| GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4 via the JAK2-STAT3 pathway. | GPRC5A promotes gallbladder cancer metastasis by upregulating TNS4 via the JAK2-STAT3 pathway.
Yang J, Li X, Chen S, Li G, Pu P, Yang Y, Wu W, Geng Y, Liu Y. | 09/24/2024 |
| GPRC5A promotes paclitaxel resistance and glucose content in NSCLC. | GPRC5A promotes paclitaxel resistance and glucose content in NSCLC.
Wang Y, Gao L, Wang F, Yu C, Chen C, Xia C. | 08/7/2024 |
| Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation. | Influence of GPRC5A-Regulated ABCB1 Expression on Lung Adenocarcinoma Proliferation.
Li Y, Cui WW, Yang ZF, Liu WH, Bian MW, Deng J, Wang T. | 05/7/2024 |
| [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts]. | [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts].
Hu YH, Shang LL, Ge SH. | 05/1/2024 |
| Deciphering the molecular regulatory of RAB32/GPRC5A axis in chronic obstructive pulmonary disease. | Deciphering the molecular regulatory of RAB32/GPRC5A axis in chronic obstructive pulmonary disease.
Wu Y, He B, Hua J, Hu W, Han Y, Zhang J., Free PMC Article | 03/12/2024 |
| The G protein-coupled receptor GPRC5A-a phorbol ester and retinoic acid-induced orphan receptor with roles in cancer, inflammation, and immunity. | The G protein-coupled receptor GPRC5A-a phorbol ester and retinoic acid-induced orphan receptor with roles in cancer, inflammation, and immunity.
Iglesias González PA, Valdivieso AG, Santa-Coloma TA. | 12/15/2023 |
| RAI3 expression is not associated with clinical outcomes of patients with non-small cell lung cancer. | RAI3 expression is not associated with clinical outcomes of patients with non-small cell lung cancer.
Melling N, Reeh M, Ghadban T, Tachezy M, Hajek A, Izbicki JR, Grupp K., Free PMC Article | 07/31/2023 |
| Knockdown of GPRC5A inhibits cell proliferation, migration and invasion in osteosarcoma. | Knockdown of GPRC5A inhibits cell proliferation, migration and invasion in osteosarcoma.
Wang YJ, Lin SH, Chen L, Qiu HW, Wang JX. | 10/30/2021 |
| Prognostic and clinicopathological significance of GPRC5A in various cancers: A systematic review and meta-analysis. | Prognostic and clinicopathological significance of GPRC5A in various cancers: A systematic review and meta-analysis.
Dai L, Jin X, Liu Z., Free PMC Article | 10/16/2021 |
| GPRC5a suppresses the proliferation of non-small cell lung cancer under wild type p53 background. | GPRC5a suppresses the proliferation of non-small cell lung cancer under wild type p53 background.
Er J, Chao L, Yiwei L, Feng X, Fei Z, Kan W, Ruifei X. | 08/21/2021 |
| Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer. | Adaptive RSK-EphA2-GPRC5A signaling switch triggers chemotherapy resistance in ovarian cancer.
Moyano-Galceran L, Pietilä EA, Turunen SP, Corvigno S, Hjerpe E, Bulanova D, Joneborg U, Alkasalias T, Miki Y, Yashiro M, Chernenko A, Jukonen J, Singh M, Dahlstrand H, Carlson JW, Lehti K., Free PMC Article | 07/31/2021 |
| RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A. | RhoA/C inhibits proliferation by inducing the synthesis of GPRC5A.
Richter L, Oberländer V, Schmidt G., Free PMC Article | 12/12/2020 |
| Identification of Sca-1(+)Abcg1(+) bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells. | Identification of Sca-1(+)Abcg1(+) bronchioalveolar epithelial cells as the origin of lung adenocarcinoma in Gprc5a-knockout mouse model through the interaction between lung progenitor AT2 and Lgr5 cells.
Yin H, Jiang Z, Feng X, Ji Z, Jin W., Free PMC Article | 12/5/2020 |
| RAI3 knockdown enhances osteogenic differentiation of bone marrow mesenchymal stem cells via STAT3 signaling pathway. | RAI3 knockdown enhances osteogenic differentiation of bone marrow mesenchymal stem cells via STAT3 signaling pathway.
Jin C, Zhu Y, Wu Y, Tang Z, Tao L, Wei Y. | 10/24/2020 |
| GPRC5A reduction contributes to pollutant benzo[a]pyrene injury via aggravating murine fibrosis, leading to poor prognosis of IIP patients. | GPRC5A reduction contributes to pollutant benzo[a]pyrene injury via aggravating murine fibrosis, leading to poor prognosis of IIP patients.
