| dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe. | dsRNAi-mediated silencing of PIAS2beta specifically kills anaplastic carcinomas by mitotic catastrophe.
Rodrigues JS, Chenlo M, Bravo SB, Perez-Romero S, Suarez-Fariña M, Sobrino T, Sanz-Pamplona R, González-Prieto R, Blanco Freire MN, Nogueiras R, López M, Fugazzola L, Cameselle-Teijeiro JM, Alvarez CV., Free PMC Article | 07/15/2024 |
| Integrative transcriptome analysis reveals TEKT2 and PIAS2 involvement in diabetic nephropathy. | Integrative transcriptome analysis reveals TEKT2 and PIAS2 involvement in diabetic nephropathy.
Li Y, Lin H, Shu S, Sun Y, Lai W, Chen W, Hu Z, Peng H. | 10/22/2022 |
| Expression of PIAS Genes in Migraine Patients. | Expression of PIAS Genes in Migraine Patients.
Ghafouri-Fard S, Hesami O, Nazer N, Sayad A, Taheri M. | 02/5/2022 |
| PIAS2-mediated blockade of IFN-beta signaling: a basis for sporadic Parkinson disease dementia. | PIAS2-mediated blockade of IFN-β signaling: a basis for sporadic Parkinson disease dementia.
Magalhaes J, Tresse E, Ejlerskov P, Hu E, Liu Y, Marin A, Montalant A, Satriano L, Rundsten CF, Carlsen EMM, Rydbirk R, Sharifi-Zarchi A, Andersen JB, Aznar S, Brudek T, Khodosevich K, Prinz M, Perrier JM, Sharma M, Gasser T, Issazadeh-Navikas S., Free PMC Article | 02/5/2022 |
| SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation. | SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation.
Wu R, Fang J, Liu M, A J, Liu J, Chen W, Li J, Ma G, Zhang Z, Zhang B, Fu L, Dong JT., Free PMC Article | 12/26/2020 |
| PIAS genes as disease markers in bipolar disorder. | PIAS genes as disease markers in bipolar disorder.
Sayad A, Taheri M, Azari I, Oskoei VK, Ghafouri-Fard S. | 08/15/2020 |
| We are the first to reveal that mutations of rs644731 in the PIAS2 gene were significantly correlated with the progression of interstitial fibrosis and tubular atrophy in kidney transplant recipients. | Single Nucleotide Polymorphisms of Ubiquitin-Related Genes were Associated with Allograft Fibrosis of Renal Transplant Fibrosis.
Gui Z, Li W, Fei S, Guo M, Chen H, Sun L, Han Z, Tao J, Ju X, Yang H, Wei JF, Tan R, Gu M., Free PMC Article | 03/14/2020 |
| the results presented demonstrate that in heat-stressed HeLa cells, p38 MAPK pathway-dependent SUMOylation of Elk-1 and phosphorylation of PIAS2 correlate with the downregulation of transactivation by Elk-1. | p38 MAPK pathway-dependent SUMOylation of Elk-1 and phosphorylation of PIAS2 correlate with the downregulation of Elk-1 activity in heat-stressed HeLa cells.
Chowdhury D, Singh A, Gupta A, Tulsawani R, Meena RC, Chakrabarti A., Free PMC Article | 08/31/2019 |
| PIAS1expression of PIAS1 gene was increased in patients with MS compared to healthy subjects; also, there was a significant correlation between the expression of PIAS1 and PIAS2 genes with disease severity of multiple sclerosis | The investigation of relevancy between PIAS1 and PIAS2 gene expression and disease severity of multiple sclerosis.
Kouchaki E, Nikoueinejad H, Akbari H, Azimi S, Behnam M. | 08/17/2019 |
| results indicated that PIAS2-mediated SUMOylation constrained HCV replication | Protein Inhibitor of Activated STAT2 Restricts HCV Replication by Modulating Viral Proteins Degradation.
Guo J, Chen D, Gao X, Hu X, Zhou Y, Wu C, Wang Y, Chen J, Pei R, Chen X., Free PMC Article | 05/26/2018 |
| the expression of SENP8, SAE1, PIAS1, PIAS2 and ZMIZ1 is deregulated in the majority of PTC tissues, likely contributing to the PTC phenotype. | PAPILLARY THYROID CANCER IS CHARACTERIZED BY ALTERED EXPRESSION OF GENES INVOLVED IN THE SUMOYLATION PROCESS.
Tuccilli C, Baldini E, Sorrenti S, Di Gioia C, Bosco D, Ascoli V, Mian C, Barollo S, Rendina R, Coccaro C, Pepe M, Catania A, Bononi M, Tartaglia F, De Antoni E, D'Armiento M, Ulisse S. | 11/21/2015 |
| UXT is a binding protein of PIAS2, and interaction between PIAS2 and UXT may be important for the transcriptional activation of AR. | Ubiquitously expressed transcript is a novel interacting protein of protein inhibitor of activated signal transducer and activator of transcription 2.
Kong X, Ma S, Guo J, Ma Y, Hu Y, Wang J, Zheng Y., Free PMC Article | 09/26/2015 |
| PIASxalpha is a novel SUMO E3 ligase for PTEN, and it positively regulates PTEN protein level in tumor suppression. | PIASxα ligase enhances SUMO1 modification of PTEN protein as a SUMO E3 ligase.
Wang W, Chen Y, Wang S, Hu N, Cao Z, Wang W, Tong T, Zhang X., Free PMC Article | 04/12/2014 |
| These findings suggest that SUMO-1 modification of MDA5 possibly via PIAS2beta may play a role in the MDA5-mediated interferon response to viral infections. | MDA5 is SUMOylated by PIAS2β in the upregulation of type I interferon signaling.
Fu J, Xiong Y, Xu Y, Cheng G, Tang H., Free PMC Article | 02/5/2011 |
| the repressive properties of PIASxalpha/ARIP3 require its physical interaction with FLI-1, identifying PIASxalpha as a novel corepressor of FLI-1 | FLI-1 functionally interacts with PIASxalpha, a member of the PIAS E3 SUMO ligase family.
van den Akker E, Ano S, Shih HM, Wang LC, Pironin M, Palvimo JJ, Kotaja N, Kirsh O, Dejean A, Ghysdael J. | 01/21/2010 |
| PIASx may function as a co-repressor of Stat4 | PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4.
Arora T, Liu B, He H, Kim J, Murphy TL, Murphy KM, Modlin RL, Shuai K. | 01/21/2010 |
| Required for upregulation of a large group of genes in response to DNA damage, a function that is regulated by c-Myc, but not by 14-3-3eta and represses the expression of many genes | Akt and 14-3-3eta regulate Miz1 to control cell-cycle arrest after DNA damage.
Wanzel M, Kleine-Kohlbrecher D, Herold S, Hock A, Berns K, Park J, Hemmings B, Eilers M. | 01/21/2010 |
| PIASxalpha acts as a key signal integrator that permits different responses from the same transcription factor, depending on the signaling pathway that is activated. | PIASxalpha differentially regulates the amplitudes of transcriptional responses following activation of the ERK and p38 MAPK pathways.
Yang SH, Sharrocks AD. | 01/21/2010 |
| findings show that Epstein-Barr virus Rta interacts and colocalizes with PIASxalpha and PIASxbeta in the nucleus; these interactions seem to enhance Rta sumoylation | Sumoylation of Rta of Epstein-Barr virus is preferentially enhanced by PIASxbeta.
Liu ST, Wang WH, Hong YR, Chuang JY, Lu PJ, Chang LK. | 01/21/2010 |