5/focal adhesion kinase and the interleukin-6/STAT3 pathways promotes immune escape of human liver cancer cells.
Ryu J, Kang M, Lee MS, Kim HJ, Nam SH, Song HE, Lee D, Lee JW., Free PMC Article | 10/11/2014 |
| Findings demonstrate that TM4SF5 directly binds to and activates FAK in an adhesion-dependent manner, to regulate cell migration and invasion in hepatocellular carcinoma. | Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells.
Jung O, Choi S, Jang SB, Lee SA, Lim ST, Choi YJ, Kim HJ, Kim DH, Kwak TK, Kim H, Kang M, Lee MS, Park SY, Ryu J, Jeong D, Cheong HK, Kim HJ, Park KH, Lee BJ, Schlaepfer DD, Lee JW., Free PMC Article | 02/1/2014 |
| TM4SF5 is positively associated with esophageal cancer invasiveness | A high level of TM4SF5 is associated with human esophageal cancer progression and poor patient survival.
Wu YB, Huang YS, Xu YP, Sun YF, Yu DL, Zhang XQ, Long X, Zhu SQ, Zhou JL, Xu JJ. | 11/30/2013 |
| results indicate that TGFbeta1- and growth factor-mediated signalling activities mediate TM4SF5 expression leading to acquisition of mesenchymal cell features, suggesting that TM4SF5 induction may be involved in the development of liver pathologies | Cross-talk between TGFβ1 and EGFR signalling pathways induces TM4SF5 expression and epithelial-mesenchymal transition.
Kang M, Choi S, Jeong SJ, Lee SA, Kwak TK, Kim H, Jung O, Lee MS, Ko Y, Ryu J, Choi YJ, Jeong D, Lee HJ, Ye SK, Kim SH, Lee JW. | 06/9/2012 |
| Results indicate that TM4SF5-mediated epithelial-mesenchymal transition may have an important function in the gefitinib resistance of cancer cells. | Gefitinib resistance of cancer cells correlated with TM4SF5-mediated epithelial-mesenchymal transition.
Lee MS, Kim HP, Kim TY, Lee JW. | 05/12/2012 |
| involvement of JNKs in TM4SF5-mediated p27(Kip1) Ser10 phosphorylation and localization during epithelial-mesenchymal transition. | JNK signaling activity regulates cell-cell adhesions via TM4SF5-mediated p27(Kip1) phosphorylation.
Kim H, Jung O, Kang M, Lee MS, Jeong D, Ryu J, Ko Y, Choi YJ, Lee JW. | 01/14/2012 |
| TM4SF5 expression appeared to cause loss of cell-cell adhesions via proteasome suppression and thereby proteasome inhibition | Proteasome inhibition causes epithelial-mesenchymal transition upon TM4SF5 expression.
Kim JY, Nam JK, Lee SA, Lee MS, Cho SK, Park ZY, Lee JW, Cho M. | 06/18/2011 |
| TM4SF5 plays a central regulatory role in a wide variety of physiological processes through cross-talk with integrins.[review] | Modulation of signaling between TM4SF5 and integrins in tumor microenvironment.
Lee SA, Park KH, Lee JW. | 04/23/2011 |
| Data show that TM4SF5 expression facilitated migration, invadopodia formation, MMP activation, invasion, and eventually lung metastasis in vitro and in nude mice, but suppression of TM4SF5 with its shRNA blocked the effects. | Transmembrane 4 L six family member 5 (TM4SF5) enhances migration and invasion of hepatocytes for effective metastasis.
Lee SA, Kim TY, Kwak TK, Kim H, Kim S, Lee HJ, Kim SH, Park KH, Kim HJ, Cho M, Lee JW. | 02/26/2011 |