| Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm. | Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm.
Chen J, Sun M, Chen C, Jiang B, Fang Y., Free PMC Article | 11/5/2022 |
| Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer. | Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer.
Zhu T, Cen Y, Chen Z, Zhang Y, Zhao L, Wang J, Lu W, Xie X, Wang X., Free PMC Article | 06/11/2022 |
| Refining the domain architecture model of the replication origin firing factor Treslin/TICRR. | Refining the domain architecture model of the replication origin firing factor Treslin/TICRR.
Ferreira P, Sanchez-Pulido L, Marko A, Ponting CP, Boos D., Free PMC Article | 04/2/2022 |
| The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase. | The CRL4DTL E3 ligase induces degradation of the DNA replication initiation factor TICRR/TRESLIN specifically during S phase.
Wittig KA, Sansam CG, Noble TD, Goins D, Sansam CL., Free PMC Article | 12/18/2021 |
| Overexpression of TICRR and PPIF confer poor prognosis in endometrial cancer identified by gene co-expression network analysis. | Overexpression of TICRR and PPIF confer poor prognosis in endometrial cancer identified by gene co-expression network analysis.
Yang L, Cui Y, Sun X, Wang Y., Free PMC Article | 08/21/2021 |
| Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication. | Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication.
Kumagai A, Dunphy WG., Free PMC Article | 05/8/2021 |
| The conserved C-terminal domain of DUE-B is required for its binding to TopBP1, Treslin, Cdc45, and the MCM2-7 complex, as well as for the efficient loading of Treslin, Cdc45, and TopBP1 on chromatin | Interaction between DUE-B and Treslin is required to load Cdc45 on chromatin in human cells.
Poudel S, Yao J, Kemp MG, Leffak M., Free PMC Article | 04/13/2019 |
| these data uncover two distinct mechanisms by which mutp53 enhances DNA replication: (i) Both contact and conformational mutp53s can bind TopBP1 and attenuate the checkpoint response to replication stress, and (ii) during normal growth, contact (but not conformational) mutp53s can override the Cdk2 requirement to promote replication by facilitating the TopBP1/Treslin interaction. | Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.
Liu K, Lin FT, Graves JD, Lee YJ, Lin WC., Free PMC Article | 04/28/2018 |
| The extended S phase in Ensa-depleted cells is completely rescued by the overexpression of Treslin. | Ensa controls S-phase length by modulating Treslin levels.
Charrasse S, Gharbi-Ayachi A, Burgess A, Vera J, Hached K, Raynaud P, Schwob E, Lorca T, Castro A., Free PMC Article | 02/24/2018 |
| Variation at rs12913965 may affect the risk for shoulder dislocation by affecting the activity of either TICRR or ISG20. | A Genetic Marker Associated with Shoulder Dislocation.
Kim S, Kleimeyer JP, Ahmed MA, Avins AL, Fredericson M, Dragoo JL, Ioannidis JPA. | 09/23/2017 |
| phosphorylated TICRR is limiting for S-phase progression | Cyclin-dependent kinase regulates the length of S phase through TICRR/TRESLIN phosphorylation.
Sansam CG, Goins D, Siefert JC, Clowdus EA, Sansam CL., Free PMC Article | 04/25/2015 |
| Treslin is a dual replication/checkpoint protein that directly participates in ATR-mediated checkpoint signaling | Direct role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint response.
Hassan BH, Lindsey-Boltz LA, Kemp MG, Sancar A., Free PMC Article | 09/14/2013 |
| MTBP acts with Treslin/TICRR to integrate signals from cell cycle and DNA damage response pathways to control the initiation of DNA replication in human cells. | Identification of a heteromeric complex that promotes DNA replication origin firing in human cells.
Boos D, Yekezare M, Diffley JF. | 06/15/2013 |
| Results indicate that Cdk-mediated phosphorylation of Treslin during S phase is necessary for both its effective association with TopBP1 and its ability to promote DNA replication in human cells. | Direct regulation of Treslin by cyclin-dependent kinase is essential for the onset of DNA replication.
Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Free PMC Article | 09/24/2011 |
| TICRR acts in association with TopBP1 and plays an essential role in preinitiation complex formation [TICRR = TopBP1-interacting, checkpoint, and replication regulator] | A vertebrate gene, ticrr, is an essential checkpoint and replication regulator.
Sansam CL, Cruz NM, Danielian PS, Amsterdam A, Lau ML, Hopkins N, Lees JA., Free PMC Article | 10/28/2010 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Results indicate that Treslin and TopBP1 collaborate in the Cdk2-mediated loading of Cdc45 onto replication origins; treslin regulates a pivotal step in the initiation of DNA replication in vertebrates. | Treslin collaborates with TopBP1 in triggering the initiation of DNA replication.
Kumagai A, Shevchenko A, Shevchenko A, Dunphy WG., Free PMC Article | 03/8/2010 |