| Correlation of 3'-phosphoadenosine-5'-phosphosulfate synthase 1 (PAPSS1) expression with clinical parameters and prognosis in esophageal squamous cell carcinoma. | Correlation of 3'-phosphoadenosine-5'-phosphosulfate synthase 1 (PAPSS1) expression with clinical parameters and prognosis in esophageal squamous cell carcinoma.
Zhu X, Zhu P, Chen X, Zhang L, Wu C, Zhang H, Shen X, Qi Y, Chen M, Wang S, Yi X. | 02/21/2024 |
| The PAPSS1 gene is a modulator of response to cisplatin by regulating estrogen receptor alpha signaling activity in ovarian cancer cells. | The PAPSS1 gene is a modulator of response to cisplatin by regulating estrogen receptor alpha signaling activity in ovarian cancer cells.
Sun L, Ji WX, Li Y, Li ZL, Duan CC, Xia BR, Xiao L., Free PMC Article | 09/11/2023 |
| These results suggest that PAPSS1 inhibition enhances cisplatin activity in multiple preclinical model systems and that low PAPSS1 expression may serve as a biomarker for platin sensitivity in cancer patients. Developing strategies to target PAPSS1 activity in conjunction with platinum-based chemotherapy may offer an approach to improving treatment outcomes | In Vivo Validation of PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) as a Cisplatin-sensitizing Therapeutic Target.
Leung AWY, Veinotte CJ, Melong N, Oh MH, Chen K, Enfield KSS, Backstrom I, Warburton C, Yapp D, Berman JN, Bally MB, Lockwood WW. | 07/28/2018 |
| we found that ectopic expression of oncogenic KRas and HRas in cells resulted in elevated CIB1 expression. We previously described the Ca(2+)-myristoyl switch function of CIB1, and its ability to facilitate agonist-induced plasma membrane localisation of sphingosine kinase 1 (SK1), a location where SK1 is known to elicit oncogenic signalling. | CIB1 contributes to oncogenic signalling by Ras via modulating the subcellular localisation of sphingosine kinase 1.
Zhu W, Gliddon BL, Jarman KE, Moretti PAB, Tin T, Parise LV, Woodcock JM, Powell JA, Ruszkiewicz A, Pitman MR, Pitson SM., Free PMC Article | 09/9/2017 |
| These data indicate that knocking down PAPSS increases UGT2B4 transcription and mRNA stability as a compensatory response to the loss of SULT2A1 activity | Upregulation of UGT2B4 Expression by 3'-Phosphoadenosine-5'-Phosphosulfate Synthase Knockdown: Implications for Coordinated Control of Bile Acid Conjugation.
Barrett KG, Fang H, Cukovic D, Dombkowski AA, Kocarek TA, Runge-Morris M., Free PMC Article | 02/20/2016 |
| leptin signalling links a novel SFK/ERK1/2-mediated pathway and SK1 expression. | Leptin induces upregulation of sphingosine kinase 1 in oestrogen receptor-negative breast cancer via Src family kinase-mediated, janus kinase 2-independent pathway.
Alshaker H, Krell J, Frampton AE, Waxman J, Blyuss O, Zaikin A, Winkler M, Stebbing J, Yagüe E, Pchejetski D., Free PMC Article | 08/1/2015 |
| SK1 positivity and high expression were significantly associated with cancer and a shorter 5-year and overall survival. | Sphingosine kinase 1 and cancer: a systematic review and meta-analysis.
Zhang Y, Wang Y, Wan Z, Liu S, Cao Y, Zeng Z., Free PMC Article | 11/8/2014 |
| study showed expression patterns of SULT1E1 and PAPSS in breast and endometrial tissues; the estrogen sulfation enzymes were comparatively higher in the tumorous tissues than adjacent normal tissues; overexpression of SULT1E1 and PAPSS1 retarded MCF-7 cells growth in vivo and in vitro by arresting cell cycles and inducing apoptosis | Effect of estrogen sulfation by SULT1E1 and PAPSS on the development of estrogen-dependent cancers.
Xu Y, Liu X, Guo F, Ning Y, Zhi X, Wang X, Chen S, Yin L, Li X., Free PMC Article | 11/24/2012 |
| Unusual localisation signals of both PAPS synthase isoforms, are described. | Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm.