Huang Z, Wang S, Liu Y, Fan L, Zeng Y, Han H, Zhang H, Yu X, Zhang Y, Huang D, Wu Y, Jiang W, Zhu P, Zhu X, Yi X. | 08/29/2020 |
| RNA-seq revealed that GPRC5A KO PC3 cells had dysregulated expression of cell cycle-related genes, leading to cell cycle arrest at the G2/M phase. Furthermore, the registered gene expression profile data set showed that the expression level of GPRC5A in original lesions of prostate cancer patients with bone metastasis was higher than that without bone metastasis. | GPRC5A facilitates cell proliferation through cell cycle regulation and correlates with bone metastasis in prostate cancer.
Sawada Y, Kikugawa T, Iio H, Sakakibara I, Yoshida S, Ikedo A, Yanagihara Y, Saeki N, Győrffy B, Kishida T, Okubo Y, Nakamura Y, Miyagi Y, Saika T, Imai Y. | 02/8/2020 |
| Our findings demonstrated that miR342 regulates the cell proliferation of glioma by targeting GPRC5A, which indicates that miR342 is a target of interest regarding the treatment of refractory glioma, and it may provide a promising prognostic and therapeutic strategy for glioma treatment. | miR‑342 inhibits glioma cell proliferation by targeting GPRC5A.
Wang J, Yang Y, Cao Y, Tang X., Free PMC Article | 11/30/2019 |
| On the basis of our findings in human DN and in Gprc5a deficient mice, we believe that chronic reduction in Gprc5a expression plays a pathogenic role in the progression of DN. Results in cell culture support our other findings in mice showing that Gprc5a modulates EGFR and TGF-b signaling in podocytes. | Depletion of Gprc5a Promotes Development of Diabetic Nephropathy.
Ma X, Schwarz A, Sevilla SZ, Levin A, Hultenby K, Wernerson A, Lal M, Patrakka J., Free PMC Article | 09/14/2019 |
| The lung tumor suppressor gene GPRC5A played a protective role in cigarette smoke-induced lung tumor initiation. | Gprc5a depletion enhances the risk of smoking-induced lung tumorigenesis and mortality.
Guo W, Hu M, Wu J, Zhou A, Liao Y, Song H, Xu D, Kuang Y, Wang T, Jing B, Li K, Ling J, Wen D, Wu W. | 08/31/2019 |
| RAI3 overexpression is associated with poor prognosis in esophageal cancers | High levels of RAI3 expression is linked to shortened survival in esophageal cancer patients.
El Gammal AT, Melling N, Reeh M, Gebauer F, Mann O, Perez D, Bockhorn M, Bachmann K, Izbicki JR, Grupp K. | 04/6/2019 |
| GPRC5a was upregulated in pancreatic cancer (PaCa) leading to an enhanced drug resistance in PaCa cells. | The Effect of GPRC5a on the Proliferation, Migration Ability, Chemotherapy Resistance, and Phosphorylation of GSK-3β in Pancreatic Cancer.
Liu B, Yang H, Pilarsky C, Weber GF., Free PMC Article | 10/20/2018 |
| under-expressed GPRC5A during lung tumorigenesis enhances any transcriptional stimulation through an active translational status. | GPRC5A suppresses protein synthesis at the endoplasmic reticulum to prevent radiation-induced lung tumorigenesis.
Wang J, Farris AB, Xu K, Wang P, Zhang X, Duong DM, Yi H, Shu HK, Sun SY, Wang Y., Free PMC Article | 09/8/2018 |
| findings reveal an unprecedented role for GPRC5A in regulation of the ITGB1-mediated cell adhesion and it's downstream signaling, thus indicating a potential novel role for GPRC5A in human epithelial cancers. | Orphan G protein-coupled receptor GPRC5A modulates integrin β1-mediated epithelial cell adhesion.
Bulanova DR, Akimov YA, Rokka A, Laajala TD, Aittokallio T, Kouvonen P, Pellinen T, Kuznetsov SG., Free PMC Article | 09/1/2018 |
| miR-204 inhibits cell proliferation in gastric cancer by targeting CKS1B, CXCL1 and GPRC5A. | Integrated MicroRNA-mRNA Analysis Reveals miR-204 Inhibits Cell Proliferation in Gastric Cancer by Targeting CKS1B, CXCL1 and GPRC5A.
Shrestha S, Yang CD, Hong HC, Chou CH, Tai CS, Chiew MY, Chen WL, Weng SL, Chen CC, Chang YA, Lee ML, Huang WY, Hsu SD, Chen YC, Huang HD., Free PMC Article | 07/28/2018 |
| p53 overexpression and GPRC5A induction markedly inhibited tumor cell viability and induced apoptosis. | Lung cancer suppressor gene GPRC5A mediates p53 activity in non‑small cell lung cancer cells in vitro.
Jin E, Wang W, Fang M, Wang L, Wu K, Zhang Y, Zhang S, Ma S. | 06/16/2018 |