Schröder E, Gebel L, Eremeev AA, Morgner J, Grum D, Knauer SK, Bayer P, Mueller JW., Free PMC Article | 05/12/2012 |
| SK1 plays an essential role in regulating in vitro paracrine angiogenesis and lymphangiogenesis. | Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.
Anelli V, Gault CR, Snider AJ, Obeid LM., Free PMC Article | 09/13/2010 |
| PAPSS1 maps to chromosome 4q25 and may havea role in hepatocellular carcinoma | Evidence for association with hepatocellular carcinoma at the PAPSS1 locus on chromosome 4q25 in a family-based study.
Shih WL, Yu MW, Chen PJ, Wu TW, Lin CL, Liu CJ, Lin SM, Tai DI, Lee SD, Liaw YF, Shih WL, Yu MW, Chen PJ, Wu TW, Lin CL, Liu CJ, Lin SM, Tai DI, Lee SD, Liaw YF., Free PMC Articles: PMC2986632, PMC2986632 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesA systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts.
Kalsi G, Kuo PH, Aliev F, Alexander J, McMichael O, Patterson DG, Walsh D, Zhao Z, Schuckit M, Nurnberger J Jr, Edenberg H, Kramer J, Hesselbrock V, Tischfield JA, Vladimirov V, Prescott CA, Dick DM, Kendler KS, Riley BP. Evidence for association with hepatocellular carcinoma at the PAPSS1 locus on chromosome 4q25 in a family-based study.
Shih WL, Yu MW, Chen PJ, Wu TW, Lin CL, Liu CJ, Lin SM, Tai DI, Lee SD, Liaw YF, Shih WL, Yu MW, Chen PJ, Wu TW, Lin CL, Liu CJ, Lin SM, Tai DI, Lee SD, Liaw YF. | 04/22/2009 |
| a role for PAPSS1 in the cellular sulfonation pathway requirement at a stage during or shortly after MLV provirus establishment, and subsequent influence on gene expression from the viral long terminal repeat promoter | The host cell sulfonation pathway contributes to retroviral infection at a step coincident with provirus establishment.
Bruce JW, Ahlquist P, Young JA., Free PMC Article | 01/21/2010 |
| ATP-sulfurylase domain of PAPS synthetase influences these elements in adenylylsulfate kinase, which may be a mechanism between both domains the this bifunctional enzyme | Structural mechanism for substrate inhibition of the adenosine 5'-phosphosulfate kinase domain of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 and its ramifications for enzyme regulation.
Sekulic N, Konrad M, Lavie A. | 01/21/2010 |
| characterization and expression of bifunctional isoforms | Characterization and expression of human bifunctional 3'-phosphoadenosine 5'-phosphosulphate synthase isoforms.
Fuda H, Shimizu C, Lee YC, Akita H, Strott CA., Free PMC Article | 01/21/2010 |
| Results describe the crystal structure of human PAPSS1 at 1.8 angstroms resolution. | The crystal structure of human PAPS synthetase 1 reveals asymmetry in substrate binding.
Harjes S, Bayer P, Scheidig AJ. | 01/21/2010 |
| review of PAPSS biochemistry, molecular biology and genetics | Human 3'-phosphoadenosine 5'-phosphosulfate (PAPS) synthase: biochemistry, molecular biology and genetic deficiency.
Venkatachalam KV. | 01/21/2010 |
| x-ray crystallographic analysis of 3'-phosphoadenosine-5'-phosphosulfate synthetase 1 | Expression, purification and crystallization of human 3'-phosphoadenosine-5'-phosphosulfate synthetase 1.
Harjes S, Scheidig A, Bayer P. | 01/21/2010 |
| The kinetic characteristics of the individual sulfurylase and kinase activities of PAPSS isoform 1, the predominant form in human brain, are described. | Human 3'-phosphoadenosine 5'-phosphosulfate synthetase (isoform 1, brain): kinetic properties of the adenosine triphosphate sulfurylase and adenosine 5'-phosphosulfate kinase domains.
Lansdon EB, Fisher AJ, Segel IH. | 01/21/2010 |